LOCUS       NM_030127               2754 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus HtrA serine peptidase 3 (Htra3), transcript variant 1,
            mRNA.
ACCESSION   NM_030127 XM_913697 XM_922849 XM_922856
VERSION     NM_030127.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2754)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2754)
  AUTHORS   Liu,H., Xu,J., Lan,Y., Lim,H.W. and Jiang,R.
  TITLE     The Scleraxis Transcription Factor Directly Regulates Multiple
            Distinct Molecular and Cellular Processes During Early Tendon Cell
            Differentiation
  JOURNAL   Front Cell Dev Biol 9, 654397 (2021)
   PUBMED   34150754
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2754)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2754)
  AUTHORS   Li,Y., Salamonsen,L.A., Hyett,J., Costa,F.D.S. and Nie,G.
  TITLE     Maternal HtrA3 optimizes placental development to influence
            offspring birth weight and subsequent white fat gain in adulthood
  JOURNAL   Sci Rep 7 (1), 4627 (2017)
   PUBMED   28676687
  REMARK    GeneRIF: Results show that HtrA3 deletion in the mother resulted in
            intra-uterine growth restriction (IUGR). Disorganization of
            labyrinthine fetal capillaries was the major placental defect when
            HtrA3 was absent. Mice born to HtrA3-deficient mothers, independent
            of their own genotype, were significantly heavier and contained a
            larger mass of white fat.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2754)
  AUTHORS   Patterson,V.L., Thompson,B.S., Cherry,C., Wang,S.B., Chen,B. and
            Hoh,J.
  TITLE     A Phenotyping Regimen for Genetically Modified Mice Used to Study
            Genes Implicated in Human Diseases of Aging
  JOURNAL   J Vis Exp (2016)
   PUBMED   27500671
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2754)
  AUTHORS   Havis,E., Bonnin,M.A., Olivera-Martinez,I., Nazaret,N., Ruggiu,M.,
            Weibel,J., Durand,C., Guerquin,M.J., Bonod-Bidaud,C., Ruggiero,F.,
            Schweitzer,R. and Duprez,D.
  TITLE     Transcriptomic analysis of mouse limb tendon cells during
            development
  JOURNAL   Development 141 (19), 3683-3696 (2014)
   PUBMED   25249460
REFERENCE   7  (bases 1 to 2754)
  AUTHORS   Bowden,M.A., Drummond,A.E., Fuller,P.J., Salamonsen,L.A.,
            Findlay,J.K. and Nie,G.
  TITLE     High-temperature requirement factor A3 (Htra3): a novel serine
            protease and its potential role in ovarian function and ovarian
            cancers
  JOURNAL   Mol Cell Endocrinol 327 (1-2), 13-18 (2010)
   PUBMED   20540986
  REMARK    Review article
REFERENCE   8  (bases 1 to 2754)
  AUTHORS   Nie,G., Li,Y., He,H., Findlay,J.K. and Salamonsen,L.A.
  TITLE     HtrA3, a serine protease possessing an IGF-binding domain, is
            selectively expressed at the maternal-fetal interface during
            placentation in the mouse
  JOURNAL   Placenta 27 (4-5), 491-501 (2006)
   PUBMED   15951015
  REMARK    GeneRIF: Both mRNA and protein of HtrA3 were localized specifically
            in the maternal decidua.  Only the maternal decidual cells, but not
            blood vessels or uterine NK cells that are present in large
            numbers, were positive for HtrA3.
REFERENCE   9  (bases 1 to 2754)
  AUTHORS   Tocharus,J., Tsuchiya,A., Kajikawa,M., Ueta,Y., Oka,C. and
            Kawaichi,M.
  TITLE     Developmentally regulated expression of mouse HtrA3 and its role as
            an inhibitor of TGF-beta signaling
  JOURNAL   Dev Growth Differ 46 (3), 257-274 (2004)
   PUBMED   15206957
REFERENCE   10 (bases 1 to 2754)
  AUTHORS   Nie,G.Y., Li,Y., Minoura,H., Batten,L., Ooi,G.T., Findlay,J.K. and
            Salamonsen,L.A.
  TITLE     A novel serine protease of the mammalian HtrA family is
            up-regulated in mouse uterus coinciding with placentation
  JOURNAL   Mol Hum Reprod 9 (5), 279-290 (2003)
   PUBMED   12728021
  REMARK    GeneRIF: Plays an important role in the formation/function of the
            placenta.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035194.1, AK020653.1, AK008764.1 and AY156509.1.
            
            On Nov 5, 2013 this sequence version replaced NM_030127.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035194.1, AY156509.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-638               AK035194.1         3-640
            639-651             AK020653.1         323-335
            652-1024            AK035194.1         655-1027
            1025-1025           AK008764.1         147-147
            1026-2096           AK035194.1         1029-2099
            2097-2754           AY156509.1         1789-2446
FEATURES             Location/Qualifiers
     source          1..2754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 18.49 cM"
     gene            1..2754
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /note="HtrA serine peptidase 3"
                     /db_xref="GeneID:78558"
                     /db_xref="MGI:MGI:1925808"
     exon            1..837
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..1814
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; probable serine protease HTRA3;
                     pregnancy-related serine protease; toll-associated serine
                     protease; high-temperature requirement factor A3"
                     /codon_start=1
                     /product="serine protease HTRA3 isoform a precursor"
                     /protein_id="NP_084403.2"
                     /db_xref="CCDS:CCDS19233.1"
                     /db_xref="GeneID:78558"
                     /db_xref="MGI:MGI:1925808"
                     /translation="MQARALLPATLAILATLAVLALAREPPAAPCPARCDVSRCPSPR
                     CPGGYVPDLCNCCLVCAASEGEPCGRPLDSPCGDSLECVRGVCRCRWTHTVCGTDGHT
                     YADVCALQAASRRALQVSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAV
                     VHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSSSTASGRQQLKVQLQNG
                     DAYEATIQDIDKKSDIATIVIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVT
                     TGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGI
                     SFAIPSDRITRFLSEFQNKHVKDWKKRFIGIRMRTITPSLVEELKAANPDFPAVSSGI
                     YVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLNESSLLLEVRRGNDDLL
                     FSIIPEVVM"
     exon            838..937
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1160
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1355
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1388
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1503
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1552
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1648
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..2745
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2712..2717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /note="hexamer: ATTAAA"
     polyA_site      2730
                     /gene="Htra3"
                     /gene_synonym="2210021K23Rik; 9530081K03Rik; Prsp; Tasp"
                     /note="major polyA site"
ORIGIN      
        1 aagtagagta ggggttcctc tgtgaaggag agctagggac agaatttgga cttgttcatg
       61 tctctggggt tgcggtcagg tccctggcta ggactggagt attccgaagc agctcccctt
      121 tcccagaccc tcattctggg ccggcagacc tgtcacccaa agtgcacacc aggcaagcgg
      181 ggagcaggag gctccgggtg ggtccccacc agccggggcg gggtcccgtg gggcaggggc
      241 ggggctggcg gcgggcaggg ccgccccttc cagcgagggc agactgtctt ggcctttaag
      301 cgcctgctga agctcggctg agagaggccc gggtcagtcc ccacaccatg ccctgtttgc
      361 gctccgggcc agagtgcgcc tgagcggttc gggcctcggt atccccgcgg gtcttgcgcc
      421 gccgcctctc cgcgatgcag gcgcgcgcgc tgctccccgc cacgctggcc attctggcca
      481 cgctggctgt gttggctctg gcccgggagc ccccagcggc tccgtgtcct gcgcgctgcg
      541 acgtgtcgcg ctgtccgagc cctcgctgcc ctgggggcta tgtgcctgac ctctgcaact
      601 gctgcctggt gtgcgctgcc agcgagggcg agccctgcgg ccgccccctg gactctccgt
      661 gcggggacag tctggagtgc gtgcgcggcg tgtgccgctg ccgttggacc cacactgtgt
      721 gtggcacaga cgggcatact tatgccgacg tgtgcgcgct gcaggccgcc agccgtcgtg
      781 cgttgcaggt ctccgggact ccagtgcgcc agctgcagaa gggtgcctgt ccctctggtc
      841 tccaccagct gaccagtccg cggtacaagt tcaacttcat cgccgatgtg gtggagaaga
      901 ttgcgccagc tgtggtccac atagagctct ttctgagaca ccccctgttt ggccggaatg
      961 tgccgctgtc cagtggctcg ggcttcatca tgtcagaagc cggtttgatc gtcaccaacg
     1021 cccacgtggt ctccagctcc agcactgcct ccggccggca gcagctgaag gtgcagctgc
     1081 agaatgggga tgcctatgag gccaccatcc aggacatcga caagaagtcg gacattgcca
     1141 cgattgtaat ccaccccaag aaaaagctcc ctgtgttgct gctgggtcac tcagcagacc
     1201 tgcggcctgg cgagttcgtg gtggccatcg gcagcccctt tgccctgcag aacaccgtga
     1261 caacgggcat tgtcagcact gcccagcggg atggcaagga gctgggtctc cgggactcag
     1321 acatggacta tatccagacc gatgccatca tcaattacgg gaactcagga ggacccctgg
     1381 tgaacctgga tggcgaggtc atcggcatca acacgctcaa ggttgcagct ggcatctcct
     1441 ttgccatccc ctcagatcgc atcacacgct tcctctctga gttccaaaac aagcatgtga
     1501 aagactggaa gaagcgcttc attggcatcc ggatgcggac catcacgcca agtttggtgg
     1561 aggaactgaa ggccgccaac ccagactttc cagcggtcag cagtggaata tatgttcaag
     1621 aggtggttcc caattcacct tctcagagag gaggcatcca agatggcgac atcatcgtca
     1681 aagtcaatgg ccgccccctg gcggattcca gcgagctgca ggaggcagtc ctgaacgagt
     1741 cttcactcct gctggaggtg cggcgaggca atgatgatct cctcttcagc atcatccctg
     1801 aggtggtcat gtgaggctac tctcatccag tgccatgcca aagcctacag aaggtggggt
     1861 tccggccttc atgaaatcag gacaaacggc tgctgtggtc ctcagcagga tcaacagtct
     1921 cctctctggg tccagcgctg agtccaaggc tggatctaac caggggtccg gatctcagcc
     1981 ttgaccctta atttcagctc cagtagagga agcacagcgt cctttggacc agatgctcct
     2041 gatgttaccg tctgagttct ctaggcctag aagctcttag aaacctccct ggaagtctgc
     2101 ccttccccca cccccacccc agctttctgc ctctgccctc aggaaggccc acccggctcc
     2161 catcccacct cttctccctt gtatcccagt gcctcaacct ctccctgtta caggcacttt
     2221 cctgacacta ccaggcttcc atctgcctca gcacacccca cccccatggt aagacagggg
     2281 ctgcttgccc taccacccgg tatccctgga gggcaggccc tgtagctgtc ccctggagaa
     2341 gccagggtcc tgacctggag caggttaaca tccctcactg ctgagctgag ccctgtgctg
     2401 gccaggatgg acaggaagat gagtttcata atcacgtggt ctccaaccct gacagctcat
     2461 tctcccaagg tgactacacg gtggccaaag aggagcggac acctgcctga ggtgcaagga
     2521 ctgagccact tcacctctgc atgcagttct gggtgcggca gctgtctgtg aagatggcgc
     2581 cacccagcag ccagcaggct cccaagggca tctttgttct ccctagtgtt tcaagtgtat
     2641 ttgtgagcat tgctgtaaag tttctcccac tacccacatt gcttgtactg tatgtttctc
     2701 tactgtatgg cattaaagtt tacaagcaca tagctgtcaa ccagaaaaaa aaaa
//
