LOCUS       NP_038587                858 aa            linear   ROD 09-FEB-2025
DEFINITION  heat shock protein 105 kDa isoform 1 [Mus musculus].
ACCESSION   NP_038587
VERSION     NP_038587.2
DBSOURCE    REFSEQ: accession NM_013559.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 858)
  AUTHORS   Hu,Q.Z., Cao,Z.R., Zheng,W.X., Zhao,M.J., Gong,J.H., Chen,C.,
            Wu,Z.J. and Tao,R.
  TITLE     HSP110 aggravates ischemia-reperfusion injury after liver
            transplantation by promoting NF-kappaB pathway
  JOURNAL   Hepatobiliary Pancreat Dis Int 23 (4), 344-352 (2024)
   PUBMED   37648554
  REMARK    GeneRIF: HSP110 aggravates ischemia-reperfusion injury after liver
            transplantation by promoting NF-kappaB pathway.
REFERENCE   2  (residues 1 to 858)
  AUTHORS   de Thonel,A., Ahlskog,J.K., Daupin,K., Dubreuil,V., Berthelet,J.,
            Chaput,C., Pires,G., Leonetti,C., Abane,R., Barris,L.C., Leray,I.,
            Aalto,A.L., Naceri,S., Cordonnier,M., Benasolo,C., Sanial,M.,
            Duchateau,A., Vihervaara,A., Puustinen,M.C., Miozzo,F.,
            Fergelot,P., Lebigot,E., Verloes,A., Gressens,P., Lacombe,D.,
            Gobbo,J., Garrido,C., Westerheide,S.D., David,L., Petitjean,M.,
            Taboureau,O., Rodrigues-Lima,F., Passemard,S., Saberan-Djoneidi,D.,
            Nguyen,L., Lancaster,M., Sistonen,L. and Mezger,V.
  TITLE     CBP-HSF2 structural and functional interplay in Rubinstein-Taybi
            neurodevelopmental disorder
  JOURNAL   Nat Commun 13 (1), 7002 (2022)
   PUBMED   36385105
  REMARK    Erratum:[Nat Commun. 2023 Sep 28;14(1):6067. doi:
            10.1038/s41467-023-41869-4.. PMID: 37770591]
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 858)
  AUTHORS   Liu,H., Zhang,S., Liu,Y., Ma,J., Chen,W., Yin,T., Li,T., Liang,B.
            and Tao,L.
  TITLE     Knockdown of HSP110 attenuates hypoxia-induced pulmonary
            hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway
  JOURNAL   Respir Res 23 (1), 209 (2022)
   PUBMED   35986277
  REMARK    GeneRIF: Knockdown of HSP110 attenuates hypoxia-induced pulmonary
            hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 858)
  AUTHORS   Yamane,T., Saito,Y., Teshima,H., Hagino,M., Kakihana,A., Sato,S.,
            Shimada,M., Kato,Y., Kuga,T., Yamagishi,N. and Nakayama,Y.
  TITLE     Hsp105alpha suppresses Adriamycin-induced cell death via nuclear
            localization signal-dependent nuclear accumulation
  JOURNAL   J Cell Biochem 120 (10), 17951-17962 (2019)
   PUBMED   31173393
  REMARK    GeneRIF: Hsp105alpha suppresses Adriamycin-induced cell death via
            nuclear localization signal-dependent nuclear accumulation.
REFERENCE   5  (residues 1 to 858)
  AUTHORS   Hashikawa,N., Utaka,Y., Ogawa,T., Tanoue,R., Morita,Y.,
            Yamamoto,S., Yamaguchi,S., Kayano,M., Zamami,Y. and
            Hashikawa-Hobara,N.
  TITLE     HSP105 prevents depression-like behavior by increasing hippocampal
            brain-derived neurotrophic factor levels in mice
  JOURNAL   Sci Adv 3 (5), e1603014 (2017)
   PUBMED   28580422
  REMARK    GeneRIF: These observations suggest that GGA administration is a
            therapeutic candidate for depressive diseases by increasing
            hippocampal BDNF levels via HSP105 expression.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 858)
  AUTHORS   Hatayama,T., Yasuda,K. and Yasuda,K.
  TITLE     Association of HSP105 with HSC70 in high molecular mass complexes
            in mouse FM3A cells
  JOURNAL   Biochem Biophys Res Commun 248 (2), 395-401 (1998)
   PUBMED   9675148
REFERENCE   7  (residues 1 to 858)
  AUTHORS   Hunt,C.R., Goswami,P.C. and Kozak,C.A.
  TITLE     Assignment of the mouse Hsp25 and Hsp105 genes to the distal region
            of chromosome 5 by linkage analysis
  JOURNAL   Genomics 45 (2), 462-463 (1997)
   PUBMED   9344682
REFERENCE   8  (residues 1 to 858)
  AUTHORS   Hatayama,T., Takigawa,T., Takeuchi,S. and Shiota,K.
  TITLE     Characteristic expression of high molecular mass heat shock protein
            HSP105 during mouse embryo development
  JOURNAL   Cell Struct Funct 22 (5), 517-525 (1997)
   PUBMED   9431456
REFERENCE   9  (residues 1 to 858)
  AUTHORS   Yasuda,K., Nakai,A., Hatayama,T. and Nagata,K.
  TITLE     Cloning and expression of murine high molecular mass heat shock
            proteins, HSP105
  JOURNAL   J Biol Chem 270 (50), 29718-29723 (1995)
   PUBMED   8530361
REFERENCE   10 (residues 1 to 858)
  AUTHORS   Morozov,A., Subjeck,J. and Raychaudhuri,P.
  TITLE     HPV16 E7 oncoprotein induces expression of a 110 kDa heat shock
            protein
  JOURNAL   FEBS Lett 371 (3), 214-218 (1995)
   PUBMED   7556594
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF164049.1, AK165046.1, AK146697.1 and AK172913.1.
            
            On Sep 7, 2006 this sequence version replaced NP_038587.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146697.1, SRR1660815.50358.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 89.18 cM"
     Protein         1..858
                     /product="heat shock protein 105 kDa isoform 1"
                     /note="heat shock protein 105 kDa; 42 degrees C-HSP; heat
                     shock 110 kDa protein; heat shock-related 100 kDa protein
                     E7I; HSP105 42 C-HSP; heat shock protein 110"
                     /calculated_mol_wt=96277
     Region          2..381
                     /region_name="ASKHA_NBD_HSP70_HSPH1"
                     /note="nucleotide-binding domain (NBD) of heat shock
                     105kDa/110kDa protein 1 (HSPH1) and similar proteins;
                     cd11739"
                     /db_xref="CDD:466845"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q92598; propagated from
                     UniProtKB/Swiss-Prot (Q61699.2)"
     Site            471
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q61699.2)"
     Region          500..585
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61699.2)"
     Site            509
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:12558502,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61699.2)"
     Site            510
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61699.2)"
     Site            558
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747; propagated from
                     UniProtKB/Swiss-Prot (Q61699.2)"
     Site            562
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q92598; propagated from
                     UniProtKB/Swiss-Prot (Q61699.2)"
     Region          801..858
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61699.2)"
     Site            810
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (Q61699.2)"
     Site            816
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q92598; propagated from
                     UniProtKB/Swiss-Prot (Q61699.2)"
     CDS             1..858
                     /gene="Hsph1"
                     /gene_synonym="105kDa; hsp-E7I; Hsp105; Hsp110;
                     hsp110/105"
                     /coded_by="NM_013559.2:240..2816"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19885.1"
                     /db_xref="GeneID:15505"
                     /db_xref="MGI:MGI:105053"
ORIGIN      
        1 msvvgldvgs qscyiavara ggietianef sdrctpsvis fgsknrtigv aaknqqitha
       61 nntvssfkrf hgrafndpfi qkekenlsyd lvpmknggvg ikvmymdeeh ffsveqitam
      121 lltklketae nnlkkpvtdc visvpsfftd aerrsvldaa qivglnclrl mndmtavaln
      181 ygiykqdlpn aeekprvvvf vdmghssfqv sacafnkgkl kvlgtafdpf lggknfdekl
      241 vehfcaefkt kykldakski rallrlhqec eklkklmssn stdlplniec fmndkdvsgk
      301 mnrsqfeelc aellqkievp lhslmaqtql kaedvsaiei vggatripav keriakffgk
      361 dvsttlnade avargcalqc ailspafkvr efsvtdavpf pislvwnhds eetegvhevf
      421 srnhaapfsk vltflrrgpf eleafysdpq gvpypeakig rfvvqnvsaq kdgeksrvkv
      481 kvrvnthgif tistasmvek vpteeedgss leadmecpnq rptessdvdk niqqdnseag
      541 tqpqvqtdgq qtsqsppspe ltseesktpd adkanekkvd qppeakkpki kvvnvelpve
      601 anlvwqlgrd llnmyieteg kmimqdklek erndaknave ecvyefrdkl cgpyekfice
      661 qehekflrll tetedwlyee gedqakqayi dkleelmkmg tpvkvrfqea eerpkvleel
      721 gqrlqhyaki aadfrgkdek ynhidesemk kveksvnevm ewmnnvmnaq akrsldqdpv
      781 vrtheirakv kelnnvcepv vtqpkpkies pklertpngp nidkkedleg knnlgaeaph
      841 qngechpnek gsvnmdld
//
