LOCUS       NM_008312               4765 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus 5-hydroxytryptamine (serotonin) receptor 2C (Htr2c),
            transcript variant 1, mRNA.
ACCESSION   NM_008312 XM_907496 XM_920452 XM_920461
VERSION     NM_008312.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4765)
  AUTHORS   Shi,H.J., Xue,Y.R., Shao,H., Wei,C., Liu,T., He,J., Yang,Y.H.,
            Wang,H.M., Li,N., Ren,S.Q., Chang,L., Wang,Z. and Zhu,L.J.
  TITLE     Hippocampal excitation-inhibition balance underlies the 5-HT2C
            receptor in modulating depressive behaviours
  JOURNAL   Brain 147 (11), 3764-3779 (2024)
   PUBMED   38701344
  REMARK    GeneRIF: Hippocampal excitation-inhibition balance underlies the
            5-HT2C receptor in modulating depressive behaviours.
REFERENCE   2  (bases 1 to 4765)
  AUTHORS   Liu,H., He,Y., Liu,H., Brouwers,B., Yin,N., Lawler,K., Keogh,J.M.,
            Henning,E., Lee,D.K., Yu,M., Tu,L., Zhang,N., Conde,K.M., Han,J.,
            Yan,Z., Scarcelli,N.A., Liao,L., Xu,J., Tong,Q., Zheng,H., Sun,Z.,
            Yang,Y., Wang,C., He,Y., Farooqi,I.S. and Xu,Y.
  TITLE     Neural circuits expressing the serotonin 2C receptor regulate
            memory in mice and humans
  JOURNAL   Sci Adv 10 (26), eadl2675 (2024)
   PUBMED   38941473
  REMARK    GeneRIF: Neural circuits expressing the serotonin 2C receptor
            regulate memory in mice and humans.
REFERENCE   3  (bases 1 to 4765)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   4  (bases 1 to 4765)
  AUTHORS   Fletcher,P.J., Rahbarnia,A., Li,Z., Ji,X., Higgins,G.A., Funk,D.
            and Le,A.D.
  TITLE     Effects of 5-HT2C receptor stimulation in male mice on behaviour
            and Fos expression: Feeding, reward and impulsivity
  JOURNAL   Behav Brain Res 447, 114438 (2023)
   PUBMED   37059187
  REMARK    GeneRIF: Effects of 5-HT2C receptor stimulation in male mice on
            behaviour and Fos expression: Feeding, reward and impulsivity.
REFERENCE   5  (bases 1 to 4765)
  AUTHORS   Du,Y., Davisson,M.T., Kafadar,K. and Gardiner,K.
  TITLE     A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons
            among inbred mouse strains
  JOURNAL   Gene 382, 39-46 (2006)
   PUBMED   16904273
  REMARK    GeneRIF: differences between strains were found in total editing
            frequency, in the proportion of transcripts with 1 and 4 edited
            sites, in editing frequency at the A, B, E and D sites, in amino
            acid frequencies at positions 157 and 161, and in protein isoforms.
REFERENCE   6  (bases 1 to 4765)
  AUTHORS   Burns,C.M., Chu,H., Rueter,S.M., Hutchinson,L.K., Canton,H.,
            Sanders-Bush,E. and Emeson,R.B.
  TITLE     Regulation of serotonin-2C receptor G-protein coupling by RNA
            editing
  JOURNAL   Nature 387 (6630), 303-308 (1997)
   PUBMED   9153397
REFERENCE   7  (bases 1 to 4765)
  AUTHORS   Milatovich,A., Hsieh,C.L., Bonaminio,G., Tecott,L., Julius,D. and
            Francke,U.
  TITLE     Serotonin receptor 1c gene assigned to X chromosome in human (band
            q24) and mouse (bands D-F4)
  JOURNAL   Hum Mol Genet 1 (9), 681-684 (1992)
   PUBMED   1302605
REFERENCE   8  (bases 1 to 4765)
  AUTHORS   Loric,S., Launay,J.M., Colas,J.F. and Maroteaux,L.
  TITLE     New mouse 5-HT2-like receptor. Expression in brain, heart and
            intestine
  JOURNAL   FEBS Lett 312 (2-3), 203-207 (1992)
   PUBMED   1426253
REFERENCE   9  (bases 1 to 4765)
  AUTHORS   Matsuuchi,L., Gold,M.R., Travis,A., Grosschedl,R., DeFranco,A.L.
            and Kelly,R.B.
  TITLE     The membrane IgM-associated proteins MB-1 and Ig-beta are
            sufficient to promote surface expression of a partially functional
            B-cell antigen receptor in a nonlymphoid cell line
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3404-3408 (1992)
   PUBMED   1373499
REFERENCE   10 (bases 1 to 4765)
  AUTHORS   Foguet,M., Nguyen,H., Le,H. and Lubbert,H.
  TITLE     Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin
            receptor genes
  JOURNAL   Neuroreport 3 (4), 345-348 (1992)
   PUBMED   1381232
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK034512.1, AK079648.1 and
            BC098327.1.
            
            On Nov 16, 2007 this sequence version replaced NM_008312.3.
            
            Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter,
            elicits a wide array of physiological effects by binding to several
            receptor subtypes, including the 5-HT2 family of
            seven-transmembrane-spanning, G-protein-coupled receptors, which
            activate phospholipase C and D signaling pathways. This gene
            encodes the 2C subtype of serotonin receptor and its mRNA is
            subject to multiple RNA editing events, where genomically encoded
            adenosine residues are converted to inosines. RNA editing is
            predicted to alter amino acids within the second intracellular loop
            of the 5-HT2C receptor and generate receptor isoforms that differ
            in their ability to interact with G proteins and the activation of
            phospholipase C and D signaling cascades, thus modulating
            serotonergic neurotransmission in the central nervous system.
            Studies in rodents show altered patterns of RNA editing in response
            to drug treatments and stressful situations. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034512.1, AK079648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            undergoes RNA editing  :: PMID: 17307311, 17287521, 16904273,
                                      9153397
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               AK034512.1         2-399
            399-1158            AK079648.1         401-1160
            1159-4738           AK034512.1         1161-4740
            4739-4765           BC098327.1         4854-4880
FEATURES             Location/Qualifiers
     source          1..4765
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..4765
                     /gene="Htr2c"
                     /gene_synonym="5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR;
                     5-HTR2C; 5HT1c; Htr1c; SR1"
                     /note="5-hydroxytryptamine (serotonin) receptor 2C"
                     /db_xref="GeneID:15560"
                     /db_xref="MGI:MGI:96281"
     exon            1..562
                     /gene="Htr2c"
                     /gene_synonym="5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR;
                     5-HTR2C; 5HT1c; Htr1c; SR1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..620
                     /gene="Htr2c"
                     /gene_synonym="5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR;
                     5-HTR2C; 5HT1c; Htr1c; SR1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..723
                     /gene="Htr2c"
                     /gene_synonym="5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR;
                     5-HTR2C; 5HT1c; Htr1c; SR1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..1040
                     /gene="Htr2c"
                     /gene_synonym="5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR;
                     5-HTR2C; 5HT1c; Htr1c; SR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1241
                     /gene="Htr2c"
                     /gene_synonym="5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR;
                     5-HTR2C; 5HT1c; Htr1c; SR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..4750
                     /gene="Htr2c"
                     /gene_synonym="5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR;
                     5-HTR2C; 5HT1c; Htr1c; SR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4729..4734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr2c"
                     /gene_synonym="5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR;
                     5-HTR2C; 5HT1c; Htr1c; SR1"
                     /note="hexamer: ATTAAA"
     polyA_site      4750
                     /gene="Htr2c"
                     /gene_synonym="5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR;
                     5-HTR2C; 5HT1c; Htr1c; SR1"
                     /note="major polyA site"
ORIGIN      
        1 gggtaggtgc tctggttctc accaaggaag cttccttggg tgcaccaggc ttaatgattg
       61 agcccttgga gcagcaagat tgttaatctt ggttgctcct ttggcctgtc tatcccttac
      121 cttcctatta catatgaact tttcttcgtt ctgcacatcg attgtcgtcg gcgtcgtgga
      181 gatcgtcgtg gtgctccggt ggtggtcttc gtccgcttag aatagtgtag ttagttaggg
      241 gccttcaaag aagaaagaag aagcgattgg cgcggagatg ctggaggtgt cagttactat
      301 gctagagtag ggtagtaaaa caattccagc caaacctttc cggggggcgc aggttgccca
      361 caggaggtcg acttgccggc gctatccttc gcgccgagct ccctccatcc ttctttccgt
      421 cttctgagaa gcgaggttgc ggcgcgcagc tcagagcagc gcactgactg ccgcgggctc
      481 cgctgggcga ttgcagccga gtccgtttct cgtctagctg ccgccgcggc gacctgcctg
      541 gtcttcctcc cggacgctag tgggttgtca cctaaaacct gcaagcatag gccaatgaac
      601 accttctttc caaattaatt gggatgaaac aatactgtta acttcccaat tctcagtttg
      661 aaactggttg cttaaaactg aagcaataat ggtgaacctg ggcactgcgg tgcgctcact
      721 ccttgtgcac ctaattggcc tattggtttg gcagttcgat atttccataa gtccagtagc
      781 agctatagta actgacactt ttaattcctc cgatggtgga cgcttgtttc aattcccgga
      841 cggggtacaa aactggccag cactttcaat agtcgtgatt ataatcatga caataggggg
      901 caacattctc gttatcatgg cagtaagcat ggagaagaaa ctgcacaatg ctaccaatta
      961 tttcttaatg tccctagcca ttgctgatat gctggtggga ctacttgtca tgcccctgtc
     1021 tctgcttgca attctttatg attatgtctg gcctttacct agatatttgt gccccgtctg
     1081 gatttcacta gatgtgctat tttcaactgc gtccatcatg cacctctgcg ccatatcgct
     1141 ggaccggtat gtagcaatac gtaatcctat tgagcatagc cggttcaatt cgcggactaa
     1201 ggccatcatg aagattgcca tcgtttgggc aatatcaata ggagtttcag ttcctatccc
     1261 tgtgattgga ctgagggacg aaagcaaagt gttcgtgaat aatactacct gcgtgctcaa
     1321 tgacccgaac ttcgttctca tcgggtcctt cgtggcattc ttcatcccgt tgacaattat
     1381 ggtgatcacc tacttcttaa cgatctacgt cctacgccgt caaaccctga tgttacttcg
     1441 aggtcacacc gaggaggaac tgcgtaatat cagcctgaac tttctaaagt gctgctgcaa
     1501 gaagggtgat gaggaagaga acgctcccaa ccccaatcca gatcagaagc cacgtcgaaa
     1561 gaagaaagaa aagcggccta gaggcaccat gcaagctatc aacaatgaga agaaagcttc
     1621 caaagtcctt ggcattgtat tctttgtgtt tctgatcatg tggtgcccgt ttttcatcac
     1681 caatatcctg tcggtgcttt gtgggaaggc ctgtaaccaa aagctaatgg agaaacttct
     1741 caatgtgttt gtttggattg gctatgtgtg ttcaggcatc aatcctctgg tgtacactct
     1801 cttcaacaaa atttaccgaa gggctttctc taaatatttg cgctgcgatt ataagccaga
     1861 caaaaagcct cctgttcgac agattcctag ggttgctgcc actgctttgt ctgggaggga
     1921 gctcaatgtt aacatttatc ggcataccaa tgaacgtgta gttaggaaag ctaatgacac
     1981 agagcctggc atagagatgc aggtagagaa tttagagctg ccggtcaatc cctctaatgt
     2041 ggtcagcgag aggattagta gtgtgtaagc aatagcagcg cagctttcct acaggaaatc
     2101 tcttgtagga aagtccccca ctccccaccc cccaccctcc acccccagtg attttcctgt
     2161 ggatcataac taatgtaaat actgctgtgt gacaaaagag tgtttttata aatagctttg
     2221 caaccctgta ctttacaatc atgcgttaaa tagtgagatt tggggttcta tatttactgt
     2281 ttatgagaga tggagactaa tttattttga ttccttgatg gataagagtg tttgtatttt
     2341 tctctccctt ccttccgtat tccctccctt ccttgctcct tcgttgcttt cttccttcct
     2401 atcgctgttc tttttgtgaa tgtggaaaag ttgatgttca tctcaggtgg catttgcagg
     2461 agaccagaat gatgcacatg actgtggtgg tctttcaaac cacacctaaa ctaacagatt
     2521 cggtggcatc tcttccaggt taacagtaaa tatgtacttt agattctcgc tctgctcatt
     2581 cacacacgta aactcagtaa gataggttct gcccattgtg aaacatattc atcagtgagt
     2641 cagagacaga attcaacttg gttgttacac acggggtaaa tttgacattg tcagaatgtt
     2701 gtgtcggtat tttgctgcaa tgtctgtccc caaacatagt ggtattttaa catagcagct
     2761 ggttaaccag gactacagaa gtggaaggat gccaaagaaa tatacacacc aaacagcttt
     2821 tcacttctta aggacaatgt tcaaattctg attcttatgt caagcaaact gaaattagtg
     2881 ttttcattct ggtccttagt aaatacctaa ttccaagact atactgggaa accaaatccc
     2941 agagttattt cccaatccag gattcaatat caattggatt ttgagctcag aattctggaa
     3001 atgtgtgtgc tacacacaaa gtgaaatttg catgttgagc cttattaaaa tatcttaatt
     3061 atggtacctc gatctatagg acccaattta gcagtccgtt tttaagtaaa actagtatga
     3121 gaagggtaga aaactaagtt ttacttgatt aaggactacc gaattaggcc cttagaatgt
     3181 gaaaaaagta atttaaaaag atgcttttat tgaactctgg gaagaataga aatacagagt
     3241 ttccatttgg attttaaaca aaatttatct cattttcaga tccttccaag ctctctagtg
     3301 caggaaaagg ctgcagctaa cttgtgaacg tggcaagctc tccattgtgc tgtaattaca
     3361 ttcccggact ttaaatcttt gttcaaatat agtgctgtga tcctctaagt gtcagccatt
     3421 gtttcattcg tggacctgct gctctctaag aattaagtac cattttagtg aaattgaaaa
     3481 ccatgaaaag ttttcaaacc ttgctcaagt cagattatta agtctatgct gtgtgcagag
     3541 tatacacatg ttcccagtaa ctgtgtttcc atgtgtgtcc atttcacaca actgtgaata
     3601 aatttctgaa gaattcatga tgctagttct tatgcccaac agctacttgc acaccttgga
     3661 gtgagccttt taggatcttg aagtcggtaa aggcaggatc tgaatttcaa aaattcctgg
     3721 gctgtgctct caacacacag catagataaa ttcaacagtg tgccaaggag gcagtgggaa
     3781 agcggctgta tttgaggaaa ctcaaacagt ctctatttgg tttacaacac tgccaaatgt
     3841 cactcaattg cttgagcatg cccaaacatg acatgaaagt aaagtctacc tgcctgttag
     3901 gtcagttgaa ctgcatgtta aaacaattac ctgaaattga atgaggcgac ctacttctta
     3961 atgaaatgaa aatgactgaa gaaacacagc atgcattgag catgagttct gcacatacag
     4021 atggtgctgt gcatgtaaca ccatgtatgt tgcatgagtc cactgatccg tatcgatgta
     4081 aggcagagaa actgatatag aaagtgctgg agaaaactcc ttcagcagtc cctaagagac
     4141 attcagatct gaagtattgt attagagaaa attggaaaca tctgatttct ttcttaacta
     4201 tcagggcaag ctcatagcac atgttttaca gagaaataga gtataaacca tgcagttcca
     4261 aaagcactag caataagttg aatgataatc gcttatagca catttgttaa taattcttat
     4321 gtcatcaagt agtagtacat aatagtaccc aacacagcaa ttattctcaa cttgtgtgct
     4381 attcgtaagt tctgtgcggt ttggtatgaa acatatatat acataaatat aaatatatcc
     4441 atttggaagt gaatcttaca gttcagtgtt aaatctacaa acttttataa atgttttaaa
     4501 ataatccatg tgacaaatgt aaacatggtg aatttactgt caaatcattt tgatgtgcta
     4561 ttataatgta tactgtttaa gacacgtgca acagactgcc ttatattatt tcctgtaatt
     4621 tttctccttt gtcaaatggt acttttgtga atggttgtaa agtgttgtct tattacttat
     4681 tcctgtgtat taccttcttc tgagttttgt gagatttcct cttaatttat taaaatttat
     4741 taaacgatga aaaaaaaaaa aaaaa
//
