LOCUS       NM_001285482            3079 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus 5-hydroxytryptamine (serotonin) receptor 1D (Htr1d),
            transcript variant 1, mRNA.
ACCESSION   NM_001285482
VERSION     NM_001285482.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3079)
  AUTHORS   Frolova,V.S., Nikishina,Y.O., Shmukler,Y.B. and Nikishin,D.A.
  TITLE     Serotonin Signaling in Mouse Preimplantation Development: Insights
            from Transcriptomic and Structural-Functional Analyses
  JOURNAL   Int J Mol Sci 25 (23), 12954 (2024)
   PUBMED   39684667
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3079)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3079)
  AUTHORS   Zhu,P., Lu,T., Chen,Z., Liu,B., Fan,D., Li,C., Wu,J., He,L.,
            Zhu,X., Du,Y., Tian,Y. and Fan,Z.
  TITLE     5-hydroxytryptamine produced by enteric serotonergic neurons
            initiates colorectal cancer stem cell self-renewal and
            tumorigenesis
  JOURNAL   Neuron 110 (14), 2268-2282 (2022)
   PUBMED   35550066
REFERENCE   4  (bases 1 to 3079)
  AUTHORS   Moon,J.H., Kim,Y.G., Kim,K., Osonoi,S., Wang,S., Saunders,D.C.,
            Wang,J., Yang,K., Kim,H., Lee,J., Jeong,J.S., Banerjee,R.R.,
            Kim,S.K., Wu,Y., Mizukami,H., Powers,A.C., German,M.S. and Kim,H.
  TITLE     Serotonin Regulates Adult beta-Cell Mass by Stimulating Perinatal
            beta-Cell Proliferation
  JOURNAL   Diabetes 69 (2), 205-214 (2020)
   PUBMED   31806625
REFERENCE   5  (bases 1 to 3079)
  AUTHORS   Berthon,A., Faucz,F.R., Espiard,S., Drougat,L., Bertherat,J. and
            Stratakis,C.A.
  TITLE     Age-dependent effects of Armc5 haploinsufficiency on adrenocortical
            function
  JOURNAL   Hum Mol Genet 26 (18), 3495-3507 (2017)
   PUBMED   28911199
REFERENCE   6  (bases 1 to 3079)
  AUTHORS   Langlois,X., Gerard,C., Darmon,M., Chauveau,J., Hamon,M. and el
            Mestikawy,S.
  TITLE     Immunolabeling of central serotonin 5-HT1D beta receptors in the
            rat, mouse, and guinea pig with a specific anti-peptide antiserum
  JOURNAL   J Neurochem 65 (6), 2671-2681 (1995)
   PUBMED   7595565
REFERENCE   7  (bases 1 to 3079)
  AUTHORS   Birkeland,M.L., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Barclay,A.N.
  TITLE     Gene structure and chromosomal localization of the mouse homologue
            of rat OX40 protein
  JOURNAL   Eur J Immunol 25 (4), 926-930 (1995)
   PUBMED   7737295
REFERENCE   8  (bases 1 to 3079)
  AUTHORS   Wilkie,T.M., Chen,Y., Gilbert,D.J., Moore,K.J., Yu,L., Simon,M.I.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Identification, chromosomal location, and genome organization of
            mammalian G-protein-coupled receptors
  JOURNAL   Genomics 18 (2), 175-184 (1993)
   PUBMED   8288218
REFERENCE   9  (bases 1 to 3079)
  AUTHORS   Maroteaux,L., Saudou,F., Amlaiky,N., Boschert,U., Plassat,J.L. and
            Hen,R.
  TITLE     Mouse 5HT1B serotonin receptor: cloning, functional expression, and
            localization in motor control centers
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 3020-3024 (1992)
   PUBMED   1557407
REFERENCE   10 (bases 1 to 3079)
  AUTHORS   Weydert,A., Cloez-Tayarani,I., Fillion,M.P., Simon-Chazottes,D.,
            Guenet,J.L. and Fillion,G.
  TITLE     Molecular cloning of two partial serotonin 5-HT1D receptor
            sequences in mouse and one in guinea pig
  JOURNAL   C R Acad Sci III 314 (10), 429-435 (1992)
   PUBMED   1521164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082016.1, BY728591.1, AL670673.15, AW487918.1 and AI853647.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3 and 4 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103536.1, SRR17784647.1413243.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN02415124
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AK082016.1         2-110
            110-252             BY728591.1         110-252
            253-277             AL670673.15        87133-87157
            278-654             AW487918.1         10-386              c
            655-3062            AK082016.1         501-2908
            3063-3079           AI853647.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3079
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.74 cM"
     gene            1..3079
                     /gene="Htr1d"
                     /gene_synonym="5-HT-1D; 5-HT1D; Gpcr14; Htr1db"
                     /note="5-hydroxytryptamine (serotonin) receptor 1D"
                     /db_xref="GeneID:15552"
                     /db_xref="MGI:MGI:96276"
     exon            1..252
                     /gene="Htr1d"
                     /gene_synonym="5-HT-1D; 5-HT1D; Gpcr14; Htr1db"
                     /inference="alignment:Splign:2.1.0"
     exon            253..410
                     /gene="Htr1d"
                     /gene_synonym="5-HT-1D; 5-HT1D; Gpcr14; Htr1db"
                     /inference="alignment:Splign:2.1.0"
     exon            411..3065
                     /gene="Htr1d"
                     /gene_synonym="5-HT-1D; 5-HT1D; Gpcr14; Htr1db"
                     /inference="alignment:Splign:2.1.0"
     CDS             1126..2250
                     /gene="Htr1d"
                     /gene_synonym="5-HT-1D; 5-HT1D; Gpcr14; Htr1db"
                     /note="serotonin receptor 1D; G-protein coupled receptor
                     14; 5-hydroxytryptamine (serotonin) receptor 1D beta"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1D"
                     /protein_id="NP_001272411.1"
                     /db_xref="CCDS:CCDS18806.1"
                     /db_xref="GeneID:15552"
                     /db_xref="MGI:MGI:96276"
                     /translation="MSPPNQSLEGLPQEASNRSLNVTGAWDPEVLQALRISLVVVLSV
                     ITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWN
                     FGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVW
                     IISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIY
                     VAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKI
                     KLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPAL
                     FDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKVVHFRKIS"
     polyA_site      2337
                     /gene="Htr1d"
                     /gene_synonym="5-HT-1D; 5-HT1D; Gpcr14; Htr1db"
                     /note="major polyA site"
     regulatory      2644..2649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr1d"
                     /gene_synonym="5-HT-1D; 5-HT1D; Gpcr14; Htr1db"
                     /note="hexamer: ATTAAA"
     polyA_site      2672
                     /gene="Htr1d"
                     /gene_synonym="5-HT-1D; 5-HT1D; Gpcr14; Htr1db"
     regulatory      3046..3051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr1d"
                     /gene_synonym="5-HT-1D; 5-HT1D; Gpcr14; Htr1db"
                     /note="hexamer: AATAAA"
     polyA_site      3065
                     /gene="Htr1d"
                     /gene_synonym="5-HT-1D; 5-HT1D; Gpcr14; Htr1db"
ORIGIN      
        1 aagcaaggcg tggaatagct gctgagttct cagtgtgctg gtgtgccaga tgtcaaacag
       61 ctgtgtgggt gctggtgggt gtttccggat ctccctatgc actccccccc aaaggagact
      121 caaagacaca acttttacca gggatgaaga gtcgcggtca cttcatgatg ctaatagggt
      181 caattcatca agaacacata accagtctac tggtggatgc tggtgataac aagacatgag
      241 aatatacaaa cacccctact aaacgctgaa taagggagct ggcggtcata tctgctgccc
      301 caactttggg atcactctgc ttgcccagca ggaaactgta ctcattccac ctctggtgtg
      361 tggccgggac gcttcctacc tccggtctgt cctgagaggc tgctttcccg cctcagagct
      421 tccaagcaca gctcggtgaa ccagcggtga cccatttgtt ttgcctcctt ctagctcatg
      481 cattctttga gtcttggtca cgggaatgtt ttgtctggtc agacgcaaag ccgtcagcag
      541 gacagaacca acgctgaaca ctcatgatgt gtcggcaggg gcctgggaaa aggcagctcc
      601 tggtggcgca cctctgaatc agctgtttct ttttgtctct ggctttaaaa gctctctgga
      661 actgacctga tatccagagt cttctccaag tatgaacagg gaaacgaagt tttcgttaaa
      721 tatgttgacg tcttatgttt tgaaaagcag tagagtgtca aaggcgagaa ccccagaatc
      781 ctgcccatcc tcctgtgaga ccttggtaat tatctaacaa acttatcatg tgtccactgg
      841 gctggaccat ctgccaggag gagtcccaga aacccaagat gccttggggt ttatctgctt
      901 ccggaagcag ctagccgtgg ttgtggtgtt cttccctgcc cacgtcttga gttttagttt
      961 ttttgttttg ttttgttttt tgtttttttt ttttctgtgc tccgtcctga tgtatacggc
     1021 cttcacagtt gtgaagccaa aggatgacct tgctctgtgg atcggactgc ggtgaaggag
     1081 cgagccgtgt gtgtagaagt ctgtgggaag agacgagcac tgagcatgtc tcctccaaac
     1141 cagtccctag aaggccttcc tcaggaggcc tccaacagat ccctgaatgt gacaggggct
     1201 tgggacccag aggtcctgca ggctctcaga atctcgctcg tggtggtgct gtccgtcatc
     1261 acactggcca ctgtcctctc caatgccttc gtccttacca ccattctact caccaagaag
     1321 ctccacaccc cagccaatta tctcattggc tccttggcca ccacggacct cctggtttct
     1381 atcttggtca tgcccatcag catagcctac accaccaccc gcacctggaa ctttggccag
     1441 atcctgtgtg acatctgggt gtcttctgac atcacgtgct gcacggcctc catcttgcat
     1501 ctctgtgtca ttgctctgga cagatactgg gccatcaccg atgccctgga gtacagcaag
     1561 cgtcgaaccg caggccacgc agcagccatg attgcggccg tctggatcat ctctatttgt
     1621 atctccatcc ctccactctt ctggcggcag gccacggctc acgaggagat gtccgactgc
     1681 ctggtgaaca catctcagat ttcttacacc atctactcga cctgtggcgc cttctatatc
     1741 ccatccatct tgctcattat cctgtatggc cgcatatacg tggccgcccg gagtcgaatc
     1801 ctgaacccac cctccctcta cgggaagcgc ttcaccacgg cacagcttat cacaggctct
     1861 gctggctctt cgctctgctc gctcaacccc agcctccatg agagccacac acacacagtt
     1921 ggctcccctc tctttttcaa ccaggtgaaa atcaagcttg ctgatagcat cctagaacgc
     1981 aagaggatct ctgcagcccg agaaaggaaa gccactaaga ccctgggcat cattctgggg
     2041 gcctttatca tctgctggtt gcctttcttt gtagtatcat tggtcctccc catctgcagg
     2101 gactcttgtt ggatccaccc ggccctcttt gacttcttca cgtggctagg ttatttaaac
     2161 tctctcatta accccgtcat ctacactgtg ttcaacgaag actttcgaca agcgtttcag
     2221 aaagtcgtcc atttccggaa gatctcatag tcggatttgg gggtgactct tgtttgcctg
     2281 ttatgtcctg taaccccact ggggttgcct ttttaaaaat tactgccatt tctctgagac
     2341 ccgggttgat ttgtgctatc ttgggtcttt ggcttaaatt aatagatttg ttctgtgttt
     2401 gattgccagc atcctccaga cccctgaatc atctaaagct aggtcactgt gttgtgtaaa
     2461 ggggagacag gactgacagc atcccttaac ataatattct catggttctc tgggttggaa
     2521 gaaatataac tgtaggaccc aggtgagaaa atgtctttct ctctagcagg cttggaggga
     2581 aggccttctg gtctacctgg gattttacag agtttttgag aatgggtgtg attactgact
     2641 tgaattaaaa aagaatttgg agttagaaag gaggggttgt catctcctgg agctcattga
     2701 ttagaagata acacccagga attgtttcca ctgggtcctg gctgtccata aggaaagtgg
     2761 tatcagtggc ccagcgtaga tggagagaaa gtcagaaaga ggcagcagga gagaggtata
     2821 cttgggacca gatcagctct gcatccttca ttcttccctc tgtctctatt acgcaatgtt
     2881 ccgaagttaa aacccaccat cctgccgctc aagaagactg accggtacgg gacactcgag
     2941 gctttgaatg ggacacccta ttctgccttt tttgattttt ttcccctgaa ttattctttt
     3001 ttacaaccct tgtccttgga gttcttaaga tgttgagcgt taccaaataa accgcatgag
     3061 acacaaaaaa aaaaaaaaa
//
