LOCUS       NM_015755               5009 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus hormonally upregulated Neu-associated kinase (Hunk),
            mRNA.
ACCESSION   NM_015755 XM_917770
VERSION     NM_015755.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5009)
  AUTHORS   Ramos Solis,N., Cannon,A., Dilday,T., Abt,M., Oblak,A.L.,
            Soloff,A.C., Kaplan,M.H. and Yeh,E.S.
  TITLE     HUNK as a key regulator of tumor-associated macrophages in triple
            negative breast cancer
  JOURNAL   Oncoimmunology 13 (1), 2364382 (2024)
   PUBMED   38846083
  REMARK    GeneRIF: HUNK as a key regulator of tumor-associated macrophages in
            triple negative breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5009)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5009)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5009)
  AUTHORS   Reed,K.R., Korobko,I.V., Ninkina,N., Korobko,E.V., Hopkins,B.R.,
            Platt,J.L., Buchman,V. and Clarke,A.R.
  TITLE     Hunk/Mak-v is a negative regulator of intestinal cell proliferation
  JOURNAL   BMC Cancer 15, 110 (2015)
   PUBMED   25881306
  REMARK    GeneRIF: Hunk has a role in normal intestinal proliferation and
            homeostasis and, although it does not alter overall survival rates,
            activity of this kinase does impact on tumour initiation rates
            during the early stages in tumourigenesis in the small intestine.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5009)
  AUTHORS   Billingsley,C.N., Allen,J.R., Baumann,D.D., Deitz,S.L.,
            Blazek,J.D., Newbauer,A., Darrah,A., Long,B.C., Young,B.,
            Clement,M., Doerge,R.W. and Roper,R.J.
  TITLE     Non-trisomic homeobox gene expression during craniofacial
            development in the Ts65Dn mouse model of Down syndrome
  JOURNAL   Am J Med Genet A 161A (8), 1866-1874 (2013)
   PUBMED   23843306
REFERENCE   6  (bases 1 to 5009)
  AUTHORS   Korobko,I.V., Korobko,E.V. and Kiselev,S.L.
  TITLE     The MAK-V protein kinase regulates endocytosis in mouse
  JOURNAL   Mol Gen Genet 264 (4), 411-418 (2000)
   PUBMED   11129044
REFERENCE   7  (bases 1 to 5009)
  AUTHORS   Gardner,H.P., Belka,G.K., Wertheim,G.B., Hartman,J.L., Ha,S.I.,
            Gimotty,P.A., Marquis,S.T. and Chodosh,L.A.
  TITLE     Developmental role of the SNF1-related kinase Hunk in
            pregnancy-induced changes in the mammary gland
  JOURNAL   Development 127 (20), 4493-4509 (2000)
   PUBMED   11003847
REFERENCE   8  (bases 1 to 5009)
  AUTHORS   Gardner,H.P., Wertheim,G.B., Ha,S.I., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Marquis,S.T. and Chodosh,L.A.
  TITLE     Cloning and characterization of Hunk, a novel mammalian
            SNF1-related protein kinase
  JOURNAL   Genomics 63 (1), 46-59 (2000)
   PUBMED   10662544
REFERENCE   9  (bases 1 to 5009)
  AUTHORS   Chodosh,L.A., D'Cruz,C.M., Gardner,H.P., Ha,S.I., Marquis,S.T.,
            Rajan,J.V., Stairs,D.B., Wang,J.Y. and Wang,M.
  TITLE     Mammary gland development, reproductive history, and breast cancer
            risk
  JOURNAL   Cancer Res 59 (7 Suppl), 1765-1771s (1999)
   PUBMED   10197594
  REMARK    Review article
REFERENCE   10 (bases 1 to 5009)
  AUTHORS   Korobko,I.V., Kabishev,A.A. and Kiselev,S.L.
  TITLE     [Identification of the new protein kinase specifically transcribed
            in mouse tumors with high metastatic potential]
  JOURNAL   Dokl Akad Nauk 354 (4), 554-556 (1997)
   PUBMED   9273061
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC131339.3 and
            AC133505.3.
            
            On Nov 17, 2006 this sequence version replaced NM_015755.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF055919.2, AF167987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AC131339.3         98184-98503         c
            321-613             AC131339.3         52094-52386         c
            614-669             AC131339.3         37535-37590         c
            670-805             AC131339.3         31085-31220         c
            806-933             AC131339.3         20632-20759         c
            934-1069            AC131339.3         12321-12456         c
            1070-1232           AC131339.3         8918-9080           c
            1233-1316           AC131339.3         3567-3650           c
            1317-1364           AC133505.3         121453-121500       c
            1365-1545           AC133505.3         115766-115946       c
            1546-5009           AC133505.3         109806-113269       c
FEATURES             Location/Qualifiers
     source          1..5009
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 51.71 cM"
     gene            1..5009
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /note="hormonally upregulated Neu-associated kinase"
                     /db_xref="GeneID:26559"
                     /db_xref="MGI:MGI:1347352"
     exon            1..320
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2204
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase MAK-V"
                     /codon_start=1
                     /product="hormonally up-regulated neu tumor-associated
                     kinase"
                     /protein_id="NP_056570.1"
                     /db_xref="CCDS:CCDS28315.1"
                     /db_xref="GeneID:26559"
                     /db_xref="MGI:MGI:1347352"
                     /translation="MPAAAGDGLLGEPAAPGGDGGAEDTTRPAAACEGSFLPAWVSGV
                     SRERLRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDT
                     YVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLDE
                     AEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSD
                     PFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQK
                     MVDKAMNPLPTQLSTGAVNFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTY
                     PNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGK
                     SDIQDSICYKTQLYQIEKCRATKEPYEASLDTWTRDFEFHAVQDKKPKEQEKRGDFLH
                     RPFSKKLDKNLPSHKQPSPSLITQLQSTKALLKDRKASKSGFPDKDSFVCRNLFRKTS
                     DSNCVASSSMEFIPVPPPRTPRIVKKLEPHQPGPGSASILPKEEPLLLDMVRSFESVD
                     REDHIELLSPSHHYRILSSPVSLARRNSSERTLSQGLLSGSTSPLQTPLHSTLVSFAH
                     EEKNSPPKEEGVCSPPPVPSNGLLQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPS
                     SERSLDASMSPLQPTAPSSLSFDMADGVKGQC"
     exon            321..613
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /inference="alignment:Splign:2.1.0"
     exon            614..669
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /inference="alignment:Splign:2.1.0"
     exon            670..805
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /inference="alignment:Splign:2.1.0"
     exon            806..933
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1069
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1232
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1316
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1364
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1545
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..5009
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4962..4967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
                     /note="hexamer: AATATA"
     polyA_site      5006
                     /gene="Hunk"
                     /gene_synonym="Bstk1; Mak-v"
ORIGIN      
        1 agggcagccc cgggagccgg aggaggagcg gctgcgagcg cgggagccga gcgagcgcga
       61 tgccggcagc ggcgggggac gggctcttgg gcgagccggc ggcaccgggg ggcgatggag
      121 gcgcggagga cacgaccagg ccggcggcgg cctgcgaggg aagtttcctg cccgcctggg
      181 tgagcggcgt gtcccgcgag cggctccggg acttccagca ccacaagcgc gtgggcaact
      241 acctcatcgg cagcaggaag ctgggagagg gctccttcgc caaggtgcgc gaggggctgc
      301 acgtgctgac gggagaaaag gtagctatca aggtcatcga taagaaaaga gccaagaaag
      361 acacctacgt caccaaaaac ctgcgtcgag aggggcagat ccagcagatg atccgacacc
      421 ccaacatcac acagctcctg gacatcttgg agacagagaa cagctactac ctggtcatgg
      481 agctgtgtcc tggtggcaac ctcatgcaca agatctacga aaagaaacgg ttggatgaag
      541 ccgaggcccg cagatacatc cggcaactca tctctgcggt ggaacacctg caccgtgcgg
      601 gggtggttca cagagacttg aagatagaga atttgctact agatgaagac aataatatca
      661 agctgattga ctttggcttg agcaactgtg cagggatcct aggttactcg gatccattca
      721 gcacacagtg tggcagccct gcctatgctg cgccagaact gcttgccagg aagaaatatg
      781 gccccaaaat tgatgtctgg tcaataggcg tgaacatgta tgccatgctg acggggaccc
      841 tacctttcac tgtggagcct ttcagcctga gggctctgta tcagaagatg gtggacaaag
      901 caatgaatcc cctgccgacc cagctctcca caggggccgt caactttctg cgctccctcc
      961 tggaaccaga ccctgtgaag aggccgaata tccagcaagc gctggcgaat cgctggttga
     1021 atgagaatta cactggaaag gtgccctgca atgtcaccta tcccaacagg atttctttgg
     1081 aagacctgag tcccagcgtg gtgctgcaca tgactgaaaa gctgggctat aagaacagtg
     1141 acgtcatcaa cacggtgctc tccaaccgcg cctgccacat cctggccatc tacttcctgt
     1201 tgaacaagaa acttgagcgc tatttgtcag ggaaatcaga tatccaagat agcatctgct
     1261 acaagaccca gctctaccag atagagaagt gcagagccac caaggagccc tatgaggcct
     1321 ccctggatac ctggacgagg gactttgaat tccatgctgt gcaggataaa aagcccaaag
     1381 aacaagaaaa aagaggtgat tttctccacc gtccgttttc caagaagttg gacaagaatc
     1441 tgccttctca caaacagcca tcgccctcgc tgatcacaca gctccagagt accaaagccc
     1501 tgctcaaaga caggaaggcc tccaagtcag gcttccccga caaagattcc ttcgtctgcc
     1561 gcaatctttt ccgaaaaacc tctgattcca attgtgtggc ttcttcttcc atggaattca
     1621 tccctgtccc acctcccagg acaccaagga ttgtaaagaa actagagcca caccaaccag
     1681 ggccgggaag tgccagcatc ctccccaagg aagagcccct gctgctggat atggtacgct
     1741 cctttgagtc tgtggatcga gaggaccaca tagaactgct gtccccttct caccattata
     1801 ggatcctgag ctcgcctgtg agcctggctc gtaggaattc tagtgagagg acactctccc
     1861 aggggctgct gtccggaagt acctcacctc tccaaactcc actgcattcc acgctggtct
     1921 cttttgccca cgaagaaaag aacagccccc cgaaagagga gggtgtgtgt tcaccgcctc
     1981 ccgttcccag taatggcctc ctgcagcctc tggggagccc caactgtgtg aagagcaggg
     2041 gacggttccc catgatgggc atcggacaga tgctgaggaa gcggcaccag agcctgcagc
     2101 cttcctcaga gaggtccctg gacgccagca tgtcccctct gcagcccaca gccccctcca
     2161 gcctctcctt tgacatggcc gacggtgtca agggccagtg ttaacctggg atggcaagat
     2221 tctgggtctc tgtgaggaca gccacggaac agggctccac acaggcaggc accagggcat
     2281 gggtgaacaa cctcacggga gcatccttta ttcttttata cctgccacac aaagtcccac
     2341 gcttgtatca gctgaagtcc acagactcaa agtccacaca cttacttagg gaccctctga
     2401 gacgctgcga ctagggggag ggggaggggg cgaactgtgg gaatcacacc ttccagcctg
     2461 agattttctt tgctatatca ccaatcactg agccctctcc aggatccccc cagtgggctc
     2521 agagctaaaa accacacctc catctgctgg gccaatcaga tttccagact ggtaccaggt
     2581 tgtccctccc ctccgctctg tgtgtctctc acagttctgt aactgaccgt cagtggtcag
     2641 ttacagtctc acgcggacgt gccactcgct ggtaaggacg ttcacccaac ctagggatcc
     2701 ctctacagag ggaagcaacc cccctttccc taacagtgag tccccacaga gtgctgagtc
     2761 acagtgctgg accgggagga agatgggatg gcgcctcaga cagagatgga acccagcaga
     2821 gagaacccag gaggaagacg aagactcatt aaacgctcat tcctgtgcaa cgttttgaca
     2881 ggtttttctt tcctctcttt ctttttcccc tgaccttttc tttttgggtt gaaatttgct
     2941 gaggattgaa cgaacttgtc caaagagatc tttctttata tgaagtcatt aattaaattt
     3001 tttttttttt ttaaagacag ggtctcatta agtagcccaa gctggcttca aactcatgat
     3061 cctcctgcct cagtctccaa agtgctgaga ttacaagtat atatccgtgt ctggctcaaa
     3121 atagcaattc aaaaacaaaa actagttggc cagatgaaaa gtagttttac caaattcacg
     3181 tgtttttgtt tttctgagag gctgcagctc agatggccga aaggctggct tgggtggcaa
     3241 caggaggacc acagtggcct gcctgcctaa gggatagtag cctagccatc ctgtgtttat
     3301 accgtggcaa cagcagaagg catagaactt agctccagat ggctctggag agagagaaag
     3361 gattcttaaa gcagagttga gacagcaaga agcagggaat tcgctgtgtc atgctgttct
     3421 gccgtggtta gaacttagct gttctgctgg gagctaggag caggcttgcc gccccctggg
     3481 aacacgctca caagacggtt cgtccccaaa ggaaacagtg ccccccaaac aggctttcag
     3541 tccatgctgt aatctgcacc ttcccctcca ggattgaacc aaagatgcat ttccggtttt
     3601 gtgactgtgc cactctgtgt gtctcttgtg gaacctggtg ttgtctgatc ctgtccggct
     3661 ggcgctggat ggaggactgt ctctgtgtgc atcgtgggcc ctggtactta gcagaggaca
     3721 aagggcactg ttgtcaggag gggaagactt ggcacgggct ggaccacagt tagtttagaa
     3781 gttatggaac agctcagaat cttctggcct ttgactattt cagatggggt cagagaccag
     3841 agctgtagcc aggaagccag gttcatcatc ttggtccatc gattctaaag tgggcaaatt
     3901 tctgtgacgt cacaaagccg gcctttgcca gtgagggctg agacacagta caactgcctc
     3961 tcatttactg gtggcgggcg gcttcctttg gcctctcaga gctctgactg aactagaaga
     4021 gaacacggat ttggctgacc ctggaagaaa gctgctctag tcctggctga atttggtaag
     4081 acctggacta cttaaacttt agggagggac tgactccctc ccgaggaccc attacaggag
     4141 gaggccaggc ttttctccca gagctgatgg tgttcttcat tcagcatggc ttccgttcag
     4201 ctcccaggac ttgacactga aaatagaact ctttaagcag agagaagagg agagccatcc
     4261 acagacgctc tccgtatttg atgtgacgtg tttgagcttt gacgggtgaa gagtcctttt
     4321 aaaagataac tgccagctgc aggcatctgg ctctgcaaag ctggtaggat gtgtacctgt
     4381 gtactgtgcc cgcccccttt ctcctagccc tttatgtctt tttctgactg tttgcttttc
     4441 tcgtatgtat gtgtgcctgt gttggtgcga gcctgtggag aaagagtctc ccatccttca
     4501 aatgcttcga gaacagcgtc agatgtacaa ctagtttgcc tgcgttgcta ctggtacctt
     4561 ggactctgaa ctcaggttac ccacctgagt cctcagtagg cagtggaccc attgagaggc
     4621 aaatgagaac aggagggaga caagctgtgt tctggggcgc acataaacac ctgacagacg
     4681 agtctaggaa accgcgtgaa agaagaaatg ttaaattctt tattgtttta ttatatttat
     4741 acggaaaatg tggctatcct tttgttaagt gcagagtgta ttgtctgttt gacccatgac
     4801 tgtctgtcct tcatgaatga gtctttgcct gtgattctag tcagcctgtg gctactgatg
     4861 ggaacggccg atctgtcatc atgtgaagtc caggaggaag agtctatttt agtcatacga
     4921 tttggtcatg agtaaggact atatttatgt caccactatt gaatatatgt acttttataa
     4981 tggctgtgaa atacactttt tcctcacaa
//
