LOCUS       NM_001042489            2790 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus hydrogen voltage-gated channel 1 (Hvcn1), transcript
            variant 1, mRNA.
ACCESSION   NM_001042489
VERSION     NM_001042489.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   Li,Y., Xie,Y., Liu,R., Wang,Z., Chen,P., Wang,M., Yu,Z., Wang,W.
            and Luo,X.
  TITLE     Knockout of microglial Hv1 proton channel reduces neurotoxic A1
            astrocytes and neuronal damage via the ROS/STAT3 pathway after
            spinal cord injury
  JOURNAL   Glia 71 (10), 2418-2436 (2023)
   PUBMED   37395288
  REMARK    GeneRIF: Knockout of microglial Hv1 proton channel reduces
            neurotoxic A1 astrocytes and neuronal damage via the ROS/STAT3
            pathway after spinal cord injury.
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Zhao,R., Lopez,B., Schwingshackl,A. and Goldstein,S.A.N.
  TITLE     Protection from acute lung injury by a peptide designed to inhibit
            the voltage-gated proton channel
  JOURNAL   iScience 26 (1), 105901 (2022)
   PUBMED   36660473
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2790)
  AUTHORS   Coe,D., Poobalasingam,T., Fu,H., Bonacina,F., Wang,G., Morales,V.,
            Moregola,A., Mitro,N., Cheung,K.C., Ward,E.J., Nadkarni,S.,
            Aksentijevic,D., Bianchi,K., Norata,G.D., Capasso,M. and
            Marelli-Berg,F.M.
  TITLE     Loss of voltage-gated hydrogen channel 1 expression reveals
            heterogeneous metabolic adaptation to intracellular acidification
            by T cells
  JOURNAL   JCI Insight 7 (10), e147814 (2022)
   PUBMED   35472029
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2790)
  AUTHORS   Alvear-Arias,J.J., Carrillo,C., Villar,J.P., Garcia-Betancourt,R.,
            Pena-Pichicoi,A., Fernandez,A., Fernandez,M., Carmona,E.M.,
            Pupo,A., Neely,A., Alvarez,O., Garate,J., Barajas-Martinez,H.,
            Larsson,H.P., Lopez-Rodriguez,A., Latorre,R. and Gonzalez,C.
  TITLE     Expression of Hv1 proton channels in myeloid-derived suppressor
            cells (MDSC) and its potential role in T cell regulation
  JOURNAL   Proc Natl Acad Sci U S A 119 (15), e2104453119 (2022)
   PUBMED   35377790
  REMARK    GeneRIF: Expression of Hv1 proton channels in myeloid-derived
            suppressor cells (MDSC) and its potential role in T cell
            regulation.
REFERENCE   5  (bases 1 to 2790)
  AUTHORS   Pang,H., Li,J., Wang,Y., Su,X., Gao,Y. and Li,S.J.
  TITLE     Mice lacking the proton channel Hv1 exhibit sex-specific
            differences in glucose homeostasis
  JOURNAL   J Biol Chem 297 (4), 101212 (2021)
   PUBMED   34547291
  REMARK    GeneRIF: Mice lacking the proton channel Hv1 exhibit sex-specific
            differences in glucose homeostasis.
REFERENCE   6  (bases 1 to 2790)
  AUTHORS   Koch,H.P., Kurokawa,T., Okochi,Y., Sasaki,M., Okamura,Y. and
            Larsson,H.P.
  TITLE     Multimeric nature of voltage-gated proton channels
  JOURNAL   Proc Natl Acad Sci U S A 105 (26), 9111-9116 (2008)
   PUBMED   18583477
REFERENCE   7  (bases 1 to 2790)
  AUTHORS   Suenaga,T., Arase,H., Yamasaki,S., Kohno,M., Yokosuka,T.,
            Takeuchi,A., Hattori,T. and Saito,T.
  TITLE     Cloning of B cell-specific membrane tetraspanning molecule BTS
            possessing B cell proliferation-inhibitory function
  JOURNAL   Eur J Immunol 37 (11), 3197-3207 (2007)
   PUBMED   17948262
REFERENCE   8  (bases 1 to 2790)
  AUTHORS   Sasaki,M., Takagi,M. and Okamura,Y.
  TITLE     A voltage sensor-domain protein is a voltage-gated proton channel
  JOURNAL   Science 312 (5773), 589-592 (2006)
   PUBMED   16556803
  REMARK    GeneRIF: reported that VSOP, a four-transmembrane protein similar
            to the voltage-sensor domain of voltage-gated ion channels is a
            voltage-gated proton channel [VSOP]
REFERENCE   9  (bases 1 to 2790)
  AUTHORS   Reiter,J.F. and Skarnes,W.C.
  TITLE     Tectonic, a novel regulator of the Hedgehog pathway required for
            both activation and inhibition
  JOURNAL   Genes Dev 20 (1), 22-27 (2006)
   PUBMED   16357211
REFERENCE   10 (bases 1 to 2790)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF749152.1, CF734112.1, AK002854.1 and AC127266.4.
            
            On Nov 5, 2013 this sequence version replaced NM_001042489.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021548.1, AK154880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               CF749152.1         1-165
            166-879             CF734112.1         1-714
            880-2766            AK002854.1         743-2629
            2767-2790           AC127266.4         44480-44503         c
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.23 cM"
     gene            1..2790
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /note="hydrogen voltage-gated channel 1"
                     /db_xref="GeneID:74096"
                     /db_xref="MGI:MGI:1921346"
     exon            1..193
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /inference="alignment:Splign:2.1.0"
     exon            194..244
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /inference="alignment:Splign:2.1.0"
     exon            245..376
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /inference="alignment:Splign:2.1.0"
     CDS             356..1165
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /note="voltage sensor domain-only protein"
                     /codon_start=1
                     /product="voltage-gated hydrogen channel 1"
                     /protein_id="NP_001035954.1"
                     /db_xref="CCDS:CCDS19644.1"
                     /db_xref="GeneID:74096"
                     /db_xref="MGI:MGI:1921346"
                     /translation="MTSHDPKAVTRRTKVAPTKRMSRFLKHFTVVGDDYHTWNVNYKK
                     WENEEEEEEPAPTSAEGEGNAEGPDAEAGSASTPRQSLDFRSRLRKLFSSHRFQVIII
                     CLVVLDALLVLAELLLDLKIIEPDEQDYAVTAFHYMSFAILVFFMLEIFFKIFVFRLE
                     FFHHKFEILDAFVVVVSFVLDLVLLFKSHHFEALGLLILLRLWRVARIINGIIISVKT
                     RSERQILRLKQINIQLATKIQHLEFSCSEKEQEIERLNKLLKQNGLLGDVN"
     exon            377..649
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /inference="alignment:Splign:2.1.0"
     exon            650..754
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /inference="alignment:Splign:2.1.0"
     exon            755..986
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /inference="alignment:Splign:2.1.0"
     exon            987..1099
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /inference="alignment:Splign:2.1.0"
     exon            1100..2790
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /inference="alignment:Splign:2.1.0"
     regulatory      2747..2752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /note="hexamer: AATAAA"
     polyA_site      2766
                     /gene="Hvcn1"
                     /gene_synonym="0610039P13Rik; BTS; HV1; mVSOP; Vsop."
                     /note="major polyA site"
ORIGIN      
        1 gttagtgcct ctcagcacac tagtgcctcc gtaggccttt gagtttgcag cagcaataag
       61 ttcgagcagc tctggaaact cccgccacac cacaccccca aaggcaaggg ccctccccct
      121 gggctcttca gagctggggt gtgcctgagt ctctaccctg ggatgagaac agagctaagc
      181 agactgctgc caggtggaga gagccagcca gccactgcaa aggagtgctg caaactacca
      241 gcaggtactg ctcaaacgga ccttcgagga cagattgcgg agcgtctact cgagacagca
      301 gggtgacaag tctgcctcca gttctctcac tgttggatct tgagacaaca ggaaaatgac
      361 ttcccatgac ccaaaggccg tcactcgcag aaccaaggtg gctcccacca agaggatgag
      421 caggttcttg aaacacttta cggtggttgg ggacgactac cacacgtgga atgtcaacta
      481 caagaagtgg gagaatgagg aggaggagga ggagccagcg cccacatcag cagagggtga
      541 gggcaatgct gagggcccag atgccgaggc tggctctgcc tccacgccca ggcagtccct
      601 ggacttcagg agccgactga ggaaactctt cagttcccac aggtttcagg tcatcatcat
      661 ctgcctggtg gtcctggacg ccctcctcgt gcttgctgaa ctcctcctgg atttgaagat
      721 catcgagccg gacgagcaag actatgcggt cacggcgttc cactacatga gctttgccat
      781 cctggtcttc ttcatgttgg agattttttt caagatcttc gtcttccgct tagagttctt
      841 ccaccacaag tttgagatcc tggatgcctt cgtggtggtg gtgtctttcg tccttgacct
      901 tgtcctcttg tttaaaagcc accacttcga agctctaggg ctgctgatct tgcttcggct
      961 ctggagggtg gcccggatca tcaatggcat catcatctcc gtgaagacac gctcagaacg
     1021 gcagatctta aggctaaagc agataaatat ccaactggcc accaagatcc agcatctgga
     1081 attcagctgc tccgagaagg aacaagaaat tgagcggctc aacaagctgt tgaaacagaa
     1141 tggacttctc ggggacgtga actagccttc cagacactcc gcctggagta gctgggctgt
     1201 ggccagagag ccagcctgtg gtgcaaagtc cagtctccat ctctgccttg gcttgcaccc
     1261 cgggatgctg gggacacatc ttcactggta ctgctgtctc cttggcgtcc acgccctacg
     1321 cttgcagcaa agggatcatc gcaccaacct tttctcaagc tggactccac tgtcgctcaa
     1381 aaatgatcaa ggaggctggg cttgtaaagc caacttaatg cacatcctga aaggagctgg
     1441 agcccgcacc ccgaaccagc tcactctgga aaacctttct ctactagaat gtccccagct
     1501 tctcctgctg cctccctagg ggagccatca tggtacccag tccctcctct gcagcatcca
     1561 gctgtaccat cagcttcaaa ctggctctgt acccactagc agctctttca gttactgtac
     1621 aattaatgtg taaaataagc cctctccttc ccagggctca cccaccacat tctctcctcg
     1681 gtggcagccc acaccagccc accagttata cagccagcac atggcagggt cccaaggctg
     1741 ccctgagggc cctgtaatta gcacaatctt gggatacaac ccccttgtgg gcacacagtt
     1801 ttacatagct ccttgctggt ttgtacctct caaatgccaa caggcattct gaaaacaact
     1861 cccactagac cagggatgat gcactgacga ggaggctctc catgcactgc cacgtcacac
     1921 tctgttcccg ctcatctccc agagggccgt gccctttgac ctgtatgtgc agggtgctgg
     1981 acccatctga cccaacacca cagcccagca gagtaaagtt tctgagagtt ttaaaaggca
     2041 gtggagtaga gcagagggct gcttgaaggg taacagcaag gggaggcggc agctaggttc
     2101 atgtcctctt gcgcctaggg cccaggtgcg cactgccgcg gaagggaaga tcttcaggat
     2161 gggtactcct gcggggtcag ctcatcacac aaacgggaag aagaagctga agggtagcct
     2221 ggcgttgatg gtgggtgggg ctcggaagcc tgcctctgca ggggctgaca catccacaaa
     2281 tgtcactgca gtggaaatga ccacggtcct ctcaggccct gggaggggct gcaaggaaaa
     2341 gacagagtgg acaccctcac catctcctcg ctcacagcca gctgccctaa ggcaggcact
     2401 aaggcggctg aggagcgctc tgccgcagac cacgctggta cagcagagct ggtccaacca
     2461 cagttcagtg ctcacaaata aaacctgtca ggcttttcct ctaagtacaa gttaaagaat
     2521 tatcatgaac ttttttaaga ctcaaaatta agttaggcat gattgatggc acatgcctgt
     2581 taatgctcag gggcctgagg ccgagggtca gtttgagacc agcctgggct ccatgagaag
     2641 acccagcagg caaagcagca cgtgggagct gtgaggacga ccccagcccc aataccccct
     2701 tgtaaaggaa ctgaaatcta gagagaaata acctttcatt ccaagtaata aacctttccc
     2761 accacccttg ctgtcatggg gctttctgta
//
