LOCUS       NM_001348727            2446 bp    mRNA    linear   ROD 14-JAN-2022
DEFINITION  Mus musculus hydroxyacyl-thioester dehydratase type 2 (Htd2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001348727
VERSION     NM_001348727.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2446)
  AUTHORS   Zeng M, Xu J, Zhang Z, Zou X, Wang X, Cao K, Lv W, Cui Y, Long J,
            Feng Z and Liu J.
  TITLE     Htd2 deficiency-associated suppression of alpha-lipoic acid
            production provokes mitochondrial dysfunction and insulin
            resistance in adipocytes
  JOURNAL   Redox Biol 41, 101948 (2021)
   PUBMED   33774475
  REMARK    GeneRIF: Htd2 deficiency-associated suppression of alpha-lipoic
            acid production provokes mitochondrial dysfunction and insulin
            resistance in adipocytes.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139029.10.
            
            On Jan 14, 2022 this sequence version replaced NM_001348727.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3079371.1,
                                           SRR7652917.674341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC139029.10        183743-183918
            177-276             AC139029.10        187114-187213
            277-361             AC139029.10        187323-187407
            362-438             AC139029.10        190870-190946
            439-517             AC139029.10        192125-192203
            518-2446            AC139029.10        193314-195242
FEATURES             Location/Qualifiers
     source          1..2446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..2446
                     /gene="Htd2"
                     /note="hydroxyacyl-thioester dehydratase type 2"
                     /db_xref="GeneID:109729085"
                     /db_xref="MGI:MGI:5827763"
     exon            1..176
                     /gene="Htd2"
                     /inference="alignment:Splign:2.1.0"
     exon            177..276
                     /gene="Htd2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..361
                     /gene="Htd2"
                     /inference="alignment:Splign:2.1.0"
     exon            362..438
                     /gene="Htd2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..517
                     /gene="Htd2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..2446
                     /gene="Htd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             688..1164
                     /gene="Htd2"
                     /EC_number="4.2.1.59"
                     /codon_start=1
                     /product="hydroxyacyl-thioester dehydratase type 2,
                     mitochondrial"
                     /protein_id="NP_001335656.1"
                     /db_xref="CCDS:CCDS88564.1"
                     /db_xref="GeneID:109729085"
                     /db_xref="MGI:MGI:5827763"
                     /translation="MWRGLQRRLWQHHVVPTGQCFQYVHTKVGDRAELSRAFTQQDVA
                     TFSELTGDANPLHLSEDFAKHSKFGKTIVHGVLINGLISALLGTKMPGPGCVFLSQEI
                     KFPAPLYVGEVVLASAEVKRLKQSVAVVAVSCCVIESKKTVMEGWVKVMVPEAPRS"
ORIGIN      
        1 atgcgtctgt ggggcggtgc gaatgtaaat atcaccagtt ttccaggtcc gaacttgggc
       61 tgctgcgtgg gaactccgac ccatgccgaa ttctagcggc gtgcaagagt caggaacgcg
      121 gttattccag tgatcctctc cgtcctgggc cgaggcggtt tagcctcgcg gggcaggtgt
      181 ccatgttgga agatgccagc gactgcatat gaaagagtag tttacaagag cccctcagag
      241 tatcactaca tgaaagtctg tctgtaagtc cctcttagag tttcaagaac atggggttgg
      301 actgaacgtg gcacagttca aacagctgct cgtctcagcc ctgagagacc tgtttgggga
      361 ggtcggtgcc gctctgcctg tggatgttct cacctacgat gagaagacac tgtcggccat
      421 cttgagaata tgcagcagtg gtctggtcaa attatggagt tctttgacct tgtttggagc
      481 ctataaaagc aagaagtgtg ccttcagagt gattcaggtg tctccctttc tccttgcatt
      541 atctggcaat agcagggaac aagtattgga ctgaatactc ttacaggtcc agatacttcc
      601 actctccaca gtgtccttag gtgtctacat tatttgaaaa cagacgaagg ctaaagcccc
      661 tgttggtgac atttggagat actgaagatg tggcgtgggc ttcagaggag actgtggcaa
      721 catcatgtgg taccaacagg gcagtgtttt cagtatgtgc acacgaaagt tggagaccga
      781 gcggagctca gcagagcctt cacacagcag gatgtagcta ccttctcaga gttaacggga
      841 gatgccaatc ctttgcattt aagtgaagat tttgcaaaac actccaagtt tggaaagaca
      901 attgttcacg gagttttgat aaatggactt atttcagctc tcctgggcac caaaatgcca
      961 gggccaggct gtgtgtttct ttcccaggaa attaaatttc ctgctcctct atatgttgga
     1021 gaggtggtct tagcatctgc agaagtgaaa aggctgaagc agtctgttgc tgttgttgca
     1081 gtgtcctgtt gtgtaataga aagtaagaag acagttatgg aaggctgggt taaagttatg
     1141 gtcccggaag ctcctagatc ctgaaataca aatttaaagt tatacattta aaaacctgtg
     1201 ctcttattat caaatgacac ccggggaggt gggctgctgc tcttcctgga ggaatgctgg
     1261 tatatccaga agctgtgtgt ggaaggggag acttccagat tggtgcatgg tttgtccaga
     1321 cttaaatatg tgcaagatct cattgtctat caaggtttgg attttttttt tccaattaaa
     1381 aaaacaattg agaggggctg gagagatggc ttatcagtta ggatcactgg ctgctcttcc
     1441 agagtatctg ggttcaattc ctaataccca catagctgct cacaactgta tgtaacttca
     1501 gtctcaggtg atccaacacc atcttctggc ctgtgccgaa actacctgca catggtacac
     1561 agacatacat gcatacgtgc aagcaaaata caaatacaat aatagtaaga taaaaatctt
     1621 tttaaattgg gaagactatc ttcatgtttt actttcagaa tttgaaacag ttatatttgt
     1681 atttgataac gtctacgtca gtgttgaggg attttcttgc tggatttata ccaccatgta
     1741 taccaagtgc agcaatgcaa gtataactgc agcaatgcaa gtagagccat ctctgaacac
     1801 ctaattctga gaccctttct cagcggcttc tgggctaggc ttataattcc ttacaccaag
     1861 atgtaatctt ttgttgcatg tggtgccact ggcctttagt tcccacttag gaggcagagg
     1921 caggcagaat ttaaagctaa cctgtgtgcg tagcaagttc tagaacagcc agggctacat
     1981 aaagagaccc tgtcaaacca ataaaaacaa aaaatgacat ttaattcaaa tttctctgta
     2041 acttgccttt cagggttttg ctgttactgg tgaggggttt ccatgcagcc acgactcagt
     2101 tatataaagt cctagcatgg cagcattgtt ggaaataata gaaacagaat tcatcagagg
     2161 gccgggccta gaaatattag ccagtgttct ccttccatgt ggcttcccat gagtgaattg
     2221 ggtgactttt ctgaattgga agttggctgt tctacattga tcaggttaac atgctgatct
     2281 ttcagagagc tggccaatct gtttgttagt attttaaaac cgaaggaaag catctggaat
     2341 gtaaaggtgc tgttttaagg gttctaattc tctcccgctc ttgaaaacgt ggatctactt
     2401 aaaaaaaaaa acaaaaaaag caacaacaat aaaactatta tatgtg
//
