LOCUS       NM_019564               2051 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus HtrA serine peptidase 1 (Htra1), mRNA.
ACCESSION   NM_019564
VERSION     NM_019564.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Beaufort,N., Ingendahl,L., Merdanovic,M., Schmidt,A.,
            Podlesainski,D., Richter,T., Neumann,T., Kuszner,M., Vetter,I.R.,
            Stege,P., Burston,S.G., Filipovic,A., Ruiz-Blanco,Y.B.,
            Bravo-Rodriguez,K., Mieres-Perez,J., Beuck,C., Uebel,S., Zobawa,M.,
            Schillinger,J., Malik,R., Todorov-Volgyi,K., Rey,J., Roberti,A.,
            Hagemeier,B., Wefers,B., Muller,S.A., Wurst,W., Sanchez-Garcia,E.,
            Zimmermann,A., Hu,X.Y., Clausen,T., Huber,R., Lichtenthaler,S.F.,
            Schmuck,C., Giese,M., Kaiser,M., Ehrmann,M. and Dichgans,M.
  TITLE     Rational correction of pathogenic conformational defects in HTRA1
  JOURNAL   Nat Commun 15 (1), 5944 (2024)
   PUBMED   39013852
  REMARK    GeneRIF: Rational correction of pathogenic conformational defects
            in HTRA1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2051)
  AUTHORS   Shi,H., Yuan,M., Cai,J., Lan,L., Wang,Y., Wang,W., Zhou,J.,
            Wang,B., Yu,W., Dong,Z., Deng,D., Qian,Q., Li,Y., Zhou,X. and
            Liu,J.
  TITLE     HTRA1-driven detachment of type I collagen from endoplasmic
            reticulum contributes to myocardial fibrosis in dilated
            cardiomyopathy
  JOURNAL   J Transl Med 22 (1), 297 (2024)
   PUBMED   38515161
  REMARK    GeneRIF: HTRA1-driven detachment of type I collagen from
            endoplasmic reticulum contributes to myocardial fibrosis in dilated
            cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2051)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2051)
  AUTHORS   Zhang,S., Mo,X., Jin,Y., Niu,Z., Yao,M., Zhang,Y., Li,L., Hu,G. and
            Ning,W.
  TITLE     Single-cell transcriptome analysis reveals cellular heterogeneity
            and highlights Fstl1-regulated alveolar myofibroblasts in mouse
            lung at birth
  JOURNAL   Genomics 115 (5), 110677 (2023)
   PUBMED   37406975
REFERENCE   5  (bases 1 to 2051)
  AUTHORS   Murayama,M., Hirata,H., Shiraki,M., Iovanna,J.L., Yamaza,T.,
            Kukita,T., Komori,T., Moriishi,T., Ueno,M., Morimoto,T.,
            Mawatari,M. and Kukita,A.
  TITLE     Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and
            suppresses age-related bone loss in male mice
  JOURNAL   J Cell Physiol 238 (3), 566-581 (2023)
   PUBMED   36715607
  REMARK    GeneRIF: Nupr1 deficiency downregulates HtrA1, enhances SMAD1
            signaling, and suppresses age-related bone loss in male mice.
REFERENCE   6  (bases 1 to 2051)
  AUTHORS   Funatsu,N., Inoue,T. and Nakamura,S.
  TITLE     Gene expression analysis of the late embryonic mouse cerebral
            cortex using DNA microarray: identification of several region- and
            layer-specific genes
  JOURNAL   Cereb Cortex 14 (9), 1031-1044 (2004)
   PUBMED   15142957
REFERENCE   7  (bases 1 to 2051)
  AUTHORS   Tocharus,J., Tsuchiya,A., Kajikawa,M., Ueta,Y., Oka,C. and
            Kawaichi,M.
  TITLE     Developmentally regulated expression of mouse HtrA3 and its role as
            an inhibitor of TGF-beta signaling
  JOURNAL   Dev Growth Differ 46 (3), 257-274 (2004)
   PUBMED   15206957
  REMARK    GeneRIF: HtrA1 and HtrA3 show similar expression patterns and share
            the same inhibitory activity on TGF-beta signaling
REFERENCE   8  (bases 1 to 2051)
  AUTHORS   Oka,C., Tsujimoto,R., Kajikawa,M., Koshiba-Takeuchi,K., Ina,J.,
            Yano,M., Tsuchiya,A., Ueta,Y., Soma,A., Kanda,H., Matsumoto,M. and
            Kawaichi,M.
  TITLE     HtrA1 serine protease inhibits signaling mediated by Tgfbeta family
            proteins
  JOURNAL   Development 131 (5), 1041-1053 (2004)
   PUBMED   14973287
  REMARK    GeneRIF: During embryo development, HtrA1 was expressed in specific
            areas where signaling by Tgfbeta family proteins plays important
            regulatory roles
REFERENCE   9  (bases 1 to 2051)
  AUTHORS   Marker,P.C., Dahiya,R. and Cunha,G.R.
  TITLE     Spontaneous mutation in mice provides new insight into the genetic
            mechanisms that pattern the seminal vesicles and prostate gland
  JOURNAL   Dev Dyn 226 (4), 643-653 (2003)
   PUBMED   12666202
REFERENCE   10 (bases 1 to 2051)
  AUTHORS   Gray,C.W., Ward,R.V., Karran,E., Turconi,S., Rowles,A.,
            Viglienghi,D., Southan,C., Barton,A., Fantom,K.G., West,A.,
            Savopoulos,J., Hassan,N.J., Clinkenbeard,H., Hanning,C.,
            Amegadzie,B., Davis,J.B., Dingwall,C., Livi,G.P. and Creasy,C.L.
  TITLE     Characterization of human HtrA2, a novel serine protease involved
            in the mammalian cellular stress response
  JOURNAL   Eur J Biochem 267 (18), 5699-5710 (2000)
   PUBMED   10971580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB193609.1, AF179369.1 and AI429470.1.
            
            On May 1, 2009 this sequence version replaced NM_019564.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013516.1, AK132270.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CB193609.1         1-29
            30-2034             AF179369.1         1-2005
            2035-2051           AI429470.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2051
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 73.2 cM"
     gene            1..2051
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /note="HtrA serine peptidase 1"
                     /db_xref="GeneID:56213"
                     /db_xref="MGI:MGI:1929076"
     exon            1..541
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            542..641
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            642..846
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1041
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1074
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1189
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1247
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1343
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..2039
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2017..2022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /note="hexamer: ATTAAA"
     polyA_site      2039
                     /gene="Htra1"
                     /gene_synonym="HTRA; L56; Prss11; RSPP11"
                     /note="major polyA site"
ORIGIN      
        1 aagaccccga cacaccgtcc cgagcgcggt ttttcggctg tggtccagcc cgtggccgtc
       61 ggagtcgtca tgcagtccct gcgtaccacg ctcctgtctt tgctactgct gctgctagcg
      121 gctccttcct tggcgttgcc gtcggggacc ggccgctcgg ccccagctgc caccgtctgt
      181 cccgagcact gcgatcccac ccgctgcgcc ccgccgccca cggactgcga gggtggccgc
      241 gtccgcgacg cgtgcggctg ctgcgaggtg tgcggcgcgc tcgagggtgc agcgtgcggc
      301 ctgcaggagg gtccctgcgg cgaggggctg caatgcgtag tgcccttcgg ggtgccggcc
      361 tcggccacag tacgacggcg cgcacaggcc ggcctgtgcg tgtgtgccag cagcgagccg
      421 gtgtgtggta gcgacgccaa gacctacacc aacctgtgcc agctgcgcgc cgccagccgc
      481 cgctccgaga agcttcgcca gccgccggtc atcgtcctgc agcgcggcgc ctgcggccaa
      541 gggcaggaag atcccaacag tttgcgtcat aagtacaact ttattgctga tgtggtggag
      601 aagatcgccc cggctgtggt tcacattgaa ctatatcgca agcttccttt ctcgaagagg
      661 gaggtgccag tggccagtgg gtcaggattc atcgtatcgg aggatggact gattgtgaca
      721 aatgctcacg tggtcaccaa caaaaaccgg gtcaaggttg agctgaagaa tggagctacc
      781 tatgaagcca aaatcaagga tgtggatgaa aaggcggaca ttgcgcttat caagattgac
      841 caccagggaa agctgccagt cctgctgctc ggccgctcct cagagctgag acctggagaa
      901 tttgtagttg ccattggaag ccccttttct cttcaaaaca cagtcaccac tgggatcgtc
      961 agcaccaccc agcgaggcgg caaagagctg ggacttcgga actccgatat ggactacatt
     1021 cagacagacg ctatcatcaa ttatggaaat tccggaggcc cgttagtaaa cctggatggc
     1081 gaggtgattg ggattaacac cttgaaggtg acggcgggca tctccttcgc aattccatcc
     1141 gataagataa aaaagttctt gacagagtcc cacgatcgac aggccaaagg gaaagctgtc
     1201 accaagaaga agtatattgg gatccgaatg atgtcgctca catctagcaa agccaaagag
     1261 ctgaaggacc gtcaccgaga cttcccggat gtgctctctg gggcatatat cattgaagtc
     1321 attcctgaca ccccggcaga agccggaggg ctcaaggaaa atgacgtcat catcagcatc
     1381 aacggacagt ctgtggtcac tgccaatgac gtcagcgatg tcatcaaaaa ggagaacacc
     1441 ctgaacatgg ttgtccgcag gggcaatgaa gacattgtga ttaccgtgat tcctgaagaa
     1501 atcgacccct aggcagaggc aggagccaga cttcatgttt ccctcaaaga ctccagggga
     1561 tggcgcatga gaactgagct ggtgacgcag gacacccggg acctttgtcc aacattttgc
     1621 ttgttcaggg aacacccctg ccgacagaat ccttcttgat agtttgcggg caaaacaaat
     1681 gtaatgttgc aggtgcacag gcagaagtcc tgccttctgt atgctatgta tgcagcgtgc
     1741 ttttccttac aagcttgggc tgttcctgct tacacagtca acatttgtcc cttcccttag
     1801 cctaagttgt ctgactaatg cagttgacgg atgcgtaggc aagaggaagg tcctcgcagc
     1861 catggtcttg ggcgtgttta cacttttcct ccgagtcggc actcagagga atttgatgcc
     1921 ccgagaccac aggtgggtga ccctggcttc tgagatggcc aaaaatgcct cttaggaatc
     1981 ctggaacccg gagtacagtg actttgagtt tcagctatta aaatacttct tcatacgtaa
     2041 aaaaaaaaaa a
//
