LOCUS       NM_030704               1825 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus heat shock protein 8 (Hspb8), mRNA.
ACCESSION   NM_030704
VERSION     NM_030704.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1825)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1825)
  AUTHORS   Ling,J., Yu,S., Xiong,F. and Li,S.
  TITLE     HSPB8 up-regulation alleviates cognitive dysfunction in a mouse
            model of sepsis-associated encephalopathy
  JOURNAL   Int Immunopharmacol 122, 110448 (2023)
   PUBMED   37399610
  REMARK    GeneRIF: HSPB8 up-regulation alleviates cognitive dysfunction in a
            mouse model of sepsis-associated encephalopathy.
REFERENCE   3  (bases 1 to 1825)
  AUTHORS   Zhou,F., Li,F., Hou,Y. and Yang,B.
  TITLE     HSPB8-Mediated Actin Filament Reorganization by Promoting
            Autophagic Flux Confers Resilience to Blood-Brain Barrier (BBB)
            Injury in an In Vitro Model of Ischemic Stroke
  JOURNAL   ACS Chem Neurosci 14 (16), 2868-2875 (2023)
   PUBMED   37522952
  REMARK    GeneRIF: HSPB8-Mediated Actin Filament Reorganization by Promoting
            Autophagic Flux Confers Resilience to Blood-Brain Barrier (BBB)
            Injury in an In Vitro Model of Ischemic Stroke.
REFERENCE   4  (bases 1 to 1825)
  AUTHORS   Jennings,M.J., Kagiava,A., Vendredy,L., Spaulding,E.L., Stavrou,M.,
            Hathazi,D., Gruneboom,A., De Winter,V., Gess,B., Schara,U.,
            Pogoryelova,O., Lochmuller,H., Borchers,C.H., Roos,A.,
            Burgess,R.W., Timmerman,V., Kleopa,K.A. and Horvath,R.
  TITLE     NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in
            patients and mice
  JOURNAL   Brain 145 (11), 3999-4015 (2022)
   PUBMED   35148379
REFERENCE   5  (bases 1 to 1825)
  AUTHORS   Chang,Y., Wu,Y., Jiang,X., Zhu,J., Wang,C., Ma,R. and Li,G.
  TITLE     HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic
            Mice via Inhibiting NLRP3 Inflammation Activation
  JOURNAL   Oxid Med Cell Longev 2022, 9251835 (2022)
   PUBMED   35958024
  REMARK    GeneRIF: HSPB8 Overexpression Ameliorates Cognitive Impairment in
            Diabetic Mice via Inhibiting NLRP3 Inflammation Activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1825)
  AUTHORS   Klingenspor,M., Xu,P., Cohen,R.D., Welch,C. and Reue,K.
  TITLE     Altered gene expression pattern in the fatty liver dystrophy mouse
            reveals impaired insulin-mediated cytoskeleton dynamics
  JOURNAL   J Biol Chem 274 (33), 23078-23084 (1999)
   PUBMED   10438476
REFERENCE   7  (bases 1 to 1825)
  AUTHORS   Welch,C.L., Xia,Y.R., Gu,L.J., Machleder,D., Mehrabian,M.,
            Wen,P.Z., Webb,N., de Villiers,W.J., van der Westhuyzen,D. and
            Lusis,A.J.
  TITLE     Srb1 maps to mouse chromosome 5 in a region harboring putative QTLs
            for plasma lipoprotein levels
  JOURNAL   Mamm Genome 8 (12), 942-944 (1997)
   PUBMED   9383292
REFERENCE   8  (bases 1 to 1825)
  AUTHORS   Klingenspor,M., Bodnar,J., Welch,C., Xia,Y.R., Lusis,A.J. and
            Reue,K.
  TITLE     Localization of ubiquitin gene family members to mouse chromosomes
            5, 11, and 18
  JOURNAL   Mamm Genome 8 (10), 789-790 (1997)
   PUBMED   9321482
REFERENCE   9  (bases 1 to 1825)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   10 (bases 1 to 1825)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005052.1 and AI326838.1.
            
            On May 8, 2015 this sequence version replaced NM_030704.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005052.1, BC003971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1501              AK005052.1         1-1501
            1502-1825           AI326838.1         1-324               c
FEATURES             Location/Qualifiers
     source          1..1825
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.41 cM"
     gene            1..1825
                     /gene="Hspb8"
                     /gene_synonym="Cryac; D5Ucla4; E2IG1; H11; H11K;
                     HSP20-like; HSP22"
                     /note="heat shock protein 8"
                     /db_xref="GeneID:80888"
                     /db_xref="MGI:MGI:2135756"
     exon            1..752
                     /gene="Hspb8"
                     /gene_synonym="Cryac; D5Ucla4; E2IG1; H11; H11K;
                     HSP20-like; HSP22"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..976
                     /gene="Hspb8"
                     /gene_synonym="Cryac; D5Ucla4; E2IG1; H11; H11K;
                     HSP20-like; HSP22"
                     /note="heat shock 27kDa protein 8; crystallin, alpha C;
                     heat shock protein 20-like protein; alpha-crystallin C
                     chain; small stress protein-like protein HSP22"
                     /codon_start=1
                     /product="heat shock protein beta-8"
                     /protein_id="NP_109629.1"
                     /db_xref="CCDS:CCDS19600.1"
                     /db_xref="GeneID:80888"
                     /db_xref="MGI:MGI:2135756"
                     /translation="MADGQLPFPCSYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDL
                     TAPWPEWALPRLSSAWPGTLRSGMVPRGPPATARFGVPAEGRSPPPFPGEPWKVCVNV
                     HSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPATVFASLSP
                     EGLLIIEAPQVPPYSPFGESSFNNELPQDNQEVTCS"
     exon            753..816
                     /gene="Hspb8"
                     /gene_synonym="Cryac; D5Ucla4; E2IG1; H11; H11K;
                     HSP20-like; HSP22"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1816
                     /gene="Hspb8"
                     /gene_synonym="Cryac; D5Ucla4; E2IG1; H11; H11K;
                     HSP20-like; HSP22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1792..1797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspb8"
                     /gene_synonym="Cryac; D5Ucla4; E2IG1; H11; H11K;
                     HSP20-like; HSP22"
                     /note="hexamer: AATAAA"
     polyA_site      1813
                     /gene="Hspb8"
                     /gene_synonym="Cryac; D5Ucla4; E2IG1; H11; H11K;
                     HSP20-like; HSP22"
                     /note="major polyA site"
ORIGIN      
        1 gagaagtttc taggctcgcg agtccccgag ctttattaaa ctcctggctg tgctcaagac
       61 ctcagcaggc tttggctggg agccggggca gcctgggagg aaggcagccg gtggcttact
      121 gatagccaag cgagagagag aggccctctg ggattctgct gggcccgctt agggaggggg
      181 tcacctttgt aagccaggac cccagctcaa ttctgggcag ccagcggatg gttgggctcg
      241 tggctgaagg aagatcagca ttttctgaag tggagaacta aattctgaaa gccatctcaa
      301 gccacatcac cttgctgtgt gacctttggg taggtggctc tgtctctctg agcctctgtt
      361 tccccctcta agttcgacca acatcatggc tgacgggcaa ttgcctttcc cgtgctccta
      421 cccaagccgc ctgcgccgag acccctttcg ggactcaccg ctctcctccc gccttctgga
      481 cgatggcttt ggcatggacc cttttccaga cgacttgaca gccccttggc cagagtgggc
      541 tttgcctcgg ctctcctctg cctggcctgg aaccctaagg tctggcatgg taccccgagg
      601 gcctccagcc acagctaggt ttggagtgcc cgctgagggc aggagtcccc cacccttccc
      661 tggggagcct tggaaagtgt gtgtcaacgt gcacagcttc aagccggaag agctgatggt
      721 aaagaccaag gatggatacg tggaagtttc aggcaaacat gaagagaagc agcaggaagg
      781 tgggattgtc tccaagaact tcaccaagaa aatacagctc cctgcagaag tggatccagc
      841 cactgtattt gcctcgcttt ctccagaggg cctgctcatc atcgaggctc cccaggtccc
      901 tccgtactca ccctttggag agagcagctt caacaacgag cttcctcaag acaaccagga
      961 agtcacctgt tcctaagacg tcagccttgg tccttcttcg ctcccatccc cagccccagg
     1021 gactctctga tttgagggta cactacttta gcagcactca gatttaaggc aactcagatg
     1081 ttgggggatg ggagggagaa ccgaacgacc gtccctggat gatgtagtaa tagatttctc
     1141 cacagggtga cgcaatgggt cagccttgct tggttgcgtt aggtcaaagg attgggaggt
     1201 ttttcttcat cttatctggg tgaagacgtc tcgcagtcta cagttgcaaa acaagcaaat
     1261 ggggactgaa gatttcatgt taaattttta ccttgcagtt aatgcaagag ttgcttttct
     1321 ctggggacct tcccatcacc cagatccctg ctctggaccc tccttctacg tggcttggtt
     1381 gatgggactc attggctcac ctcagtgtgt ttctaaactc tttgtctaga agaggttatg
     1441 ggcaggtctt atatccccat atgggattta tccttcacca cacaacacag tgcctttttt
     1501 ttgcagcatg accccatggc tctcaaacca tcaccaccaa gaactctggg agcccctcag
     1561 ttaattctct ggctaaggtc cccctttatt gtgtcccctg tgtccaagtc acatttttac
     1621 agagagctgt cttggagcag ctccgcaagg aaccaagcaa aggccagaca gcctgcacgc
     1681 aggctagtgg cattgtgtgt gtgtttgagg ggtggggagg atgtgtgtgt ctttgttgtg
     1741 tgaattgtgc tgttgtttag agggaaaata acggtgaata ataatgatga taataaagga
     1801 gctgatgttc ttagcaaaaa aaaaa
//
