LOCUS       NM_001360629            1508 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus HSPA (heat shock 70kDa) binding protein, cytoplasmic
            cochaperone 1 (Hspbp1), transcript variant 2, mRNA.
ACCESSION   NM_001360629 XM_006540288
VERSION     NM_001360629.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1508)
  AUTHORS   Zhao,T., Hong,Y., Yin,P., Li,S. and Li,X.J.
  TITLE     Differential HspBP1 expression accounts for the greater
            vulnerability of neurons than astrocytes to misfolded proteins
  JOURNAL   Proc Natl Acad Sci U S A 114 (37), E7803-E7811 (2017)
   PUBMED   28847953
REFERENCE   2  (bases 1 to 1508)
  AUTHORS   Rogon,C., Ulbricht,A., Hesse,M., Alberti,S., Vijayaraj,P., Best,D.,
            Adams,I.R., Magin,T.M., Fleischmann,B.K. and Hohfeld,J.
  TITLE     HSP70-binding protein HSPBP1 regulates chaperone expression at a
            posttranslational level and is essential for spermatogenesis
  JOURNAL   Mol Biol Cell 25 (15), 2260-2271 (2014)
   PUBMED   24899640
  REMARK    GeneRIF: Male HSPBP1knockout mice are sterile because of impaired
            meiosis and massive apoptosis of spermatocytes.
REFERENCE   3  (bases 1 to 1508)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   4  (bases 1 to 1508)
  AUTHORS   Kettern,N., Rogon,C., Limmer,A., Schild,H. and Hohfeld,J.
  TITLE     The Hsc/Hsp70 co-chaperone network controls antigen aggregation and
            presentation during maturation of professional antigen presenting
            cells
  JOURNAL   PLoS One 6 (1), e16398 (2011)
   PUBMED   21283720
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1508)
  AUTHORS   Zhang,C., Xu,Z., He,X.R., Michael,L.H. and Patterson,C.
  TITLE     CHIP, a cochaperone/ubiquitin ligase that regulates protein quality
            control, is required for maximal cardioprotection after myocardial
            infarction in mice
  JOURNAL   Am J Physiol Heart Circ Physiol 288 (6), H2836-H2842 (2005)
   PUBMED   15665051
  REMARK    GeneRIF: Provides a critical cardioprotective effect in the setting
            of ischemia-reperfusion injury due in part to increased apoptosis
            in cardiac cells.
REFERENCE   6  (bases 1 to 1508)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161197.9.
            
            On Feb 8, 2018 this sequence version replaced XM_006540288.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088469.1, SRR7652917.751946.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC161197.9         82869-82956
            89-383              AC161197.9         83284-83578
            384-588             AC161197.9         85802-86006
            589-813             AC161197.9         89919-90143
            814-969             AC161197.9         102992-103147
            970-1066            AC161197.9         103234-103330
            1067-1178           AC161197.9         104358-104469
            1179-1508           AC161197.9         107005-107334
FEATURES             Location/Qualifiers
     source          1..1508
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.69 cM"
     gene            1..1508
                     /gene="Hspbp1"
                     /gene_synonym="1500019G21Rik"
                     /note="HSPA (heat shock 70kDa) binding protein,
                     cytoplasmic cochaperone 1"
                     /db_xref="GeneID:66245"
                     /db_xref="MGI:MGI:1913495"
     exon            1..88
                     /gene="Hspbp1"
                     /gene_synonym="1500019G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            89..383
                     /gene="Hspbp1"
                     /gene_synonym="1500019G21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1253
                     /gene="Hspbp1"
                     /gene_synonym="1500019G21Rik"
                     /note="hsp70-interacting protein 1; heat shock
                     protein-binding protein 1; SPA) binding protein,
                     cytoplasmic cochaperone 1"
                     /codon_start=1
                     /product="hsp70-binding protein 1"
                     /protein_id="NP_001347558.1"
                     /db_xref="CCDS:CCDS20740.1"
                     /db_xref="GeneID:66245"
                     /db_xref="MGI:MGI:1913495"
                     /translation="MADKGSGGSRLPLALPPASQGCSSGGSGSSAGGSGNPRPPRNLQ
                     GLLQMAITAGSQEPDPPPEPMSEERRQWLQEAMSAAFRGQREEVEQMKNCLRVLSQAT
                     PAMAGEAELATDQQEREGALELLADLCENMDNAADFCQLSGMHLLVGRYLEAGAAGLR
                     WRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDSCDTVRVKALFAISCLVREQE
                     AGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLV
                     ALVRTEHSPFHEHVLGALCSLVTDFPQGVRECREPELGLEELLRHRCQLLQQREEYQE
                     ELEFCEKLLQTCFSSPTDDSMDR"
     exon            384..588
                     /gene="Hspbp1"
                     /gene_synonym="1500019G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            589..813
                     /gene="Hspbp1"
                     /gene_synonym="1500019G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            814..969
                     /gene="Hspbp1"
                     /gene_synonym="1500019G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1066
                     /gene="Hspbp1"
                     /gene_synonym="1500019G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1178
                     /gene="Hspbp1"
                     /gene_synonym="1500019G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1508
                     /gene="Hspbp1"
                     /gene_synonym="1500019G21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtatttccgg taaagatggc ggcgcccagt agagtcaggt gcagcctagt ctatctttag
       61 gcgtggtggc agctctagac ccggcaagac cttcaagagt cgacccatcc ggacaccatt
      121 gctgcctcag cggtgaccat caatttcctt taaacacatt cttccttcac agaaagtcca
      181 tggcagacaa aggctcaggg ggcagtcgcc tccctcttgc gttgcctccg gcctctcagg
      241 gttgctcgtc agggggcagt ggttcctcgg cggggggctc aggcaacccc cggcctccac
      301 ggaacctcca aggcctgctg cagatggcta ttactgcggg ttctcaggag ccagaccccc
      361 ctccagaacc catgagcgag gagagacgcc aatggctgca ggaagccatg tcggccgcct
      421 tccggggcca gcgagaggag gtggagcaga tgaagaactg cctccgggtc ctgtcccagg
      481 ccacacccgc aatggctggc gaagctgagc tggccactga ccagcaggag cgtgaaggcg
      541 cactagagct gctggcagac ctgtgcgaga acatggacaa tgcagcagat ttctgccagc
      601 tgtcaggcat gcatctgctg gtgggtcgat acctggaggc aggggctgca gggctgcgct
      661 ggagggcagc acaactcatc ggcacatgca gtcagaacgt tgcagccatc caggagcagg
      721 tgttgggctt gggtgccctg cgcaagctac ttcggctgct cgaccgggac tcctgcgaca
      781 cggtacgagt caaggctctc ttcgccatct cctgtcttgt ccgagagcag gaggctgggt
      841 tgctgcagtt cctccgcctg gatggattct cagtgctgat gcgggccatg cagcagcaag
      901 tgcagaagct caaggtcaag tcagcattcc tgctgcagaa cttgctggtg ggccaccctg
      961 agcacaaagg aaccctttgc tccatgggga tggtccagca gctggtggcc cttgtgagga
     1021 cagaacacag tcctttccat gagcatgtgc ttggagccct gtgcagcctt gtgacagatt
     1081 tccctcaggg tgttcgtgaa tgccgggagc ctgagctggg cctggaggaa ctgctccgcc
     1141 accgctgcca gctgctgcag cagcgtgagg agtaccagga ggagctggag ttctgtgaaa
     1201 agctgttaca gacctgtttc tctagcccta ccgacgacag catggatcgc tgagaccagg
     1261 tggctccttg ctttctctcc gtgggaaccc caggcctcct gcctccctcc ttcccaggca
     1321 ctctctctta agggattgcc aggccttgtt tgggcctggg cctgggcctg ccagcccatc
     1381 tctgggtagc cccctggagg ggttgctgag aaaggtgctg gccccttgat cccctccctt
     1441 gctttctgtc atcctttctt ctcatgtcca cactgctctt caaataaaaa catttctcct
     1501 gctccctt
//
