LOCUS       NM_010482               4728 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus 5-hydroxytryptamine (serotonin) receptor 1B (Htr1b),
            transcript variant 1, mRNA.
ACCESSION   NM_010482
VERSION     NM_010482.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4728)
  AUTHORS   Frolova,V.S., Nikishina,Y.O., Shmukler,Y.B. and Nikishin,D.A.
  TITLE     Serotonin Signaling in Mouse Preimplantation Development: Insights
            from Transcriptomic and Structural-Functional Analyses
  JOURNAL   Int J Mol Sci 25 (23), 12954 (2024)
   PUBMED   39684667
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4728)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4728)
  AUTHORS   Reggiani,J.D.S., Jiang,Q., Barbini,M., Lutas,A., Liang,L.,
            Fernando,J., Deng,F., Wan,J., Li,Y., Chen,C. and Andermann,M.L.
  TITLE     Brainstem serotonin neurons selectively gate retinal information
            flow to thalamus
  JOURNAL   Neuron 111 (5), 711-726 (2023)
   PUBMED   36584680
  REMARK    GeneRIF: Brainstem serotonin neurons selectively gate retinal
            information flow to thalamus.
REFERENCE   4  (bases 1 to 4728)
  AUTHORS   Li,L., Wyler,S.C., Leon-Mercado,L.A., Xu,B., Oh,Y., Swati, Chen,X.,
            Wan,R., Arnold,A.G., Jia,L., Wang,G., Nautiyal,K., Hen,R.,
            Sohn,J.W. and Liu,C.
  TITLE     Delineating a serotonin 1B receptor circuit for appetite
            suppression in mice
  JOURNAL   J Exp Med 219 (8) (2022)
   PUBMED   35796804
REFERENCE   5  (bases 1 to 4728)
  AUTHORS   Zhu,P., Lu,T., Chen,Z., Liu,B., Fan,D., Li,C., Wu,J., He,L.,
            Zhu,X., Du,Y., Tian,Y. and Fan,Z.
  TITLE     5-hydroxytryptamine produced by enteric serotonergic neurons
            initiates colorectal cancer stem cell self-renewal and
            tumorigenesis
  JOURNAL   Neuron 110 (14), 2268-2282 (2022)
   PUBMED   35550066
REFERENCE   6  (bases 1 to 4728)
  AUTHORS   Harwood,G., Lockyer,M., Giles,H. and Fairweather,N.
  TITLE     Cloning and characterisation of the rabbit 5-HT1D alpha and 5-HT1D
            beta receptors
  JOURNAL   FEBS Lett 377 (1), 73-76 (1995)
   PUBMED   8543023
REFERENCE   7  (bases 1 to 4728)
  AUTHORS   Bell,R., Donaldson,C. and Gracey,D.
  TITLE     Differential effects of CGS 12066B and CP-94,253 on murine social
            and agonistic behaviour
  JOURNAL   Pharmacol Biochem Behav 52 (1), 7-16 (1995)
   PUBMED   7501681
REFERENCE   8  (bases 1 to 4728)
  AUTHORS   Saudou,F., Amara,D.A., Dierich,A., LeMeur,M., Ramboz,S., Segu,L.,
            Buhot,M.C. and Hen,R.
  TITLE     Enhanced aggressive behavior in mice lacking 5-HT1B receptor
  JOURNAL   Science 265 (5180), 1875-1878 (1994)
   PUBMED   8091214
REFERENCE   9  (bases 1 to 4728)
  AUTHORS   Simon-Chazottes,D., Cloez-Tayarani,I., Fillion,M.P., Guenet,J.L.
            and Fillion,G.
  TITLE     The serotonin 5-HT1B receptor subtype (Htr1b) gene maps to mouse
            chromosome 9
  JOURNAL   Mamm Genome 4 (7), 397-398 (1993)
   PUBMED   8358175
REFERENCE   10 (bases 1 to 4728)
  AUTHORS   Maroteaux,L., Saudou,F., Amlaiky,N., Boschert,U., Plassat,J.L. and
            Hen,R.
  TITLE     Mouse 5HT1B serotonin receptor: cloning, functional expression, and
            localization in motor control centers
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 3020-3024 (1992)
   PUBMED   1557407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158998.2.
            
            On Feb 12, 2019 this sequence version replaced NM_010482.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3990280.1,
                                           SRR11927932.2279724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC158998.2         121495-121641
            148-4728            AC158998.2         122456-127036
FEATURES             Location/Qualifiers
     source          1..4728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 44.61 cM"
     gene            1..4728
                     /gene="Htr1b"
                     /gene_synonym="5-HT-1B"
                     /note="5-hydroxytryptamine (serotonin) receptor 1B"
                     /db_xref="GeneID:15551"
                     /db_xref="MGI:MGI:96274"
     exon            1..147
                     /gene="Htr1b"
                     /gene_synonym="5-HT-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            148..4728
                     /gene="Htr1b"
                     /gene_synonym="5-HT-1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             467..1627
                     /gene="Htr1b"
                     /gene_synonym="5-HT-1B"
                     /note="serotonin receptor 1B; 5-HT1B receptor; 5-HT<1B>
                     receptor"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1B"
                     /protein_id="NP_034612.1"
                     /db_xref="CCDS:CCDS23370.1"
                     /db_xref="GeneID:15551"
                     /db_xref="MGI:MGI:96274"
                     /translation="MEEQGIQCAPPPPAASQTGVPLTNLSHNCSADGYIYQDSIALPW
                     KVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPIS
                     TMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVEYSAKRTPK
                     RAAIMIVLVWVFSISISLPPFFWRQAKAEEEMLDCFVNTDHVLYTVYSTVGAFYLPTL
                     LLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRAPDVPSE
                     SGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMP
                     ICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG"
     regulatory      3959..3964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr1b"
                     /gene_synonym="5-HT-1B"
                     /note="hexamer: AATAAA"
     polyA_site      3983
                     /gene="Htr1b"
                     /gene_synonym="5-HT-1B"
                     /note="major polyA site"
     regulatory      4700..4705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr1b"
                     /gene_synonym="5-HT-1B"
                     /note="hexamer: AATAAA"
     polyA_site      4728
                     /gene="Htr1b"
                     /gene_synonym="5-HT-1B"
                     /note="major polyA site"
ORIGIN      
        1 gcactaagtc tgtggcagcg actaaagacg tgggttgact gcggagcgca aagactcaaa
       61 gctctcagag gctagaacag gacgtcccat tacccattcc ctgcttgaaa ggcgactcca
      121 agtttcaggg tcgggagaag ggacaaggga acctgagaga agctggactg ggtgggccag
      181 tgctttattc acccgggcga agacggggag tggagaggag ctagcagacg cggcagcagc
      241 gcctggcgca ctggaagtgc aggggacgcg cccgcaggct tggtggccgc gcctgtgacc
      301 tctcctttgg gctgagaaca caggcggagg agttactgag gagcccacgg aactggctag
      361 ccaaaggaga caagcctata gtctccatga tcctcccgtc ctctgttctt tccctggtcc
      421 gctccatgtt caagagctgc gctccgcagc caggacgagg agagctatgg aggagcaggg
      481 tattcagtgc gccccgccgc ctcccgccgc ctcccagaca ggggtacctc tcaccaacct
      541 ctcccacaac tgcagcgccg acggctacat ttaccaggac tccatcgccc tgccctggaa
      601 agtcctgctg gttgctttgt tggcgctcat caccttggcc accacgctct ccaacgcctt
      661 tgtaatcgct acggtgtatc ggacccggaa gctacacacc ccggctaact acctgatcgc
      721 ctctctggca gtcactgacc tgctcgtgtc catcctggtg atgcccatca gcaccatgta
      781 cacggtcact ggacgctgga cactaggcca ggtggtctgc gacttctggc tgtcgtcgga
      841 tatcacctgt tgcactgctt ccatcatgca tctctgtgtc atcgccctgg accgctactg
      901 ggccatcacc gatgcggtgg agtattctgc taaaaggact cccaaaaggg cggccatcat
      961 gatcgtgctg gtgtgggtct tctccatctc tatttcgttg ccacccttct tctggcgtca
     1021 agccaaagca gaggaggaga tgctggactg ctttgtgaac accgaccacg tcctctacac
     1081 ggtctactcc acggtgggcg ctttctattt acccaccctg ctcctcatcg ccctctatgg
     1141 ccgcatctat gtggaagccc gctctcggat tttgaaacag acacccaaca agaccggcaa
     1201 gcgcttgacc cgagcccagt tgataacaga ctccccggga tccacatcct cggtcacctc
     1261 cattaactcc cgggctccgg acgtgcccag tgagtccggg tctcctgtgt acgtgaacca
     1321 agtcaaagtg cgagtctcag acgccctgct ggaaaagaag aaactcatgg ccgctaggga
     1381 gcgcaaagcc accaagaccc tagggatcat tttaggagca tttattgtgt gttggctgcc
     1441 cttcttcatc atctccctgg tgatgcctat ctgtaaggat gcctgctggt ttcacatggc
     1501 catttttgac ttcttcaatt ggttaggcta tcttaactcc ctcatcaacc ccatcatcta
     1561 caccatgtcc aatgaggact tcaaacaagc gttccacaaa ctgatacgct ttaagtgcgc
     1621 aggttgactt gtcaatggca gtggggtcgc ctaagcgacc tttggggacc aagttgggtc
     1681 ttttcacagg taggtcaaat cttctttccc tgttactggg tggaagcaag gctctctctt
     1741 ctgggcaagg gcaatggatc ctcagaggcc ccggcagaag cctagcttct ctgagagagc
     1801 actctggaat gtgaacaacg caaactactg taaagcttcc atacccgagg aacttagctt
     1861 cctccactca aagtccgggc tcagcacaga tcctccagca gccattcaca caaaaggttg
     1921 caacttttta acattggtga tggatgggta tccctgcccc gttttgtatc atggatgttg
     1981 ttgccctcta agccagtagc acttgtagat gttgtctgag gcctgagaca cctctacata
     2041 cagcctggca gtacttgaac ttgacaatta atactctatg ctctggggag aactctgtgt
     2101 tacagcttaa gttttaaaca ctttggcatc cttcagtctt catttattta tttaaatttg
     2161 gtcggagaaa cttgtggatt tggtgcttca aacactgaat gtggcttgga cggcacagag
     2221 caaccttgaa gagttaacag caaaattctg atgctaagat ctctattttt attacaatca
     2281 aaaattatat gggggtggtg ggtgggcatg ggagaagggg agtgatactc agaatcaaca
     2341 cctaagattg tttgttttct gcagatttct aattttttta attcctgttt agtgatcgtc
     2401 aatccacagc tcttaacaac tcaaaacatg atgtgtgcta gtgccaaagt ctgcaggctg
     2461 ctttgttttc taatctcacg tacctgtcat ttcacacact taaatcccca cggaaagagg
     2521 ataggctggg ttgctcagcc caacctgcag ctgtcagagt tcaagtggat tagagttgta
     2581 tactgttcct taacaagaaa gtagcttttt tcattatcca gttccatgct gcgcagagga
     2641 gactgaagaa acacaagcga cttcttatat aattgaggaa tgaaggggga aataggagga
     2701 tgtatatttt gacttgtaaa aaaaaactta aaaattgcat gagacaattt ttgataatca
     2761 tttgcactct ctcccatctg tgattccttt gtgtgtgaat ttttaaagta accaagagag
     2821 ctggtttccc tgttcagaaa tcttgaaaat gcccccaata ctattaaagt gtgtgtgagt
     2881 gtgtgagtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgaga gagagagaga gagagagaga
     2941 gagagagaga gagagagaga gagagagaga ttccagcttg ttttgtcctt actattaaag
     3001 tttgggcagg agcagctagg aagattacac attagaaatg tagaaaagcc gagaaagcct
     3061 gaaaacaaac ctattttctt tataacttat atagaaccaa acctcaggct tattaaacaa
     3121 ccaggaaact ggcaagcctt ctagccttgg aaacattagt gacctgccac ttcagtgact
     3181 agaacattgg aaataattta agcgtatctc tttttctaag tttcaataac acttagttat
     3241 tttggattca ctttaggggg tacataatac agtaaaatca catcctagaa gatgaaaaaa
     3301 atgcactttc ttaataaaaa gaagcagtcc tgaagggtta actgtaagaa caaatgtgta
     3361 tgtggaatgt ttaatatgcc aaagaagatt cacagtcctt gcttcagagg ctgtctgcac
     3421 tggagacctt ttgtctgcag aaggaagttg tctttataaa atggatccac tccctgtgtg
     3481 aagctgccca gtccagatca tcacacaata gatgtagtga gctgaattat actgcttgcc
     3541 tactgtgcag accttcacat tgggtaatga ctcttgaaaa gatgctattc aaaagttcac
     3601 atgtactgta ggtaaaaaag ggaatttcaa ccaacattat acctgacact ggagtaggat
     3661 gaaatcttag gcattagata atcctataga ctgggatcta tagtttattc tgttggatcc
     3721 ctagcttctt tgtttgtgct ttgtgacatt tctcctatgg aggaatgcac atagagcatg
     3781 catttgtttt ttatattgtt aatatgttgg tcttctgttt gtgtagctgc gttttcttgg
     3841 ggcctaagag gcaattaagt caacttctaa gagccttagt ggaaaattaa tggaaacaaa
     3901 tagccacttg caaaatgatt tctttatagg gcacctacaa tgattgtgtc attatgttaa
     3961 taaacatggt cgatttagtg aaatgggttg tttgccattt tgtaaatcac ccaccttaat
     4021 tattgcttga gtatttggct gaactgactg aatttggggc atcgtgtatc caatagaagc
     4081 ttgcaaacct ttgtagtgat aagagatcta ggatcatcgt ccagcattgc acatgatatg
     4141 caaggtgtat attcatccca ggggtacgca tttaggactg ttaagctcct ttgcagttcc
     4201 tattgcatat aagcatagtt tgtttcttaa actggacaca tgtctttttt gcagaacata
     4261 aaatgggaga tggagatgtt taacttgcat agaaatgaaa ctatattttc attgactatg
     4321 gtaacaaata ccattttcca tattgtttaa ttgcacaaaa tttcactcaa gtatatgaat
     4381 gtatactcat ctaaaattac aaatattgtc ttgtgtttgt aggaacttta gagtttcctt
     4441 taaaaaaaaa ggaccctgca cccaaggaat gaatgtttaa ggaattcaac aaatttccta
     4501 tagaacaata ttgttcactt cctctctatt atcttagttt taccttcttt aagcaggaag
     4561 cactgagagg actctagctc actcaagcag taatgtctca gactgtgtgt atttgttgga
     4621 gttctgtgtc tgaaattgcc tttggtattt cacctctcag aaaatgtgta attggaaaat
     4681 aaatttaggt atatgatgaa ataaaagtcc ttttttgtgt tctaaaaa
//
