LOCUS       NM_008308               4591 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus 5-hydroxytryptamine (serotonin) receptor 1A (Htr1a),
            mRNA.
ACCESSION   NM_008308
VERSION     NM_008308.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4591)
  AUTHORS   Zhu,C.P., Liu,S.Q., Wang,K.Q., Xiong,H.L., Aristu-Zabalza,P.,
            Boyer-Diaz,Z., Feng,J.F., Song,S.H., Luo,C., Chen,W.S., Zhang,X.,
            Dong,W.H., Gracia-Sancho,J. and Xie,W.F.
  TITLE     Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to
            Decrease Portal Hypertension
  JOURNAL   Gastroenterology 167 (5), 993-1007 (2024)
   PUBMED   38906512
  REMARK    GeneRIF: Targeting 5-Hydroxytryptamine Receptor 1A in the Portal
            Vein to Decrease Portal Hypertension.
REFERENCE   2  (bases 1 to 4591)
  AUTHORS   Wu,Q.Y., Lin,L.H., Lu,K., Deng,S.F., Li,W.M., Xu,Y., Zhang,B. and
            Liu,J.H.
  TITLE     Astrocytic 5-HT1A receptor mediates age-dependent hippocampal LTD
            and fear memory extinction in male mice
  JOURNAL   Exp Mol Med 56 (8), 1763-1775 (2024)
   PUBMED   39085354
  REMARK    GeneRIF: Astrocytic 5-HT1A receptor mediates age-dependent
            hippocampal LTD and fear memory extinction in male mice.
REFERENCE   3  (bases 1 to 4591)
  AUTHORS   Luo,Y.J., Bao,H., Crowther,A., Li,Y.D., Chen,Z.K., Tart,D.S.,
            Asrican,B., Zhang,L. and Song,J.
  TITLE     Sex-specific expression of distinct serotonin receptors mediates
            stress vulnerability of adult hippocampal neural stem cells in mice
  JOURNAL   Cell Rep 43 (5), 114140 (2024)
   PUBMED   38656873
REFERENCE   4  (bases 1 to 4591)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4591)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   6  (bases 1 to 4591)
  AUTHORS   Avraham,K.B., Fletcher,C., Overdier,D.G., Clevidence,D.E., Lai,E.,
            Costa,R.H., Jenkins,N.A. and Copeland,N.G.
  TITLE     Murine chromosomal location of eight members of the hepatocyte
            nuclear factor 3/fork head winged helix family of transcription
            factors
  JOURNAL   Genomics 25 (2), 388-393 (1995)
   PUBMED   7789972
REFERENCE   7  (bases 1 to 4591)
  AUTHORS   O'Brien,E.P., Novak,E.K., Zhen,L., Manly,K.F., Stephenson,D. and
            Swank,R.T.
  TITLE     Molecular markers near two mouse chromosome 13 genes, muted and
            pearl, which cause platelet storage pool deficiency (SPD)
  JOURNAL   Mamm Genome 6 (1), 19-24 (1995)
   PUBMED   7719021
REFERENCE   8  (bases 1 to 4591)
  AUTHORS   Douville,P., Seldin,M.F. and Carbonetto,S.
  TITLE     Genetic mapping of the integrin alpha 1 gene (Vla1) to mouse
            chromosome 13
  JOURNAL   Genomics 14 (2), 503-505 (1992)
   PUBMED   1427867
REFERENCE   9  (bases 1 to 4591)
  AUTHORS   Oakey,R.J., Caron,M.G., Lefkowitz,R.J. and Seldin,M.F.
  TITLE     Genomic organization of adrenergic and serotonin receptors in the
            mouse: linkage mapping of sequence-related genes provides a method
            for examining mammalian chromosome evolution
  JOURNAL   Genomics 10 (2), 338-344 (1991)
   PUBMED   1676978
REFERENCE   10 (bases 1 to 4591)
  AUTHORS   Sundaresan,S., Yang-Feng,T.L. and Francke,U.
  TITLE     Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse
            chromosome 13
  JOURNAL   Somat Cell Mol Genet 15 (5), 465-469 (1989)
   PUBMED   2781417
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114573.11.
            
            On Oct 3, 2022 this sequence version replaced NM_008308.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK140194.1, AK049884.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4591              AC114573.11        35523-40113
FEATURES             Location/Qualifiers
     source          1..4591
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 56.92 cM"
     gene            1..4591
                     /gene="Htr1a"
                     /gene_synonym="Gpcr18"
                     /note="5-hydroxytryptamine (serotonin) receptor 1A"
                     /db_xref="GeneID:15550"
                     /db_xref="MGI:MGI:96273"
     exon            1..4591
                     /gene="Htr1a"
                     /gene_synonym="Gpcr18"
                     /inference="alignment:Splign:2.1.0"
     CDS             723..1988
                     /gene="Htr1a"
                     /gene_synonym="Gpcr18"
                     /note="5-HT-1A; serotonin receptor 1A; G-protein coupled
                     receptor 18; 5-HT1A receptor"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1A"
                     /protein_id="NP_032334.2"
                     /db_xref="CCDS:CCDS26756.1"
                     /db_xref="GeneID:15550"
                     /db_xref="MGI:MGI:96273"
                     /translation="MDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLG
                     TLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKW
                     TLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLT
                     WLIGFLISIPPMLGWRTPEDRSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRI
                     FRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPC
                     ANGAVRQGEDDATLEVIEVHRVGNSKGHLPLPSESGATSYVPACLERKNERTAEAKRK
                     MALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGAIINWLGYSN
                     SLLNPVIYAYFNKDFQNAFKKIIKCKFCR"
     regulatory      4191..4196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr1a"
                     /gene_synonym="Gpcr18"
                     /note="hexamer: AATAAA"
     polyA_site      4216
                     /gene="Htr1a"
                     /gene_synonym="Gpcr18"
     regulatory      4492..4497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr1a"
                     /gene_synonym="Gpcr18"
                     /note="hexamer: AGTAAA"
     polyA_site      4514
                     /gene="Htr1a"
                     /gene_synonym="Gpcr18"
                     /note="major polyA site"
     regulatory      4539..4544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr1a"
                     /gene_synonym="Gpcr18"
                     /note="hexamer: AATAAA"
     polyA_site      4562
                     /gene="Htr1a"
                     /gene_synonym="Gpcr18"
     regulatory      4569..4574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htr1a"
                     /gene_synonym="Gpcr18"
                     /note="hexamer: AATAAA"
     polyA_site      4591
                     /gene="Htr1a"
                     /gene_synonym="Gpcr18"
ORIGIN      
        1 ggactggaat gtaaagactc ctggctacag ggagaggagg gcggggaccc agaagaagga
       61 ggcactcggg actagggaag tgttggatgg cggtgggggt taacgtggga ggaagggaga
      121 ctagctgtct gagcgacaca caggactaaa gaaagagagg tgagaaggaa aggggaactg
      181 gaagggaagg ccagtgggag gaagccggga gaaggaagct gggaaaagag aagcagactg
      241 gagaaggcag gagagatgga gagacagaga gaaggaacta ggagatgagg gtcatcgagt
      301 gacccgggag gatggggttt ctggaatcca gagacttctg agactattag ttactcggga
      361 gagtccggcc cccacgcagc cagttggaca gcgacaaagt gaaatggaca gcgcgagaca
      421 gatattacag ccatctctcc agcacccaga gatttggaag atgctttcag cccaactaca
      481 gtttcctagc tggagcctct gagcgctcag gacccgcggg agccaagcaa gagagcgccg
      541 gtgagtgctc ctctcagatg ccttcgccag agcaagtaag aacttcccgc tccagtctct
      601 agatcccctc ccttcgaaac tccccagaaa ggaaggaaga ccctaggggg aggggcgagg
      661 gagatcccct tgcatttctt tttccctccc ttccccccac cccagcggga gtgcaggcag
      721 gcatggatat gttcagtctt ggccagggca acaacaccac aacgtccctg gagcccttcg
      781 ggacaggcgg caacgatact ggcctctcca acgtgacctt cagctaccaa gtgatcacct
      841 ctcttttgct ggggacgctc attttctgcg cggtgctcgg caatgcctgc gtggttgctg
      901 ccatcgccct ggagcgctcc cttcagaatg ttgccaacta tctcatcggc tccttggcgg
      961 tcaccgatct catggtgtca gtgctggtgc tgcccatggc tgctctgtac caggtgctca
     1021 acaagtggac tctgggtcag gtcacctgtg acctgtttat cgccctggat gtgctgtgct
     1081 gcacttcgtc catcctgcac ctgtgcgcca tcgcgctaga caggtactgg gcaatcaccg
     1141 accctataga ctacgtgaac aagaggacgc cccggcgcgc cgctgcgctg atctcgctca
     1201 cttggctcat tggctttctc atctccatcc cgcctatgct gggctggcgc accccggaag
     1261 accgctcgaa ccccaacgag tgcaccatca gcaaggacca cgggtacacc atctactcca
     1321 ctttcggcgc tttctatatt ccgctgctgc tcatgctggt cctctatggg cgcatcttca
     1381 gagccgcgcg cttccgaatc cgcaagacgg tcaagaaggt ggaaaagaag ggagcgggca
     1441 ccagcttcgg aacatcgtcg gccccgcccc ccaagaagag cctgaatggt cagccaggta
     1501 gtggggactg caggcgcagt gctgagaaca gggcggtggg gactccgtgc gctaatgggg
     1561 cggtgagaca gggtgaggac gacgccaccc tggaggtgat cgaggtgcat cgagtgggca
     1621 actccaaagg gcaccttcct ctgcccagcg aatcaggagc tacctcctat gtccccgcct
     1681 gcttggagag aaaaaatgag cgcactgctg aggcaaagcg caagatggcc ttggcccgtg
     1741 agaggaagac agtgaagaca ctgggcatca tcatgggcac cttcatcctc tgctggctgc
     1801 cctttttcat tgtggccctg gtcctacctt tctgtgagag cagttgccac atgcctgagt
     1861 tgttgggtgc cataattaac tggctaggct actccaactc cctgctcaac ccagttattt
     1921 atgcttattt caacaaagac tttcaaaacg cttttaagaa gatcatcaag tgcaagttct
     1981 gccgctgatg atgatgatgg tggtggtagt ggtggtaata gtggtggtga tggagaagga
     2041 agaagtggag gaagagtgta gggcttacag gacccttcct gttcactcaa tatccccgcc
     2101 ctggaagcaa cacctaagaa aacttgcttt tcctagaaca cgcagcttct tagcccatgg
     2161 ctttcagatc ttctctctct atctcatttt aaggggacag tgctttttgc agaaatctta
     2221 gagaacccct agcatctgtt tgtaaaatta ttggctcggt ctttggccct aggatcagtt
     2281 ttgatagttg caataacctc ctctctattc gaaatcccaa ttcttcacga tggaagttta
     2341 aacctcggcg attcaaggaa gaaaacccaa acagaaaata taaactgtat ggacatctac
     2401 catgcccact aggactgcca ccctctgccc tatatctgga actttgaggt tcaagactgc
     2461 tctgtctctc cctccctctt gctctagaaa catctgttcc ctttgggtgt caatgtacac
     2521 tgctgattct ggtctccatg cactcacggc tggtctggga aagttggaac tactttgggt
     2581 tatggtgccc tggaattgtt tgccttgctg aatagcaaaa gatccctttc cccaatgcac
     2641 agcacccact ttctgtattt tgtttgtttg tttgttttaa ctcaaaatca agtgacaaag
     2701 atgtctgctg gagtggactt ataagcaaga agccaggccc aaaaggaaga gccaagaagg
     2761 cctgcggatg ttttcctgtc ctggtgtcag cactcaccaa agaaattgac aatcagacta
     2821 tttggaagga agagttttat tcctgtagtt tgttggcttt tctgtaagtt ctggaaaggc
     2881 cttgtggact gcagaaggcg cccactgctg gccagggagg gctcattgag ggtgctgaga
     2941 tgcccgggat ggctcacctc accctcagtt tcttttctag gagtgagcta tgccagagca
     3001 gctcaccttg agtttgcagc ctccgggttc ctccactcac ctctcacagt atccaggagc
     3061 tagtagagaa gtttgagttt gtgcaagagg ttggagactt agaatttcta aggaagtgtg
     3121 ggtgtgaggc acgtagagga ggtaaggagc aaaagggctc ctaagtgctt ccaactcctg
     3181 cggcgtgccc agggggtggg ggtgacctaa aggggcaatt ttaagcatag gatgcaaagt
     3241 ttctcaatct accccttccc cctttcaagg aacagcattg tgtagcattt cctaaaaatg
     3301 cccggattta ttctccggga cattctgtgc tcacacaaat ttcgcagatc tctgggctct
     3361 cattgtgaag ggtatcaaca cctcaccatt acctacctag gatcttgatc tcagagacct
     3421 aaaagagaga gcgatctctg tggagtccca gccaagtcag cccccaaatt ctgagggtaa
     3481 aaccagtttt gtgtcctctc aatttttaaa gcatttttct ccgctagggg ttcttttcct
     3541 gctgttattt ttgctgtccc acccccacct cagagaagaa aattatttag gtgcttcctt
     3601 tgaatgtaca tttctagcta agtgagaggg catcaaatgg ttttgcgtta tatctgaact
     3661 tcgaattttc tgttgaataa tggtttcctt ttcaagcaat tatacggaga tttttttcac
     3721 cccccatccc cttcagctgt atctttccaa tgtctgcacc tgctgttttg aaaacccgtg
     3781 ctgcattttt ttttaaattg ccaaagttgc tggtgagatc tcccccttgt gtttataaac
     3841 agggagaaag gactgccctg ccacatgaag ccattgtttt tatttgttaa actgagcaaa
     3901 gtttcttttg ctctactcta aagtgggaat gagtattaca gtcccttgca acagagccat
     3961 ttcagaatgt aagcctgtag ggtgtccaca cctgagagac tgacaggggg ttctgtggag
     4021 aagacgcact gggctgggct tctccagtac aaacagtact tgtttgtaaa tttagcttgc
     4081 tttatttgtt tgtttgttta tttatttatc acaaaaatga agtagaacta tatggccaaa
     4141 taatattttt ctgtatgctt tactattttt agaccagatc atttacttga aataaagatc
     4201 atttacttga aataaatcaa tccctaaatt tcagatgtta aattggaaac caagacctct
     4261 aacttccagt tctctgtatt tttttttttc caattaggaa tgtttgaccg tgatggggga
     4321 ggggcattgc tcttgttact ttgagaaaga gactttaaac aagactggaa agggggcacc
     4381 cagctggaat ataattgcca agtaatagag caatcagaga actaagtgca acatgccgca
     4441 cagctctaaa gaacccctga tgcttgtttt attttaaaat acttgtatta cagtaaaatg
     4501 ttaatgcatc aaaattggcc ttcacttttc cttgtgataa taaaggactt tagtaatggc
     4561 aatgctgtaa taaactaaga ccagtaacct a
//
