LOCUS       NM_008313               4657 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus 5 hydroxytryptamine (serotonin) receptor 4 (Htr4),
            transcript variant 1, mRNA.
ACCESSION   NM_008313
VERSION     NM_008313.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4657)
  AUTHORS   Hu,S., Kou,Y., Liu,X., Rong,W., Han,H. and Zhang,G.
  TITLE     Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight
            junction barrier dysfunction in the colon of type 1 diabetic mice
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (12), 1874-1883 (2023)
   PUBMED   37766457
  REMARK    GeneRIF: Activation of the 5-hydroxytryptamine 4 receptor
            ameliorates tight junction barrier dysfunction in the colon of type
            1 diabetic mice.
REFERENCE   2  (bases 1 to 4657)
  AUTHORS   Karayol,R., Medrihan,L., Warner-Schmidt,J.L., Fait,B.W., Rao,M.N.,
            Holzner,E.B., Greengard,P., Heintz,N. and Schmidt,E.F.
  TITLE     Serotonin receptor 4 in the hippocampus modulates mood and anxiety
  JOURNAL   Mol Psychiatry 26 (6), 2334-2349 (2021)
   PUBMED   33441982
REFERENCE   3  (bases 1 to 4657)
  AUTHORS   Bhattarai,Y., Jie,S., Linden,D.R., Ghatak,S., Mars,R.A.T.,
            Williams,B.B., Pu,M., Sonnenburg,J.L., Fischbach,M.A., Farrugia,G.,
            Sha,L. and Kashyap,P.C.
  TITLE     Bacterially Derived Tryptamine Increases Mucus Release by
            Activating a Host Receptor in a Mouse Model of Inflammatory Bowel
            Disease
  JOURNAL   iScience 23 (12), 101798 (2020)
   PUBMED   33299969
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4657)
  AUTHORS   Okumura,M., Hamada,A., Ohsaka,F., Tsuruta,T., Hira,T. and
            Sonoyama,K.
  TITLE     Expression of serotonin receptor HTR4 in glucagon-like
            peptide-1-positive enteroendocrine cells of the murine intestine
  JOURNAL   Pflugers Arch 472 (10), 1521-1532 (2020)
   PUBMED   32870377
  REMARK    GeneRIF: Expression of serotonin receptor HTR4 in glucagon-like
            peptide-1-positive enteroendocrine cells of the murine intestine.
REFERENCE   5  (bases 1 to 4657)
  AUTHORS   Kobayashi,K., Mikahara,Y., Murata,Y., Morita,D., Matsuura,S.,
            Segi-Nishida,E. and Suzuki,H.
  TITLE     Predominant Role of Serotonin at the Hippocampal Mossy Fiber
            Synapse with Redundant Monoaminergic Modulation
  JOURNAL   iScience 23 (4), 101025 (2020)
   PUBMED   32283526
REFERENCE   6  (bases 1 to 4657)
  AUTHORS   Claeysen,S., Sebben,M., Becamel,C., Bockaert,J. and Dumuis,A.
  TITLE     Novel brain-specific 5-HT4 receptor splice variants show marked
            constitutive activity: role of the C-terminal intracellular domain
  JOURNAL   Mol Pharmacol 55 (5), 910-920 (1999)
   PUBMED   10220570
REFERENCE   7  (bases 1 to 4657)
  AUTHORS   Claeysen,S., Faye,P., Sebben,M., Taviaux,S., Bockaert,J. and
            Dumuis,A.
  TITLE     5-HT4 receptors: cloning and expression of new splice variants
  JOURNAL   Ann N Y Acad Sci 861, 49-56 (1998)
   PUBMED   9928238
  REMARK    Review article
REFERENCE   8  (bases 1 to 4657)
  AUTHORS   Claeysen,S., Sebben,M., Journot,L., Bockaert,J. and Dumuis,A.
  TITLE     Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor
  JOURNAL   FEBS Lett 398 (1), 19-25 (1996)
   PUBMED   8946946
REFERENCE   9  (bases 1 to 4657)
  AUTHORS   Ullmer,C., Schmuck,K., Kalkman,H.O. and Lubbert,H.
  TITLE     Expression of serotonin receptor mRNAs in blood vessels
  JOURNAL   FEBS Lett 370 (3), 215-221 (1995)
   PUBMED   7656980
REFERENCE   10 (bases 1 to 4657)
  AUTHORS   Gerald,C., Adham,N., Kao,H.T., Olsen,M.A., Laz,T.M.,
            Schechter,L.E., Bard,J.A., Vaysse,P.J., Hartig,P.R., Branchek,T.A.
            et al.
  TITLE     The 5-HT4 receptor: molecular cloning and pharmacological
            characterization of two splice variants
  JOURNAL   EMBO J 14 (12), 2806-2815 (1995)
   PUBMED   7796807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152454.5 and AC131714.4.
            
            On Apr 27, 2007 this sequence version replaced NM_008313.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141625.1, AK141587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AC152454.5         88262-88426         c
            166-238             AC152454.5         71553-71625         c
            239-364             AC152454.5         333-458             c
            365-565             AC131714.4         94624-94824         c
            566-719             AC131714.4         80178-80331         c
            720-1288            AC131714.4         70403-70971         c
            1289-4657           AC131714.4         40552-43920         c
FEATURES             Location/Qualifiers
     source          1..4657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 35.1 cM"
     gene            1..4657
                     /gene="Htr4"
                     /gene_synonym="5-HT-4; 5-HT4; 5-HT<4L>; 5HTR4"
                     /note="5 hydroxytryptamine (serotonin) receptor 4"
                     /db_xref="GeneID:15562"
                     /db_xref="MGI:MGI:109246"
     exon            1..165
                     /gene="Htr4"
                     /gene_synonym="5-HT-4; 5-HT4; 5-HT<4L>; 5HTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            166..238
                     /gene="Htr4"
                     /gene_synonym="5-HT-4; 5-HT4; 5-HT<4L>; 5HTR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1379
                     /gene="Htr4"
                     /gene_synonym="5-HT-4; 5-HT4; 5-HT<4L>; 5HTR4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     5-hydroxytryptamine receptor 4"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 4 isoform 1"
                     /protein_id="NP_032339.2"
                     /db_xref="CCDS:CCDS29291.1"
                     /db_xref="GeneID:15562"
                     /db_xref="MGI:MGI:109246"
                     /translation="MDKLDANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAV
                     CRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVL
                     LTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVLPMFISFLPIMQG
                     WNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVT
                     AKEHAQQIQMLQRAGATSESRPQPADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFF
                     VTNIVDPFIDYTVPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERY
                     KRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPSDT"
     exon            239..364
                     /gene="Htr4"
                     /gene_synonym="5-HT-4; 5-HT4; 5-HT<4L>; 5HTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            365..565
                     /gene="Htr4"
                     /gene_synonym="5-HT-4; 5-HT4; 5-HT<4L>; 5HTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            566..719
                     /gene="Htr4"
                     /gene_synonym="5-HT-4; 5-HT4; 5-HT<4L>; 5HTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            720..1288
                     /gene="Htr4"
                     /gene_synonym="5-HT-4; 5-HT4; 5-HT<4L>; 5HTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..4657
                     /gene="Htr4"
                     /gene_synonym="5-HT-4; 5-HT4; 5-HT<4L>; 5HTR4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggcgggg tgcgctactc agcgcagcag cagcggcaga agcagggttc tgcgctaaag
       61 gtggccgcag caatctgcta gggtgccgct ctccctagcc ttccgcagcc gcgtggtgct
      121 gggagtgtgc caggagatca gaaccccagg agcccacgtg tgcagggtcc tgtgggcact
      181 gaaatccaac gtcctcatgc ccatttcctg taatggacaa acttgatgct aatgtgagtt
      241 ccaacgaggg tttcaggtcc gtggagaagg tcgtgctgct cacgttcctt gcagtggtta
      301 tcctgatggc catcttgggc aacctgctgg tgatggtggc tgtgtgcagg gacaggcagc
      361 tcaggaaaat aaaaaccaac tatttcattg tgtctctcgc ctttgctgac ctgctggttt
      421 cggtgctggt gatgcccttt ggtgccattg agctggtcca agacatctgg gcttatgggg
      481 agatgttctg cctggtccgg acctctctgg atgtcctact taccacagca tcgatctttc
      541 acctgtgctg tatttccctg gacaggtatt acgccatctg ctgccagcct ttggtttata
      601 ggaacaagat gacccctcta cgcatcgcat taatgttggg aggctgctgg gtccttccca
      661 tgtttatatc ttttctcccc ataatgcaag gctggaacaa catcggcata gttgatgtga
      721 tagagaaaag gaaattcagc cacaactcta actccacgtg gtgtgtcttc atggtcaaca
      781 agccctatgc tatcacctgc tctgtggtgg ccttctacat cccgtttctc ctcatggtgc
      841 tggcctatta ccgaatctat gtcactgcta aggagcatgc ccagcagata cagatgttac
      901 aacgggcagg agccacctct gaaagcaggc cccagccagc tgaccagcac agcacacatc
      961 gcatgaggac agagaccaag gcagccaaga ctttatgtgt catcatgggc tgcttctgtt
     1021 tctgctgggc ccccttcttt gtcaccaata ttgtggaccc tttcatagac tacactgtcc
     1081 ccgagcaggt gtggactgct ttcctctggc ttggctatat caattcgggg ttgaaccctt
     1141 ttctctatgc cttcttgaat aagtctttca gacgtgcctt cctcatcatc ctctgctgtg
     1201 atgatgagcg ctacaaaaga ccccccattc tgggccagac tgtcccctgt tcaaccacaa
     1261 ccattaatgg atccacccat gtactaaggg atacagtgga atgtggtggc cagtgggaga
     1321 gtcggtgtca cctcacagca acttctcctt tggtggctgc tcagcccagt gatacttaag
     1381 cccctgggac aatgacctag aagacagctg tggcttgaaa cgaagccagt cctaagctgc
     1441 tacttgtgtg tatgtggctg gccctggcac tctcttctcc aaggctttcc aagagcatga
     1501 ggcaatccgc actggacttt cccgccagga atccagcagg cggtatttga ggaagtcagg
     1561 ggagagaagg gcttcctcct tcccttcgct ttctgtttct caagagttct tcttcctgga
     1621 gtctccactc ttgcttggtg gtctctgaag tctatgacct agtctccttg ctgttttcag
     1681 tctgtcctgt aaacgtttac tgtgttcaat tttctgtttc caaacatgcc ttctttgaag
     1741 tgtcatctta cagatactgt caaaacatgt gcatgtcttt atcacatttc ttgcttggtc
     1801 acatctacca tagctgtgtt cagacactcc accatctttc ctttgctctc ttctctgctg
     1861 ggcccttgtt cactttcttt cctttgtctg ggtatagaca tgtatcctct tggccaaccc
     1921 tgtgtcagcc acagaactct gttttctttt tcctgtgttt agtggtacca ttctcttcag
     1981 gacaggctcc atccatttgc agtcggagac acagaagaga gatccgtcag tgggaaacgg
     2041 tctctgcaga aaccctggaa ggaagtcagg accagatcta tctcatctga gagatttcac
     2101 tttcctttca gcttagcaca cctaaagagc cttaggcagg gctggttcat cacatgcatc
     2161 tattaagaga tgctcagact cttctatgag cttgtggtga aacacacagt agcagctcaa
     2221 aacctcagag tatggctttg ctgcttccag tggaccttac tgatggatgc tcaccttgtg
     2281 gagccttgtc actcttgcta tcttctaggt ggagaagtcc agaaatgcta gtaatgagaa
     2341 aacagaatct ggctccaagt cagaggaccc aaatgtaagc ccaggccctg cttctgaaac
     2401 gctgtgagac catgaacaat gtctttccat ctatgaattt cactctctac attgccaaat
     2461 ttaacttgga gcagaggagt ctttaagatt tctttccatt tctaagacaa taggatgctg
     2521 ctatagcctg ccatctgcta cctcaaaagc tcatggcctg cctacctgtt ggctttgttt
     2581 caaaggaatg gccctcctga tttgggcatg ctagacttct gacttgatca tctgtgcaaa
     2641 ctggtgaaac acagtgaacc tggtgtcttt cactcaaagc cgagtccata gtttgtctca
     2701 actacccgag agcaaaggct ctggtgatgg aagcaccact tctcagagcc aggtgaggtt
     2761 cagctttcgc cttgactgtg gtttgattcc acctcaggac tatgcactgc accgttctct
     2821 tgagcttctc gtggaatggc acttgctatt cctgtcagca ttgactttca ttctggaact
     2881 gaacttggca ggaaatagac tttggaatga ggaagagaag attgccaaaa ccagtcaaat
     2941 gccaaaaaag aattctctgt tatgtgaaga cttaaatttt cttgagcacg agtcttagca
     3001 aaaggaagta gaccctgaga gagaactcct atatgctgct ggggaaagaa aaaaaaaagc
     3061 tctgtgctaa gaaatattga tgctgagatg gttcgtgtca aaactgatcc aatggagcag
     3121 ttctcactgg aggcctcttc tcgtcaacca tgaagagagt tgaagcatca ccttgcatac
     3181 tgacgttgta gcgggatcag tccactttga tttttaactc cttgcttcct tgccgtggct
     3241 aagctcagca ctcatttgga ggcaagcagt gttttgaagc tggttctttt taatacaaga
     3301 gatgagatgc aaccaacttg cctcgactga ccatatgccc accccgtcaa cgaacatggt
     3361 ggtgggtgag tggctcaggc actgagtcaa tgatggactg gctgagtgga tggaattgaa
     3421 agctggatgg tgtgagcctc aggaacactt ctgagtactc tgaaacagtt gatgtggaga
     3481 gaaattatgt ttatggagac attttgtaaa atataaaggg gcagctcata tgtttgttat
     3541 tattatgggt attttgaatt actgtgctct caagaccact tttttttttc actaaaaaat
     3601 gaggtcagtt tagagtgagg tttctgtgtt ggaaacaaaa cccagagcaa cccttgggta
     3661 ccaacatgcc cctgggtact cattccttat taattgcttc tcattggttg cttagcccac
     3721 acatttatac atcacccttc atttaaaggg atttctttgt tctcaaaggg gtgaatagag
     3781 aaggagaccg tgggcaagtt ttggtaagaa tggctctaat tttatatgta acttcatagt
     3841 ttcataagct aagttcatat acctgctttt tatataaaaa tgtatctgaa aaaaattccc
     3901 tatacataaa actaattccc accttacaaa taaaatatat acataatata tatttattta
     3961 atatatatac atatacacta tatatgtaca tatataatat atattatatt aaatgtggac
     4021 caatgtatga atggccagct gacaagaatg ttacataatg ggtcactaag ttactgaaca
     4081 aggatagact ttgatatttc ctgacctgat gataagccac tgttgactac agcataatgt
     4141 cgttttatct aatactttta ttttgtttac agtttgtcca tgtgtagtta ccagtggggc
     4201 cacttgtatt atttgtagtt caatgaagcc tctagtataa tcaatccagt aagtacatgt
     4261 gtgcctgctg ttgagaacat gaagcataaa tcttacgagt ttaggggttg gggagttcca
     4321 actatggtgt catgaactgg ttggctatac ctgtggttta ttgacgctaa tatttttaag
     4381 gtaccaagag ccctgattat taccttgttt ccatggaaag catccttggt tttatgacag
     4441 atccttttga tgcagtttcc aggaatatgt tcttggaaaa cacagggacc ttcacaggtt
     4501 ttgtttttaa actgattaat tatatttatt gataaaatat tgttatatta cacatgtttg
     4561 tatgacttca tctgtacatg tttaaataag ttatacatta tgacaaatct taaatcataa
     4621 aagaaataat tgagttttga gtatgcaata aaatgcc
//
