LOCUS       NM_008310               2509 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus 5-hydroxytryptamine (serotonin) receptor 1F (Htr1f),
            mRNA.
ACCESSION   NM_008310 XM_359054
VERSION     NM_008310.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2509)
  AUTHORS   Scholpa,N.E., Simmons,E.C., Thompson,A.D., Carroll,S.S. and
            Schnellmann,R.G.
  TITLE     5-HT1F receptor agonism induces mitochondrial biogenesis and
            increases cellular function in brain microvascular endothelial
            cells
  JOURNAL   Front Cell Neurosci 18, 1365158 (2024)
   PUBMED   38510106
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2509)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2509)
  AUTHORS   Zhu,P., Lu,T., Chen,Z., Liu,B., Fan,D., Li,C., Wu,J., He,L.,
            Zhu,X., Du,Y., Tian,Y. and Fan,Z.
  TITLE     5-hydroxytryptamine produced by enteric serotonergic neurons
            initiates colorectal cancer stem cell self-renewal and
            tumorigenesis
  JOURNAL   Neuron 110 (14), 2268-2282 (2022)
   PUBMED   35550066
REFERENCE   4  (bases 1 to 2509)
  AUTHORS   Simmons,E.C., Scholpa,N.E., Cleveland,K.H. and Schnellmann,R.G.
  TITLE     5-hydroxytryptamine 1F Receptor Agonist Induces Mitochondrial
            Biogenesis and Promotes Recovery from Spinal Cord Injury
  JOURNAL   J Pharmacol Exp Ther 372 (2), 216-223 (2020)
   PUBMED   31776207
REFERENCE   5  (bases 1 to 2509)
  AUTHORS   Dupre,T.V., Jenkins,D.P., Muise-Helmericks,R.C. and
            Schnellmann,R.G.
  TITLE     The 5-hydroxytryptamine receptor 1F stimulates mitochondrial
            biogenesis and angiogenesis in endothelial cells
  JOURNAL   Biochem Pharmacol 169, 113644 (2019)
   PUBMED   31542386
REFERENCE   6  (bases 1 to 2509)
  AUTHORS   Wen,X.Y., Bryce,D.M. and Breitman,M.L.
  TITLE     Characterization of lpd (lipid defect): a novel mutation on mouse
            chromosome 16 associated with a defect in triglyceride metabolism
  JOURNAL   Hum Mol Genet 7 (4), 743-750 (1998)
   PUBMED   9499429
REFERENCE   7  (bases 1 to 2509)
  AUTHORS   Danielson,P.E., Watson,J.B., Gerendasy,D.D., Erlander,M.G.,
            Lovenberg,T.W., de Lecea,L., Sutcliffe,J.G. and Frankel,W.N.
  TITLE     Chromosomal mapping of mouse genes expressed selectively within the
            central nervous system
  JOURNAL   Genomics 19 (3), 454-461 (1994)
   PUBMED   7910582
REFERENCE   8  (bases 1 to 2509)
  AUTHORS   Adham,N., Kao,H.T., Schecter,L.E., Bard,J., Olsen,M., Urquhart,D.,
            Durkin,M., Hartig,P.R., Weinshank,R.L. and Branchek,T.A.
  TITLE     Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1
            receptor subtype coupled to the inhibition of adenylate cyclase
  JOURNAL   Proc Natl Acad Sci U S A 90 (2), 408-412 (1993)
   PUBMED   8380639
REFERENCE   9  (bases 1 to 2509)
  AUTHORS   Amlaiky,N., Ramboz,S., Boschert,U., Plassat,J.L. and Hen,R.
  TITLE     Isolation of a mouse '5HT1E-like' serotonin receptor expressed
            predominantly in hippocampus
  JOURNAL   J Biol Chem 267 (28), 19761-19764 (1992)
   PUBMED   1328180
REFERENCE   10 (bases 1 to 2509)
  AUTHORS   McAllister,G., Charlesworth,A., Snodin,C., Beer,M.S., Noble,A.J.,
            Middlemiss,D.N., Iversen,L.L. and Whiting,P.
  TITLE     Molecular cloning of a serotonin receptor from human brain (5HT1E):
            a fifth 5HT1-like subtype
  JOURNAL   Proc Natl Acad Sci U S A 89 (12), 5517-5521 (1992)
   PUBMED   1608964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045364.1.
            
            On Dec 11, 2007 this sequence version replaced NM_008310.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045364.1, BB643744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2509              AK045364.1         70-2578
FEATURES             Location/Qualifiers
     source          1..2509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 37.1 cM"
     gene            1..2509
                     /gene="Htr1f"
                     /gene_synonym="Htr1eb"
                     /note="5-hydroxytryptamine (serotonin) receptor 1F"
                     /db_xref="GeneID:15557"
                     /db_xref="MGI:MGI:99842"
     exon            1..160
                     /gene="Htr1f"
                     /gene_synonym="Htr1eb"
                     /inference="alignment:Splign:2.1.0"
     exon            161..268
                     /gene="Htr1f"
                     /gene_synonym="Htr1eb"
                     /inference="alignment:Splign:2.1.0"
     exon            269..2509
                     /gene="Htr1f"
                     /gene_synonym="Htr1eb"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1411
                     /gene="Htr1f"
                     /gene_synonym="Htr1eb"
                     /note="5-HT-1F; 5-HT-1E-beta; serotonin receptor 1F;
                     5-HT1F; 5-hydroxytryptamine (serotonin) receptor 1E beta"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1F"
                     /protein_id="NP_032336.1"
                     /db_xref="CCDS:CCDS28267.1"
                     /db_xref="GeneID:15557"
                     /db_xref="MGI:MGI:99842"
                     /translation="MDFLNASDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLV
                     IAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVLCDIWLSV
                     DIICCTCSILHLSAIALDRYRAITDAVEYARKRTPRHAGIMITIVWVISVFISMPPLF
                     WRHQGTSRDDECVIKHDHIVSTIYSTFGAFYIPLVLILILYYKIYRAARTLYHKRQAS
                     RMIKEELNGQVFLESGEKSIKLVSTSYMLEKSLSDPSTDFDRIHSTVKSPRSELKHEK
                     SWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCEKCKISEEMSNFLAW
                     LGYLNSLINPLIYTIFNEDFKKAFQKLVRCRY"
     regulatory      1417..1422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr1f"
                     /gene_synonym="Htr1eb"
                     /note="hexamer: AAGAAA"
     polyA_site      1434
                     /gene="Htr1f"
                     /gene_synonym="Htr1eb"
                     /note="major polyA site"
ORIGIN      
        1 gtcggccctc gagtggactg gcgtctggaa cccgccctag agctgcgccc caagctgcag
       61 cgcgcattca gctcgccacc caagagcagc cgggacgcgc tgttgtcgcc agagaacgac
      121 cgcggcgggc tagggaccag agccccttag cttcgctctg gggaagctga gttgagatgg
      181 cattgaactg tgaatggctg actaatttct caccagatca ggaggtgaag tgagaatgaa
      241 gaccaacagt tgagcctgcc acaccacggt attcatttct tcaactatat taacatttta
      301 acaaaaaaaa atggattttt taaacgcatc agaccaaaac ttgacctctg aggaactgtt
      361 aaaccgaatg ccatccaaaa ttctggtatc cctcactctg tctgggctgg cattgatgac
      421 aaccaccatc aactccctcg tgatcgctgc gatcattgtg actcggaagc tgcaccaccc
      481 agccaactat ttaatttgtt ccttggcagt tacagatttt cttgtagctg tcctggtgat
      541 gcccttcagt attgtgtaca ttgtgagaga gagctggatt atgggacaag tactctgtga
      601 catttggctg agtgtcgaca tcatctgttg tacgtgttcc atcttgcatc tgtcggctat
      661 agccttggat aggtaccgcg ccatcacaga tgcagttgaa tacgccagga agaggactcc
      721 caggcatgcc ggcatcatga tcacgatcgt gtgggttata tctgtgttca tctctatgcc
      781 tcctctcttc tggaggcacc aaggaactag ccgtgatgat gagtgtgtca tcaaacatga
      841 ccacattgtt tccacaattt actccacgtt tggagctttc tacatcccgc ttgtattgat
      901 attgatcctc tactacaaaa tatacagagc agcaaggaca ctgtaccaca agagacaagc
      961 gagtcggatg ataaaggagg agctgaacgg tcaagtcttc ttggagagcg gtgagaagag
     1021 cattaaactg gtctccacat cctacatgtt agaaaaatcc ttgtccgatc catcaacgga
     1081 ctttgataga attcacagca ccgtgaaaag tcccagatcg gaactgaagc atgagaaatc
     1141 ttggagaaga cagaaaatct caggcaccag agaacgcaaa gcagccacta ccctgggatt
     1201 gatcttgggt gcatttgtaa tatgttggct gccctttttt gtaaaagaat tggttgttaa
     1261 tgtctgtgaa aaatgtaaaa tttctgaaga aatgtcaaac tttttggcat ggcttggtta
     1321 cctgaattcc cttataaatc cactgattta taccatcttt aatgaagact tcaagaaagc
     1381 tttccaaaaa cttgtacgat gccgatatta ggataaaaga aacctaattt taaagtgcgg
     1441 aggctttatt tgttgggggg aggggcaggg ataattaaat gaatgtaaag taagaaaaca
     1501 tttaaatttt tagagaaaat atattaaaac tgctaaaatt ataagaggat aaatttattt
     1561 ttaatagcac caagaaaata agatgtattc atttggccat aattttaatg ttctcaagat
     1621 taggaaataa tttatgcagc tcagctcgta atattttgtc tatgcaatat acctaagaag
     1681 ctaactagaa atacatatat ataataattg ataatatatg catatatatt atcaattaca
     1741 atgctttcca ggtttatatg ttacaacaac tagagacatt tttaactagc atctttccac
     1801 tggtaatttc tgtcacctca ttgcttaacc actatttata gaaaaatatt caatgtaatg
     1861 ctactattgc cccttctcca tcttctccac tacaaaggtg gagatatagc aacagcagct
     1921 cctatttagc cttagcagag aagatatgaa gctcagcggc tttgatagtg tcctcacatt
     1981 tggacagtaa aaataatcat ccaatgagct agatatggga aatatttcaa tatcctgcat
     2041 tttctgcaca tttgcaatct ttacttattt tgatatcaag ttctagaata atattatctt
     2101 aaccatatat ctgtatttaa aatcaaagcc ccaaggttag aggaaaggtt tattatgcaa
     2161 ttactgtata attgttatat acattgcccc ctgtctagga atcaagctct aaacactaag
     2221 gaccttaact aactcactgt aattaacata cttctagtgt aaattttatt tttctccacc
     2281 aatattatta ggtccagttt ttataactca tctccatatc ttaagatctg aacatcattt
     2341 cttttttatt acagagaata taataaaaaa cttaaaactt tgctttgact ttataaaaaa
     2401 aagtttttcc tattataatt aggacacctt tcacaaatca agaccatttg aaaaacaacg
     2461 tatttgaaaa acgacacata catttgaaat gtaaataaag aaaatatct
//
