LOCUS       NM_019752               1739 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus HtrA serine peptidase 2 (Htra2), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_019752
VERSION     NM_019752.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1739)
  AUTHORS   Shen,T., Wang,S., Huang,C., Zhu,S., Zhu,X., Li,N., Wang,H.,
            Huang,L., Ren,M., Han,Z., Ge,J., Chen,Z. and Ouyang,K.
  TITLE     Cardiac-specific deletion of heat shock protein 60 induces
            mitochondrial stress and disrupts heart development in mice
  JOURNAL   Biochem Biophys Res Commun 710, 149883 (2024)
   PUBMED   38588611
REFERENCE   2  (bases 1 to 1739)
  AUTHORS   Liu,Q., Yan,X., Yuan,Y., Li,R., Zhao,Y., Fu,J., Wang,J. and Su,J.
  TITLE     HTRA2/OMI-Mediated Mitochondrial Quality Control Alters Macrophage
            Polarization Affecting Systemic Chronic Inflammation
  JOURNAL   Int J Mol Sci 25 (3), 1577 (2024)
   PUBMED   38338855
  REMARK    GeneRIF: HTRA2/OMI-Mediated Mitochondrial Quality Control Alters
            Macrophage Polarization Affecting Systemic Chronic Inflammation.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1739)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   4  (bases 1 to 1739)
  AUTHORS   Nam,M.K., Shin,H.A., Yun,H., Yoo,S.A. and Rhim,H.
  TITLE     Delayed hair cycle in mnd2 mutant mice lacking HtrA2 serine
            protease activity
  JOURNAL   Biochem Biophys Res Commun 641, 102-109 (2023)
   PUBMED   36525924
  REMARK    GeneRIF: Delayed hair cycle in mnd2 mutant mice lacking HtrA2
            serine protease activity.
REFERENCE   5  (bases 1 to 1739)
  AUTHORS   Gao,M., Qiu,Y., Cao,T., Li,D., Wang,J., Jiao,Y., Chen,Z. and
            Huang,J.
  TITLE     Insufficient HtrA2 causes meiotic defects in aging germinal vesicle
            oocytes
  JOURNAL   Reprod Biol Endocrinol 20 (1), 173 (2022)
   PUBMED   36539842
  REMARK    GeneRIF: Insufficient HtrA2 causes meiotic defects in aging
            germinal vesicle oocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1739)
  AUTHORS   Jang,W., Weber,J.S., Tokito,M.K., Holzbaur,E.L. and Meisler,M.H.
  TITLE     Mouse p150Glued (dynactin 1) cDNA sequence and evaluation as a
            candidate for the neuromuscular disease mutation mnd2
  JOURNAL   Biochem Biophys Res Commun 231 (2), 344-347 (1997)
   PUBMED   9070275
REFERENCE   7  (bases 1 to 1739)
  AUTHORS   Patel,A., Rochelle,J.M., Jones,J.M., Sumegi,J., Uhl,G.R.,
            Seldin,M.F., Meisler,M.H. and Gregor,P.
  TITLE     Mapping of the taurine transporter gene to mouse chromosome 6 and
            to the short arm of human chromosome 3
  JOURNAL   Genomics 25 (1), 314-317 (1995)
   PUBMED   7774940
REFERENCE   8  (bases 1 to 1739)
  AUTHORS   Swaroop,A., Yang-Feng,T.L., Liu,W., Gieser,L., Barrow,L.L.,
            Chen,K.C., Agarwal,N., Meisler,M.H. and Smith,D.I.
  TITLE     Molecular characterization of a novel human gene, SEC13R, related
            to the yeast secretory pathway gene SEC13, and mapping to a
            conserved linkage group on human chromosome 3p24-p25 and mouse
            chromosome 6
  JOURNAL   Hum Mol Genet 3 (8), 1281-1286 (1994)
   PUBMED   7987303
REFERENCE   9  (bases 1 to 1739)
  AUTHORS   Barrow,L.L., Simin,K., Jones,J.M., Lee,D.C. and Meisler,M.H.
  TITLE     Conserved linkage of early growth response 4, annexin 4, and
            transforming growth factor alpha on mouse chromosome 6
  JOURNAL   Genomics 19 (2), 388-390 (1994)
   PUBMED   8188273
REFERENCE   10 (bases 1 to 1739)
  AUTHORS   Jones,J.M., Albin,R.L., Feldman,E.L., Simin,K., Schuster,T.G.,
            Dunnick,W.A., Collins,J.T., Chrisp,C.E., Taylor,B.A. and
            Meisler,M.H.
  TITLE     mnd2: a new mouse model of inherited motor neuron disease
  JOURNAL   Genomics 16 (3), 669-677 (1993)
   PUBMED   8325640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104324.21, AF175324.1 and BM899329.1.
            
            On Jul 18, 2009 this sequence version replaced NM_019752.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049880.1, AF175324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC104324.21        90997-91112         c
            117-1709            AF175324.1         13-1605
            1710-1739           BM899329.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..1739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..1739
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /note="HtrA serine peptidase 2"
                     /db_xref="GeneID:64704"
                     /db_xref="MGI:MGI:1928676"
     exon            1..651
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1522
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /EC_number="3.4.21.108"
                     /note="serine protease OMI; serine protease 25; serine
                     proteinase OMI; omi stress-regulated endoprotease; high
                     temperature requirement protein A2; protease, serine, 25;
                     motor neuron degeneration 2"
                     /codon_start=1
                     /product="serine protease HTRA2, mitochondrial"
                     /protein_id="NP_062726.3"
                     /db_xref="CCDS:CCDS20267.1"
                     /db_xref="GeneID:64704"
                     /db_xref="MGI:MGI:1928676"
                     /translation="MAALKAGRGANWSLRAWRALGGIFWRKPPLLAPDLRALLTSGTP
                     DSQIWMTYGTPSLPAQVPEGFLASRADLTSRTPDLWARLNVGTSGSSDQEARRSPGSR
                     RREWLAVAVGAGGAVVLLLWGWGRGLSTVLAAVPAPPPTSPRSQYNFIADVVEKTAPA
                     VVYIEILDRHPFSGREVPISNGSGFVVASDGLIVTNAHVVADRRRVRVRLPSGDTYEA
                     MVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVS
                     SAQRPARDLGLPQNNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIP
                     SDRLREFLHRGEKKNSWFGTSGSQRRYIGVMMLTLTPSILIELQLREPSFPDVQHGVL
                     IHKVILGSPAHRAGLRPGDVILAIGEKLAQNAEDVYEAVRTQSQLAVRIRRGSETLTL
                     YVTPEVTE"
     exon            652..856
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1051
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1084
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1190
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1260
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1356
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1725
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /note="hexamer: AATAAA"
     regulatory      1696..1701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /note="hexamer: ATTATA"
     polyA_site      1709
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
                     /note="major polyA site"
     polyA_site      1725
                     /gene="Htra2"
                     /gene_synonym="mnd2; Omi; Prss25"
ORIGIN      
        1 ctggagagga gcgcgtcctg acgggactac gtttcccggc atgcgctgaa cagctaccgt
       61 cgtgccctgc ttctcctaga ccgcttgccg ggttctagag gaccgcctct gagtagggcg
      121 ggcgaggaga gtcgaggcgg agctgatggc tgcgctgaaa gcggggcggg gtgcaaactg
      181 gagccttcgg gcatggcggg ctttgggggg catcttctgg aggaagcctc ccctgttagc
      241 tcctgacctc cgggctctgc tgacgtcagg aactcctgac tctcagatct ggatgactta
      301 tgggaccccc agtctcccgg cccaggtgcc tgaggggttc cttgcatcac gggcagatct
      361 gacgtctagg accccggatc tctgggcacg attgaatgtg gggacttcag gctccagtga
      421 ccaggaggcc cgcaggagcc ctggaagccg tcggcgcgaa tggctggcgg tggcggtggg
      481 cgcaggaggt gcagtggtgc tgctgttgtg gggttggggt cggggtcttt ccacggtgct
      541 ggctgctgtt cctgctccgc cacccacttc tccccggagc cagtacaatt tcatcgcaga
      601 tgtggtggag aagacagccc ctgctgtggt ctatatcgag atcctagacc ggcacccttt
      661 ctccggccgt gaagtcccca tctcaaacgg atcaggattc gtagtggctt cagatgggct
      721 catcgttacc aacgcccacg tggtggctga tcggcgccga gtacgagtga ggctgcctag
      781 cggggatact tatgaggcca tggtcacagc tgtggatccc gtagcagaca ttgccacact
      841 gaggattcaa accaaggagc ctcttcccac actgcccctc ggccgctctg ctgatgtccg
      901 gcaaggggag tttgttgttg ccatgggaag cccctttgca ctgcagaaca cgatcacatc
      961 tggtattgtc agctctgctc agcgcccagc cagggacctg ggactccctc aaaacaacgt
     1021 ggaatacatt cagaccgatg cagctattga ttttggaaat tctggtggtc ccctggttaa
     1081 cctggatggg gaggtgattg gagtgaacac catgaaggtg acagctggaa tctcctttgc
     1141 catcccttct gatcgcctta gggagtttct gcatcgcggg gaaaagaaaa attcctggtt
     1201 tggaaccagt gggtcccagc gccgctacat tggagtgatg atgctgaccc tgactcccag
     1261 catccttatt gaactacagc tccgtgagcc aagcttccct gatgttcagc atggtgtcct
     1321 cattcataaa gttatcctgg gctcccccgc acacagggct ggtctgcggc ctggtgatgt
     1381 gatcttggcc attggggaga aattggcaca aaatgctgaa gatgtttatg aagctgttcg
     1441 aacccaatca cagctggcag tgcggatccg gcgcggatca gagacactga ccttatatgt
     1501 gacccccgag gtcacagaat gaatgactgg accggcaaga gtgtgaagct cttgccctga
     1561 tctcctcctt gctttcctag cctaggttct gagtgcatgt gggtagagga ggagtcagtg
     1621 aacctgcgga gggcaagtcc ctctaaccgc tgcatcagtc ctgggctccg aagaacacat
     1681 tttatataaa ataaaattat acctagcaac atgttacagt caaaaaaaaa aaaaaaaaa
//
