LOCUS       NM_001146049            1482 bp    mRNA    linear   ROD 20-AUG-2024
DEFINITION  Mus musculus HIV-1 Tat interactive protein 2 (Htatip2), transcript
            variant 2, mRNA.
ACCESSION   NM_001146049
VERSION     NM_001146049.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1482)
  AUTHORS   Liu,X.L., Hou,Y.Y., Su,S.H., Wu,X. and Wang,Z.F.
  TITLE     Investigating TIP30-Mediated regulation of mTORC1 signaling as a
            therapeutic strategy for coxsackievirus B3-Induced viral
            myocarditis
  JOURNAL   Virology 597, 110156 (2024)
   PUBMED   38981316
  REMARK    GeneRIF: Investigating TIP30-Mediated regulation of mTORC1
            signaling as a therapeutic strategy for coxsackievirus B3-Induced
            viral myocarditis.
REFERENCE   2  (bases 1 to 1482)
  AUTHORS   Zhang,Y., Liu,X., Sun,K., Luo,Y., Yang,J., Li,A., Kiupel,M.,
            Fenske,S., Biel,M., Mi,Q.S., Wang,H. and Xiao,H.
  TITLE     Hyperpolarization-activated cyclic nucleotide-gated cation channel
            3 promotes HCC development in a female-biased manner
  JOURNAL   Cell Rep 42 (10), 113157 (2023)
   PUBMED   37733590
REFERENCE   3  (bases 1 to 1482)
  AUTHORS   Patel,T., Hammelman,J., Aziz,S., Jang,S., Closser,M.,
            Michaels,T.L., Blum,J.A., Gifford,D.K. and Wichterle,H.
  TITLE     Transcriptional dynamics of murine motor neuron maturation in vivo
            and in vitro
  JOURNAL   Nat Commun 13 (1), 5427 (2022)
   PUBMED   36109497
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1482)
  AUTHORS   Grund,A., Szaroszyk,M., Korf-Klingebiel,M., Malek Mohammadi,M.,
            Trogisch,F.A., Schrameck,U., Gigina,A., Tiedje,C., Gaestel,M.,
            Kraft,T., Hegermann,J., Batkai,S., Thum,T., Perrot,A.,
            Remedios,C.D., Riechert,E., Volkers,M., Doroudgar,S., Jungmann,A.,
            Bauer,R., Yin,X., Mayr,M., Wollert,K.C., Pich,A., Xiao,H.,
            Katus,H.A., Bauersachs,J., Muller,O.J. and Heineke,J.
  TITLE     TIP30 counteracts cardiac hypertrophy and failure by inhibiting
            translational elongation
  JOURNAL   EMBO Mol Med 11 (10), e10018 (2019)
   PUBMED   31468715
REFERENCE   5  (bases 1 to 1482)
  AUTHORS   Yang,W., Xiao,L., Li,C., Liu,X., Liu,M., Shao,Q., Wang,D., Huang,A.
            and He,C.
  TITLE     TIP30 inhibits oligodendrocyte precursor cell differentiation via
            cytoplasmic sequestration of Olig1
  JOURNAL   Glia 63 (4), 684-698 (2015)
   PUBMED   25530119
  REMARK    GeneRIF: Data suggest that TIP30 plays a negative regulatory role
            in oligodendroglial differentiation.
REFERENCE   6  (bases 1 to 1482)
  AUTHORS   McLaughlin,M.E., Kruger,G.M., Slocum,K.L., Crowley,D.,
            Michaud,N.A., Huang,J., Magendantz,M. and Jacks,T.
  TITLE     The Nf2 tumor suppressor regulates cell-cell adhesion during tissue
            fusion
  JOURNAL   Proc Natl Acad Sci U S A 104 (9), 3261-3266 (2007)
   PUBMED   17360635
REFERENCE   7  (bases 1 to 1482)
  AUTHORS   Matsumoto,S., Banine,F., Struve,J., Xing,R., Adams,C., Liu,Y.,
            Metzger,D., Chambon,P., Rao,M.S. and Sherman,L.S.
  TITLE     Brg1 is required for murine neural stem cell maintenance and
            gliogenesis
  JOURNAL   Dev Biol 289 (2), 372-383 (2006)
   PUBMED   16330018
REFERENCE   8  (bases 1 to 1482)
  AUTHORS   Stefan,M., Claiborn,K.C., Stasiek,E., Chai,J.H., Ohta,T.,
            Longnecker,R., Greally,J.M. and Nicholls,R.D.
  TITLE     Genetic mapping of putative Chrna7 and Luzp2 neuronal
            transcriptional enhancers due to impact of a transgene-insertion
            and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman
            syndromes
  JOURNAL   BMC Genomics 6, 157 (2005)
   PUBMED   16280085
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1482)
  AUTHORS   Jiang,C., Ito,M., Piening,V., Bruck,K., Roeder,R.G. and Xiao,H.
  TITLE     TIP30 interacts with an estrogen receptor alpha-interacting
            coactivator CIA and regulates c-myc transcription
  JOURNAL   J Biol Chem 279 (26), 27781-27789 (2004)
   PUBMED   15073177
REFERENCE   10 (bases 1 to 1482)
  AUTHORS   Ito,M., Jiang,C., Krumm,K., Zhang,X., Pecha,J., Zhao,J., Guo,Y.,
            Roeder,R.G. and Xiao,H.
  TITLE     TIP30 deficiency increases susceptibility to tumorigenesis
  JOURNAL   Cancer Res 63 (24), 8763-8767 (2003)
   PUBMED   14695192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY292123.1, AK144837.1 and AW121187.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            a downstream translational start codon, compared to variant 1. The
            resulting isoform (b) is shorter at the N-terminus, compared to
            isoform a. Variants 2-5 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144837.1, SRR5189676.50681.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY292123.1         3-25
            24-1456             AK144837.1         2-1434
            1457-1482           AW121187.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..1482
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 31.44 cM"
     gene            1..1482
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="HIV-1 Tat interactive protein 2"
                     /db_xref="GeneID:53415"
                     /db_xref="MGI:MGI:1859271"
     exon            1..206
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     exon            207..458
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..992
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="isoform b is encoded by transcript variant 2;
                     tat-interacting protein 30 kDa; oxidoreductase HTATIP2;
                     HIV-1 tat interactive protein 2, 30 kDa homolog; HIV-1 tat
                     interactive protein 2, homolog"
                     /codon_start=1
                     /product="oxidoreductase HTATIP2 isoform b"
                     /protein_id="NP_001139521.1"
                     /db_xref="CCDS:CCDS52260.1"
                     /db_xref="GeneID:53415"
                     /db_xref="MGI:MGI:1859271"
                     /translation="MADKEALPKLREDFKMQNKSVFILGASGETGKVLLKEILGQNLF
                     SKVTLIGRRKLTFEEEAYKNVNQEVVDFEKLDVYASAFQGHDVGFCCLGTTRSKAGAE
                     GFVRVDRDYVLKSAELAKAGGCKHFNLLSSRGADKSSSFLYLQVKGEVEAKVEELKFD
                     RLSVFRPGVLLCDRQESRPGEWLARKFFGSLPDSWASGYAVPVVTVVRAMLNNLVSPS
                     SGQMELLENKAILHLGKDRDVPKL"
     exon            459..566
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     exon            567..704
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     exon            705..766
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1465
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1056..1061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="hexamer: TATAAA"
     polyA_site      1077
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="major polyA site"
     regulatory      1442..1447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="hexamer: AATAAA"
     polyA_site      1457
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
     polyA_site      1461
                     /gene="Htatip2"
                     /gene_synonym="Cc3; Tip30"
                     /note="major polyA site"
ORIGIN      
        1 gggccgcgag cgcgctgtca cccggaagac gtcgcggccg gtaggctccg gctggacctc
       61 ttggggctcc ttgccgggag gggagacagc ggggctgcag gcggcgagat gctcggtccc
      121 acggtgctgg gcacggtcgt agccgcgctg gtggcttcaa tgctactgtt gcagagtggg
      181 gacgaggggt ccggggctgc tcccagggta aagagtgtca cctagcactc tgagacagga
      241 cccacgggtg ttgtttcccc agcatggcgg acaaggaagc actgccgaag cttcgggaag
      301 acttcaagat gcagaataaa tccgtcttta ttttgggcgc cagcggggaa actggcaaag
      361 tacttttaaa ggaaatcctg ggacagaacc tgttttccaa agtaacgctc attggtcgga
      421 ggaagctcac cttcgaggag gaagcttata aaaatgtgaa tcaagaagtg gtggactttg
      481 agaagctgga tgtctatgct tctgcctttc aaggtcatga tgttggattc tgttgcctgg
      541 gcaccaccag aagcaaggct ggagcggaag ggtttgttcg tgttgaccga gattatgtgc
      601 tcaagtctgc agagctggcg aaagcaggag ggtgcaaaca tttcaacttg ctgtcctcca
      661 ggggggccga taagtccagc agtttcttat acctacaagt aaagggagaa gtggaagcca
      721 aggttgaaga attaaagttt gatcgactct cagtgtttcg gccaggagtc ctactgtgtg
      781 acaggcaaga gtctcgtcca ggcgaatggc tggctaggaa attcttcggc tctctgccag
      841 actcttgggc cagtgggtac gctgtgcctg tggtgacggt ggttagagcg atgctgaaca
      901 acctggtgag tcccagcagc ggacaaatgg aacttctgga aaataaggcc atcctccacc
      961 tggggaaaga cagggatgtg cccaaactgt gaccatgctg gaggacattc gtgaaaacct
     1021 cagtgcctgt caccaaatca gtcatttggg ggctctataa aaagtctctt tgtggtcctt
     1081 tgtggtgtgc ttctccttag ccaagcggct ccatcagaaa atggcactac tccacgtcag
     1141 ttgttgagag ccccgttgct catgtaatca tccaggcagc ttttggagaa caggtttata
     1201 tcatagactt atactttgta ggttgcaaac agggatctct ggaggtcccg gtgcctttgg
     1261 gtgtaaggcc agctttgaag cactcctcca gggccacctg agcagagggg ccctagcact
     1321 acaggcagtc tcgtctcctg gcggcacggt gctgttgggc tgcatgtagc tgagtgaaca
     1381 ctgtgccttg attctctgtc agcacagaag ctgtaagaca agcttctgta tttcaccgag
     1441 gaataaaaat aaatggagaa accctaaaaa aaaaaaaaaa aa
//
