LOCUS       NM_008311               2082 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus 5-hydroxytryptamine (serotonin) receptor 2B (Htr2b),
            mRNA.
ACCESSION   NM_008311
VERSION     NM_008311.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2082)
  AUTHORS   Frolova,V.S., Nikishina,Y.O., Shmukler,Y.B. and Nikishin,D.A.
  TITLE     Serotonin Signaling in Mouse Preimplantation Development: Insights
            from Transcriptomic and Structural-Functional Analyses
  JOURNAL   Int J Mol Sci 25 (23), 12954 (2024)
   PUBMED   39684667
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2082)
  AUTHORS   Li,T., Wei,L., Zhang,X., Fu,B., Zhou,Y., Yang,M., Cao,M., Chen,Y.,
            Tan,Y., Shi,Y., Wu,L., Xuan,C., Du,Q. and Hu,R.
  TITLE     Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis
            via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition
  JOURNAL   Mol Cancer Res 22 (6), 538-554 (2024)
   PUBMED   38381131
  REMARK    GeneRIF: Serotonin Receptor HTR2B Facilitates Colorectal Cancer
            Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal
            Transition.
REFERENCE   3  (bases 1 to 2082)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2082)
  AUTHORS   Benhadda,A., Delhaye,C., Moutkine,I., Marques,X., Russeau,M., Le
            Magueresse,C., Roumier,A., Levi,S. and Maroteaux,L.
  TITLE     5-HT1A and 5-HT2B receptor interaction and co-clustering regulate
            serotonergic neuron excitability
  JOURNAL   iScience 26 (8), 107401 (2023)
   PUBMED   37575185
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2082)
  AUTHORS   Albertini,G., D'Andrea,I., Druart,M., Bechade,C., Nieves-Rivera,N.,
            Etienne,F., Le Magueresse,C., Rebsam,A., Heck,N., Maroteaux,L. and
            Roumier,A.
  TITLE     Serotonin sensing by microglia conditions the proper development of
            neuronal circuits and of social and adaptive skills
  JOURNAL   Mol Psychiatry 28 (6), 2328-2342 (2023)
   PUBMED   37217677
REFERENCE   6  (bases 1 to 2082)
  AUTHORS   Bonhaus,D.W., Bach,C., DeSouza,A., Salazar,F.H., Matsuoka,B.D.,
            Zuppan,P., Chan,H.W. and Eglen,R.M.
  TITLE     The pharmacology and distribution of human 5-hydroxytryptamine2B
            (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C
            receptors
  JOURNAL   Br J Pharmacol 115 (4), 622-628 (1995)
   PUBMED   7582481
REFERENCE   7  (bases 1 to 2082)
  AUTHORS   Loric,S., Launay,J.M., Colas,J.F. and Maroteaux,L.
  TITLE     New mouse 5-HT2-like receptor. Expression in brain, heart and
            intestine
  JOURNAL   FEBS Lett 312 (2-3), 203-207 (1992)
   PUBMED   1426253
REFERENCE   8  (bases 1 to 2082)
  AUTHORS   Kursar,J.D., Nelson,D.L., Wainscott,D.B., Cohen,M.L. and Baez,M.
  TITLE     Molecular cloning, functional expression, and pharmacological
            characterization of a novel serotonin receptor
            (5-hydroxytryptamine2F) from rat stomach fundus
  JOURNAL   Mol Pharmacol 42 (4), 549-557 (1992)
   PUBMED   1331748
REFERENCE   9  (bases 1 to 2082)
  AUTHORS   Foguet,M., Hoyer,D., Pardo,L.A., Parekh,A., Kluxen,F.W.,
            Kalkman,H.O., Stuhmer,W. and Lubbert,H.
  TITLE     Cloning and functional characterization of the rat stomach fundus
            serotonin receptor
  JOURNAL   EMBO J 11 (9), 3481-3487 (1992)
   PUBMED   1505525
REFERENCE   10 (bases 1 to 2082)
  AUTHORS   Foguet,M., Nguyen,H., Le,H. and Lubbert,H.
  TITLE     Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin
            receptor genes
  JOURNAL   Neuroreport 3 (4), 345-348 (1992)
   PUBMED   1381232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157768.4.
            
            On Aug 21, 2018 this sequence version replaced NM_008311.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033713.1, BC023690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC157768.4         58956-59057         c
            103-685             AC157768.4         57611-58193         c
            686-886             AC157768.4         49499-49699         c
            887-2082            AC157768.4         46114-47309         c
FEATURES             Location/Qualifiers
     source          1..2082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.94 cM"
     gene            1..2082
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /note="5-hydroxytryptamine (serotonin) receptor 2B"
                     /db_xref="GeneID:15559"
                     /db_xref="MGI:MGI:109323"
     exon            1..102
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /inference="alignment:Splign:2.1.0"
     exon            103..685
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..1776
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /note="NP75 protein; serotonin receptor 2B"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 2B"
                     /protein_id="NP_032337.2"
                     /db_xref="CCDS:CCDS35644.1"
                     /db_xref="GeneID:15559"
                     /db_xref="MGI:MGI:109323"
                     /translation="MASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQ
                     TVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLV
                     GLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPI
                     QANQCNSRATAFIKITVVWLISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMV
                     FGSLAAFFAPLTIMVVTYFLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSS
                     PEKVAMLDGSHRDKILPNSSDETLMRRMSSVGKRSAQTISNEQRASKALGVVFFLFLL
                     MWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGR
                     YITCNYRATKSVKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPMRLRSS
                     TIQSSSIILLDTLLTENDGDKAEEQVSYI"
     exon            686..886
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /inference="alignment:Splign:2.1.0"
     exon            887..2082
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2080
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
ORIGIN      
        1 gctaagactc agagcaagtc agtgggggag gatctgccag gagagggagt ccaactgaac
       61 agacacagga cggctggctt aggaagccac agaagacaag cgtcttctgg aatctaagcc
      121 tctagaaaat ctaaaatgtg gatgtcttac ctgcaaacac ggacagacgt gtacacagtc
      181 ccatcttcga gagcctgaat ctttttagaa ggaagaagtc accttggctg tgagtgtctg
      241 gtaggtttgc taaatgcttt gctaaagcag atgacttgct tagctactga ccatgctgac
      301 cactgtctgg aactggactg agtcaccaaa aggcgaatgg cttcatctta taaaatgtct
      361 gaacaaagca caacttctga gcacatttta cagaagacat gtgatcacct gatcctgact
      421 aaccgttctg gattagagac agactcagta gcagaggaaa tgaagcagac tgtggaggga
      481 caggggcata cagtgcactg ggcagctctc ctgatactcg cggtgataat acccaccatt
      541 ggtgggaaca tccttgtgat tctggctgtt gcactggaga aaaggctgca gtacgctacc
      601 aactactttt taatgtcctt ggcgatagca gatttgctgg ttggattgtt tgtgatgccg
      661 attgccctct tgacaatcat gtttgaggct atatggcccc tcccactggc cctgtgtcct
      721 gcctggttat tcctcgatgt tctcttttca actgcctcca tcatgcatct ctgtgccatt
      781 tccctggacc gctatatagc catcaaaaag ccaattcagg ccaatcagtg caactcccgg
      841 gctactgcat tcatcaagat tacagtggta tggttaattt caataggcat cgccatccca
      901 gtccctatta aaggaatcga gactgatgtg attaatccac acaatgtcac ctgtgagctg
      961 acaaaggacc gctttggcag ttttatggtc tttgggtcac tggctgcttt cttcgcacct
     1021 ctcaccatca tggtagtcac ttactttctc accattcaca ctttacagaa gaaagcttac
     1081 ttggtcaaaa ataagccacc tcaacgccta acacggtgga ctgtgcccac agttttccta
     1141 agggaagact catccttttc atcaccagaa aaggtggcaa tgctggatgg gtctcacagg
     1201 gataaaattc tacctaactc aagtgatgag acacttatgc gaagaatgtc ctcagttgga
     1261 aaaagatcag cccaaaccat ttctaatgag cagagagcct cgaaggccct tggagtcgtg
     1321 tttttccttt ttctgcttat gtggtgcccc ttttttatta caaatctaac tttagctctg
     1381 tgtgattcct gcaatcagac cactctcaaa acactcctgg agatatttgt gtggataggc
     1441 tacgtttcct cgggggtgaa tcctctgatc tatacactct tcaataagac atttcgggaa
     1501 gcatttggca ggtacatcac ctgcaattac cgagccacaa agtcagtaaa agcacttagg
     1561 aagttttcca gtacactttg ttttgggaat tcaatggtag aaaactctaa atttttcaca
     1621 aaacatggaa ttcgaaatgg gatcaaccct gccatgtacc agagcccaat gaggctccga
     1681 agttcaacca ttcagtcctc atcaatcatc ctcctcgata cccttctcac tgaaaacgat
     1741 ggcgacaaag cggaagagca ggtcagctac atatagcaga acgggccgcc ctcatctgag
     1801 agaggtgatg agcaggacgc acgcgcaaca tggaaaggta cagagtgaat gaaaacccca
     1861 ccctctcctg agtgaagtac caaggctgtc cagcttcctt atctaaacaa actcaagcat
     1921 ggctaaagta gatctgatgg cttcaaacaa acgcaatctc tactctggtt ttcaaataca
     1981 attaaataag ttgataaatt tcagtctttt aaaaaaaaag aatgtcaaca aatttttaag
     2041 tttctaatgt gtgtaaagtt gtgttaagaa agaaataaaa tg
//
