LOCUS       NM_008315               3393 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus 5-hydroxytryptamine (serotonin) receptor 7 (Htr7),
            transcript variant 1, mRNA.
ACCESSION   NM_008315
VERSION     NM_008315.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3393)
  AUTHORS   Frolova,V.S., Nikishina,Y.O., Shmukler,Y.B. and Nikishin,D.A.
  TITLE     Serotonin Signaling in Mouse Preimplantation Development: Insights
            from Transcriptomic and Structural-Functional Analyses
  JOURNAL   Int J Mol Sci 25 (23), 12954 (2024)
   PUBMED   39684667
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3393)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3393)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 3393)
  AUTHORS   Rodnyy,A.Y., Kondaurova,E.M., Bazovkina,D.V., Kulikova,E.A.,
            Ilchibaeva,T.V., Kovetskaya,A.I., Baraboshkina,I.A.,
            Bazhenova,E.Y., Popova,N.K. and Naumenko,V.S.
  TITLE     Serotonin 5-HT7 receptor overexpression in the raphe nuclei area
            produces antidepressive effect and affects brain serotonin system
            in male mice
  JOURNAL   J Neurosci Res 100 (7), 1506-1523 (2022)
   PUBMED   35443076
  REMARK    GeneRIF: Serotonin 5-HT7 receptor overexpression in the raphe
            nuclei area produces antidepressive effect and affects brain
            serotonin system in male mice.
REFERENCE   5  (bases 1 to 3393)
  AUTHORS   Gellynck,E., Laenen,K., Andressen,K.W., Lintermans,B., De
            Martelaere,K., Matthys,A., Levy,F.O., Haegeman,G., Vanhoenacker,P.
            and Van Craenenbroeck,K.
  TITLE     Cloning, genomic organization and functionality of 5-HT(7) receptor
            splice variants from mouse brain
  JOURNAL   Gene 426 (1-2), 23-31 (2008)
   PUBMED   18793707
  REMARK    GeneRIF: Cloning, genomic organization and functionality of 5-HT7
            receptor splice variants from mouse brain are reported.
REFERENCE   6  (bases 1 to 3393)
  AUTHORS   Wright,A., Kawakami,Y. and Pavan,W.
  TITLE     Mart1 is located on mouse chromosome 19 and is excluded as a
            candidate for ep and ru
  JOURNAL   Mamm Genome 8 (5), 377-378 (1997)
   PUBMED   9107690
REFERENCE   7  (bases 1 to 3393)
  AUTHORS   Ullmer,C., Schmuck,K., Kalkman,H.O. and Lubbert,H.
  TITLE     Expression of serotonin receptor mRNAs in blood vessels
  JOURNAL   FEBS Lett 370 (3), 215-221 (1995)
   PUBMED   7656980
REFERENCE   8  (bases 1 to 3393)
  AUTHORS   Danielson,P.E., Watson,J.B., Gerendasy,D.D., Erlander,M.G.,
            Lovenberg,T.W., de Lecea,L., Sutcliffe,J.G. and Frankel,W.N.
  TITLE     Chromosomal mapping of mouse genes expressed selectively within the
            central nervous system
  JOURNAL   Genomics 19 (3), 454-461 (1994)
   PUBMED   7910582
REFERENCE   9  (bases 1 to 3393)
  AUTHORS   Lovenberg,T.W., Baron,B.M., de Lecea,L., Miller,J.D., Prosser,R.A.,
            Rea,M.A., Foye,P.E., Racke,M., Slone,A.L., Siegel,B.W. et al.
  TITLE     A novel adenylyl cyclase-activating serotonin receptor (5-HT7)
            implicated in the regulation of mammalian circadian rhythms
  JOURNAL   Neuron 11 (3), 449-458 (1993)
   PUBMED   8398139
REFERENCE   10 (bases 1 to 3393)
  AUTHORS   Plassat,J.L., Amlaiky,N. and Hen,R.
  TITLE     Molecular cloning of a mammalian serotonin receptor that activates
            adenylate cyclase
  JOURNAL   Mol Pharmacol 44 (2), 229-236 (1993)
   PUBMED   8394987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133874.10 and BC116986.1.
            
            On Jan 31, 2018 this sequence version replaced NM_008315.2.
            
            Transcript Variant: This variant (1, also known as 5-HT7a) lacks an
            alternate exon in the 3' coding region, compared to variant 2. The
            encoded isoform (1) is shorter and has a distinct C-terminus,
            compared to isoform 2. 5-HT7a cited in PMID 18793707.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138150.1, BC116986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC133874.10        197403-197427       c
            26-1478             BC116986.1         1-1453
            1479-3393           AC133874.10        98485-100399        c
FEATURES             Location/Qualifiers
     source          1..3393
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 30.3 cM"
     gene            1..3393
                     /gene="Htr7"
                     /gene_synonym="5-HT-X; 5-HT7"
                     /note="5-hydroxytryptamine (serotonin) receptor 7"
                     /db_xref="GeneID:15566"
                     /db_xref="MGI:MGI:99841"
     exon            1..655
                     /gene="Htr7"
                     /gene_synonym="5-HT-X; 5-HT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1454
                     /gene="Htr7"
                     /gene_synonym="5-HT-X; 5-HT7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     5-hydroxytryptamine receptor 7; serotonin receptor 7"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 7 isoform 1"
                     /protein_id="NP_032341.2"
                     /db_xref="CCDS:CCDS29769.1"
                     /db_xref="GeneID:15566"
                     /db_xref="MGI:MGI:99841"
                     /translation="MMDVNSSGRPDLYGHLRSLILPEVGRRLQDLSPDGGAHSVVSSW
                     MPHLLSGFPEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGN
                     CLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNV
                     FIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITL
                     PPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH
                     KFSGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGI
                     IVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNR
                     DLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNCDHCGKKGHDT"
     exon            656..1411
                     /gene="Htr7"
                     /gene_synonym="5-HT-X; 5-HT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..3393
                     /gene="Htr7"
                     /gene_synonym="5-HT-X; 5-HT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3029..3034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr7"
                     /gene_synonym="5-HT-X; 5-HT7"
                     /note="hexamer: AATAAA"
     regulatory      3051..3056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr7"
                     /gene_synonym="5-HT-X; 5-HT7"
                     /note="hexamer: AATAAA"
     polyA_site      3052
                     /gene="Htr7"
                     /gene_synonym="5-HT-X; 5-HT7"
                     /note="major polyA site"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr7"
                     /gene_synonym="5-HT-X; 5-HT7"
                     /note="hexamer: AATAAA"
     polyA_site      3084
                     /gene="Htr7"
                     /gene_synonym="5-HT-X; 5-HT7"
     polyA_site      3098
                     /gene="Htr7"
                     /gene_synonym="5-HT-X; 5-HT7"
ORIGIN      
        1 tggctgggcc gcgcggagcc gagcgggcaa ggtgaatcca gccctggggc cggctgccgg
       61 agcgcttggc gggggcgccg gctccatggg cagcggcgct cggcacgatg atggacgtta
      121 acagcagcgg ccgccccgac ctctacggcc atctccgctc tctcatcctg ccggaggtgg
      181 ggcgcaggct gcaggacctg agccccgacg gtggcgccca ctcggtggtg agctcctgga
      241 tgccgcacct gctgagcggc ttcccagagg tgacagctag cccggcgccc acctgggacg
      301 cgcccccgga caatgtctcc ggctgcgggg agcagatcaa ctatggcaga gtcgagaaag
      361 ttgtgatcgg ctccatcctg acgctcatca cgctgctgac gatcgcgggc aactgcctgg
      421 tggtgatctc ggtgtgcttt gtcaagaagc tccgccagcc ctccaactac ctgattgtgt
      481 ccctggcgct ggctgacctc tcggtggccg tggcggtcat gcctttcgtt agtgtcacgg
      541 acctcatcgg gggcaagtgg atcttcggcc acttcttctg caacgtcttc atcgccatgg
      601 acgtcatgtg ctgcacggcc tcgatcatga ccctgtgcgt gatcagcatc gacaggtacc
      661 ttgggatcac caggcccctc acgtaccccg tgaggcagaa tgggaaatgt atggccaaaa
      721 tgattctgtc ggtctggctt ctctctgcct ccatcacctt acctcctctc ttcggatggg
      781 ctcagaatgt gaacgatgac aaagtgtgct tgatcagcca ggattttggc tacacgatct
      841 actccaccgc agtggcgttt tatatcccca tgtcggtcat gctgttcatg tactatcaga
      901 tttacaaggc cgccaggaag agcgcagcca aacacaagtt ctcaggcttc ccacgcgtgc
      961 agccggagag cgtcatctcc ctgaatggcg tggtgaaact ccagaaggag gtggaagagt
     1021 gtgcgaacct ttcgagactg ctcaaacacg aaaggaaaaa catttccatc ttcaagaggg
     1081 aacagaaagc agccactacc ttggggatca tcgtgggagc cttcacggtg tgctggctgc
     1141 cgtttttcct cttgtccaca gcaaggccct ttatctgtgg cacctcctgt agctgcatcc
     1201 cgctgtgggt ggagaggaca tgtctgtggc tgggctatgc aaactctctc attaaccctt
     1261 ttatatatgc cttcttcaac cgggacctga ggaccaccta tcgtagccta ctccagtgcc
     1321 agtaccggaa tatcaaccgg aagctctctg ctgcaggcat gcacgaagcc ctgaaacttg
     1381 ctgagaggcc tgagagaagc gagtttgtgc tacaaaactg tgaccactgt gggaaaaaag
     1441 gtcatgatac atgatccaga gcggaaccct ggagaagaag taatgcagaa cagggggaaa
     1501 caacgaaacc attggctgag actgcacaac agaacttggc ttctgtcttc ttggcatggc
     1561 tgaaatgtga caaggggtga tctgttgtac aaagtgtatc ttgagggaga tggcaacctc
     1621 tctctgtttt tttctgtgga tcagtgatat tgtgtttaaa tgaaaaaaaa tgctcagtgt
     1681 cagacagcca gtcatctctg cggtaagcac actacagcgc tgggttctgg gaggggaggg
     1741 aagcagtttc tggtgctttc cacaaatcca catccatgag agtgggggga aatcctaacg
     1801 cacaattccc atgcttcccg tctaggcttt gtggtaactc ttcaggaacc attcatgaga
     1861 cagagttcat tttgtggtct atcagaaggg tgtctttcca agcaaactgc agtaagcatc
     1921 gtgttgaatg tgttgcatgt ccatgttaga aaacagaaac cagtcatcag cgaacacaag
     1981 cgattccccg gagcagtgtt cattcaaagc ttctgttaaa tactgtggct tttctgcagg
     2041 gtccttgtga ctttccacca gtgtatgtcc accgttaaat cctttatcat tatggtgtaa
     2101 ctcaggaaca gatctcagga tggagagagg cagaaaacct gaataaagct tttccttgta
     2161 ctcacactcc tgaaggctcc tgagagagaa tggtaactgg agaagagtga atgccgcatc
     2221 actgcattgt atattaacat gattcttggc atgttgttta ctctcatctt ctacaagggt
     2281 acaaggagcc cacggggctg gtccataatg gtgtgttatg agcagggagt gtggcaatag
     2341 catatccatg aatgattgtg gttgtttctg gagacagtat aaacatggtc atccaactgg
     2401 actgtttgaa ttgtgtgaat tagctctcac ttgaaccccc attgttaata ctctggaaca
     2461 ccattctgtt tcatgtggag aatttgtctc tgtgttctct gtatcttaaa tcaaatgtgt
     2521 gcctgatgaa ttctgtccct taactccctc ccaccaataa aaatggtcaa agttaaggac
     2581 agataaggaa acagaaaggt tttttttgtg gatagtatca tttaaatgtt actatgtagt
     2641 agtctgggtg aaggagaggg aaaggcacag atcagaagag tacccatgcc tacaagggga
     2701 catgaatgaa aacctttatt tgataaaaag agaactgaaa gagaatatta ttttcctaca
     2761 gttaaggagg ctgtcctttc acaggataaa atagagttac aaagtggatt atggacttct
     2821 tccagatgtc actgatgttt attatgagag caggacccct ttcctgtgga ggggaggtag
     2881 gcactgtcct ttcagacaaa gtgtgtacaa attcctgagc tgcagattcg ctagagtgaa
     2941 cgtatatact tatattcata atttaaataa caattatgtc atatacatgt tgttaaattt
     3001 gaaaaaaatg ttttattaca tcacatcaaa taaaggttat ttgtagctgt aataaagtaa
     3061 cttaagtaat tgtttttaat aaaaggtctg atgtcataca tgttattcta caaaggatgg
     3121 tgggggtggg gtgcatactc tgagcttgcg cttgcttgct aaacctctaa caggtacctg
     3181 gggatgatgg tgcacaccta taaccctaac acacaggaag cagaggcagg gggatctcaa
     3241 gtttgaagac agtctgagtt tacatctaga gacattttta aaaaagttcc tagaaagtaa
     3301 ttgacaggtt tatcctaaat tacatttcaa tgtagaaacc tatctcttta gtaattaaaa
     3361 aaaattgaat aaaaaagtgt ttgttgattt gat
//
