LOCUS       NM_001377096            3743 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus 5-hydroxytryptamine (serotonin) receptor 6 (Htr6),
            mRNA.
ACCESSION   NM_001377096 XM_011250196
VERSION     NM_001377096.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3743)
  AUTHORS   Dupuy,V., Prieur,M., Pizzoccaro,A., Margarido,C., Valjent,E.,
            Bockaert,J., Bouschet,T., Marin,P. and Chaumont-Dubel,S.
  TITLE     Spatiotemporal dynamics of 5-HT6 receptor ciliary localization
            during mouse brain development
  JOURNAL   Neurobiol Dis 176, 105949 (2023)
   PUBMED   36496200
REFERENCE   2  (bases 1 to 3743)
  AUTHORS   Sheu,S.H., Upadhyayula,S., Dupuy,V., Pang,S., Deng,F., Wan,J.,
            Walpita,D., Pasolli,H.A., Houser,J., Sanchez-Martinez,S.,
            Brauchi,S.E., Banala,S., Freeman,M., Xu,C.S., Kirchhausen,T.,
            Hess,H.F., Lavis,L., Li,Y., Chaumont-Dubel,S. and Clapham,D.E.
  TITLE     A serotonergic axon-cilium synapse drives nuclear signaling to
            alter chromatin accessibility
  JOURNAL   Cell 185 (18), 3390-3407 (2022)
   PUBMED   36055200
REFERENCE   3  (bases 1 to 3743)
  AUTHORS   Sun,Z., Wang,B., Chen,C., Li,C. and Zhang,Y.
  TITLE     5-HT6R null mutatrion induces synaptic and cognitive defects
  JOURNAL   Aging Cell 20 (6), e13369 (2021)
   PUBMED   33960602
  REMARK    Erratum:[Aging Cell. 2023 Feb;22(2):e13777. doi:
            10.1111/acel.13777.. PMID: 36585768]
REFERENCE   4  (bases 1 to 3743)
  AUTHORS   Wang,Q., Dong,X., Hu,T., Qu,C., Lu,J., Zhou,Y., Li,J. and Pei,G.
  TITLE     Constitutive Activity of Serotonin Receptor 6 Regulates Human
            Cerebral Organoids Formation and Depression-like Behaviors
  JOURNAL   Stem Cell Reports 16 (1), 75-88 (2021)
   PUBMED   33357407
REFERENCE   5  (bases 1 to 3743)
  AUTHORS   Barbeito,P., Tachibana,Y., Martin-Morales,R., Moreno,P.,
            Mykytyn,K., Kobayashi,T. and Garcia-Gonzalo,F.R.
  TITLE     HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and
            C-terminal tails
  JOURNAL   Life Sci Alliance 4 (3), e202000746 (2020)
   PUBMED   33372037
  REMARK    GeneRIF: HTR6 and SSTR3 ciliary targeting relies on both IC3 loops
            and C-terminal tails.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3743)
  AUTHORS   Bonasera,S.J., Chu,H.M., Brennan,T.J. and Tecott,L.H.
  TITLE     A null mutation of the serotonin 6 receptor alters acute responses
            to ethanol
  JOURNAL   Neuropsychopharmacology 31 (8), 1801-1813 (2006)
   PUBMED   16452990
REFERENCE   7  (bases 1 to 3743)
  AUTHORS   Zhang,J., Shen,C.P., Xiao,J.C., Lanza,T.J., Lin,L.S., Francis,B.E.,
            Fong,T.M. and Chen,R.Z.
  TITLE     Effects of mutations at conserved TM II residues on ligand binding
            and activation of mouse 5-HT6 receptor
  JOURNAL   Eur J Pharmacol 534 (1-3), 77-82 (2006)
   PUBMED   16612839
REFERENCE   8  (bases 1 to 3743)
  AUTHORS   Zhang,S. and Gershenfeld,H.K.
  TITLE     Genetic contributions to body weight in mice: relationship of
            exploratory behavior to weight
  JOURNAL   Obes Res 11 (7), 828-838 (2003)
   PUBMED   12855751
REFERENCE   9  (bases 1 to 3743)
  AUTHORS   Kohen,R., Fashingbauer,L.A., Heidmann,D.E., Guthrie,C.R. and
            Hamblin,M.W.
  TITLE     Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis
            studies of the third cytoplasmic loop
  JOURNAL   Brain Res Mol Brain Res 90 (2), 110-117 (2001)
   PUBMED   11406289
REFERENCE   10 (bases 1 to 3743)
  AUTHORS   Cox,G.A., Lutz,C.M., Yang,C.L., Biemesderfer,D., Bronson,R.T.,
            Fu,A., Aronson,P.S., Noebels,J.L. and Frankel,W.N.
  TITLE     Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant
            mice
  JOURNAL   Cell 91 (1), 139-148 (1997)
   PUBMED   9335342
  REMARK    Erratum:[Cell 1997 Dec 12;91(6):861]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805923.6.
            
            On Dec 13, 2019 this sequence version replaced XM_011250196.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662773.895212.1,
                                           SRR10662774.1040792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AL805923.6         132623-132760       c
            139-1426            AL805923.6         131232-132519       c
            1427-1585           AL805923.6         119264-119422       c
            1586-3743           AL805923.6         116896-119053       c
FEATURES             Location/Qualifiers
     source          1..3743
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.57 cM"
     gene            1..3743
                     /gene="Htr6"
                     /gene_synonym="5-HT6"
                     /note="5-hydroxytryptamine (serotonin) receptor 6"
                     /db_xref="GeneID:15565"
                     /db_xref="MGI:MGI:1196627"
     exon            1..138
                     /gene="Htr6"
                     /gene_synonym="5-HT6"
                     /inference="alignment:Splign:2.1.0"
     exon            139..1426
                     /gene="Htr6"
                     /gene_synonym="5-HT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             707..2029
                     /gene="Htr6"
                     /gene_synonym="5-HT6"
                     /note="5-HT-6; serotonin receptor 6"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 6"
                     /protein_id="NP_001364025.1"
                     /db_xref="GeneID:15565"
                     /db_xref="MGI:MGI:1196627"
                     /translation="MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAAN
                     SLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLW
                     TAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFL
                     PLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQ
                     AVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKALKASLTLGILL
                     SMFFVTWLPFFVASIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALG
                     RFVPCVHCPPEHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGL
                     QLTAQLLLPGEATRDPPPPTRAPTVVNFFVTDSVEPEIRQHPLGSPMN"
     exon            1427..1585
                     /gene="Htr6"
                     /gene_synonym="5-HT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..3743
                     /gene="Htr6"
                     /gene_synonym="5-HT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3724..3729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr6"
                     /gene_synonym="5-HT6"
                     /note="hexamer: AATAAA"
     polyA_site      3743
                     /gene="Htr6"
                     /gene_synonym="5-HT6"
                     /note="major polyA site"
ORIGIN      
        1 gaagcgtcgc gggctcctgc gcaccatctc cccggctcgg gagccctatg cccgccgcgc
       61 caccagccgc tgcctgtagt ctccagcccc gcggcgcttg ccgcagtcgc cggcagcgga
      121 tcacccgcga gcgcccaggt ctggcccggc ccggtccgcg gcctccggta cccgggatcc
      181 ttcagtgcct aggggagaaa ggagacctgc tttccgccgc cgagctgcgc tcctgttctt
      241 gggccacccc attgcgaccc ccacgcgcga cagctcgtga tcaagcgtac tcacacgccc
      301 accctcctca gagagactgc cccgaccgga aggcgggagt tcgcctcctg ctcccacctc
      361 cccagccgtg cctctggcca ggagccccac ccccatcctt aggcatcccc ggtggctcta
      421 ttccattcca gggctctcat ccagccccag cccaactttc atggactcgg cgcatcggta
      481 cccctcccca aacttcttac ccgagtactc caggtggccc cgccatagga ggcgccccta
      541 caatctctcc ccgacctctt gtaatggttg ctcggtgacc taagaaccct gttttgccac
      601 ctactcctct gaggtgcagt ttttacccat cttgctttct cttcctttgg cttcaccctg
      661 tatccgcatt caccatatcc tgtcctggtc ctcaacccta gtccccatgg ttccagagcc
      721 cggccctgtc aacagtagca ccccagcctg gggccccggg ccaccgccag ccccaggggg
      781 cagcggctgg gtggccgctg cgctgtgcgt ggtcatcgtg ctgacggcag ccgccaattc
      841 gctgctgatc gcgctcatct gcacgcagcc cgcgctgcgc aacacgtcta acttcttcct
      901 ggtgtcgctc ttcacgtcgg acctgatggt gggattggtg gtgatgcccc cagccatgct
      961 gaacgcgctg tatgggcgct gggtgctagc tcgcggcctc tgtctgcttt ggaccgcctt
     1021 cgacgtgatg tgctgcagcg cctccattct caacctctgc ctcatcagcc tggaccgcta
     1081 cctgctcatc ctctcgccgc tgcgctacaa gctgcgcatg acagccccgc gtgccctggc
     1141 gctcatcctg ggtgcctgga gcctcgccgc gctggcctcc ttcctgcccc tcttgctggg
     1201 ctggcatgaa ctgggcaaag ctcgaacatc tgccccgggc cagtgccgcc tattggccag
     1261 cctgccttat gtcctcgtgg cgtccggcgt cacctttttc ctgccttcgg gtgccatctg
     1321 cttcacctac tgcaggatct tgctggctgc ccgcaagcag gcggtgcaag tggcctcgct
     1381 caccacgggc acggctacgg ctggccaggc cttggaaacc ttgcaggtgc ccaggacacc
     1441 acgcccaggg atggagtctg ctgacagtag gcgtctgacc accaagcata gcaggaaggc
     1501 cttgaaggcc agcctgaccc tcggcatcct gctgagcatg ttctttgtca cctggctgcc
     1561 cttctttgtg gccagcatag ctcaggccgt atgtgactgc atctctccag gtctcttcga
     1621 tgtcctcaca tggctgggat actgtaatag caccatgaac cctatcatct atcccctctt
     1681 catgcgggac ttcaagaggg ccctgggcag gttcgtgccg tgtgtccact gtcccccgga
     1741 gcaccgggcc agccccgcct ccccctccat gtggacctct cacagtggtg ccaggccagg
     1801 cctcagcctg cagcaggtgc tgcccctgcc tctgccaccc aactcagatt cagactcagc
     1861 ttcagggggc acctcgggcc tgcagctcac agcccagctt ttgctgcctg gagaggcgac
     1921 ccgggacccc ccgccaccca ccagggcccc tactgtggtc aacttcttcg tcacagactc
     1981 tgtggagcct gagatacggc agcatccact tggttccccc atgaactgac caggtcaaga
     2041 gctggccagc ggaggccaca ttcccagagg cctcagccca ttctccctaa gagtgggagg
     2101 tggtaggtct cccgagagca tgccgagtgt cctgagggat cctcggctag cccccatctt
     2161 ctacttgaag gctccttgac atgagagata atctgaaaca tcgtagggta ttccagtaca
     2221 atgttgcttg tggtttgtgt agtgtggctg gcggggggtg gggggcagtg tctcggagct
     2281 gtgccatttg gttcagttca gcaggaaagc aatcagtcct cagccctttt tgttaagtgg
     2341 gaagaacgta ttcctctaga caccccagtt cctgactggc ccaatcctgt tatccaaagt
     2401 gccatctctg ggttgttggg gttcctgtag gctctgggga gcttattcaa agtgcccacc
     2461 cctctggaga tgggctcaat cgacattgta tgttcatgag ctttgccaag tctgcctttg
     2521 ctgaactttc agacctgcca gcccctagga ggggggtggc aactttaaga agtagcttag
     2581 gctggaggct gggcagccag aaatatgacc ttttcctcag ctgtatgctg catttcttgg
     2641 gcttggcaca ggtctcaagg tagagtagga gtgataccac ctgtaagaca atgtggatgg
     2701 tatgcccaga acctgtgagg ggccagtggg tggtaaatcc tattgcttta actcttggtt
     2761 agccggattc tggctctggt agaagggtag caagtgtccc tccctccttc ttccagcctt
     2821 ccctccctct ctccctccct ccctccctcc ctctcttcct tttgttttga tttgttctag
     2881 gctctcaagt aactcatgtt tccctatgtg gccaaggatg accctgaact tgtaatcctc
     2941 ttgcctctac ctcccaagtg ctggggtcac agggatacac cacacaccag attatatggt
     3001 gctgggggtg aaactcaggg cttcatgcat tctgggaaag cactctacca gtggagctgt
     3061 gtccctaggg cctcctgttt tctgttaggt cagcctcaca tatactaggc aagcgctctc
     3121 cacggggcca catctcagcc ccattgtcta ttccagccca gattgggctc ccagcctcct
     3181 tgctttgctg ggtggagact gtaccactca gggactcttt ctagtcccat cctgttcttc
     3241 tgcctctaga ggcccagggg atggtgacag atcctgtaca accttaagtg tgggtttcct
     3301 ctaccccagc ttccccagct gatggaggca gagcagcccc tcatcctgcc tgtccccttt
     3361 ggttcttcct agggtcactg aaagaaagaa cagctgcttg ggtaggcagc atacagctga
     3421 agagggatgt gtgcccctgg cttgggggtg aagccacaga caggcaggtg ggctctggtt
     3481 tggcacgggg cttgcatttg tgggtaaggg caggggactc ccttactcca tgctgctcca
     3541 cactgaattc cccttcagca gctgcaggtc tttctttgag cctgtgttcc agcgacccgg
     3601 gctcccggac tctctcccta tggccaggag ctctccttgg tgctgaccgt gctcaactgg
     3661 gccctggcag caaggctctg gtgcttccgg ctttctctgc cactgggcct gcctgaggga
     3721 ctcaataaac acaagctgaa gga
//
