LOCUS       NM_013559               3478 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus heat shock 105kDa/110kDa protein 1 (Hsph1), transcript
            variant 1, mRNA.
ACCESSION   NM_013559
VERSION     NM_013559.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3478)
  AUTHORS   Hu,Q.Z., Cao,Z.R., Zheng,W.X., Zhao,M.J., Gong,J.H., Chen,C.,
            Wu,Z.J. and Tao,R.
  TITLE     HSP110 aggravates ischemia-reperfusion injury after liver
            transplantation by promoting NF-kappaB pathway
  JOURNAL   Hepatobiliary Pancreat Dis Int 23 (4), 344-352 (2024)
   PUBMED   37648554
  REMARK    GeneRIF: HSP110 aggravates ischemia-reperfusion injury after liver
            transplantation by promoting NF-kappaB pathway.
REFERENCE   2  (bases 1 to 3478)
  AUTHORS   de Thonel,A., Ahlskog,J.K., Daupin,K., Dubreuil,V., Berthelet,J.,
            Chaput,C., Pires,G., Leonetti,C., Abane,R., Barris,L.C., Leray,I.,
            Aalto,A.L., Naceri,S., Cordonnier,M., Benasolo,C., Sanial,M.,
            Duchateau,A., Vihervaara,A., Puustinen,M.C., Miozzo,F.,
            Fergelot,P., Lebigot,E., Verloes,A., Gressens,P., Lacombe,D.,
            Gobbo,J., Garrido,C., Westerheide,S.D., David,L., Petitjean,M.,
            Taboureau,O., Rodrigues-Lima,F., Passemard,S., Saberan-Djoneidi,D.,
            Nguyen,L., Lancaster,M., Sistonen,L. and Mezger,V.
  TITLE     CBP-HSF2 structural and functional interplay in Rubinstein-Taybi
            neurodevelopmental disorder
  JOURNAL   Nat Commun 13 (1), 7002 (2022)
   PUBMED   36385105
  REMARK    Erratum:[Nat Commun. 2023 Sep 28;14(1):6067. doi:
            10.1038/s41467-023-41869-4.. PMID: 37770591]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3478)
  AUTHORS   Liu,H., Zhang,S., Liu,Y., Ma,J., Chen,W., Yin,T., Li,T., Liang,B.
            and Tao,L.
  TITLE     Knockdown of HSP110 attenuates hypoxia-induced pulmonary
            hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway
  JOURNAL   Respir Res 23 (1), 209 (2022)
   PUBMED   35986277
  REMARK    GeneRIF: Knockdown of HSP110 attenuates hypoxia-induced pulmonary
            hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3478)
  AUTHORS   Yamane,T., Saito,Y., Teshima,H., Hagino,M., Kakihana,A., Sato,S.,
            Shimada,M., Kato,Y., Kuga,T., Yamagishi,N. and Nakayama,Y.
  TITLE     Hsp105alpha suppresses Adriamycin-induced cell death via nuclear
            localization signal-dependent nuclear accumulation
  JOURNAL   J Cell Biochem 120 (10), 17951-17962 (2019)
   PUBMED   31173393
  REMARK    GeneRIF: Hsp105alpha suppresses Adriamycin-induced cell death via
            nuclear localization signal-dependent nuclear accumulation.
REFERENCE   5  (bases 1 to 3478)
  AUTHORS   Hashikawa,N., Utaka,Y., Ogawa,T., Tanoue,R., Morita,Y.,
            Yamamoto,S., Yamaguchi,S., Kayano,M., Zamami,Y. and
            Hashikawa-Hobara,N.
  TITLE     HSP105 prevents depression-like behavior by increasing hippocampal
            brain-derived neurotrophic factor levels in mice
  JOURNAL   Sci Adv 3 (5), e1603014 (2017)
   PUBMED   28580422
  REMARK    GeneRIF: These observations suggest that GGA administration is a
            therapeutic candidate for depressive diseases by increasing
            hippocampal BDNF levels via HSP105 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3478)
  AUTHORS   Hatayama,T., Yasuda,K. and Yasuda,K.
  TITLE     Association of HSP105 with HSC70 in high molecular mass complexes
            in mouse FM3A cells
  JOURNAL   Biochem Biophys Res Commun 248 (2), 395-401 (1998)
   PUBMED   9675148
REFERENCE   7  (bases 1 to 3478)
  AUTHORS   Hunt,C.R., Goswami,P.C. and Kozak,C.A.
  TITLE     Assignment of the mouse Hsp25 and Hsp105 genes to the distal region
            of chromosome 5 by linkage analysis
  JOURNAL   Genomics 45 (2), 462-463 (1997)
   PUBMED   9344682
REFERENCE   8  (bases 1 to 3478)
  AUTHORS   Hatayama,T., Takigawa,T., Takeuchi,S. and Shiota,K.
  TITLE     Characteristic expression of high molecular mass heat shock protein
            HSP105 during mouse embryo development
  JOURNAL   Cell Struct Funct 22 (5), 517-525 (1997)
   PUBMED   9431456
REFERENCE   9  (bases 1 to 3478)
  AUTHORS   Yasuda,K., Nakai,A., Hatayama,T. and Nagata,K.
  TITLE     Cloning and expression of murine high molecular mass heat shock
            proteins, HSP105
  JOURNAL   J Biol Chem 270 (50), 29718-29723 (1995)
   PUBMED   8530361
REFERENCE   10 (bases 1 to 3478)
  AUTHORS   Morozov,A., Subjeck,J. and Raychaudhuri,P.
  TITLE     HPV16 E7 oncoprotein induces expression of a 110 kDa heat shock
            protein
  JOURNAL   FEBS Lett 371 (3), 214-218 (1995)
   PUBMED   7556594
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF164049.1, AK165046.1, AK146697.1 and AK172913.1.
            
            On Sep 7, 2006 this sequence version replaced NM_013559.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146697.1, SRR1660815.50358.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                CF164049.1         1-33
            34-1164             AK165046.1         2-1132
            1165-2209           AK146697.1         1084-2128
            2210-2942           AK165046.1         2178-2910
            2943-3478           AK172913.1         1840-2375
FEATURES             Location/Qualifiers
     source          1..3478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 89.18 cM"
     gene            1..3478
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /note="heat shock 105kDa/110kDa protein 1"
                     /db_xref="GeneID:15505"
                     /db_xref="MGI:MGI:105053"
     exon            1..346
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..2816
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /note="isoform 1 is encoded by transcript variant 1; heat
                     shock protein 105 kDa; 42 degrees C-HSP; heat shock 110
                     kDa protein; heat shock-related 100 kDa protein E7I;
                     HSP105 42 C-HSP; heat shock protein 110"
                     /codon_start=1
                     /product="heat shock protein 105 kDa isoform 1"
                     /protein_id="NP_038587.2"
                     /db_xref="CCDS:CCDS19885.1"
                     /db_xref="GeneID:15505"
                     /db_xref="MGI:MGI:105053"
                     /translation="MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSK
                     NRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIK
                     VMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAA
                     QIVGLNCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKG
                     KLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKL
                     MSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAED
                     VSAIEIVGGATRIPAVKERIAKFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREF
                     SVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQ
                     GVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEEEDG
                     SSLEADMECPNQRPTESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEES
                     KTPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIM
                     QDKLEKERNDAKNAVEECVYEFRDKLCGPYEKFICEQEHEKFLRLLTETEDWLYEEGE
                     DQAKQAYIDKLEELMKMGTPVKVRFQEAEERPKVLEELGQRLQHYAKIAADFRGKDEK
                     YNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLDQDPVVRTHEIRAKVKELNNVCE
                     PVVTQPKPKIESPKLERTPNGPNIDKKEDLEGKNNLGAEAPHQNGECHPNEKGSVNMD
                     LD"
     exon            347..404
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            405..545
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            546..668
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            669..768
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            769..902
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1147
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1376
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1483
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1617
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1826
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1958
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2096
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2222
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2330
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2450
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2612
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..3478
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaaaatgct gcagattctg gaaagttctc ctcagtaggc tacataaggc tgagcgattg
       61 ggacctcccc ttttggattg gtagctgagc ggcggcggct gcgtgagaga ggcgggcggc
      121 ggagagcggt ggcagagact gagcgcagtc ttgcagggta agccggaggc atcttcccga
      181 ctggtcggga gcaggacgag cacgcagcgg acccgaggcg gaggcggacc gggccagcca
      241 tgtcggtggt tgggctagac gtaggctcac agagctgcta cattgcggtg gcgcgggccg
      301 ggggcatcga gaccatcgcc aacgagttca gcgaccgctg caccccgtca gtcatatcat
      361 ttggatcaaa aaacagaaca attggagttg cagccaaaaa ccagcaaatc actcatgcaa
      421 acaatacggt ctctagcttt aagagatttc atggcagagc attcaatgac cccttcattc
      481 agaaggaaaa ggagaacctg agctatgatt tggtcccaat gaaaaatggt ggcgtgggaa
      541 taaaggtcat gtacatggat gaagaacatt tcttcagtgt ggagcagata acagccatgc
      601 tgctgactaa gttaaaggaa actgcagaaa acaacctcaa gaagccagtg acagactgtg
      661 tcatctcagt cccatccttc ttcacagatg ctgagcgaag gtctgtgctg gatgctgcgc
      721 agattgtggg cttgaactgc ttgcggctca tgaatgacat gacggctgtt gctttgaatt
      781 atgggattta taagcaagat ctcccgaatg ccgaggagaa gccacgggtg gtggtgtttg
      841 ttgacatggg acactcatct ttccaagtgt ctgcctgtgc ttttaacaaa ggaaaactga
      901 aggttctagg cacagctttt gatcccttct taggaggaaa gaactttgat gagaagctag
      961 tagaacattt ttgtgctgaa tttaaaacca agtacaaatt ggatgcaaaa tccaaaattc
     1021 gagccctcct tcgtctccat caggagtgtg aaaagttgaa aaagctcatg agttctaaca
     1081 gcacggacct gccgctgaac atcgagtgct ttatgaatga caaggatgtc tctgggaaga
     1141 tgaacaggtc acagtttgaa gaactgtgtg ctgagctcct gcaaaaaata gaggtccccc
     1201 ttcactcgtt gatggcacag actcagctca aggctgaaga tgtgagtgcc attgagatag
     1261 tgggaggtgc cacaagaatc ccagctgtga aagaaagaat tgccaagttc tttggaaaag
     1321 atgtcagcac cacgctcaat gcagacgaag ctgtggccag aggctgtgca ctgcagtgtg
     1381 caattctttc tccggcattt aaagttagag agttctctgt caccgatgca gttccttttc
     1441 caatatctct ggtctggaac cacgactcgg aagaaacgga aggtgtgcac gaggtgttca
     1501 gtcggaacca tgctgctcct ttctccaaag tgctcacctt cctgagaagg gggccctttg
     1561 agctagaagc tttctattct gaccctcaag gagttccata tccagaagca aaaataggcc
     1621 gttttgttgt tcagaatgtt tctgcacaga aagatggaga gaagtcgaga gtgaaggtca
     1681 aagtgcgtgt gaacacacat ggcatcttca ccatctccac ggcttccatg gtggagaagg
     1741 tcccgaccga ggaagaggat ggctcctctc tcgaggcaga catggaatgt ccaaaccaga
     1801 ggccaacaga aagctcggat gtggataaaa atatccagca agacaacagt gaagctggaa
     1861 cacagcccca ggtacaaact gatggtcaac aaacctcaca gtctccccct tcacctgaac
     1921 ttacctcaga agaaagcaaa accccagatg ctgacaaagc aaatgaaaag aaagttgatc
     1981 agcctccaga agccaagaaa cctaaaataa aggtggtaaa tgttgagctg cctgtagaag
     2041 ccaacttggt atggcagtta gggagagacc ttcttaacat gtatattgag acagagggca
     2101 agatgatcat gcaagacaag ctggagaagg agcggaacga cgccaagaac gccgtggagg
     2161 agtgtgtata tgagttcagg gacaagctat gtggaccata tgagaaattc atatgtgagc
     2221 aggaacatga gaagttcttg aggcttctaa cagagacgga agactggctg tatgaggaag
     2281 gggaggacca ggctaagcag gcatacattg acaagttgga agagctgatg aaaatgggca
     2341 ctcctgttaa agtcagattt caagaagctg aggaacgacc gaaagtgttg gaggagctgg
     2401 ggcagcgcct gcagcactat gccaagattg cagcggactt cagaggcaag gatgagaaat
     2461 acaaccacat tgatgaatca gaaatgaaga aggttgagaa gtctgttaat gaggtgatgg
     2521 agtggatgaa taatgtcatg aatgctcagg ctaaaagaag tcttgatcaa gaccctgttg
     2581 ttcgaactca tgaaatcaga gcgaaggtca aggaattgaa caatgtttgt gaacctgttg
     2641 taactcaacc caaaccaaaa atcgagtcac ctaaactgga gagaactcca aatggcccaa
     2701 atattgacaa gaaagaagat ttagaaggca aaaataatct tggtgctgaa gctccgcatc
     2761 agaatggtga atgccaccct aatgagaagg gctctgtcaa catggacctg gactaggctc
     2821 tgtgctggct ccctccccca cttcatgaga tgtgtttgcc atagtatgtg atcctgtata
     2881 acagactgag tctatttata ttttcttttt tttaagactg tctagaaatt ttgtgtatta
     2941 tgaggggaaa aaaggaaaag cttgaatctg tgtagtctct gaccctaagt gagaatgact
     3001 ttggtgtcag ggtcctgtgg agttgtgccc cacactgagc tctgtacagt attgctgctc
     3061 atacactgag gaggtggggt cgtcttctga ggatatgaac tacactgctt ggtcacacgc
     3121 tgggatcaga atcttaagca gttattcttg ccaagggttt tgttttgttt tgcattttgc
     3181 tcttcatttc cgcatgtgtg tggctgtggt tgtttataaa tgagactaag tctgatttgc
     3241 ataagggctt tcaaaaatta agtctgtcca gtagagtgat tttgctttca ttattaccaa
     3301 gtcaagagta caacagagct agtgaaccgt agcagcatgc gaagcagggc tgtgaactat
     3361 caccacacag tgcattgtcc cgtggaggtg tgacacggga gacacacgtg tggatcatgt
     3421 gatcattgtg aacacctcgt gagctttaaa ataaagtcca ccctgtggtg tcatttct
//
