LOCUS       NM_016865               1426 bp    mRNA    linear   ROD 20-AUG-2024
DEFINITION  Mus musculus HIV-1 Tat interactive protein 2 (Htatip2), transcript
            variant 1, mRNA.
ACCESSION   NM_016865
VERSION     NM_016865.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1426)
  AUTHORS   Liu,X.L., Hou,Y.Y., Su,S.H., Wu,X. and Wang,Z.F.
  TITLE     Investigating TIP30-Mediated regulation of mTORC1 signaling as a
            therapeutic strategy for coxsackievirus B3-Induced viral
            myocarditis
  JOURNAL   Virology 597, 110156 (2024)
   PUBMED   38981316
  REMARK    GeneRIF: Investigating TIP30-Mediated regulation of mTORC1
            signaling as a therapeutic strategy for coxsackievirus B3-Induced
            viral myocarditis.
REFERENCE   2  (bases 1 to 1426)
  AUTHORS   Zhang,Y., Liu,X., Sun,K., Luo,Y., Yang,J., Li,A., Kiupel,M.,
            Fenske,S., Biel,M., Mi,Q.S., Wang,H. and Xiao,H.
  TITLE     Hyperpolarization-activated cyclic nucleotide-gated cation channel
            3 promotes HCC development in a female-biased manner
  JOURNAL   Cell Rep 42 (10), 113157 (2023)
   PUBMED   37733590
REFERENCE   3  (bases 1 to 1426)
  AUTHORS   Patel,T., Hammelman,J., Aziz,S., Jang,S., Closser,M.,
            Michaels,T.L., Blum,J.A., Gifford,D.K. and Wichterle,H.
  TITLE     Transcriptional dynamics of murine motor neuron maturation in vivo
            and in vitro
  JOURNAL   Nat Commun 13 (1), 5427 (2022)
   PUBMED   36109497
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1426)
  AUTHORS   Grund,A., Szaroszyk,M., Korf-Klingebiel,M., Malek Mohammadi,M.,
            Trogisch,F.A., Schrameck,U., Gigina,A., Tiedje,C., Gaestel,M.,
            Kraft,T., Hegermann,J., Batkai,S., Thum,T., Perrot,A.,
            Remedios,C.D., Riechert,E., Volkers,M., Doroudgar,S., Jungmann,A.,
            Bauer,R., Yin,X., Mayr,M., Wollert,K.C., Pich,A., Xiao,H.,
            Katus,H.A., Bauersachs,J., Muller,O.J. and Heineke,J.
  TITLE     TIP30 counteracts cardiac hypertrophy and failure by inhibiting
            translational elongation
  JOURNAL   EMBO Mol Med 11 (10), e10018 (2019)
   PUBMED   31468715
REFERENCE   5  (bases 1 to 1426)
  AUTHORS   Yang,W., Xiao,L., Li,C., Liu,X., Liu,M., Shao,Q., Wang,D., Huang,A.
            and He,C.
  TITLE     TIP30 inhibits oligodendrocyte precursor cell differentiation via
            cytoplasmic sequestration of Olig1
  JOURNAL   Glia 63 (4), 684-698 (2015)
   PUBMED   25530119
  REMARK    GeneRIF: Data suggest that TIP30 plays a negative regulatory role
            in oligodendroglial differentiation.
REFERENCE   6  (bases 1 to 1426)
  AUTHORS   McLaughlin,M.E., Kruger,G.M., Slocum,K.L., Crowley,D.,
            Michaud,N.A., Huang,J., Magendantz,M. and Jacks,T.
  TITLE     The Nf2 tumor suppressor regulates cell-cell adhesion during tissue
            fusion
  JOURNAL   Proc Natl Acad Sci U S A 104 (9), 3261-3266 (2007)
   PUBMED   17360635
REFERENCE   7  (bases 1 to 1426)
  AUTHORS   Matsumoto,S., Banine,F., Struve,J., Xing,R., Adams,C., Liu,Y.,
            Metzger,D., Chambon,P., Rao,M.S. and Sherman,L.S.
  TITLE     Brg1 is required for murine neural stem cell maintenance and
            gliogenesis
  JOURNAL   Dev Biol 289 (2), 372-383 (2006)
   PUBMED   16330018
REFERENCE   8  (bases 1 to 1426)
  AUTHORS   Stefan,M., Claiborn,K.C., Stasiek,E., Chai,J.H., Ohta,T.,
            Longnecker,R., Greally,J.M. and Nicholls,R.D.
  TITLE     Genetic mapping of putative Chrna7 and Luzp2 neuronal
            transcriptional enhancers due to impact of a transgene-insertion
            and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman
            syndromes
  JOURNAL   BMC Genomics 6, 157 (2005)
   PUBMED   16280085
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1426)
  AUTHORS   Jiang,C., Ito,M., Piening,V., Bruck,K., Roeder,R.G. and Xiao,H.
  TITLE     TIP30 interacts with an estrogen receptor alpha-interacting
            coactivator CIA and regulates c-myc transcription
  JOURNAL   J Biol Chem 279 (26), 27781-27789 (2004)
   PUBMED   15073177
REFERENCE   10 (bases 1 to 1426)
  AUTHORS   Ito,M., Jiang,C., Krumm,K., Zhang,X., Pecha,J., Zhao,J., Guo,Y.,
            Roeder,R.G. and Xiao,H.
  TITLE     TIP30 deficiency increases susceptibility to tumorigenesis
  JOURNAL   Cancer Res 63 (24), 8763-8767 (2003)
   PUBMED   14695192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY292123.1, AK151254.1 and AW121187.1.
            
            On Mar 26, 2009 this sequence version replaced NM_016865.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004083.1, AK151254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BY292123.1         3-82
            81-1404             AK151254.1         2-1325
            1405-1426           AW121187.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 31.44 cM"
     gene            1..1426
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="HIV-1 Tat interactive protein 2"
                     /db_xref="GeneID:53415"
                     /db_xref="MGI:MGI:1859271"
     exon            1..206
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..936
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="isoform a is encoded by transcript variant 1;
                     tat-interacting protein 30 kDa; oxidoreductase HTATIP2;
                     HIV-1 tat interactive protein 2, 30 kDa homolog; HIV-1 tat
                     interactive protein 2, homolog"
                     /codon_start=1
                     /product="oxidoreductase HTATIP2 isoform a"
                     /protein_id="NP_058561.2"
                     /db_xref="CCDS:CCDS85310.1"
                     /db_xref="GeneID:53415"
                     /db_xref="MGI:MGI:1859271"
                     /translation="MLGPTVLGTVVAALVASMLLLQSGDEGSGAAPSMADKEALPKLR
                     EDFKMQNKSVFILGASGETGKVLLKEILGQNLFSKVTLIGRRKLTFEEEAYKNVNQEV
                     VDFEKLDVYASAFQGHDVGFCCLGTTRSKAGAEGFVRVDRDYVLKSAELAKAGGCKHF
                     NLLSSRGADKSSSFLYLQVKGEVEAKVEELKFDRLSVFRPGVLLCDRQESRPGEWLAR
                     KFFGSLPDSWASGYAVPVVTVVRAMLNNLVSPSSGQMELLENKAILHLGKDRDVPKL"
     exon            207..402
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     exon            403..510
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     exon            511..648
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     exon            649..710
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     exon            711..1409
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1000..1005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="hexamer: TATAAA"
     polyA_site      1021
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="major polyA site"
     regulatory      1386..1391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="hexamer: AATAAA"
     polyA_site      1401
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
     polyA_site      1405
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="major polyA site"
ORIGIN      
        1 gggccgcgag cgcgctgtca cccggaagac gtcgcggccg gtaggctccg gctggacctc
       61 ttggggctcc ttgccgggag gggagacagc ggggctgcag gcggcgagat gctcggtccc
      121 acggtgctgg gcacggtcgt agccgcgctg gtggcttcaa tgctactgtt gcagagtggg
      181 gacgaggggt ccggggctgc tcccagcatg gcggacaagg aagcactgcc gaagcttcgg
      241 gaagacttca agatgcagaa taaatccgtc tttattttgg gcgccagcgg ggaaactggc
      301 aaagtacttt taaaggaaat cctgggacag aacctgtttt ccaaagtaac gctcattggt
      361 cggaggaagc tcaccttcga ggaggaagct tataaaaatg tgaatcaaga agtggtggac
      421 tttgagaagc tggatgtcta tgcttctgcc tttcaaggtc atgatgttgg attctgttgc
      481 ctgggcacca ccagaagcaa ggctggagcg gaagggtttg ttcgtgttga ccgagattat
      541 gtgctcaagt ctgcagagct ggcgaaagca ggagggtgca aacatttcaa cttgctgtcc
      601 tccagggggg ccgataagtc cagcagtttc ttatacctac aagtaaaggg agaagtggaa
      661 gccaaggttg aagaattaaa gtttgatcga ctctcagtgt ttcggccagg agtcctactg
      721 tgtgacaggc aagagtctcg tccaggcgaa tggctggcta ggaaattctt cggctctctg
      781 ccagactctt gggccagtgg gtacgctgtg cctgtggtga cggtggttag agcgatgctg
      841 aacaacctgg tgagtcccag cagcggacaa atggaacttc tggaaaataa ggccatcctc
      901 cacctgggga aagacaggga tgtgcccaaa ctgtgaccat gctggaggac attcgtgaaa
      961 acctcagtgc ctgtcaccaa atcagtcatt tgggggctct ataaaaagtc tctttgtggt
     1021 cctttgtggt gtgcttctcc ttagccaagc ggctccatca gaaaatggca ctactccacg
     1081 tcagttgttg agagccccgt tgctcatgta atcatccagg cagcttttgg agaacaggtt
     1141 tatatcatag acttatactt tgtaggttgc aaacagggat ctctggaggt cccggtgcct
     1201 ttgggtgtaa ggccagcttt gaagcactcc tccagggcca cctgagcaga ggggccctag
     1261 cactacaggc agtctcgtct cctggcggca cggtgctgtt gggctgcatg tagctgagtg
     1321 aacactgtgc cttgattctc tgtcagcaca gaagctgtaa gacaagcttc tgtatttcac
     1381 cgaggaataa aaataaatgg agaaacccta aaaaaaaaaa aaaaaa
//
