LOCUS       NM_008317               2995 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus hyaluronoglucosaminidase 1 (Hyal1), transcript variant
            1, mRNA.
ACCESSION   NM_008317
VERSION     NM_008317.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2995)
  AUTHORS   Huang,H., Hu,X., Wu,J., Song,C., Tian,Z. and Jiang,B.
  TITLE     Hyaluronan degradation by HYAL2 is essential for odontoblastic
            differentiation and migration of mouse dental papilla cells
  JOURNAL   Matrix Biol 129, 1-14 (2024)
   PUBMED   38490466
REFERENCE   2  (bases 1 to 2995)
  AUTHORS   Wang,X., Zhang,Y., Yu,J., Ma,Y., Xu,Y., Shi,J., Qi,Z. and Liu,X.
  TITLE     Identification and analysis of key circRNAs in the mouse embryonic
            ovary provides insight into primordial follicle development
  JOURNAL   BMC Genomics 25 (1), 139 (2024)
   PUBMED   38310234
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2995)
  AUTHORS   Xing,H., Li,S., Fu,Y., Wan,X., Zhou,A., Cao,F., Sun,Q., Hu,N.,
            Ma,M., Li,W. and Cao,C.
  TITLE     HYAL1 deficiency attenuates lipopolysaccharide-triggered renal
            injury and endothelial glycocalyx breakdown in septic AKI in mice
  JOURNAL   Ren Fail 45 (1), 2188966 (2023)
   PUBMED   37563795
  REMARK    GeneRIF: HYAL1 deficiency attenuates lipopolysaccharide-triggered
            renal injury and endothelial glycocalyx breakdown in septic AKI in
            mice.
REFERENCE   4  (bases 1 to 2995)
  AUTHORS   Puissant,E., Gilis,F., Tevel,V., Vandeweerd,J.M., Flamion,B.,
            Jadot,M. and Boonen,M.
  TITLE     Hyaluronidase 1 deficiency decreases bone mineral density in mice
  JOURNAL   Sci Rep 12 (1), 10142 (2022)
   PUBMED   35710820
  REMARK    GeneRIF: Hyaluronidase 1 deficiency decreases bone mineral density
            in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2995)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2995)
  AUTHORS   Shuttleworth,T.L., Wilson,M.D., Wicklow,B.A., Wilkins,J.A. and
            Triggs-Raine,B.L.
  TITLE     Characterization of the murine hyaluronidase gene region reveals
            complex organization and cotranscription of Hyal1 with downstream
            genes, Fus2 and Hyal3
  JOURNAL   J Biol Chem 277 (25), 23008-23018 (2002)
   PUBMED   11929860
  REMARK    GeneRIF: Characterization of the murine hyaluronidase gene region
            reveals complex organization and cotranscription of Hyal1 with
            downstream genes, Fus2 and Hyal3.
REFERENCE   7  (bases 1 to 2995)
  AUTHORS   De Maeyer,E. and De Maeyer-Guignard,J.
  TITLE     The growth rate of two transplantable murine tumors, 3LL lung
            carcinoma and B16F10 melanoma, is influenced by Hyal-1, a locus
            determining hyaluronidase levels and polymorphism
  JOURNAL   Int J Cancer 51 (4), 657-660 (1992)
   PUBMED   1601526
REFERENCE   8  (bases 1 to 2995)
  AUTHORS   De Maeyer-Guignard,J. and De Maeyer,E.
  TITLE     Linkage analysis of the Gi alpha 2 gene on mouse chromosome 9
  JOURNAL   Mamm Genome 3 (10), 601-603 (1992)
   PUBMED   1421769
REFERENCE   9  (bases 1 to 2995)
  AUTHORS   De Maeyer-Guignard,J., Cachard-Thomas,A. and De Maeyer,E.
  TITLE     Linkage analysis of the murine Hyal-1 locus on chromosome 9
  JOURNAL   J Exp Zool 258 (2), 246-248 (1991)
   PUBMED   2022949
REFERENCE   10 (bases 1 to 2995)
  AUTHORS   Fiszer-Szafarz,B. and De Maeyer,E.
  TITLE     Hyal-1, a locus determining serum hyaluronidase polymorphism, on
            chromosome 9 in mice
  JOURNAL   Somat Cell Mol Genet 15 (1), 79-83 (1989)
   PUBMED   2916164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672219.7.
            
            On May 14, 2019 this sequence version replaced NM_008317.5.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021636.1, AF422176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AL672219.7         150099-150227
            130-1053            AL672219.7         150702-151625
            1054-1143           AL672219.7         152030-152119
            1144-2995           AL672219.7         152249-154100
FEATURES             Location/Qualifiers
     source          1..2995
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.17 cM"
     gene            1..2995
                     /gene="Hyal1"
                     /gene_synonym="Fus2; Hya1; Hyal-1; Nat6"
                     /note="hyaluronoglucosaminidase 1"
                     /db_xref="GeneID:15586"
                     /db_xref="MGI:MGI:96298"
     exon            1..129
                     /gene="Hyal1"
                     /gene_synonym="Fus2; Hya1; Hyal-1; Nat6"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1458
                     /gene="Hyal1"
                     /gene_synonym="Fus2; Hya1; Hyal-1; Nat6"
                     /EC_number="3.2.1.35"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; hyaluronidase-1; N-acetyltransferase 6; Protein
                     fusion-2; Protein fus-2"
                     /codon_start=1
                     /product="hyaluronidase-1 isoform 1 precursor"
                     /protein_id="NP_032343.3"
                     /db_xref="CCDS:CCDS23497.1"
                     /db_xref="GeneID:15586"
                     /db_xref="MGI:MGI:96298"
                     /translation="MKPFSPEVSPGSSPATAGHLLRISTLFLTLLELAQVCRGSVVSN
                     RPFITVWNGDTHWCLTEYGVDVDVSVFDVVANKEQSFQGSNMTIFYREELGTYPYYTP
                     TGEPVFGGLPQNASLVTHLAHTFQDIKAAMPEPDFSGLAVIDWEAWRPRWAFNWDSKD
                     IYRQRSMELVQAEHPDWPETLVEAAAKNQFQEAAEAWMAGTLQLGQVLRPRGLWGYYG
                     FPDCYNNDFLSLNYTGQCPVFVRDQNDQLGWLWNQSYALYPSIYLPAALMGTEKSQMY
                     VRHRVQEALRVAIVSRDPHVPVMPYVQIFYEMTDYLLPLEELEHSLGESAAQGVAGAV
                     LWLSSDKTSTKESCQAIKAYMDSTLGPFIVNVTSAALLCSEALCSGHGRCVRHPSYPE
                     ALLTLNPASFSIELTHDGRPPSLKGTLSLKDRAQMAMKFRCRCYRGWRGKWCDKRGM"
     exon            130..1053
                     /gene="Hyal1"
                     /gene_synonym="Fus2; Hya1; Hyal-1; Nat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1143
                     /gene="Hyal1"
                     /gene_synonym="Fus2; Hya1; Hyal-1; Nat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..2995
                     /gene="Hyal1"
                     /gene_synonym="Fus2; Hya1; Hyal-1; Nat6"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2995
                     /gene="Hyal1"
                     /gene_synonym="Fus2; Hya1; Hyal-1; Nat6"
                     /note="major polyA site"
ORIGIN      
        1 agcagccgcc gcagcttctc taagctggtg caactaggac cagcttgcgg gacagaatcc
       61 ggccaagaca tgcttgggct tacacagcat gctcagaaag tttggagaat gaagcccttc
      121 agtcctgagg tttccccagg ctcatcccct gccaccgcag gccacctgct tcgcatctct
      181 actctcttcc tgactttgct cgagttggcc caagtctgca gaggttccgt ggtatccaac
      241 cggccattca tcactgtttg gaatggagac actcattggt gcctgacgga gtatggagtg
      301 gatgtggatg tcagtgtctt cgatgtggtt gccaacaagg agcagagttt ccaaggctct
      361 aacatgacaa ttttctacag agaggaattg ggcacctacc cctactatac acccacaggg
      421 gaacccgtat ttggtggtct gccccagaat gccagcctgg ttacccacct tgctcacaca
      481 ttccaggaca tcaaggctgc catgcctgaa cctgacttct caggactggc agtcattgat
      541 tgggaggctt ggcgcccacg gtgggccttc aactgggaca gcaaggacat ttatcggcag
      601 cgctcaatgg aactggtcca ggcagagcac cctgattggc cagaaacttt agtggaggca
      661 gcagccaaaa accagttcca ggaagctgca gaggcctgga tggcaggcac cctccaactg
      721 gggcaggtac tgcgtccccg tggcctctgg ggctactatg gcttccctga ctgctacaac
      781 aacgactttc taagtctcaa ctacacaggc cagtgcccag tattcgtccg tgatcagaac
      841 gaccagctag ggtggttgtg gaaccagagc tatgcccttt accccagtat ttatttgcct
      901 gcagcactga tgggcacaga gaagtcacag atgtacgttc gacaccgtgt gcaagaggcg
      961 ctccgtgtgg ctatagtttc cagagacccc catgtgcccg taatgcccta cgtccagatc
     1021 ttctatgaaa tgacagatta tcttctgccc ctggaggaac tggagcacag cctgggggag
     1081 agtgcagccc agggagtggc aggagcagtg ctctggctaa gctcagacaa aacaagtacc
     1141 aaggaatcat gccaggccat taaagcatac atggattcca cacttgggcc cttcatcgtg
     1201 aacgtgacca gtgcagctct tttgtgcagc gaagctctgt gttccggcca tggtcgctgt
     1261 gtccgccatc caagttatcc tgaggctctc ctcaccctca accctgccag tttctccatt
     1321 gagctaacac atgatggcag gcccccgagc ctcaagggta ccctctcact taaggaccgg
     1381 gcgcagatgg ctatgaaatt caggtgccga tgctaccgtg gatggagagg caagtggtgt
     1441 gacaagcggg gtatgtgatg attagctgca cccaactgca cacactgaac acctgacata
     1501 cccagggcct acctaggact tcctcaaata cagtcacatg cccataagtc acaggagtac
     1561 actccaccac tgacatggcc acaggcacat aggcacagtc acgggaatag tcacatagtg
     1621 aatcagagtt taggacaggc actatccatt ctgagcctag aaggacctaa ttgtcagcag
     1681 gatcacaggc agttcctcca gaatctatga gtcagcagac acaaaagctg gcatttgcca
     1741 tatgtcagct ctgtgccaag ccctatgcta ataagcaagc actagaagtg ggctaactca
     1801 ttcagtcttt gcaatggaca tgcagggaag ctgagccttt ttcattcact tacctcacac
     1861 aagctaccca gccactgagg gttgcccagc aagaagagac aagcaaggcc aggcatggat
     1921 gatgcacacc ttagatccca gtacttggga ggcaaggcca gcctggtcta catattgagc
     1981 tccaggacag ccaggactac acagagagac actgttggcg catgccttta atcccagcac
     2041 ttgggaggca gaggcaggcc aatttctgag tttgaggcca gcctcgtcta cagagtgagt
     2101 tccaggacag ccagggctac acagagaaac cctgtctcaa aaacaaaaaa aacaaacaaa
     2161 aaaaaccaaa caaacaaaaa acaaaacaaa acaaccaacc aaccaggaga gatgcatttt
     2221 gaaatctagg ctatctagct ccaaagatag aaccttgcac acctactgca tgctgatggt
     2281 accctcagag ggctggggaa acacaagcat cactctatag gatccctgaa tctgctcaga
     2341 gtactagcat cactcaaccc ggcaaacaaa gctgtcttat attacttagc tgtttaatta
     2401 gctcctaaaa taggcaggtc tcagaaccca gaaggcactg gaaaggctct atactttcat
     2461 ccaattgtgt tgtctgaaga cgactgcttt ccatgatcag gaggaagttc cacctgatca
     2521 ggccatttcc accaacccac gaggactgga gaccctacaa gagcggaaac aaagtgaaac
     2581 tctcatttct ttgagcctgg agctaggaga ggggcaggcg gagctgaaca caggcaagct
     2641 gctagaagcc ggctagagcc aagaggaggc ggagccaacg aaaggaaact acgggcctag
     2701 ttgccagtca ccaccggaag ggaagaagcc agggacagaa tgggcctaca ggagttctgt
     2761 tgtgacgctc agaaccaggg gcggggtgtc taggtaggga cgttccgggc gggcactgag
     2821 aacttaggag gaggtgctct gtctcctgcg aagactgcag tgagtcctcc gtactgctgg
     2881 gaccagcgta ggcagaccga ggagttggag ccagagacag cgagttaccc gaccgagcgc
     2941 aggcaggacg tggatcatcc cggaattcgg ctttaacatg tcagtatcac cctca
//
