LOCUS       NM_020274               2411 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 5-hydroxytryptamine (serotonin) receptor 3B (Htr3b),
            mRNA.
ACCESSION   NM_020274
VERSION     NM_020274.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   McCoy,M.E. and Kamitakahara,A.K.
  TITLE     Ontogeny and Trophic Factor Sensitivity of Gastrointestinal
            Projecting Vagal Sensory Cell Types
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   36973009
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Moon,J.H., Kim,Y.G., Kim,K., Osonoi,S., Wang,S., Saunders,D.C.,
            Wang,J., Yang,K., Kim,H., Lee,J., Jeong,J.S., Banerjee,R.R.,
            Kim,S.K., Wu,Y., Mizukami,H., Powers,A.C., German,M.S. and Kim,H.
  TITLE     Serotonin Regulates Adult beta-Cell Mass by Stimulating Perinatal
            beta-Cell Proliferation
  JOURNAL   Diabetes 69 (2), 205-214 (2020)
   PUBMED   31806625
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2411)
  AUTHORS   Bhattarai,Y., Schmidt,B.A., Linden,D.R., Larson,E.D., Grover,M.,
            Beyder,A., Farrugia,G. and Kashyap,P.C.
  TITLE     Human-derived gut microbiota modulates colonic secretion in mice by
            regulating 5-HT3 receptor expression via acetate production
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 313 (1), G80-G87 (2017)
   PUBMED   28408644
  REMARK    GeneRIF: It was concluded that epithelial 5-HT3 receptor may
            function as a mediator of gut microbiota-driven change in
            intestinal secretion.
REFERENCE   6  (bases 1 to 2411)
  AUTHORS   Chetty,N., Coupar,I.M., Chess-Williams,R. and Kerr,K.P.
  TITLE     Demonstration of 5-HT(3) receptor function and expression in the
            mouse bladder
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 375 (6), 359-368 (2007)
   PUBMED   17607564
  REMARK    GeneRIF: 5-HT mediates enhanced neurogenic contractions of the
            mouse bladder muscle by an action at 5-HT(3) receptors. The
            presence of the 5-HT(3) receptor was confirmed by the expression of
            both 5-HT(3A) and 5-HT(3B) receptor subunits.
REFERENCE   7  (bases 1 to 2411)
  AUTHORS   Stewart,A., Davies,P.A., Kirkness,E.F., Safa,P. and Hales,T.G.
  TITLE     Introduction of the 5-HT3B subunit alters the functional properties
            of 5-HT3 receptors native to neuroblastoma cells
  JOURNAL   Neuropharmacology 44 (2), 214-223 (2003)
   PUBMED   12623220
  REMARK    GeneRIF: The 5-HT3B subunit alters the functional properties of
            5-HT3 receptors native to neuroblastoma cells.(rat 5-Ht3B)
REFERENCE   8  (bases 1 to 2411)
  AUTHORS   Liu,M.T., Rayport,S., Jiang,Y., Murphy,D.L. and Gershon,M.D.
  TITLE     Expression and function of 5-HT3 receptors in the enteric neurons
            of mice lacking the serotonin transporter
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 283 (6), G1398-G1411 (2002)
   PUBMED   12388212
  REMARK    GeneRIF: adaptive changes occur in the subunit composition of
            enteric 5-HT(3) receptors of 5-HT transporter -/- mice that are
            reflected in 5-HT(3) receptor affinity and desensitization
REFERENCE   9  (bases 1 to 2411)
  AUTHORS   Allan,A.M., Galindo,R., Chynoweth,J., Engel,S.R. and Savage,D.D.
  TITLE     Conditioned place preference for cocaine is attenuated in mice
            over-expressing the 5-HT(3) receptor
  JOURNAL   Psychopharmacology (Berl) 158 (1), 18-27 (2001)
   PUBMED   11685380
REFERENCE   10 (bases 1 to 2411)
  AUTHORS   Hanna,M.C., Davies,P.A., Hales,T.G. and Kirkness,E.F.
  TITLE     Evidence for expression of heteromeric serotonin 5-HT(3) receptors
            in rodents
  JOURNAL   J Neurochem 75 (1), 240-247 (2000)
   PUBMED   10854267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK085213.1.
            
            On Sep 19, 2009 this sequence version replaced NM_020274.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085213.1, BC046990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2176              AK085213.1         2-2177
            2177-2411           AK085213.1         2186-2420
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.54 cM"
     gene            1..2411
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /note="5-hydroxytryptamine (serotonin) receptor 3B"
                     /db_xref="GeneID:57014"
                     /db_xref="MGI:MGI:1861899"
     exon            1..245
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1519
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /note="5-hydroxytryptamine receptor 3B; 5-HT3-B; serotonin
                     receptor 3B; 5-HT3 receptor subunit B"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 3B precursor"
                     /protein_id="NP_064670.1"
                     /db_xref="CCDS:CCDS23160.1"
                     /db_xref="GeneID:57014"
                     /db_xref="MGI:MGI:1861899"
                     /translation="MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVR
                     PVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSVWYREVWNDEFLSWNSSLFDEIQEI
                     SLPLSALWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPF
                     DIQNCSLTFNSILHTVEDIDLGFLRNREDIENDKRAFMNDSEWQLLSVSSTYHIRQSS
                     AGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVG
                     YTVFRVNMSDEVPRSAGCTPLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSGQERP
                     LMCLQGDSDAEESRLYLGAPRADVTESPVHQEHRVPSDTLKDFWFQFRSINNSLRTRD
                     QIHQKEVEWLAILYRFDQLLFRIYLAVLGLYTVTLCSLWALWSRM"
     exon            246..406
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            407..451
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            452..561
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            562..731
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            732..889
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1100
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1283
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..2411
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2010..2015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /note="hexamer: AATACA"
     polyA_site      2030
                     /gene="Htr3b"
                     /gene_synonym="5-HT3B"
                     /note="major polyA site"
ORIGIN      
        1 gtcttgtcca gtcggatgtt tacaaaatag cagcaccaag gttaccacac atgagcaaac
       61 aggagaagag ggtggagggg tgctgagagg tgcaaggtca agcagtgtcc cccggctcgc
      121 cagcctgcct gcccaccagc ctgcctgccc accagccggc agccatcgct cttctctggt
      181 acctgcccca gaataggcaa gtgcgatgat tcttctgtgg tcctgcctcc tggtggctgt
      241 agtaggtatc ctaggtacag cgacacctca gcctgggaat tcttctctgc accgtctcac
      301 caggcagctc ttacaacagt accacaagga ggtcagacca gtttacaact gggctgaggc
      361 caccactgtc tacctggacc tttgcgtcca tgctgtattg gatgtggatg tgcagaatca
      421 aaaattaaag acaagcgtgt ggtaccgaga ggtttggaac gatgagtttt tgtcctggaa
      481 ctctagtctg ttcgatgaga ttcaagagat ctctctccct ctcagtgccc tctgggcccc
      541 tgatatcatc attaatgagt ttgtggatgt tgaaagatct cctgacctgc cctatgtata
      601 cgtgaactct tctggcacca ttagaaacca caagcccatc caggtggtct ccgcatgcag
      661 tttgcagaca tatgctttcc cctttgatat ccagaactgc agcctcacct ttaatagcat
      721 tctgcacaca gtggaagaca tagacctggg cttcctgagg aatagagaag acatcgagaa
      781 tgacaaaagg gcttttatga atgacagtga gtggcagctt ctttctgtgt cctctactta
      841 ccacatccgg cagagcagcg ctggagactt cgcacagatt cggttcaacg tagtgatccg
      901 cagatgtcca ttggcctacg ttgtgagcct cttgatacct agcatcttcc tgatgctcgt
      961 ggacctggga agcttctact tgccccccaa ctgccgtgca agaattgtgt tcaagaccaa
     1021 tgtgctggtg ggctatacgg tcttcagggt caacatgtct gatgaagtgc caagaagtgc
     1081 agggtgcaca cctctgattg gggtcttctt taccgtctgc atggccctct tggttctcag
     1141 tttatccaaa tccatcttgc tgatcaaatt cctctatgag gagcggcaca gtgggcaaga
     1201 acggcctctt atgtgccttc aaggcgactc tgatgccgag gagtctagat tgtacctcgg
     1261 ggctccacgt gctgacgtca cagagtcccc ggtccatcag gagcatcggg tcccatcaga
     1321 tactctgaag gatttctggt tccagttccg gtccatcaac aactctcttc gaactcggga
     1381 tcagattcac cagaaggagg tggagtggct ggccatcctg tatcgctttg atcagctgct
     1441 cttccgaatc taccttgccg tgctggggct ctataccgtc accttatgct ctctctgggc
     1501 actgtggagc agaatgtgac aatggagacc gctggtctca cttgatatgg ggttacaaca
     1561 tgtagggaaa gctgaacagt gcttggagag ggtctgaaaa gaaggggtgg gtagcctcca
     1621 ggatgctatt gtctcttttc agtgactaca gagacaagta tcttattggc tattgaccaa
     1681 accagtaaac ctacatgttc ataataaaga tgtctaaaca gaatagagta tgcagtgaca
     1741 agcaagcttt cactctccct gaaccagcag caactgcgta cacttaggtt taaggaaaaa
     1801 aaagtttgct tttagatttt tgaagctggg tctcttatag tccaggctaa ccttgaaccc
     1861 ctgacattcc agcctctacc ttccaattgc tgaggttgca tgtattgtgc caccatgtcc
     1921 agctccattt gatatcttct gcttcaacag tctatatgtt agcttggctt aagccctgct
     1981 caaacctgct taaatcctcc aggttcatca atacattatt gtctcctcaa ttctgtcttt
     2041 ggtctcatgt tattttataa ccttctcccc ttaaatattt ggtagccttt ttaatgcatg
     2101 tgtgtataag aggaagaaga gggatataca tacatacata catacataca tacatacata
     2161 catacataca tacatagatt acctaatggg ctacatgctt ccggcccctg acgctgagcc
     2221 tggttctatc actgcccatt taggagacct cagacttcac ttcagtttgc cttatttaaa
     2281 gcagggggtg tcaatattta ctctttctat atcatagaat tatgaaggca aaaatcaagc
     2341 caaatggctc aacggtatct tgaaaagtac aaaatagatg atgaaaataa acttgagact
     2401 tgcctgctat c
//
