LOCUS       XM_030251448           15848 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  PREDICTED: Mus musculus HECT, UBA and WWE domain containing 1
            (Huwe1), transcript variant X24, mRNA.
ACCESSION   XM_030251448
VERSION     XM_030251448.1
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000086.8) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15848
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="X"
     gene            1..15848
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /note="HECT, UBA and WWE domain containing 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 12 mRNAs, 170 ESTs, 1546 long SRA reads, 1 Protein,
                     and 99% coverage of the annotated genomic feature by
                     RNAseq alignments, including 24 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:59026"
                     /db_xref="MGI:MGI:1926884"
     CDS             2186..15334
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase HUWE1 isoform X6"
                     /protein_id="XP_030107308.1"
                     /db_xref="GeneID:59026"
                     /db_xref="MGI:MGI:1926884"
                     /translation="MSWMLVCDRPEKEQLKMLLLAVLNFTALLIEYSFSRHLYSSIEH
                     LTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENG
                     FGLAECCRDLQMLKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISE
                     SPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNA
                     LQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCT
                     GTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGM
                     MEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDL
                     CRKECPFVIKPKIQRPSTTQEGEEMETDMDVADVTMESSPGSSISMEHRLDVELRASS
                     SNSSTSISGPGPGPGPGPGPGPGPGPGPGPGPGPGPGPGPGPGPGPGPRPGVQCIPQR
                     AALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVV
                     TVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQS
                     FVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDAT
                     TAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEEEEVQ
                     AMQSFNSAQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFV
                     NQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDLIL
                     SSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHAYIMMFVHTC
                     RVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQ
                     ADMQKLVPKDEKAGTTQGGKRSDGEQDGTAGSMDASAQGLLEGIELDGDTLAPMETDE
                     PSSSDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQRRS
                     HHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPML
                     FDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLD
                     AWLMLVEKMVNPTTVLESPHSLPAKLPGGVQSFPQFSALRFLVVTQKAAFTCIKNLWN
                     RKPLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEEAGQEEGGSRREPQ
                     VNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIIGGVVRDLSMSEEDQ
                     MMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLE
                     QDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWE
                     AADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVV
                     ESSGILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQM
                     TKYLQSNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTT
                     MVQVNEETGNRRPVMLTLLRVPRLSKNSKSSNGQELEKTLEESKETDIKHKENKGNDI
                     PLALESTNTEKEASLDETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLR
                     LCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTM
                     EKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIA
                     LPAPRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSSLPVIPDTIKEVIYDMLNALA
                     AYHAPEEADKSDPKPGGTTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSLNSQ
                     VFAADGAPAETSTTGTSQGEGASTPEETREGKKDKEGDRTSEEGKQKSKGSKPLMPTS
                     TILRLLAELVRSYVGIATLIANYSYTVGQSELIKEDCSVLAFVLDHLLPHTQNAEDKD
                     TPALARLFLASLAAAGSGTDAQVALVNEVKAALGRALAMAESTEKHARLQAVMCIIST
                     IMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKGLVNDLARVPHSLDLSSPNMANTV
                     NAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQGASQDSSSHQQDPGEPGEAEV
                     QEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELLERD
                     GGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQ
                     EEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELDEDYPDMN
                     ASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSLTLGSG
                     SSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRLLGPSAAADILQ
                     LSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGTLSSIPTALT
                     RWTEECKVLDAESMHDCVSVVKVPIVNHLEFLRDEELEERREKRRKQLAEEETKIIDK
                     GKEDKENRDQSAQCTVTKTNDSTEQNVSDGTPMPDSYPTTPSSTDAPTSESKETLGTL
                     QPSQQQPALPPPPSLGEIPQELQSPAEEVANSTQLLMPIELEELGPTRPSGEAETTQM
                     ELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTPAAGSSE
                     QPTAGSSTPGDAPSVVAEVQGRPDVSRESNQPPEDSSPPASSESSSTRDSAVAISGAD
                     SRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRS
                     APSSNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTP
                     MDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLF
                     GHSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDT
                     LLRLRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSI
                     LQRSSESELCIETPKLSTSEERGKKSSKSCASSSHENRPLDLLHKMESKSSNQLSWLS
                     VSMDAALGCRTNIFQIQRSGGRKHTEKHASSGSTVHIHPQAAPVVCRHVLDTLIQLAK
                     VFPSHFTQQRTKETNCESDRERGSKQACSPCSSQSSSSGICTDFWDLLVKLDNMNVSR
                     KGKNSVKSVPVSSGGEGETSPHSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLI
                     SIALPENKVSEVQTNSSNSGSSTAATSNTSTTTTTTTTATAPTPTPPAATTPVTSAPA
                     LVAATAISTITVAASTTVTTPTTATTTVSTSTTKGSKSPAKVGEGGSGIDFKMVSSGL
                     TENQLQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTL
                     CKQIGTLLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQSRFDMAENVVI
                     VASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRL
                     GSSGLGSASSIQAAVRQLEAEADAIIQMVREGQRARRQQQAATSESSNQSETSVRREE
                     SPMDVDQPSPSAQDTQSIVISDGTPQGEKEKEEKPPELPLLSEQLSLDELWDMLGECL
                     KELEESHDQHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAP
                     LTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADG
                     PFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKS
                     PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPS
                     SHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFY
                     QGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQ
                     MRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK
                     YQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRD
                     DRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA"
ORIGIN      
        1 ggtaggagga gccttatatc cagtgtgagc tgtgcagccg tgggggtggg gggggctttg
       61 taagccgagg gcgagggagg gggctggggg ggggggacaa gattgctact ggcctcagac
      121 cctgcacact gttgcaggcc tcgccaagcc cctgcggcgg agtcctctgc ggcctccagc
      181 agagagctag ctgcatcttt ggggacagca ggacagcggg gaagcagcga acagcgcgca
      241 agagagcggc caacagtggg gatgcgaggt accggcattg gccctggcct agtggcccta
      301 gaaaagaagt aaaggcccag ccttcagttt ttctcttaag ggttggagga aggcggcttc
      361 aagaggaaaa ggaaggagcg tgcacctggt ctcgcgagat ctcatgtttc ctaaaggcga
      421 ggcgcgggcg gtctcctgcg gtgaattacg aaggtctcgg cgaggctgaa cgtaatatcg
      481 cgatagttcc tacggcgcat gcgggagccg gcggcggcat gctggctccg ccccgtagtg
      541 ctccgtgagg ttgtgcgtca tttgcttttc gcttcgcgtg gggtgagagc ggagcggtgg
      601 cgatttgggg tttggtggca agcgagggtt gggacgggct gggctcagtt tttcctggtc
      661 cggtggaggt tctcctggga tcacgcgaag gcggcggccg aggttggcta ctgagtgcag
      721 gagctgcgga ggcgcgagca gcgtcttctg gtgctgccgt tcttagccgg taccagacgt
      781 taaggagatg acgaatggcg aaacgtcgtg gtgccggtaa atccttcctg agctgaagac
      841 catcctgttt cttaccggtt aaagcgacac catttccccc ggcctctgcc tcgtgtgggc
      901 ctgcctttgc cccaccaatc gctcttcgcc tctgttttcg tcgtcgcagt gggcgggttg
      961 ggaagtgcgg gagggagtcc atagttcatt gggtagtggg ctggggatta gattaaaaag
     1021 tgggagagag ggacgcacct aagattgttc tcataattat tgcgcgcttg ctgcttctca
     1081 gcccttgcag cgacccatat gaaaccccta gtttttcttg atccgaggtg ggctctgctt
     1141 ccctgctccc gcggctttcg ggctaaggtt tgagaggtca atctgtagag tcattagagt
     1201 accttccctt tcccaaattc tgtctccctg tcaaatcgct cagctacgtg aatatcggga
     1261 tgcattatta aggggagaag ttaaaaaaaa tcctatcact cctcctctgt agtcctaatt
     1321 tagagcctag cctgaatcat ctaccctgtc ccatgtcctt ccgtggtgct tttggcgcag
     1381 atgttaaaag agcttatctt attccctgca tttactccat ctttgtggat ggatcagcag
     1441 taaccttcca ttttcctagg tcctcttgct tgtttatccc tgacgcgggg acagcgtact
     1501 gatttcttca actttgaatg ttttgagacc atacttgggc agaacaataa acgggtagat
     1561 ctctgagaag agaggaagga gtggcagtac caaataaaaa ctttgtctaa ggttcagtga
     1621 caaagttcaa cctgaatttc caggatgttt atcgtttgtc tcccagtatg gccaaaaagc
     1681 acttatgaag gtccttcagt agcctgacct gagtgttagt gcttcagagg aacaaaccag
     1741 tagaccagaa cttggtcagg aagtttcagg aagctattgg agcagtgttg ggatttccca
     1801 ccaggatgac tatgattggc tgtgatttta gatcttaaat cagaaaactg aaaacatgaa
     1861 agtagacagg actaaactga aaaagacacc tactgaagct gtggggattg cccttccaag
     1921 cattaaggca aaggacaaaa taccaaaatg gaaatgtaaa ataccatatc caaaataaaa
     1981 ggacacatga caatagccat tctaacagcc tgcagactgc agagccttaa tagacaaact
     2041 caaagtttgt aatgatgagc aactcctctt ggaactgcag caaatcaaaa catggaacat
     2101 tggcaagtgt gagttatatc actgggtgga tctgttggac cgctttgatg gaattctggc
     2161 agatgctgga caaacagtgg agaatatgtc atggatgctt gtatgtgata ggccagaaaa
     2221 agaacagctg aaaatgcttc tattggctgt attgaacttc acagccttgc tcattgagta
     2281 cagcttttct cggcatctgt acagttccat agagcatttg acaactttat tggcttcctc
     2341 tgatatgcaa gtggtgctgg cagtccttaa ccttctatat gtatttagca aaagatcaaa
     2401 ctatatcaca cgtcttggat ctgacaagag gactccgcta ctgacacggc tgcagcattt
     2461 ggcagagagc tggggtggaa aggagaatgg ctttggactt gcagaatgtt gcagagactt
     2521 gcaaatgttg aaatatccac ccagtgcaac cacactacac tttgaatttt atgcagatcc
     2581 tggagctgag gtcaaaattg agaagaggac aactagtaat acactacatt atattcacat
     2641 agaacaactt gacaagattt cagaaagtcc ttctgaaata atggaatctc ttaccaaaat
     2701 gtacagcatt cctaaggata agcagatgct gttatttaca catatacgac tggcccatgg
     2761 cttttctaat cacaggaagc ggttacaagc tgttcaggcc agactgcatg caatatctat
     2821 attagtctat tctaatgcct tgcaagagtc agcaaacagt atcttgtata atgggttgat
     2881 agaggagttg gtagatgtcc ttcaaataac agataagcag ctcatggaaa ttaaagctgc
     2941 ttctttacga acgttaacat caattgttca tttggagaga actcccaagc tcagcagtat
     3001 tattgactgt actggaactg cctcctacca tggatttttg cctgtacttg tgcggaactg
     3061 cattcaggcc atgattgatc cttccatgga cccatacccc catcagtttg ccacagctct
     3121 tttctccttt ttgtaccatc tggctagcta cgatgctggt ggtgaagcct tggtctcctg
     3181 tggaatgatg gaagccttac taaaggtcat aaagtttctt ggtgatgaac aagaccagat
     3241 aacatttgta accagagctg tcagagtggt tgaccttatc accaacctgg acatggcagc
     3301 ttttcagtct catagtggtc tttctatctt catctataga cttgagcacg aagtagattt
     3361 gtgtcgtaaa gaatgccctt tcgtgatcaa gccaaagatc cagagaccca gtaccactca
     3421 agaaggagaa gaaatggaaa ctgatatgga tgttgcagat gtaactatgg aaagcagtcc
     3481 aggctcgtcc atatctatgg agcaccggct ggatgttgaa ttaagggcat caagttccaa
     3541 cagcagcact agcatctctg gccctggccc gggtcctggc cctggtccgg gtcctggccc
     3601 tggtcctggc cctggtcctg gtcctggccc tggccctggc cctggccccg gccctggccc
     3661 tggtcctggc cctggacccc gtcctggagt tcagtgtatt ccacaacgag cagcacttct
     3721 caagtccatg ttgaatttcc tcaagaaggc cattcaagac cctgctttct cagatggcat
     3781 acgacatgtg atggatggtt ctttacctac ctctctgaaa cacatcatca gcaatgcaga
     3841 atactatggt ccatcactct tcctcctagc tactgaagtg gtgactgtgt ttgtatttca
     3901 agagccatca ctgctgtcct cactccagga caatggactg acagatgtca tgctgcatgc
     3961 actgctcatc aaagatgttc ctgctacaag ggaagtcctc ggttccctcc caaatgtatt
     4021 cagtgcactt tgcttgaatg cccgaggtct tcagtctttt gtacaatgtc agccatttga
     4081 acgtctcttc aaagttcttc tgtctcctga ttacctccca gccatgcgga ggaggaggag
     4141 ttctgatccc cttggggata ctgcatccaa cctggggagt gctgttgatg agctcatgag
     4201 acaccagcct accctcaaaa cagatgcaac aactgccatc atcaagttac ttgaagaaat
     4261 ctgtaatctt ggaagagatc ctaaatacat ttgtcagaag ccatctattc agaaagcgga
     4321 tggtactgct actgctcctc ctccaaggtc taatcatgct gcagaagagg cttccagtga
     4381 agatgaggag gaagaggaag tacaggccat gcagagcttt aattctgccc agcagaatga
     4441 aactgagcct aatcagcagg tcgttggtac cgaggaacgt atacctatac ccctcatgga
     4501 ttacatcctt aatgtgatga aatttgtgga atctattttg agcaacaata caacagatga
     4561 ccactgtcaa gaatttgtaa accagaaagg actcttacct ttggttacca ttttgggtct
     4621 tcccaatctg cccattgact ttcccacatc tgctgcctgt caggctgttg caggtgtctg
     4681 caaatccata ttgaccctgt cacatgaacc caaagttctt caagaaggtc tccttcaatt
     4741 agacttgatc ctttcctcct tggagccttt acatcggccg attgaatccc ctgggggctc
     4801 agtgttactg agagaattgg catgtgcagg caatgttgct gatgctaccc tctcagctca
     4861 ggccacgcct ctgttgcatg cactcactgc agcccatgct tacatcatga tgtttgttca
     4921 cacttgcaga gttggacaga gtgaaattcg ttctatctca gtaaaccagt ggggttcaca
     4981 attgggtttg agtgttctga gcaagctaag ccagttatac tgttctctgg tgtgggaaag
     5041 cactgtcctc ctctctctat gtacccccaa cagcctacca tctggatgtg aatttggtca
     5101 agcggacatg cagaaactag ttccaaagga tgagaaggca ggtacgaccc agggcggaaa
     5161 aagatcagat ggagaacagg atggaactgc tggaagcatg gatgcatctg cccagggttt
     5221 attagaagga attgaactag atggtgacac actggcaccc atggagacag atgaaccttc
     5281 ttcttcagat tctaagggca aatctaaaat cacacctgcc atggctgcaa gaattaaaca
     5341 aatcaagccg ttgctgtcag cttcttccag attaggccga gcacttgctg agctctttgg
     5401 actccttgtt aagctttgtg tgggttctcc tgtccgccaa aggaggagcc atcatgctgc
     5461 cagtaccacc actgcaccaa cacctgctgc tagatcaaca gcttcagccc tcactaagct
     5521 actcacaaaa ggcttatcat ggcagccccc accatataca cccactcccc gcttcaggct
     5581 gacgttcttc atctgttcag ttggattcac ctctccaatg ctctttgatg agagaaagta
     5641 tccttaccac cttatgctgc agaaatttct ctgctctggt ggtcacaatg ctctttttga
     5701 aactttcaac tgggctctat ccatgggagg aaaagttcct gtttctgagg gattggaaca
     5761 ttcagatcta cctgatggta caggagaatt cctagatgcc tggcttatgc ttgtagaaaa
     5821 gatggtaaat cccaccacgg tgcttgaatc tccacattcg ttgcctgcta aattgcctgg
     5881 aggagtccag agctttccac aatttagtgc ccttcgcttc cttgtagtaa ctcaaaaagc
     5941 agcctttact tgtatcaaga acctgtggaa ccggaaaccc cttaaagtat atgggggaag
     6001 aatggctgag tctatgctgg ccattttgtg ccacattctc cgaggggaac ctgtgattcg
     6061 agaaagactg agcaaagaga aggaaggatc tcgaggagaa gaagaagcag gccaggaaga
     6121 aggtggctca cgcagagaac ctcaagtcaa ccagcaacag ctacaacagc tcatggacat
     6181 gggtttcaca agagaacatg ccatggaggc actgttgaat accagtacga tggaacaagc
     6241 aacagagtac cttttaaccc accctcctcc aatcatagga ggagttgttc gggatcttag
     6301 catgtcagaa gaggaccaga tgatgagagc aattgctatg tctctgggac aggatattcc
     6361 aatggatcaa agggcagagt cacctgagga agttgcttgc cggaaggagg aagaagagcg
     6421 taaagctcga gaaaaacaag aagaggaaga agctaaatgt ctagagaagt ttcaagatgc
     6481 tgaccccttg gaacaagatg agctccacac tttcacagat acaatgttac caggctgctt
     6541 ccatcttctt gatgagttgc ctgatacagt gtaccgtgtt tgtgatctga tcatgacagc
     6601 tatcaaacgt aatggagctg actatcgtga tatgattcta aagcaagttg tcaaccaggt
     6661 gtgggaagct gctgatgtat tgatcaaagc tgctcttcct ctaacaacaa gtgacacaaa
     6721 aacagtttca gagtggatca gtcagatggc taccctgcca caggcctcca atttggctac
     6781 tagaatcttg cttttaacac tactttttga ggagttgaag ttaccttgtg cctgggtggt
     6841 tgaatcaagt ggcattctta atgtcctaat caaactctta gaagtggttc aaccctgcct
     6901 acaggctgcc aaagagcaaa aggaagtcca gaccccaaag tggatcaccc cagtgttgct
     6961 ccttattgat ttttatgaaa agacagccat ctcatcaaag agaagagccc aaatgactaa
     7021 gtacctacag tccaacagca acaactggcg ctggtttgat gaccgctctg ggcgttggtg
     7081 tagttacagt gctagcaaca acagcaccat tgattctgcc tggaaatctg gagaaacaag
     7141 tgtaagattc actgctggcc gacgaagata cactgtccag ttcactacaa tggtgcaggt
     7201 taatgaagaa acaggaaacc gacgccctgt gatgctgact ctcctcaggg tgccacgact
     7261 gagtaagaac tcaaaaagca gcaatggaca ggaactagag aagacactgg aagaaagcaa
     7321 ggagaccgat atcaaacata aagaaaataa aggcaatgat atccccttag ctctagagag
     7381 cacaaacact gaaaaagagg caagcctgga tgaaacaaaa attggggaga tcctaatcca
     7441 gggcctgaca gaagatatgg tgactgttct aatccgtgcc tgtgtgagca tgctgggagt
     7501 ccctgtggac ccagacactt tgcatgccac ccttcgtctc tgtttaaggc tcacccgaga
     7561 ccacaaatat gccatgatgt ttgcagaact gaagagtaca cgaatgatct tgaatttgac
     7621 ccagagctca ggtttcaatg ggtttacccc cttagtcacc cttctcttaa ggcacatcat
     7681 tgaggatcct tgtactcttc gtcatactat ggaaaaggtt gttcgctcgg cagccacaag
     7741 tggagctggt agtactacat ctggtgttgt atctggcagc ctcggttctc gggagatcaa
     7801 ctatatcctt agagtcctag gaccagctgc ctgccgcaat ccagacatat tcacagaagt
     7861 agccaattgc tgtatccgca ttgcccttcc agcccctcga ggctcaggaa ctgcttcaga
     7921 tgatgaattt gagaatctta gaattaaagg tcctaatgct gtacagctgg taaagacaac
     7981 acctttgaag ccctcatctc tgcctgtcat tcctgatact attaaggaag ttatctatga
     8041 tatgctgaat gctttggctg cataccatgc tccagaggaa gcagacaaat ctgatcctaa
     8101 acctggggga acgacccaag aggttggcca gctcctgcaa gacatgggtg acgatgtata
     8161 ccagcagtac cggtcactta ctcgtcagag cagtgacttt gatacacagt caggtttttc
     8221 cttaaatagt caggtttttg ctgcagatgg tgcccctgct gaaacttcca caactggaac
     8281 ctcccaagga gagggagctt caactccaga ggagactcga gaagggaaga aagataaaga
     8341 aggggaccgt acatctgagg aaggcaagca gaaaagcaag ggcagcaaac ctttaatgcc
     8401 tacctctact atccttcgtc ttctggcaga gttggtgagg tcctatgttg gtattgctac
     8461 cctgattgca aactacagct ataccgtggg ccagtctgag ctgatcaaag aggactgcag
     8521 tgtgctagct tttgtcctgg accacctcct cccacacacc cagaatgcag aagacaagga
     8581 tacacctgcc ctggcacgtc tattccttgc aagtctggct gctgcgggga gtggcacaga
     8641 tgctcaagtg gccctagtga atgaagtgaa agcagccctg ggacgggcgc ttgctatggc
     8701 tgagagtaca gagaagcacg ccagacttca ggcagtgatg tgtatcatca gtactatcat
     8761 ggaatcctgc ccctccacct ccagcttcta cagtagtgct acagccaaga ctcagcataa
     8821 tggcatgaac aacatcattc gactgttcct aaagaaggga ctagtcaatg acctggccag
     8881 agttcctcac agcctagacc tgtccagtcc caatatggcc aacacagtca atgctgctct
     8941 aaaacccttg gaaacacttt cccggattgt aaatcaaccc agtagccttt ttggcagcaa
     9001 gagtgcttct agcaagaaca agtctgagca ggatgctcaa ggagcttctc aggactccag
     9061 cagccatcag caagatccag gcgagcctgg ggaggcagaa gtgcaggagg aggatcatga
     9121 tgtcactcag acagaggtgg cagatgggga tatcatggat ggggaggctg aaaccgactc
     9181 agtggtgatt gccgggcagc ctgaggtgct cagttcacaa gagatgcagg ttgaaaatga
     9241 actggaggac ctgatagatg agttgcttga gagggatggc ggatctggga acagtacaat
     9301 tatagtgagc agaagtggag aggatgaatc acaagaggac gtgctgatgg atgaagctcc
     9361 ttccaacctc agccaagctt ccaccttgca ggccaaccga gaagattcca tgaatatcct
     9421 ggaccctgag gatgaggagg aacatactca ggaagaggac agcagtggca gtaacgagga
     9481 tgaggatgat agtcaggatg aagaggagga ggaggaggaa gatgaggaag atgatcagga
     9541 ggatgatgaa ggtgaagaag gagatgaaga tgatgacgac gatggttctg agatggaatt
     9601 ggatgaggat taccctgata tgaacgcttc tcccttggtc cgatttgagc gctttgaccg
     9661 ggaggatgat ctcatcattg agtttgacaa catgttctcc agtgctacag acattccccc
     9721 atccccagga aatatcccta ccacccaccc attgatggta cgtcatgcag atcacagttc
     9781 cctgacactg ggcagtggtt cttccacaac tcgtcttacc cagggcatcg gtcgcagtca
     9841 aaggaccctc agacagctca ctgccaatac aggccatacc attcatgttc actaccctgg
     9901 gaatcgccag cctaaccctc ctcttatact ccagaggttg cttggtccct ctgcagctgc
     9961 tgacattctt cagctgagca gcagccttcc attacaaagc cgaggccggg cccgcctcct
    10021 agtgggcaat gatgacgtcc atatcatcgc caggtctgat gacgagctgc tggatgactt
    10081 ttttcatgac cagagtacag ccactagcca agcaggaacc ctgtccagca tcccaacagc
    10141 tctaacccga tggacagagg aatgcaaagt tcttgatgct gagagtatgc atgactgtgt
    10201 ttcagtggtt aaagtgccca ttgtcaatca cctggaattc ttgagagatg aggagctaga
    10261 agagagaagg gagaaacgca ggaaacaatt ggctgaggaa gaaacaaaaa taatagacaa
    10321 aggcaaagaa gacaaggaga acagagatca gagtgcacag tgtactgtaa ctaagacaaa
    10381 tgactccact gaacagaatg tctcagatgg gactcctatg cctgacagct atccaacaac
    10441 cccctcttca acggatgcac ctacatctga gtccaaggaa acacttggta ccctacaacc
    10501 ctcccagcaa cagccagcac ttccaccccc accatcctta ggagagattc ctcaggaact
    10561 acagtcccct gctgaagaag tggcaaactc tacacagcta ttgatgccta tagagttgga
    10621 ggaattgggt cccacaagac caagtggaga agcagaaaca actcaaatgg aattgtctcc
    10681 agctcccacc ataacctctc tttccccaga gagagctgaa gattcagacg cgttaacagc
    10741 tgtcagcagt cagctggaag gttctcccat ggacaccagc agcctggctt cctgtacgtt
    10801 agaagaggct gtgggtgaca ctccagcagc tggcagttct gagcagccca cagcaggtag
    10861 ttccactcct ggggatgcgc catcagttgt ggcagaagtg caaggcagac ctgatgtatc
    10921 aagagaatcc aaccagccac ctgaggacag ctccccccct gcatcctcgg agagttcttc
    10981 cactagagat tctgccgtgg ccatctctgg agcagattct cgtggaattc tagaagagcc
    11041 actaccttca acaagcagtg aagaagaaga tccccttgct ggtatcagtc tccctgaagg
    11101 tgtggatccc tcctttctgg ctgctctccc tgatgatatc cgtcgggaag tcctacagaa
    11161 ccagctgggc atacgtccac caacccgaag tgctccctcc tcaaatagct cagctcctgc
    11221 agtagtgggg aaccctggtg taactgaagt gagccctgag ttcctggctg ccctacctcc
    11281 agctattcaa gaggaagtgc tagcacagca gagagctgaa cagcagcgac gggaactggc
    11341 tcagaatgcg agctcagaca cccccatgga ccctgtgact ttcattcaga ctttgccctc
    11401 agatctgcgc cgtagtgtcc tagaggatat ggaagacagt gtgttagctg tgatgccacc
    11461 tgacattgca gctgaggctc aagctctaag acgagaacaa gaagcccgac agcggcagct
    11521 catgcatgag cgtctttttg gacacagtag tacttctgca ctctctgcca ttctccgaag
    11581 cccggctttt accagtcgcc tgagtggcaa ccgtggggtc cagtatactc gccttgctgt
    11641 acagaggggt ggcaccttcc agatgggggg tagcagcagc cataataggc cttctggcag
    11701 taatgtggac acactactcc gcctccgagg acgactcctt ctagaccatg aagccctgtc
    11761 ttgcctcttg gtcctacttt ttgtggatga gccaaagctc aatactagcc gtctacaccg
    11821 agtactgaga aatctctgct atcatgccca gacccgccac tgggtcatcc gcagcctcct
    11881 gtccattttg cagcgcagca gtgaaagtga gttatgcatt gagacaccta agctctccac
    11941 aagtgaagaa aggggcaaga aatcaagcaa gagctgtgca tcaagcagtc atgagaaccg
    12001 tcccctggat ctgctccaca agatggagtc caaaagttcc aatcagctct cctggctctc
    12061 agtatcaatg gatgctgctt taggctgtag gactaacata ttccagattc aacgttctgg
    12121 agggcgtaaa catacagaga agcatgcaag cagtggttcc actgtccaca tccaccccca
    12181 ggctgctcct gttgtttgca gacatgtttt ggatacactc attcagttgg ccaaggtgtt
    12241 tcccagccac tttacacagc agcggaccaa agaaacaaac tgtgagagtg atcgggaacg
    12301 gggcagtaag caggcctgca gcccatgctc ctcacagtcc tccagcagtg gcatctgtac
    12361 agacttctgg gacttattgg taaaactgga caacatgaat gttagccgaa aaggcaagaa
    12421 ctccgtgaag tcagtaccag tgagctctgg tggtgaaggg gaaacttccc cacacagcct
    12481 tgaagcctct ccactggggc agctcatgaa catgttgtca catccagtca tccgccggag
    12541 ttctctctta actgagaaac tcctgagact cctctctctc atctcaattg ctctcccaga
    12601 aaacaaagta tcagaagtgc aaactaactc cagcaacagt ggttcctcca ctgctgccac
    12661 ctcaaacaca tctactacta ccaccaccac cactactgcc actgccccca cgcccacacc
    12721 cccagctgca actacccctg tcacttctgc tccagctctg gttgctgcca cagctatttc
    12781 caccattact gtagctgctt ctaccacagt gactaccccc acaactgcta ccactactgt
    12841 ttcaacttct actactaaag gcagcaaatc tccagcaaag gttggtgaag gaggcagtgg
    12901 tatagacttc aaaatggtgt cctctggcct cactgaaaac cagctacagc tctctgtaga
    12961 ggtgttgaca tcccactctt gttctgaaga aggcttggaa gatgcggcca atgtgttact
    13021 gcagctctct cgtggggact ctggtacccg ggacactgtt cttaagctgc tactaaatgg
    13081 agcccgccat ctgggttata ccctctgtaa acagataggt accctactcg ctgaactacg
    13141 ggaatataat ctggagcagc agcggcgagc ccaatgcgag accctctctc ctgatggcct
    13201 acctgaggag caaccacaga ccaccaaact gaaaggcaaa atgcagagca ggtttgacat
    13261 ggctgaaaat gtggtaattg tggcatctca gaagcgaccc ttgggtggcc gggagctcca
    13321 gctgccttct atgtccatgt tgacatccaa gacatctacc cagaagttct tcttgagggt
    13381 actacaggtc atcatccagc tgcgggatga cacacgacga gctaacaaga aagccaagca
    13441 gacaggcagg ctaggttcct ccggtttagg ctcagctagc agcatccagg cagctgttcg
    13501 gcagctggag gctgaggctg atgccattat acaaatggta cgtgagggtc aaagggcgcg
    13561 gagacagcaa caagcagcaa cgtcggagtc ttctaaccag tcagagacat ctgtccggag
    13621 agaggaatcg cccatggatg tggaccagcc atctcctagt gctcaagata ctcagtccat
    13681 tgtaatctca gatggaacac cacagggaga gaaggagaaa gaggagaaac cacctgagtt
    13741 acccctgctc agtgagcaac tgagcctaga tgaactgtgg gacatgctag gggaatgttt
    13801 aaaagaactg gaggaatctc atgaccagca tgcagtatta gtgctacagc ctgctgtcga
    13861 ggccttcttt ttggtccatg ccacagagcg ggagagcaag cctcctgtcc gagatacccg
    13921 tgagagccag ctggcacaca tcaaggatga acctcctcca ctctcccccg cccccttaac
    13981 cccagccact ccatcctccc ttgacccatt cttctccagg gagccctcat ctatgcacat
    14041 ttcctcgagc ctgccccctg acacacagaa gttccttcgc tttgcagaga ctcaccgcac
    14101 tgtgttaaac cagatactac ggcagtctac cacccatctt gctgatgggc cttttgctgt
    14161 cttggtagat tatatccgtg tcctcgactt tgatgtcaag cgcaaatatt tccgccaaga
    14221 gctggagcgt ttggacgaag ggctccggaa agaagatatg gcagtgcatg tccgccgtga
    14281 ccatgtattt gaagactcct atcgtgagct gcatcgcaaa tctcctgaag aaatgaagaa
    14341 tcgattgtat atagtgtttg aaggagaaga agggcaggat gctggggggc tcctgcgaga
    14401 gtggtacatg atcatctctc gagagatgtt caaccctatg tatgccttgt tccgtacctc
    14461 acctggtgac cgggtcacct acaccatcaa tccatcttcc cactgtaacc ccaaccacct
    14521 cagctacttc aagtttgttg gacgaattgt agccaaagct gtatatgaca accgcctcct
    14581 ggagtgctac tttactaggt ctttctacaa acacatcttg ggcaaatctg tcaggtatac
    14641 agatatggag agtgaagatt accacttcta ccagggccta gtttatctgc ttgaaaatga
    14701 tgtctctaca ttaggctatg acctcacctt cagcactgag gttcaagaat ttggagtatg
    14761 tgaagttcgt gacctcaaac ccaatggagc caacatcttg gtaacagagg agaacaagaa
    14821 ggaatatgta cacctggttt gccagatgag aatgacagga gccatccgca aacagctggc
    14881 agccttcttg gagggcttct atgaaatcat tccaaagcgc ctcatatcca tctttactga
    14941 gcaggaatta gagctgctca tatcagggct gcctaccatc gacattgatg atctaaaatc
    15001 taacactgag taccacaagt accaatccaa ctctattcag atccagtggt tttggagagc
    15061 attgcgttcc tttgaccaag cagaccgtgc caagttcctc cagtttgtca caggtacttc
    15121 caaggtaccc ctacaaggat ttgctgccct tgaaggtatg aatggcattc agaagtttca
    15181 gattcatcga gatgacagat ccacagatcg cctgccttca gctcacacat gttttaatca
    15241 actggacctg cctgcctatg agagctttga gaagctccgc cacatgctac tattggccat
    15301 ccaggaatgc tctgaaggct ttgggctggc ctaataaata aggccctgcc tacttctgtg
    15361 gggtttttct accattgttg gacctgggga ggggggtgga tttaaaagat ccagaaagaa
    15421 aatgtcaaaa tccaataaat gaaattcacc aactcaccat gtgtgtccca gctgcccatc
    15481 ttccctagtg catacctgtt cgcttctcat tctcttttgt ctcccctttc ctcgcctctc
    15541 ccttttccat gccgtccatg atccccaccc catgtgttaa gaaggcagta gcctttacag
    15601 ggacctgttt gtcccaaatg aacagtgtgc tcctcagatt ctgtgttcag aaggatttgc
    15661 tgcattgaga cttgaaacct ttggataggg gaaaaattat atatatatat atttttttgt
    15721 tctgtttgca tttcttaatt tgtgcttgga atgtgttgat gtgcacagct aatgattcaa
    15781 tgcgagacaa gattggcatc tgtgttgtgg aggtttcaaa taaagagcac tcttcataac
    15841 tcactttt
//
