LOCUS       NM_021523              14582 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus HECT, UBA and WWE domain containing 1 (Huwe1), mRNA.
ACCESSION   NM_021523 XM_136108
VERSION     NM_021523.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 14582)
  AUTHORS   Amici,D.R., Alhayek,S., Klein,A.T., Wang,Y.Z., Wilen,A.P., Song,W.,
            Zhu,P., Thakkar,A., King,M.A., Steffeck,A.W., Alasady,M.J.,
            Peek,C., Savas,J.N. and Mendillo,M.L.
  TITLE     Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for
            mammalian life
  JOURNAL   Life Sci Alliance 7 (5), e202302370 (2024)
   PUBMED   38453366
  REMARK    GeneRIF: Tight regulation of a nuclear HAPSTR1-HUWE1 pathway
            essential for mammalian life.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14582)
  AUTHORS   Feng,W.W., Bang,S., Takacs,E.M., Day,C., Crawford,K.J.,
            Al-Sheyab,R., Almufarrej,D.B., Wells,W., Ilchenko,S., Kasumov,T.,
            Kon,N., Novak,C.M., Gu,W. and Kurokawa,M.
  TITLE     Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver
            disease through lipid metabolic rewiring
  JOURNAL   iScience 26 (12), 108405 (2023)
   PUBMED   38047073
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 14582)
  AUTHORS   Spanjaard,A., Stratigopoulou,M., de Groot,D., Aslam,M., van den
            Berk,P.C.M., Stappenbelt,C., Ayidah,M., Catsman,J.J.I.,
            Pardieck,I.N., Kreft,M., Arens,R., Guikema,J.E.J. and Jacobs,H.
  TITLE     Huwe1 supports B-cell development, B-cell-dependent immunity,
            somatic hypermutation and class switch recombination by regulating
            proliferation
  JOURNAL   Front Immunol 13, 986863 (2023)
   PUBMED   36700204
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 14582)
  AUTHORS   Masui,O., Corbel,C., Nagao,K., Endo,T.A., Kezuka,F.,
            Diabangouaya,P., Nakayama,M., Kumon,M., Koseki,Y., Obuse,C.,
            Koseki,H. and Heard,E.
  TITLE     Polycomb repressive complexes 1 and 2 are each essential for
            maintenance of X inactivation in extra-embryonic lineages
  JOURNAL   Nat Cell Biol 25 (1), 134-144 (2023)
   PUBMED   36635505
REFERENCE   5  (bases 1 to 14582)
  AUTHORS   Wu,Y., Jiao,H., Yue,Y., He,K., Jin,Y., Zhang,J., Zhang,J., Wei,Y.,
            Luo,H., Hao,Z., Zhao,X., Xia,Q., Zhong,Q. and Zhang,J.
  TITLE     Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for
            degradation and suppresses ferroptosis in acute liver injury
  JOURNAL   Cell Death Differ 29 (9), 1705-1718 (2022)
   PUBMED   35260822
  REMARK    GeneRIF: Ubiquitin ligase E3 HUWE1/MULE targets transferrin
            receptor for degradation and suppresses ferroptosis in acute liver
            injury.
REFERENCE   6  (bases 1 to 14582)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 14582)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   8  (bases 1 to 14582)
  AUTHORS   Plafker,S.M. and Macara,I.G.
  TITLE     Ribosomal protein L12 uses a distinct nuclear import pathway
            mediated by importin 11
  JOURNAL   Mol Cell Biol 22 (4), 1266-1275 (2002)
   PUBMED   11809816
REFERENCE   9  (bases 1 to 14582)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 14582)
  AUTHORS   Tsuchiya,K.D. and Willard,H.F.
  TITLE     Chromosomal domains and escape from X inactivation: comparative X
            inactivation analysis in mouse and human
  JOURNAL   Mamm Genome 11 (10), 849-854 (2000)
   PUBMED   11003698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954855.8, BX571795.3 and AL672180.11.
            
            On Jul 1, 2022 this sequence version replaced NM_021523.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY772010.3, DQ097265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AL954855.8         45416-45661
            247-387             AL954855.8         48812-48952
            388-456             AL954855.8         77316-77384
            457-555             AL954855.8         82148-82246
            556-762             AL954855.8         82869-83075
            763-915             AL954855.8         85095-85247
            916-978             BX571795.3         6899-6961
            979-1056            BX571795.3         8657-8734
            1057-1104           BX571795.3         9581-9628
            1105-1173           BX571795.3         9706-9774
            1174-1273           BX571795.3         10324-10423
            1274-1374           BX571795.3         12268-12368
            1375-1525           BX571795.3         12655-12805
            1526-1653           BX571795.3         12899-13026
            1654-1794           BX571795.3         13642-13782
            1795-1900           BX571795.3         13990-14095
            1901-2002           BX571795.3         16349-16450
            2003-2083           BX571795.3         16851-16931
            2084-2190           BX571795.3         18480-18586
            2191-2368           BX571795.3         18834-19011
            2369-2460           BX571795.3         20055-20146
            2461-2672           BX571795.3         20744-20955
            2673-2730           BX571795.3         26641-26698
            2731-2907           BX571795.3         27662-27838
            2908-3153           BX571795.3         30715-30960
            3154-3287           BX571795.3         32477-32610
            3288-3382           BX571795.3         32995-33089
            3383-3574           BX571795.3         34900-35091
            3575-3791           BX571795.3         36682-36898
            3792-3914           BX571795.3         37260-37382
            3915-4152           BX571795.3         38674-38911
            4153-4383           BX571795.3         39261-39491
            4384-4506           BX571795.3         41764-41886
            4507-4602           BX571795.3         42265-42360
            4603-4872           BX571795.3         42926-43195
            4873-5025           BX571795.3         44566-44718
            5026-5153           BX571795.3         45851-45978
            5154-5235           BX571795.3         46172-46253
            5236-5412           BX571795.3         46912-47088
            5413-5572           BX571795.3         47199-47358
            5573-5931           BX571795.3         47922-48280
            5932-6127           BX571795.3         50005-50200
            6128-6295           BX571795.3         51103-51270
            6296-6441           BX571795.3         52745-52890
            6442-6508           BX571795.3         53369-53435
            6509-6726           BX571795.3         54626-54843
            6727-6938           BX571795.3         57083-57294
            6939-7121           BX571795.3         57681-57863
            7122-7294           BX571795.3         60011-60183
            7295-7443           BX571795.3         60536-60684
            7444-7519           BX571795.3         61538-61613
            7520-7618           BX571795.3         62447-62545
            7619-7752           BX571795.3         63133-63266
            7753-7921           BX571795.3         63458-63626
            7922-8150           BX571795.3         64910-65138
            8151-8329           BX571795.3         65591-65769
            8330-8419           BX571795.3         66042-66131
            8420-8574           BX571795.3         66283-66437
            8575-8620           AL672180.11        2080-2125
            8621-8908           AL672180.11        4017-4304
            8909-9164           AL672180.11        5463-5718
            9165-9295           AL672180.11        5912-6042
            9296-9510           AL672180.11        6697-6911
            9511-9799           AL672180.11        6990-7278
            9800-9902           AL672180.11        7422-7524
            9903-10449          AL672180.11        8252-8798
            10450-11059         AL672180.11        9447-10056
            11060-11175         AL672180.11        10917-11032
            11176-11332         AL672180.11        11133-11289
            11333-11465         AL672180.11        12203-12335
            11466-11668         AL672180.11        12567-12769
            11669-11796         AL672180.11        13350-13477
            11797-11896         AL672180.11        14533-14632
            11897-12055         AL672180.11        17502-17660
            12056-12301         AL672180.11        18024-18269
            12302-12419         AL672180.11        18634-18751
            12420-12560         AL672180.11        19215-19355
            12561-12848         AL672180.11        19934-20221
            12849-12954         AL672180.11        20335-20440
            12955-13072         AL672180.11        21610-21727
            13073-13254         AL672180.11        22420-22601
            13255-13445         AL672180.11        22811-23001
            13446-14582         AL672180.11        24152-25288
FEATURES             Location/Qualifiers
     source          1..14582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..14582
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /note="HECT, UBA and WWE domain containing 1"
                     /db_xref="GeneID:59026"
                     /db_xref="MGI:MGI:1926884"
     exon            1..246
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..387
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..456
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..13548
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /EC_number="2.3.2.26"
                     /note="upstream regulatory element binding protein 1;
                     Mcl-1 ubiquitin ligase; URE-B1; E3Histone; URE-binding
                     protein 1; HECT, UBA and WWE domain-containing protein 1;
                     HECT-type E3 ubiquitin transferase HUWE1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase HUWE1"
                     /protein_id="NP_067498.4"
                     /db_xref="CCDS:CCDS41176.1"
                     /db_xref="GeneID:59026"
                     /db_xref="MGI:MGI:1926884"
                     /translation="MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTW
                     NIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPEKEQLKMLLLAVLNFTAL
                     LIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLL
                     TRLQHLAESWGGKENGFGLAECCRDLQMLKYPPSATTLHFEFYADPGAEVKIEKRTTS
                     NTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQA
                     VQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSI
                     VHLERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYH
                     LASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSH
                     SGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPSTTQEGEEMETDMDGVQCIPQRAALL
                     KSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVVTVFV
                     FQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQC
                     QPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAII
                     KLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEEEEVQAMQS
                     FNSAQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKG
                     LLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDLILSSLE
                     PLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHAYIMMFVHTCRVGQ
                     SEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQ
                     KLVPKDEKAGTTQGGKRSDGEQDGTAGSMDASAQGLLEGIELDGDTLAPMETDEPSSS
                     DSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQRRSHHAA
                     STTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDER
                     KYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLM
                     LVEKMVNPTTVLESPHSLPAKLPGGVQSFPQFSALRFLVVTQKAAFTCIKNLWNRKPL
                     KVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEEAGQEEGGSRREPQVNQQ
                     QLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIIGGVVRDLSMSEEDQMMRA
                     IAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDEL
                     HTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADV
                     LIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSG
                     ILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYL
                     QSNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQV
                     NEETGNRRPVMLTLLRVPRLSKNSKSSNGQELEKTLEESKETDIKHKENKGNDIPLAL
                     ESTNTEKEASLDETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLR
                     LTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVV
                     RSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAP
                     RGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSSLPVIPDTIKEVIYDMLNALAAYHA
                     PEEADKSDPKPGGTTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSLNSQVFAA
                     DGAPAETSTTGTSQGEGASTPEETREGKKDKEGDRTSEEGKQKSKGSKPLMPTSTILR
                     LLAELVRSYVGIATLIANYSYTVGQSELIKEDCSVLAFVLDHLLPHTQNAEDKDTPAL
                     ARLFLASLAAAGSGTDAQVALVNEVKAALGRALAMAESTEKHARLQAVMCIISTIMES
                     CPSTSSFYSSATAKTQHNGMNNIIRLFLKKGLVNDLARVPHSLDLSSPNMANTVNAAL
                     KPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQGASQDSSSHQQDPGEPGEAEVQEED
                     HDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELLERDGGSG
                     NSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDS
                     SGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELDEDYPDMNASPL
                     VRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSLTLGSGSSTT
                     RLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRLLGPSAAADILQLSSS
                     LPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGTLSSIPTALTRWTE
                     ECKVLDAESMHDCVSVVKVPIVNHLEFLRDEELEERREKRRKQLAEEETKIIDKGKED
                     KENRDQSAQCTVTKTNDSTEQNVSDGTPMPDSYPTTPSSTDAPTSESKETLGTLQPSQ
                     QQPALPPPPSLGEIPQELQSPAEEVANSTQLLMPIELEELGPTRPSGEAETTQMELSP
                     APTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTPAAGSSEQPTA
                     GSSTPGDAPSVVAEVQGRPDVSRESNQPPEDSSPPASSESSSTRDSAVAISGADSRGI
                     LEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRSAPSS
                     NSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPV
                     TFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSS
                     TSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRL
                     RGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRS
                     SESELCIETPKLSTSEERGKKSSKSCASSSHENRPLDLLHKMESKSSNQLSWLSVSMD
                     AALGCRTNIFQIQRSGGRKHTEKHASSGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPS
                     HFTQQRTKETNCESDRERGSKQACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKN
                     SVKSVPVSSGGEGETSPHSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIAL
                     PENKVSEVQTNSSNSGSSTAATSNTSTTTTTTTTATAPTPTPPAATTPVTSAPALVAA
                     TAISTITVAASTTVTTPTTATTTVSTSTTKGSKSPAKVGEGGSGIDFKMVSSGLTENQ
                     LQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQI
                     GTLLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQ
                     KRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSG
                     LGSASSIQAAVRQLEAEADAIIQMVREGQRARRQQQAATSESSNQSETSVRREESPMD
                     VDQPSPSAQDTQSIVISDGTPQGEKEKEEKPPELPLLSEQLSLDELWDMLGECLKELE
                     ESHDQHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTPA
                     TPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAV
                     LVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEM
                     KNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCN
                     PNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLV
                     YLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMT
                     GAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSN
                     SIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRST
                     DRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA"
     exon            457..555
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..762
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..915
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..978
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1056
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1104
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1173
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1273
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1374
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1525
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1653
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1794
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1900
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2002
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2083
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2190
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2368
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2460
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2672
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2730
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2907
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3153
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3287
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3382
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3574
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3791
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3792..3914
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..4152
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4383
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4384..4506
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4507..4602
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4603..4872
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4873..5025
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5026..5153
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5154..5235
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5236..5412
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5413..5572
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5573..5931
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5932..6127
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6128..6295
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6296..6441
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6442..6508
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6509..6726
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6727..6938
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6939..7121
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            7122..7294
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            7295..7443
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            7444..7519
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            7520..7618
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            7619..7752
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            7753..7921
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            7922..8150
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            8151..8329
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            8330..8419
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            8420..8574
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            8575..8620
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            8621..8908
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            8909..9164
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9165..9295
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9296..9510
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9511..9799
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9800..9902
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9903..10449
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            10450..11059
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            11060..11175
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            11176..11332
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            11333..11465
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            11466..11668
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            11669..11796
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            11797..11896
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            11897..12055
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            12056..12301
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            12302..12419
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            12420..12560
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            12561..12848
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            12849..12954
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            12955..13072
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            13073..13254
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            13255..13445
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     exon            13446..14582
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13648..13653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /note="hexamer: AATAAA"
     polyA_site      13670
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /note="major polyA site"
     regulatory      14033..14038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /note="hexamer: AATAAA"
     polyA_site      14053
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /note="major polyA site"
     regulatory      14557..14562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
                     /note="hexamer: AATAAA"
     polyA_site      14582
                     /gene="Huwe1"
                     /gene_synonym="5430439H10Rik; Arf-bp1; C430014N20Rik;
                     Gm1718; Ib772; LASU1; Mule; Ureb1"
ORIGIN      
        1 ggctccgccc cgtagtgctc cgtgaggttg tgcgtcattt gcttttcgct tcgcgtgggg
       61 tgagagcgga gcggtggcga tttggggttt ggtggcaagc gagggttggg acgggctggg
      121 ctcagttttt cctggtccgg tggaggttct cctgggatca cgcgaaggcg gcggccgagg
      181 ttggctactg agtgcaggag ctgcggaggc gcgagcagcg tcttctggtg ctgccgttct
      241 tagccggtcc ttcagtagcc tgacctgagt gttagtgctt cagaggaaca aaccagtaga
      301 ccagaacttg gtcaggaagt ttcaggaagc tattggagca gtgttgggat ttcccaccag
      361 gatgactatg attggctgtg attttagatc ttaaatcaga aaactgaaaa catgaaagta
      421 gacaggacta aactgaaaaa gacacctact gaagctcctg cagactgcag agccttaata
      481 gacaaactca aagtttgtaa tgatgagcaa ctcctcttgg aactgcagca aatcaaaaca
      541 tggaacattg gcaagtgtga gttatatcac tgggtggatc tgttggaccg ctttgatgga
      601 attctggcag atgctggaca aacagtggag aatatgtcat ggatgcttgt atgtgatagg
      661 ccagaaaaag aacagctgaa aatgcttcta ttggctgtat tgaacttcac agccttgctc
      721 attgagtaca gcttttctcg gcatctgtac agttccatag agcatttgac aactttattg
      781 gcttcctctg atatgcaagt ggtgctggca gtccttaacc ttctatatgt atttagcaaa
      841 agatcaaact atatcacacg tcttggatct gacaagagga ctccgctact gacacggctg
      901 cagcatttgg cagagagctg gggtggaaag gagaatggct ttggacttgc agaatgttgc
      961 agagacttgc aaatgttgaa atatccaccc agtgcaacca cactacactt tgaattttat
     1021 gcagatcctg gagctgaggt caaaattgag aagaggacaa ctagtaatac actacattat
     1081 attcacatag aacaacttga caagatttca gaaagtcctt ctgaaataat ggaatctctt
     1141 accaaaatgt acagcattcc taaggataag cagatgctgt tatttacaca tatacgactg
     1201 gcccatggct tttctaatca caggaagcgg ttacaagctg ttcaggccag actgcatgca
     1261 atatctatat tagtctattc taatgccttg caagagtcag caaacagtat cttgtataat
     1321 gggttgatag aggagttggt agatgtcctt caaataacag ataagcagct catggaaatt
     1381 aaagctgctt ctttacgaac gttaacatca attgttcatt tggagagaac tcccaagctc
     1441 agcagtatta ttgactgtac tggaactgcc tcctaccatg gatttttgcc tgtacttgtg
     1501 cggaactgca ttcaggccat gattgatcct tccatggacc cataccccca tcagtttgcc
     1561 acagctcttt tctccttttt gtaccatctg gctagctacg atgctggtgg tgaagccttg
     1621 gtctcctgtg gaatgatgga agccttacta aaggtcataa agtttcttgg tgatgaacaa
     1681 gaccagataa catttgtaac cagagctgtc agagtggttg accttatcac caacctggac
     1741 atggcagctt ttcagtctca tagtggtctt tctatcttca tctatagact tgagcacgaa
     1801 gtagatttgt gtcgtaaaga atgccctttc gtgatcaagc caaagatcca gagacccagt
     1861 accactcaag aaggagaaga aatggaaact gatatggatg gagttcagtg tattccacaa
     1921 cgagcagcac ttctcaagtc catgttgaat ttcctcaaga aggccattca agaccctgct
     1981 ttctcagatg gcatacgaca tgtgatggat ggttctttac ctacctctct gaaacacatc
     2041 atcagcaatg cagaatacta tggtccatca ctcttcctcc tagctactga agtggtgact
     2101 gtgtttgtat ttcaagagcc atcactgctg tcctcactcc aggacaatgg actgacagat
     2161 gtcatgctgc atgcactgct catcaaagat gttcctgcta caagggaagt cctcggttcc
     2221 ctcccaaatg tattcagtgc actttgcttg aatgcccgag gtcttcagtc ttttgtacaa
     2281 tgtcagccat ttgaacgtct cttcaaagtt cttctgtctc ctgattacct cccagccatg
     2341 cggaggagga ggagttctga tccccttggg gatactgcat ccaacctggg gagtgctgtt
     2401 gatgagctca tgagacacca gcctaccctc aaaacagatg caacaactgc catcatcaag
     2461 ttacttgaag aaatctgtaa tcttggaaga gatcctaaat acatttgtca gaagccatct
     2521 attcagaaag cggatggtac tgctactgct cctcctccaa ggtctaatca tgctgcagaa
     2581 gaggcttcca gtgaagatga ggaggaagag gaagtacagg ccatgcagag ctttaattct
     2641 gcccagcaga atgaaactga gcctaatcag caggtcgttg gtaccgagga acgtatacct
     2701 atacccctca tggattacat ccttaatgtg atgaaatttg tggaatctat tttgagcaac
     2761 aatacaacag atgaccactg tcaagaattt gtaaaccaga aaggactctt acctttggtt
     2821 accattttgg gtcttcccaa tctgcccatt gactttccca catctgctgc ctgtcaggct
     2881 gttgcaggtg tctgcaaatc catattgacc ctgtcacatg aacccaaagt tcttcaagaa
     2941 ggtctccttc aattagactt gatcctttcc tccttggagc ctttacatcg gccgattgaa
     3001 tcccctgggg gctcagtgtt actgagagaa ttggcatgtg caggcaatgt tgctgatgct
     3061 accctctcag ctcaggccac gcctctgttg catgcactca ctgcagccca tgcttacatc
     3121 atgatgtttg ttcacacttg cagagttgga cagagtgaaa ttcgttctat ctcagtaaac
     3181 cagtggggtt cacaattggg tttgagtgtt ctgagcaagc taagccagtt atactgttct
     3241 ctggtgtggg aaagcactgt cctcctctct ctatgtaccc ccaacagcct accatctgga
     3301 tgtgaatttg gtcaagcgga catgcagaaa ctagttccaa aggatgagaa ggcaggtacg
     3361 acccagggcg gaaaaagatc agatggagaa caggatggaa ctgctggaag catggatgca
     3421 tctgcccagg gtttattaga aggaattgaa ctagatggtg acacactggc acccatggag
     3481 acagatgaac cttcttcttc agattctaag ggcaaatcta aaatcacacc tgccatggct
     3541 gcaagaatta aacaaatcaa gccgttgctg tcagcttctt ccagattagg ccgagcactt
     3601 gctgagctct ttggactcct tgttaagctt tgtgtgggtt ctcctgtccg ccaaaggagg
     3661 agccatcatg ctgccagtac caccactgca ccaacacctg ctgctagatc aacagcttca
     3721 gccctcacta agctactcac aaaaggctta tcatggcagc ccccaccata tacacccact
     3781 ccccgcttca ggctgacgtt cttcatctgt tcagttggat tcacctctcc aatgctcttt
     3841 gatgagagaa agtatcctta ccaccttatg ctgcagaaat ttctctgctc tggtggtcac
     3901 aatgctcttt ttgaaacttt caactgggct ctatccatgg gaggaaaagt tcctgtttct
     3961 gagggattgg aacattcaga tctacctgat ggtacaggag aattcctaga tgcctggctt
     4021 atgcttgtag aaaagatggt aaatcccacc acggtgcttg aatctccaca ttcgttgcct
     4081 gctaaattgc ctggaggagt ccagagcttt ccacaattta gtgcccttcg cttccttgta
     4141 gtaactcaaa aagcagcctt tacttgtatc aagaacctgt ggaaccggaa accccttaaa
     4201 gtatatgggg gaagaatggc tgagtctatg ctggccattt tgtgccacat tctccgaggg
     4261 gaacctgtga ttcgagaaag actgagcaaa gagaaggaag gatctcgagg agaagaagaa
     4321 gcaggccagg aagaaggtgg ctcacgcaga gaacctcaag tcaaccagca acagctacaa
     4381 cagctcatgg acatgggttt cacaagagaa catgccatgg aggcactgtt gaataccagt
     4441 acgatggaac aagcaacaga gtacctttta acccaccctc ctccaatcat aggaggagtt
     4501 gttcgggatc ttagcatgtc agaagaggac cagatgatga gagcaattgc tatgtctctg
     4561 ggacaggata ttccaatgga tcaaagggca gagtcacctg aggaagttgc ttgccggaag
     4621 gaggaagaag agcgtaaagc tcgagaaaaa caagaagagg aagaagctaa atgtctagag
     4681 aagtttcaag atgctgaccc cttggaacaa gatgagctcc acactttcac agatacaatg
     4741 ttaccaggct gcttccatct tcttgatgag ttgcctgata cagtgtaccg tgtttgtgat
     4801 ctgatcatga cagctatcaa acgtaatgga gctgactatc gtgatatgat tctaaagcaa
     4861 gttgtcaacc aggtgtggga agctgctgat gtattgatca aagctgctct tcctctaaca
     4921 acaagtgaca caaaaacagt ttcagagtgg atcagtcaga tggctaccct gccacaggcc
     4981 tccaatttgg ctactagaat cttgctttta acactacttt ttgaggagtt gaagttacct
     5041 tgtgcctggg tggttgaatc aagtggcatt cttaatgtcc taatcaaact cttagaagtg
     5101 gttcaaccct gcctacaggc tgccaaagag caaaaggaag tccagacccc aaagtggatc
     5161 accccagtgt tgctccttat tgatttttat gaaaagacag ccatctcatc aaagagaaga
     5221 gcccaaatga ctaagtacct acagtccaac agcaacaact ggcgctggtt tgatgaccgc
     5281 tctgggcgtt ggtgtagtta cagtgctagc aacaacagca ccattgattc tgcctggaaa
     5341 tctggagaaa caagtgtaag attcactgct ggccgacgaa gatacactgt ccagttcact
     5401 acaatggtgc aggttaatga agaaacagga aaccgacgcc ctgtgatgct gactctcctc
     5461 agggtgccac gactgagtaa gaactcaaaa agcagcaatg gacaggaact agagaagaca
     5521 ctggaagaaa gcaaggagac cgatatcaaa cataaagaaa ataaaggcaa tgatatcccc
     5581 ttagctctag agagcacaaa cactgaaaaa gaggcaagcc tggatgaaac aaaaattggg
     5641 gagatcctaa tccagggcct gacagaagat atggtgactg ttctaatccg tgcctgtgtg
     5701 agcatgctgg gagtccctgt ggacccagac actttgcatg ccacccttcg tctctgttta
     5761 aggctcaccc gagaccacaa atatgccatg atgtttgcag aactgaagag tacacgaatg
     5821 atcttgaatt tgacccagag ctcaggtttc aatgggttta cccccttagt cacccttctc
     5881 ttaaggcaca tcattgagga tccttgtact cttcgtcata ctatggaaaa ggttgttcgc
     5941 tcggcagcca caagtggagc tggtagtact acatctggtg ttgtatctgg cagcctcggt
     6001 tctcgggaga tcaactatat ccttagagtc ctaggaccag ctgcctgccg caatccagac
     6061 atattcacag aagtagccaa ttgctgtatc cgcattgccc ttccagcccc tcgaggctca
     6121 ggaactgctt cagatgatga atttgagaat cttagaatta aaggtcctaa tgctgtacag
     6181 ctggtaaaga caacaccttt gaagccctca tctctgcctg tcattcctga tactattaag
     6241 gaagttatct atgatatgct gaatgctttg gctgcatacc atgctccaga ggaagcagac
     6301 aaatctgatc ctaaacctgg gggaacgacc caagaggttg gccagctcct gcaagacatg
     6361 ggtgacgatg tataccagca gtaccggtca cttactcgtc agagcagtga ctttgataca
     6421 cagtcaggtt tttccttaaa tagtcaggtt tttgctgcag atggtgcccc tgctgaaact
     6481 tccacaactg gaacctccca aggagaggga gcttcaactc cagaggagac tcgagaaggg
     6541 aagaaagata aagaagggga ccgtacatct gaggaaggca agcagaaaag caagggcagc
     6601 aaacctttaa tgcctacctc tactatcctt cgtcttctgg cagagttggt gaggtcctat
     6661 gttggtattg ctaccctgat tgcaaactac agctataccg tgggccagtc tgagctgatc
     6721 aaagaggact gcagtgtgct agcttttgtc ctggaccacc tcctcccaca cacccagaat
     6781 gcagaagaca aggatacacc tgccctggca cgtctattcc ttgcaagtct ggctgctgcg
     6841 gggagtggca cagatgctca agtggcccta gtgaatgaag tgaaagcagc cctgggacgg
     6901 gcgcttgcta tggctgagag tacagagaag cacgccagac ttcaggcagt gatgtgtatc
     6961 atcagtacta tcatggaatc ctgcccctcc acctccagct tctacagtag tgctacagcc
     7021 aagactcagc ataatggcat gaacaacatc attcgactgt tcctaaagaa gggactagtc
     7081 aatgacctgg ccagagttcc tcacagccta gacctgtcca gtcccaatat ggccaacaca
     7141 gtcaatgctg ctctaaaacc cttggaaaca ctttcccgga ttgtaaatca acccagtagc
     7201 ctttttggca gcaagagtgc ttctagcaag aacaagtctg agcaggatgc tcaaggagct
     7261 tctcaggact ccagcagcca tcagcaagat ccaggcgagc ctggggaggc agaagtgcag
     7321 gaggaggatc atgatgtcac tcagacagag gtggcagatg gggatatcat ggatggggag
     7381 gctgaaaccg actcagtggt gattgccggg cagcctgagg tgctcagttc acaagagatg
     7441 caggttgaaa atgaactgga ggacctgata gatgagttgc ttgagaggga tggcggatct
     7501 gggaacagta caattatagt gagcagaagt ggagaggatg aatcacaaga ggacgtgctg
     7561 atggatgaag ctccttccaa cctcagccaa gcttccacct tgcaggccaa ccgagaagat
     7621 tccatgaata tcctggaccc tgaggatgag gaggaacata ctcaggaaga ggacagcagt
     7681 ggcagtaacg aggatgagga tgatagtcag gatgaagagg aggaggagga ggaagatgag
     7741 gaagatgatc aggaggatga tgaaggtgaa gaaggagatg aagatgatga cgacgatggt
     7801 tctgagatgg aattggatga ggattaccct gatatgaacg cttctccctt ggtccgattt
     7861 gagcgctttg accgggagga tgatctcatc attgagtttg acaacatgtt ctccagtgct
     7921 acagacattc ccccatcccc aggaaatatc cctaccaccc acccattgat ggtacgtcat
     7981 gcagatcaca gttccctgac actgggcagt ggttcttcca caactcgtct tacccagggc
     8041 atcggtcgca gtcaaaggac cctcagacag ctcactgcca atacaggcca taccattcat
     8101 gttcactacc ctgggaatcg ccagcctaac cctcctctta tactccagag gttgcttggt
     8161 ccctctgcag ctgctgacat tcttcagctg agcagcagcc ttccattaca aagccgaggc
     8221 cgggcccgcc tcctagtggg caatgatgac gtccatatca tcgccaggtc tgatgacgag
     8281 ctgctggatg acttttttca tgaccagagt acagccacta gccaagcagg aaccctgtcc
     8341 agcatcccaa cagctctaac ccgatggaca gaggaatgca aagttcttga tgctgagagt
     8401 atgcatgact gtgtttcagt ggttaaagtg cccattgtca atcacctgga attcttgaga
     8461 gatgaggagc tagaagagag aagggagaaa cgcaggaaac aattggctga ggaagaaaca
     8521 aaaataatag acaaaggcaa agaagacaag gagaacagag atcagagtgc acagtgtact
     8581 gtaactaaga caaatgactc cactgaacag aatgtctcag atgggactcc tatgcctgac
     8641 agctatccaa caaccccctc ttcaacggat gcacctacat ctgagtccaa ggaaacactt
     8701 ggtaccctac aaccctccca gcaacagcca gcacttccac ccccaccatc cttaggagag
     8761 attcctcagg aactacagtc ccctgctgaa gaagtggcaa actctacaca gctattgatg
     8821 cctatagagt tggaggaatt gggtcccaca agaccaagtg gagaagcaga aacaactcaa
     8881 atggaattgt ctccagctcc caccataacc tctctttccc cagagagagc tgaagattca
     8941 gacgcgttaa cagctgtcag cagtcagctg gaaggttctc ccatggacac cagcagcctg
     9001 gcttcctgta cgttagaaga ggctgtgggt gacactccag cagctggcag ttctgagcag
     9061 cccacagcag gtagttccac tcctggggat gcgccatcag ttgtggcaga agtgcaaggc
     9121 agacctgatg tatcaagaga atccaaccag ccacctgagg acagctcccc ccctgcatcc
     9181 tcggagagtt cttccactag agattctgcc gtggccatct ctggagcaga ttctcgtgga
     9241 attctagaag agccactacc ttcaacaagc agtgaagaag aagatcccct tgctggtatc
     9301 agtctccctg aaggtgtgga tccctccttt ctggctgctc tccctgatga tatccgtcgg
     9361 gaagtcctac agaaccagct gggcatacgt ccaccaaccc gaagtgctcc ctcctcaaat
     9421 agctcagctc ctgcagtagt ggggaaccct ggtgtaactg aagtgagccc tgagttcctg
     9481 gctgccctac ctccagctat tcaagaggaa gtgctagcac agcagagagc tgaacagcag
     9541 cgacgggaac tggctcagaa tgcgagctca gacaccccca tggaccctgt gactttcatt
     9601 cagactttgc cctcagatct gcgccgtagt gtcctagagg atatggaaga cagtgtgtta
     9661 gctgtgatgc cacctgacat tgcagctgag gctcaagctc taagacgaga acaagaagcc
     9721 cgacagcggc agctcatgca tgagcgtctt tttggacaca gtagtacttc tgcactctct
     9781 gccattctcc gaagcccggc ttttaccagt cgcctgagtg gcaaccgtgg ggtccagtat
     9841 actcgccttg ctgtacagag gggtggcacc ttccagatgg ggggtagcag cagccataat
     9901 aggccttctg gcagtaatgt ggacacacta ctccgcctcc gaggacgact ccttctagac
     9961 catgaagccc tgtcttgcct cttggtccta ctttttgtgg atgagccaaa gctcaatact
    10021 agccgtctac accgagtact gagaaatctc tgctatcatg cccagacccg ccactgggtc
    10081 atccgcagcc tcctgtccat tttgcagcgc agcagtgaaa gtgagttatg cattgagaca
    10141 cctaagctct ccacaagtga agaaaggggc aagaaatcaa gcaagagctg tgcatcaagc
    10201 agtcatgaga accgtcccct ggatctgctc cacaagatgg agtccaaaag ttccaatcag
    10261 ctctcctggc tctcagtatc aatggatgct gctttaggct gtaggactaa catattccag
    10321 attcaacgtt ctggagggcg taaacataca gagaagcatg caagcagtgg ttccactgtc
    10381 cacatccacc cccaggctgc tcctgttgtt tgcagacatg ttttggatac actcattcag
    10441 ttggccaagg tgtttcccag ccactttaca cagcagcgga ccaaagaaac aaactgtgag
    10501 agtgatcggg aacggggcag taagcaggcc tgcagcccat gctcctcaca gtcctccagc
    10561 agtggcatct gtacagactt ctgggactta ttggtaaaac tggacaacat gaatgttagc
    10621 cgaaaaggca agaactccgt gaagtcagta ccagtgagct ctggtggtga aggggaaact
    10681 tccccacaca gccttgaagc ctctccactg gggcagctca tgaacatgtt gtcacatcca
    10741 gtcatccgcc ggagttctct cttaactgag aaactcctga gactcctctc tctcatctca
    10801 attgctctcc cagaaaacaa agtatcagaa gtgcaaacta actccagcaa cagtggttcc
    10861 tccactgctg ccacctcaaa cacatctact actaccacca ccaccactac tgccactgcc
    10921 cccacgccca cacccccagc tgcaactacc cctgtcactt ctgctccagc tctggttgct
    10981 gccacagcta tttccaccat tactgtagct gcttctacca cagtgactac ccccacaact
    11041 gctaccacta ctgtttcaac ttctactact aaaggcagca aatctccagc aaaggttggt
    11101 gaaggaggca gtggtataga cttcaaaatg gtgtcctctg gcctcactga aaaccagcta
    11161 cagctctctg tagaggtgtt gacatcccac tcttgttctg aagaaggctt ggaagatgcg
    11221 gccaatgtgt tactgcagct ctctcgtggg gactctggta cccgggacac tgttcttaag
    11281 ctgctactaa atggagcccg ccatctgggt tataccctct gtaaacagat aggtacccta
    11341 ctcgctgaac tacgggaata taatctggag cagcagcggc gagcccaatg cgagaccctc
    11401 tctcctgatg gcctacctga ggagcaacca cagaccacca aactgaaagg caaaatgcag
    11461 agcaggtttg acatggctga aaatgtggta attgtggcat ctcagaagcg acccttgggt
    11521 ggccgggagc tccagctgcc ttctatgtcc atgttgacat ccaagacatc tacccagaag
    11581 ttcttcttga gggtactaca ggtcatcatc cagctgcggg atgacacacg acgagctaac
    11641 aagaaagcca agcagacagg caggctaggt tcctccggtt taggctcagc tagcagcatc
    11701 caggcagctg ttcggcagct ggaggctgag gctgatgcca ttatacaaat ggtacgtgag
    11761 ggtcaaaggg cgcggagaca gcaacaagca gcaacgtcgg agtcttctaa ccagtcagag
    11821 acatctgtcc ggagagagga atcgcccatg gatgtggacc agccatctcc tagtgctcaa
    11881 gatactcagt ccattgtaat ctcagatgga acaccacagg gagagaagga gaaagaggag
    11941 aaaccacctg agttacccct gctcagtgag caactgagcc tagatgaact gtgggacatg
    12001 ctaggggaat gtttaaaaga actggaggaa tctcatgacc agcatgcagt attagtgcta
    12061 cagcctgctg tcgaggcctt ctttttggtc catgccacag agcgggagag caagcctcct
    12121 gtccgagata cccgtgagag ccagctggca cacatcaagg atgaacctcc tccactctcc
    12181 cccgccccct taaccccagc cactccatcc tcccttgacc cattcttctc cagggagccc
    12241 tcatctatgc acatttcctc gagcctgccc cctgacacac agaagttcct tcgctttgca
    12301 gagactcacc gcactgtgtt aaaccagata ctacggcagt ctaccaccca tcttgctgat
    12361 gggccttttg ctgtcttggt agattatatc cgtgtcctcg actttgatgt caagcgcaaa
    12421 tatttccgcc aagagctgga gcgtttggac gaagggctcc ggaaagaaga tatggcagtg
    12481 catgtccgcc gtgaccatgt atttgaagac tcctatcgtg agctgcatcg caaatctcct
    12541 gaagaaatga agaatcgatt gtatatagtg tttgaaggag aagaagggca ggatgctggg
    12601 gggctcctgc gagagtggta catgatcatc tctcgagaga tgttcaaccc tatgtatgcc
    12661 ttgttccgta cctcacctgg tgaccgggtc acctacacca tcaatccatc ttcccactgt
    12721 aaccccaacc acctcagcta cttcaagttt gttggacgaa ttgtagccaa agctgtatat
    12781 gacaaccgcc tcctggagtg ctactttact aggtctttct acaaacacat cttgggcaaa
    12841 tctgtcaggt atacagatat ggagagtgaa gattaccact tctaccaggg cctagtttat
    12901 ctgcttgaaa atgatgtctc tacattaggc tatgacctca ccttcagcac tgaggttcaa
    12961 gaatttggag tatgtgaagt tcgtgacctc aaacccaatg gagccaacat cttggtaaca
    13021 gaggagaaca agaaggaata tgtacacctg gtttgccaga tgagaatgac aggagccatc
    13081 cgcaaacagc tggcagcctt cttggagggc ttctatgaaa tcattccaaa gcgcctcata
    13141 tccatcttta ctgagcagga attagagctg ctcatatcag ggctgcctac catcgacatt
    13201 gatgatctaa aatctaacac tgagtaccac aagtaccaat ccaactctat tcagatccag
    13261 tggttttgga gagcattgcg ttcctttgac caagcagacc gtgccaagtt cctccagttt
    13321 gtcacaggta cttccaaggt acccctacaa ggatttgctg cccttgaagg tatgaatggc
    13381 attcagaagt ttcagattca tcgagatgac agatccacag atcgcctgcc ttcagctcac
    13441 acatgtttta atcaactgga cctgcctgcc tatgagagct ttgagaagct ccgccacatg
    13501 ctactattgg ccatccagga atgctctgaa ggctttgggc tggcctaata aataaggccc
    13561 tgcctacttc tgtggggttt ttctaccatt gttggacctg gggagggggg tggatttaaa
    13621 agatccagaa agaaaatgtc aaaatccaat aaatgaaatt caccaactca ccatgtgtgt
    13681 cccagctgcc catcttccct agtgcatacc tgttcgcttc tcattctctt ttgtctcccc
    13741 tttcctcgcc tctccctttt ccatgccgtc catgatcccc accccatgtg ttaagaaggc
    13801 agtagccttt acagggacct gtttgtccca aatgaacagt gtgctcctca gattctgtgt
    13861 tcagaaggat ttgctgcatt gagacttgaa acctttggat aggggaaaaa ttatatatat
    13921 atatattttt ttgttctgtt tgcatttctt aatttgtgct tggaatgtgt tgatgtgcac
    13981 agctaatgat tcaatgcgag acaagattgg catctgtgtt gtggaggttt caaataaaga
    14041 gcactcttca taactcactt ttcacaacgg agtttttttc aaactgaaaa agaaaacccc
    14101 atcttataca catactagac aaatgaactt tccagaaaac catttctgcc cttcctgatc
    14161 acccacccac ctccacttct ggtatagaac ttcttccttc agtcagtttc cccagagaaa
    14221 agactgacag acaccgggaa ttggggggat ttttgttatt taaaatgggt atttggaaca
    14281 cactgcagca ggtactatca aaacagttaa cccatgcaat gtttcgtttg gtaagcattt
    14341 atgataatct caagtttaat tttcttaaaa gttttggtcc ctttctagta aattttaata
    14401 agcaaaatat ttgactagct cgccacaaga ccaccttttt tgtctgtctt gtcatttgtt
    14461 tgcaagtatt cacagattat ctagtagtct cttgtggttt ttactctatc cagcacttta
    14521 tcagactttg atggttccag ccttgaacaa aaatttaata aaaaatttag ttagaaaaac
    14581 aa
//
