LOCUS       NM_013868               2768 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus heat shock protein family, member 7 (cardiovascular)
            (Hspb7), mRNA.
ACCESSION   NM_013868
VERSION     NM_013868.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2768)
  AUTHORS   Broadway-Stringer,S., Jiang,H., Wadmore,K., Hooper,C., Douglas,G.,
            Steeples,V., Azad,A.J., Singer,E., Reyat,J.S., Galatik,F.,
            Ehler,E., Bennett,P., Kalisch-Smith,J.I., Sparrow,D.B., Davies,B.,
            Djinovic-Carugo,K., Gautel,M., Watkins,H. and Gehmlich,K.
  TITLE     Insights into the Role of a Cardiomyopathy-Causing Genetic Variant
            in ACTN2
  JOURNAL   Cells 12 (5), 721 (2023)
   PUBMED   36899856
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2768)
  AUTHORS   Zieman,A.G., Poll,B.G., Ma,J. and Coulombe,P.A.
  TITLE     Altered keratinocyte differentiation is an early driver of keratin
            mutation-based palmoplantar keratoderma
  JOURNAL   Hum Mol Genet 28 (13), 2255-2270 (2019)
   PUBMED   31220272
REFERENCE   3  (bases 1 to 2768)
  AUTHORS   Wu,T., Mu,Y., Bogomolovas,J., Fang,X., Veevers,J., Nowak,R.B.,
            Pappas,C.T., Gregorio,C.C., Evans,S.M., Fowler,V.M. and Chen,J.
  TITLE     HSPB7 is indispensable for heart development by modulating actin
            filament assembly
  JOURNAL   Proc Natl Acad Sci U S A 114 (45), 11956-11961 (2017)
   PUBMED   29078393
  REMARK    GeneRIF: The authors found that deleting HSPB7 resulted in
            uncontrolled elongation of actin filaments and the formation of
            atypical actin filament bundles in cardiomyocytes.
REFERENCE   4  (bases 1 to 2768)
  AUTHORS   Liao,W.C., Juo,L.Y., Shih,Y.L., Chen,Y.H. and Yan,Y.T.
  TITLE     HSPB7 prevents cardiac conduction system defect through maintaining
            intercalated disc integrity
  JOURNAL   PLoS Genet 13 (8), e1006984 (2017)
   PUBMED   28827800
  REMARK    GeneRIF: our findings characterize HSPB7 as an intercalated disc
            protein and suggest it has an essential role in maintaining
            intercalated disc integrity and conduction function in the adult
            heart.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2768)
  AUTHORS   Tobin,S.W., Yang,D., Girgis,J., Farahzad,A., Blais,A. and
            McDermott,J.C.
  TITLE     Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in
            muscle atrophy
  JOURNAL   J Cell Sci 129 (21), 4076-4090 (2016)
   PUBMED   27632998
  REMARK    GeneRIF: these data indicate that MEF2 and AP-1 confer antagonistic
            regulation of Hspb7 gene expression in skeletal muscle, with
            implications for autophagy and muscle atrophy.
REFERENCE   6  (bases 1 to 2768)
  AUTHORS   Vos,M.J., Kanon,B. and Kampinga,H.H.
  TITLE     HSPB7 is a SC35 speckle resident small heat shock protein
  JOURNAL   Biochim Biophys Acta 1793 (8), 1343-1353 (2009)
   PUBMED   19464326
  REMARK    Erratum:[Biochim Biophys Acta. 2009 Dec;1793(12):1929-30]
REFERENCE   7  (bases 1 to 2768)
  AUTHORS   Huang,L., Min,J.N., Masters,S., Mivechi,N.F. and Moskophidis,D.
  TITLE     Insights into function and regulation of small heat shock protein
            25 (HSPB1) in a mouse model with targeted gene disruption
  JOURNAL   Genesis 45 (8), 487-501 (2007)
   PUBMED   17661394
REFERENCE   8  (bases 1 to 2768)
  AUTHORS   Kappe,G., Franck,E., Verschuure,P., Boelens,W.C., Leunissen,J.A.
            and de Jong,W.W.
  TITLE     The human genome encodes 10 alpha-crystallin-related small heat
            shock proteins: HspB1-10
  JOURNAL   Cell Stress Chaperones 8 (1), 53-61 (2003)
   PUBMED   12820654
REFERENCE   9  (bases 1 to 2768)
  AUTHORS   Krief,S., Faivre,J.F., Robert,P., Le Douarin,B.,
            Brument-Larignon,N., Lefrere,I., Bouzyk,M.M., Anderson,K.M.,
            Greller,L.D., Tobin,F.L., Souchet,M. and Bril,A.
  TITLE     Identification and characterization of cvHsp. A novel human small
            stress protein selectively expressed in cardiovascular and
            insulin-sensitive tissues
  JOURNAL   J Biol Chem 274 (51), 36592-36600 (1999)
   PUBMED   10593960
REFERENCE   10 (bases 1 to 2768)
  AUTHORS   Lowell,B.B.
  TITLE     PPARgamma: an essential regulator of adipogenesis and modulator of
            fat cell function
  JOURNAL   Cell 99 (3), 239-242 (1999)
   PUBMED   10555139
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL670285.10.
            
            On May 1, 2007 this sequence version replaced NM_013868.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030025.1, BC089584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1202              AL670285.10        97003-98204
            1203-1336           AL670285.10        98725-98858
            1337-2768           AL670285.10        100103-101534
FEATURES             Location/Qualifiers
     source          1..2768
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 74.08 cM"
     gene            1..2768
                     /gene="Hspb7"
                     /gene_synonym="27kDa; cvHsp; Hsp25-2"
                     /note="heat shock protein family, member 7
                     (cardiovascular)"
                     /db_xref="GeneID:29818"
                     /db_xref="MGI:MGI:1352494"
     exon            1..1202
                     /gene="Hspb7"
                     /gene_synonym="27kDa; cvHsp; Hsp25-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1336
                     /gene="Hspb7"
                     /gene_synonym="27kDa; cvHsp; Hsp25-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..2768
                     /gene="Hspb7"
                     /gene_synonym="27kDa; cvHsp; Hsp25-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccattcca acgtacttag gttcagccca cccctcctag gaggctgtat ttcctggtct
       61 ggaaactggc ctcaaagctc ctctttttga gttgtgttaa gatcaaagag ggctctgctg
      121 ggaagagaca gcagtggcca gagacatcgt ggaagccgga gctaaggcac ctgtcagcgg
      181 tcgaccttac ctggatgtga aatcatgtga ctaggacgct tgggcagaca ccaactctga
      241 gcctgaggta gagcgagcag actgttccca gcaactttgc cccttagacc tttcgtgtta
      301 tctgctcttt ccctgaagct gggcccaacc ccacccccac agcctcaact ccagccgcca
      361 gctctctttt cctctgcctc ttatggtcct gggagtgggg ataaggtgaa gaatcaccag
      421 tccctgtggc agatgacagg ggtcacccac acgttctatc tcccctccct gggctttctc
      481 agccttccct aagagatagc tggacctgga gcgcctcgga atccctcggg gtacctgcat
      541 gtatatactc tctcctcagg agtctaataa gggaggcaca ggccctgggg ggcacagtac
      601 aagaggagag gagggtccca ggctatcgag gggaccaaca aaccacgaag tcctggggac
      661 aggcacaggg caggacccac cccctgccct ggcaggtaca gaggtccttg gggctggagc
      721 tctggactaa cagtgccagg tggtgagctc agccttgcaa ccctgccctc ctgtgtcggg
      781 ctgtcagcag agccgtttct cccaagaaga tttccaggcc cctctgggca atgaagaggc
      841 ctaaatttag ccagcagaca aggggctggc ctcgagccca gggacagttg ggccttataa
      901 agcgctggca gtcaggggcc ccggcacgct tccgtggagg cctggaccca ctcgtttctc
      961 cagcccagcc cctgcccgtc tggacaggga cccccgctgc ctgtggatga gccatcggac
     1021 ctcctccgcc ttcagagcgg agagaagctt ccgttcctct tcctcctcct cctcctcctc
     1081 ttcttcttcg gcctcccgtg cccttccagc ccaggaccca cccatggaga aggctttgag
     1141 catgttttca gacgactttg gcagttttat gctgccccac tcggagcccc tggccttccc
     1201 agcccgtccc gggggccaag gaaacatcaa gaccctcggg gatgcctacg agtttacagt
     1261 ggacatgaga gacttctccc ctgaagacat cattgtcacc accttcaaca accacatcga
     1321 ggtgcgggct gagaagctgg cagctgatgg cacagtcatg aacacctttg ctcacaagtg
     1381 ccaactacca gaggatgtgg acccaacatc ggtgacctcg gcccttcgag aggatggtag
     1441 cctcaccatc cgggcgcggc gccaccccca cacagaacat gtccagcaga ccttccggac
     1501 tgagataaaa atctgagggt ctctccaccc ctggcctccc ccttatctcc tcccccactg
     1561 gcctgccggt gaggtcacca tgatccctga caatgacccc tcagaacatc tcagcctagg
     1621 ccccagtcac tccacacact ctcaggcccc aggtgggtca cccctgcccc aaactagggc
     1681 atccctctcc atccaacgca gtccagggac ctgtctgctc tcacccagat agaccctccc
     1741 tatctaagtt cacaatagag gggctgaggt accaacctgg agagcaagac gagggcagag
     1801 tctaacacag agtggcggct tcaatggcat ttctgcaggg caggggacca gaagcccctt
     1861 cctggcaaat gagaggctgg ccacaagcag ggcttctggc ctaggtagac tgcctcaggg
     1921 aagccagaga gatagccatg actgttacct tccttgtaac tctcgaaacc tcaaacccag
     1981 ggctacctgt caccctgagg ctctaacagc tacatgtacc agacaaagac acctgtacct
     2041 agatggggtt tattaaaatg acatgaggct cctatctcca gctgctggtg catgaggcca
     2101 gagcccaggg ctcctgggtg gcttcccctg cagagagggt cctctttgga agtgagagga
     2161 agagccagga cttgtacaca cacacacaca cacacacaca cacacacaca cacacacaca
     2221 cacacacaca cacacacaca cacacgcgcg cgcgcgcgcg cgccattgtc ctatgcctta
     2281 aatactcatt cccactggtt ggagcccaat tcaaagcatt ctaagagtca cagttagcat
     2341 ctctgttttc atcaatggag actggcgtct ctgagccagt tggatgccca ggtttgtctc
     2401 tgaagccagc gctgcctcag cggctctcag actctcccct ctgtgtactg gggacacttc
     2461 ccccccattc cacctctcct gagccacatg ccctgcttcg ccctaactgc agatggtggc
     2521 cacaagaaga accccaaacc agatctcttc tggcccccaa attcagggca aaaacccttg
     2581 tcagccttaa ccctggggga cctgggctct gactcagtct ctgcgtgtag aatcgggtgt
     2641 aaagggggaa gctcactgct aatcggggtc ccaggggcct ctacagtctt aggaccctgt
     2701 ggaggagggg gtggggtggg gtcgtgggag tctagtctat aacctgtaca caataaaagg
     2761 acaatatg
//
