LOCUS       NM_010489               1879 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus hyaluronoglucosaminidase 2 (Hyal2), transcript variant
            1, mRNA.
ACCESSION   NM_010489
VERSION     NM_010489.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   Huang,H., Hu,X., Wu,J., Song,C., Tian,Z. and Jiang,B.
  TITLE     Hyaluronan degradation by HYAL2 is essential for odontoblastic
            differentiation and migration of mouse dental papilla cells
  JOURNAL   Matrix Biol 129, 1-14 (2024)
   PUBMED   38490466
  REMARK    GeneRIF: Hyaluronan degradation by HYAL2 is essential for
            odontoblastic differentiation and migration of mouse dental papilla
            cells.
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Petrey,A.C., Obery,D.R., Kessler,S.P., Zawerton,A., Flamion,B. and
            de la Motte,C.A.
  TITLE     Platelet hyaluronidase-2 regulates the early stages of inflammatory
            disease in colitis
  JOURNAL   Blood 134 (9), 765-775 (2019)
   PUBMED   31262781
  REMARK    GeneRIF: Mice deficient in HYAL2 are more susceptible to an acute
            model of colitis, and this increased susceptibility is abrogated by
            transfusion of HYAL2-competent platelets.
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Sandireddy,R., Cibi,D.M., Gupta,P., Singh,A., Tee,N., Uemura,A.,
            Epstein,J.A. and Singh,M.K.
  TITLE     Semaphorin 3E/PlexinD1 signaling is required for cardiac
            ventricular compaction
  JOURNAL   JCI Insight 4 (16), 125908 (2019)
   PUBMED   31434798
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1879)
  AUTHORS   Del Monte-Nieto,G., Ramialison,M., Adam,A.A.S., Wu,B., Aharonov,A.,
            D'Uva,G., Bourke,L.M., Pitulescu,M.E., Chen,H., de la Pompa,J.L.,
            Shou,W., Adams,R.H., Harten,S.K., Tzahor,E., Zhou,B. and
            Harvey,R.P.
  TITLE     Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the
            building plan for trabeculation
  JOURNAL   Nature 557 (7705), 439-445 (2018)
   PUBMED   29743679
REFERENCE   5  (bases 1 to 1879)
  AUTHORS   Higuchi,Y., Nishida,Y., Kozawa,E., Zhuo,L., Arai,E., Hamada,S.,
            Morita,D., Ikuta,K., Kimata,K., Ushida,T. and Ishiguro,N.
  TITLE     Conditional knockdown of hyaluronidase 2 in articular cartilage
            stimulates osteoarthritic progression in a mice model
  JOURNAL   Sci Rep 7 (1), 7028 (2017)
   PUBMED   28765635
  REMARK    GeneRIF: Knockdown of Hyal2 in articular cartilage induced
            osteoarthritis development and progression possibly mediated by an
            imbalance of hyaluronan metabolism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1879)
  AUTHORS   Shuttleworth,T.L., Wilson,M.D., Wicklow,B.A., Wilkins,J.A. and
            Triggs-Raine,B.L.
  TITLE     Characterization of the murine hyaluronidase gene region reveals
            complex organization and cotranscription of Hyal1 with downstream
            genes, Fus2 and Hyal3
  JOURNAL   J Biol Chem 277 (25), 23008-23018 (2002)
   PUBMED   11929860
REFERENCE   7  (bases 1 to 1879)
  AUTHORS   Chang,N.S.
  TITLE     Transforming growth factor-beta1 blocks the enhancement of tumor
            necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929
            fibroblasts
  JOURNAL   BMC Cell Biol 3, 8 (2002)
   PUBMED   11960552
  REMARK    GeneRIF: Hyal-2 enhancement of tumor necrosis
            factor-alpha-stimulated cytotoxicity in fibroblasts is blocked by
            Transforming growth factor-beta1.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1879)
  AUTHORS   Lepperdinger,G., Mullegger,J. and Kreil,G.
  TITLE     Hyal2--less active, but more versatile?
  JOURNAL   Matrix Biol 20 (8), 509-514 (2001)
   PUBMED   11731268
  REMARK    Review article
REFERENCE   9  (bases 1 to 1879)
  AUTHORS   Rai,S.K., Duh,F.M., Vigdorovich,V., Danilkovitch-Miagkova,A.,
            Lerman,M.I. and Miller,A.D.
  TITLE     Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol
            (GPI)-anchored cell-surface receptor for jaagsiekte sheep
            retrovirus, the envelope protein of which mediates oncogenic
            transformation
  JOURNAL   Proc Natl Acad Sci U S A 98 (8), 4443-4448 (2001)
   PUBMED   11296287
REFERENCE   10 (bases 1 to 1879)
  AUTHORS   Strobl,B., Wechselberger,C., Beier,D.R. and Lepperdinger,G.
  TITLE     Structural organization and chromosomal localization of Hyal2, a
            gene encoding a lysosomal hyaluronidase
  JOURNAL   Genomics 53 (2), 214-219 (1998)
   PUBMED   9790770
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672219.7.
            
            On Jul 21, 2022 this sequence version replaced NM_010489.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088806.1, AK133886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AL672219.7         142275-142382
            109-1075            AL672219.7         143253-144219
            1076-1165           AL672219.7         144641-144730
            1166-1879           AL672219.7         145207-145920
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.12 cM"
     gene            1..1879
                     /gene="Hyal2"
                     /note="hyaluronoglucosaminidase 2"
                     /db_xref="GeneID:15587"
                     /db_xref="MGI:MGI:1196334"
     exon            1..108
                     /gene="Hyal2"
                     /inference="alignment:Splign:2.1.0"
     exon            109..1075
                     /gene="Hyal2"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1576
                     /gene="Hyal2"
                     /EC_number="3.2.1.35"
                     /note="hyaluronidase-2; hyal-2"
                     /codon_start=1
                     /product="hyaluronidase-2 precursor"
                     /protein_id="NP_034619.2"
                     /db_xref="CCDS:CCDS23496.1"
                     /db_xref="GeneID:15587"
                     /db_xref="MGI:MGI:1196334"
                     /translation="MRAGLGPIITLALVLEVAWAGELKPTAPPIFTGRPFVVAWNVPT
                     QECAPRHKVPLDLRAFDVKATPNEGFFNQNITTFYYDRLGLYPRFDAAGTSVHGGVPQ
                     NGSLCAHLPMLKESVERYIQTQEPGGLAVIDWEEWRPVWVRNWQEKDVYRQSSRQLVA
                     SRHPDWPSDRVMKQAQYEFEFAARQFMLNTLRYVKAVRPQHLWGFYLFPDCYNHDYVQ
                     NWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSVHSRNFVSFRVREAL
                     RVAHTHHANHALPVYVFTRPTYTRGLTGLSQVDLISTIGESAALGSAGVIFWGDSEDA
                     SSMETCQYLKNYLTQLLVPYIVNVSWATQYCSWTQCHGHGRCVRRNPSANTFLHLNAS
                     SFRLVPGHTPSEPQLRPEGQLSEADLNYLQKHFRCQCYLGWGGEQCQRNYKGAAGNAS
                     RAWAGSHLTSLLGLVAVALTWTL"
     exon            1076..1165
                     /gene="Hyal2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1879
                     /gene="Hyal2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1863..1868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hyal2"
                     /note="hexamer: ATTAAA"
     polyA_site      1879
                     /gene="Hyal2"
                     /note="major polyA site"
ORIGIN      
        1 aacagaggct cgagctgggg cagtgcttgg gcgaagggcc ggatcgggct tggttggtac
       61 caggatggcg gcggccctgg cgtgggtcct ggtggcgcct ggttcgagtt cctgagctgc
      121 taccaggcag gtaacacttc ctgtagcccc cagcatgcgg gcaggactag gtcccatcat
      181 cacactggcc ctagtgctgg aggtagcatg ggccggggag cttaagccca cagcgccgcc
      241 catcttcact ggccgaccct ttgtggtagc atggaacgtg cccacacaag aatgtgcccc
      301 acgccacaaa gtgccactgg accttagggc cttcgatgtg aaggctacac cgaatgaggg
      361 ttttttcaac cagaatatca ccaccttcta ctacgaccgt ctaggcctgt atccacgttt
      421 tgatgcagcc gggacatctg tgcatggcgg tgtgcctcag aacggcagcc tctgtgcaca
      481 cctgcccatg ctgaaggaat ctgtggaacg ctacatccag acccaggagc ctggggggct
      541 ggcagtcatt gactgggagg aatggcggcc tgtatgggtt cgaaactggc aggagaaaga
      601 tgtttaccga cagtcttcac gccagctggt ggccagtcgg caccctgact ggccatcaga
      661 cagagtaatg aagcaggccc agtacgagtt tgagttcgcc gctcggcagt tcatgttgaa
      721 cactctccgt tacgtcaagg cagtcagacc ccagcacctg tggggcttct acctctttcc
      781 tgactgctac aatcacgatt atgtacagaa ctgggagagc tacacgggcc gctgtcccga
      841 tgtggaggtg gcacggaacg accagctggc ctggctctgg gctgagagca cggctctctt
      901 tccctctgtg tacctggacg agacactggc gtcctccgta cacagccgca actttgtcag
      961 tttccgtgtt cgggaggccc ttcgagtggc tcacacccac catgccaacc acgccctccc
     1021 cgtgtacgtc ttcacgcgtc ccacatacac ccgaggactc acgggactga gccaggtgga
     1081 ccttatctct accatcggtg agagtgccgc cctgggctca gctggcgtca tcttctgggg
     1141 cgactcggaa gacgcttcaa gtatggagac ctgccaatac ctcaagaatt acctaactca
     1201 gctgctggtt ccctacatag tcaacgtgtc ctgggccacc cagtattgca gttggaccca
     1261 gtgccatggc catgggcgat gtgtgcgccg caaccccagc gccaatacct tcctgcacct
     1321 caatgccagc agcttccgcc tagtgcctgg ccataccccc agtgaacccc agcttcgacc
     1381 cgaggggcag ctcagcgaag ccgacctcaa ctacctgcag aagcactttc gctgccagtg
     1441 ctatctgggc tggggtggcg agcagtgcca acggaactat aagggggcag ctggaaatgc
     1501 cagcagagcc tgggctggat cccacctcac cagcctgctg ggtttggtag ctgtggctct
     1561 cacctggacc ttatgaggga tctctccccc tggatatcag tccagctggc ctctggtgca
     1621 aggatctcct tggcatgagg ggcctgttag gggggagaca aaagtctgga gtaggcagtg
     1681 ctcccaggat gcttagcaga gcacccatac catctgtcac ccccctgttc taagggggag
     1741 agaaacatcc cctgagatgc cctcatcttg ccagagaaga tggagaatcg agctaggcca
     1801 gagaaggcct gactctactc cctgctcctg gatagtttat aattttgggg tctcttttgt
     1861 aaattaaata taaaacaac
//
