LOCUS       NM_008303                788 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus heat shock protein 1 (chaperonin 10) (Hspe1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_008303
VERSION     NM_008303.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 788)
  AUTHORS   Jung,H.Y., Kwon,H.J., Hahn,K.R., Kim,W., Yoo,D.Y., Yoon,Y.S.,
            Kim,D.W. and Hwang,I.K.
  TITLE     Tat-heat shock protein 10 ameliorates age-related phenotypes by
            facilitating neuronal plasticity and reducing age-related genes in
            the hippocampus
  JOURNAL   Aging (Albany NY) 15 (22), 12723-12737 (2023)
   PUBMED   38011257
  REMARK    GeneRIF: Tat-heat shock protein 10 ameliorates age-related
            phenotypes by facilitating neuronal plasticity and reducing
            age-related genes in the hippocampus.
REFERENCE   2  (bases 1 to 788)
  AUTHORS   Czernik,M., Winiarczyk,D., Sampino,S., Greda,P., Parillo,S.,
            Modlinski,J.A. and Loi,P.
  TITLE     Mitochondrial function and intracellular distribution is severely
            affected in in vitro cultured mouse embryos
  JOURNAL   Sci Rep 12 (1), 16152 (2022)
   PUBMED   36167966
  REMARK    Erratum:[Sci Rep. 2022 Dec 8;12(1):21276. doi:
            10.1038/s41598-022-25820-z.. PMID: 36481919]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 788)
  AUTHORS   Sheng,X., Liu,C., Yan,G., Li,G., Liu,J., Yang,Y., Li,S., Li,Z.,
            Zhou,J., Zhen,X., Zhang,Y., Diao,Z., Hu,Y., Fu,C., Yao,B., Li,C.,
            Cao,Y., Lu,B., Yang,Z., Qin,Y., Sun,H. and Ding,L.
  TITLE     The mitochondrial protease LONP1 maintains oocyte development and
            survival by suppressing nuclear translocation of AIFM1 in mammals
  JOURNAL   EBioMedicine 75, 103790 (2022)
   PUBMED   34974310
REFERENCE   4  (bases 1 to 788)
  AUTHORS   Lu,Z., Chen,Y., Aponte,A.M., Battaglia,V., Gucek,M. and Sack,M.N.
  TITLE     Prolonged fasting identifies heat shock protein 10 as a Sirtuin 3
            substrate: elucidating a new mechanism linking mitochondrial
            protein acetylation to fatty acid oxidation enzyme folding and
            function
  JOURNAL   J Biol Chem 290 (4), 2466-2476 (2015)
   PUBMED   25505263
  REMARK    GeneRIF: heat shock protein 10 is a Sirtuin 3 substrate
REFERENCE   5  (bases 1 to 788)
  AUTHORS   Hoekstra,E.J., von Oerthel,L., van der Linden,A.J.,
            Schellevis,R.D., Scheppink,G., Holstege,F.C., Groot-Koerkamp,M.J.,
            van der Heide,L.P. and Smidt,M.P.
  TITLE     Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the
            correct specification of rostral and medial mdDA neurons
  JOURNAL   Eur J Neurosci 37 (1), 23-32 (2013)
   PUBMED   23106268
REFERENCE   6  (bases 1 to 788)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   7  (bases 1 to 788)
  AUTHORS   Fletcher,B.H., Cassady,A.I., Summers,K.M. and Cavanagh,A.C.
  TITLE     The murine chaperonin 10 gene family contains an intronless,
            putative gene for early pregnancy factor, Cpn10-rs1
  JOURNAL   Mamm Genome 12 (2), 133-140 (2001)
   PUBMED   11210183
REFERENCE   8  (bases 1 to 788)
  AUTHORS   Powell,H.C., Garrett,R.S., Muehlenbachs,A., Brett,F.M. and
            Campbell,I.L.
  TITLE     Crystalloid inclusions in brain macrophages and hemopoietic tissue
            in GFAP-IL3 mice resemble inclusions identified in multiple
            sclerosis
  JOURNAL   Ultrastruct Pathol 23 (5), 285-297 (1999)
   PUBMED   10582266
REFERENCE   9  (bases 1 to 788)
  AUTHORS   Dickson,R., Larsen,B., Viitanen,P.V., Tormey,M.B., Geske,J.,
            Strange,R. and Bemis,L.T.
  TITLE     Cloning, expression, and purification of a functional nonacetylated
            mammalian mitochondrial chaperonin 10
  JOURNAL   J Biol Chem 269 (43), 26858-26864 (1994)
   PUBMED   7929423
REFERENCE   10 (bases 1 to 788)
  AUTHORS   Hartman,D.J., Hoogenraad,N.J., Condron,R. and Hoj,P.B.
  TITLE     Identification of a mammalian 10-kDa heat shock protein, a
            mitochondrial chaperonin 10 homologue essential for assisted
            folding of trimeric ornithine transcarbamoylase in vitro
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3394-3398 (1992)
   PUBMED   1348860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV570511.1, BC099385.1 and CJ238411.1.
            
            On Apr 17, 2008 this sequence version replaced NM_008303.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG801679.1, BI659233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AV570511.1         1-189
            190-758             BC099385.1         1-569
            759-788             CJ238411.1         443-472
FEATURES             Location/Qualifiers
     source          1..788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 28.02 cM"
     gene            1..788
                     /gene="Hspe1"
                     /gene_synonym="10kDa; Hsp10; mt-cpn10"
                     /note="heat shock protein 1 (chaperonin 10)"
                     /db_xref="GeneID:15528"
                     /db_xref="MGI:MGI:104680"
     exon            1..265
                     /gene="Hspe1"
                     /gene_synonym="10kDa; Hsp10; mt-cpn10"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..571
                     /gene="Hspe1"
                     /gene_synonym="10kDa; Hsp10; mt-cpn10"
                     /note="CPN10; chaperonin 10; 10 kDa chaperonin; heat shock
                     10 kDa protein 1 (chaperonin 10); mitochondrial chaperonin
                     10"
                     /codon_start=1
                     /product="10 kDa heat shock protein, mitochondrial"
                     /protein_id="NP_032329.1"
                     /db_xref="CCDS:CCDS35570.1"
                     /db_xref="GeneID:15528"
                     /db_xref="MGI:MGI:104680"
                     /translation="MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQA
                     TVVAVGSGGKGKSGEIEPVSVKVGDKVLLPEYGGTKVVLDDKDYFLFRDSDILGKYVD
                     "
     exon            266..430
                     /gene="Hspe1"
                     /gene_synonym="10kDa; Hsp10; mt-cpn10"
                     /inference="alignment:Splign:2.1.0"
     exon            431..520
                     /gene="Hspe1"
                     /gene_synonym="10kDa; Hsp10; mt-cpn10"
                     /inference="alignment:Splign:2.1.0"
     exon            521..768
                     /gene="Hspe1"
                     /gene_synonym="10kDa; Hsp10; mt-cpn10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      664..669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspe1"
                     /gene_synonym="10kDa; Hsp10; mt-cpn10"
                     /note="hexamer: AATAAA"
     polyA_site      690
                     /gene="Hspe1"
                     /gene_synonym="10kDa; Hsp10; mt-cpn10"
                     /note="major polyA site"
     regulatory      740..745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspe1"
                     /gene_synonym="10kDa; Hsp10; mt-cpn10"
                     /note="hexamer: AATAAA"
     polyA_site      763
                     /gene="Hspe1"
                     /gene_synonym="10kDa; Hsp10; mt-cpn10"
ORIGIN      
        1 ggcggccggc ctggaaaagc ctagaaagtg ctcccctttt cttccgcctc cggccgcccg
       61 cgtcggcccc cttgcgcgga gccctcgcca ccaatcggcg cgcgcgtcgg cgtggccgcc
      121 ccctctcacg ctcggggggc tgagtgcgcc tgcgcgctgc gcggcctttt cacgtgtccc
      181 agccggccag caggactctc cttgcagcag cggcccgagt tcagagtccg gagctgcggt
      241 ggtggcggcg aaggcgagag tcatggctgg acaagctttt aggaagtttc ttccgctctt
      301 tgacagagta ttggttgaaa ggagtgctgc cgaaactgta accaaaggtg gcattatgct
      361 tccagaaaag tctcaaggaa aagtgttgca agcaacggtc gtggctgtgg ggtcaggagg
      421 gaaaggaaag agtggagaga ttgagcctgt cagtgtgaaa gttggagata aagttcttct
      481 cccagaatat ggaggcacca aagtagttct agatgacaag gattatttct tatttagaga
      541 tagtgacatt cttggaaagt atgtcgactg aaatcactgt tgaaatggtg tcacgtgaag
      601 ctgccattcc actgatgtct gaactatttc atcatgtaaa taatttccat gcctcccttt
      661 tataataaac agatgatgcc taaactgaca gccattgtct ctgaccttta gtttcactgt
      721 actgttacaa acatttccaa ataaaatgat gtaaatgagt ggacagtcaa aaaaaaaaaa
      781 aaaaaaaa
//
