LOCUS       NM_001012401            1346 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus heat shock protein, alpha-crystallin-related, B6
            (Hspb6), transcript variant 1, mRNA.
ACCESSION   NM_001012401 XM_145511
VERSION     NM_001012401.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1346)
  AUTHORS   Miao,Y., Zhong,Y., Li,Y., Qin,H., Yang,L., Cao,G., Tang,Y., Yu,T.,
            Fan,D., Lu,Y., Peng,J. and Huang,K.
  TITLE     Inhibition of HSP20 Ameliorates Steatotic Liver Disease by
            Stimulating ERK2-Dependent Autophagy
  JOURNAL   Diabetes 73 (6), 909-925 (2024)
   PUBMED   38466834
  REMARK    GeneRIF: Inhibition of HSP20 Ameliorates Steatotic Liver Disease by
            Stimulating ERK2-Dependent Autophagy.
REFERENCE   2  (bases 1 to 1346)
  AUTHORS   Gao,S., Zhang,K., Zhou,C., Song,J., Gu,Y., Cao,F., Wang,J., Xie,E.,
            Yu,C. and Qiu,J.
  TITLE     HSPB6 Deficiency Promotes the Development of Aortic Dissection and
            Rupture
  JOURNAL   Lab Invest 104 (3), 100326 (2024)
   PUBMED   38237739
  REMARK    GeneRIF: HSPB6 Deficiency Promotes the Development of Aortic
            Dissection and Rupture.
REFERENCE   3  (bases 1 to 1346)
  AUTHORS   Vafiadaki,E., Arvanitis,D.A., Eliopoulos,A.G., Kranias,E.G. and
            Sanoudou,D.
  TITLE     The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates
            Protein Associations Regulating Cytoskeletal Dynamics
  JOURNAL   Int J Mol Sci 21 (24), 9572 (2020)
   PUBMED   33339131
  REMARK    GeneRIF: The Cardioprotective PKA-Mediated Hsp20 Phosphorylation
            Modulates Protein Associations Regulating Cytoskeletal Dynamics.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1346)
  AUTHORS   Onusko,E., McDermott,M.R., Robbins,N., Liu,G., Kranias,E.G.,
            Rubinstein,J. and Koch,S.E.
  TITLE     Probenecid treatment improves outcomes in a novel mouse model of
            peripartum cardiomyopathy
  JOURNAL   PLoS One 15 (3), e0230386 (2020)
   PUBMED   32218573
  REMARK    GeneRIF: Hsp20-S10F mice treated with probenecid had decreased
            mortality, hypertrophy, TRPV2 expression and molecular parameters
            of heart failure.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1346)
  AUTHORS   Yu,D.W., Ge,P.P., Liu,A.L., Yu,X.Y. and Liu,T.T.
  TITLE     HSP20-mediated cardiomyocyte exosomes improve cardiac function in
            mice with myocardial infarction by activating Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (11), 4873-4881 (2019)
   PUBMED   31210321
  REMARK    GeneRIF: HSP20-mediated cardiomyocyte exosomes improve cardiac
            function in mice with myocardial infarction by activating Akt
            signaling pathway.
REFERENCE   6  (bases 1 to 1346)
  AUTHORS   Huang,L., Min,J.N., Masters,S., Mivechi,N.F. and Moskophidis,D.
  TITLE     Insights into function and regulation of small heat shock protein
            25 (HSPB1) in a mouse model with targeted gene disruption
  JOURNAL   Genesis 45 (8), 487-501 (2007)
   PUBMED   17661394
REFERENCE   7  (bases 1 to 1346)
  AUTHORS   Fan,G.C., Yuan,Q., Song,G., Wang,Y., Chen,G., Qian,J., Zhou,X.,
            Lee,Y.J., Ashraf,M. and Kranias,E.G.
  TITLE     Small heat-shock protein Hsp20 attenuates beta-agonist-mediated
            cardiac remodeling through apoptosis signal-regulating kinase 1
  JOURNAL   Circ Res 99 (11), 1233-1242 (2006)
   PUBMED   17068291
REFERENCE   8  (bases 1 to 1346)
  AUTHORS   Fan,G.C., Ren,X., Qian,J., Yuan,Q., Nicolaou,P., Wang,Y.,
            Jones,W.K., Chu,G. and Kranias,E.G.
  TITLE     Novel cardioprotective role of a small heat-shock protein, Hsp20,
            against ischemia/reperfusion injury
  JOURNAL   Circulation 111 (14), 1792-1799 (2005)
   PUBMED   15809372
REFERENCE   9  (bases 1 to 1346)
  AUTHORS   Fan,G.C., Chu,G., Mitton,B., Song,Q., Yuan,Q. and Kranias,E.G.
  TITLE     Small heat-shock protein Hsp20 phosphorylation inhibits
            beta-agonist-induced cardiac apoptosis
  JOURNAL   Circ Res 94 (11), 1474-1482 (2004)
   PUBMED   15105294
  REMARK    GeneRIF: Recombinant mouse Hsp20 translocates to and interacts with
            actin cytoskeleton in response to isoproterenol stimulation and
            prevents ss-agonist-induced apoptosis in adult rat cardiomyocytes.
REFERENCE   10 (bases 1 to 1346)
  AUTHORS   Chu,G., Egnaczyk,G.F., Zhao,W., Jo,S.H., Fan,G.C., Maggio,J.E.,
            Xiao,R.P. and Kranias,E.G.
  TITLE     Phosphoproteome analysis of cardiomyocytes subjected to
            beta-adrenergic stimulation: identification and characterization of
            a cardiac heat shock protein p20
  JOURNAL   Circ Res 94 (2), 184-193 (2004)
   PUBMED   14615292
  REMARK    GeneRIF: identification and characterization of a cardiac isoform
            of p20 associated with beta-adrenergic signaling in adult
            cardiomyocytes.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK627709.1, BC089621.1 and BQ176401.1.
            
            On Jun 9, 2018 this sequence version replaced NM_001012401.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089621.1, DV049563.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 CK627709.1         29-29
            2-1326              BC089621.1         2-1326
            1327-1346           BQ176401.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.56 cM"
     gene            1..1346
                     /gene="Hspb6"
                     /gene_synonym="Gm479; Hsp20"
                     /note="heat shock protein, alpha-crystallin-related, B6"
                     /db_xref="GeneID:243912"
                     /db_xref="MGI:MGI:2685325"
     exon            1..232
                     /gene="Hspb6"
                     /gene_synonym="Gm479; Hsp20"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..523
                     /gene="Hspb6"
                     /gene_synonym="Gm479; Hsp20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cardiac heat shock protein p20; heat shock protein beta-6"
                     /codon_start=1
                     /product="heat shock protein beta-6 isoform 1"
                     /protein_id="NP_001012401.1"
                     /db_xref="CCDS:CCDS21097.1"
                     /db_xref="GeneID:243912"
                     /db_xref="MGI:MGI:2685325"
                     /translation="MEIPVPVQPSWLRRASAPLPGFSAPGRLFDQRFGEGLLEAELAS
                     LCPAAIAPYYLRAPSVALPTAQVSTDSGYFSVLLDVKHFLPEEISVKVVDDHVEVHAR
                     HEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQAQLPSPPA
                     AK"
     exon            233..355
                     /gene="Hspb6"
                     /gene_synonym="Gm479; Hsp20"
                     /inference="alignment:Splign:2.1.0"
     exon            356..1330
                     /gene="Hspb6"
                     /gene_synonym="Gm479; Hsp20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1306..1311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspb6"
                     /gene_synonym="Gm479; Hsp20"
                     /note="hexamer: AATAAA"
     polyA_site      1327
                     /gene="Hspb6"
                     /gene_synonym="Gm479; Hsp20"
                     /note="major polyA site"
ORIGIN      
        1 actgcggggc ccagggtggc agcgtaggaa caggatggag atccccgtgc ctgtgcagcc
       61 ttcttggctg cgccgtgctt cagctccttt accaggtttc tctgctccgg gacgcctctt
      121 tgaccagcgt ttcggcgaag ggctgcttga ggcagagctg gcttcactgt gccctgctgc
      181 gatcgccccc tactatctgc gcgcccccag tgtggcgtta cccacagccc aggtgtccac
      241 ggactctggg tatttttccg tgctgctgga tgtgaagcac ttcttgccag aggaaatctc
      301 tgtcaaggtg gttgacgacc atgtggaggt ccatgctcgg cacgaggagc gcccggatga
      361 acacggattc attgctcgag agttccaccg ccgataccgc ctgcctcctg gtgtggaccc
      421 tgctgctgtg acctcagcac tgtctcctga gggtgtcctg tccatccagg ccacaccagc
      481 gtcggcccag gcccaacttc cgtcaccacc tgctgccaag taggggtccc agctgcacag
      541 gaccgaaccc aggaagcctc tttaggctct cttttaaaag ccgatctgac tccactgccc
      601 agccagatgt cccaatcgcc gtcaagacag cctttcccaa ccacacctag atgtccttcg
      661 gagacctttc cacccctaag cctacctgag ccctagtaac ctagacagcc tccctaagcc
      721 ctctcccagc tttccggccc gacccaggac acctctctag ggacgctact gtcacccctc
      781 agtcaaggct cccatcaaat tgaccccact ttgggcttct atcaccacgc aggcctccta
      841 ccgcacttgt aacctgtgta gaatacccca aggtgacacc agagtacagt gtagtcacct
      901 aattctccac atggagaaac tgcatgggct ttccacatca gaacatccaa gcctagtcca
      961 ccagtcctac ccactagtcc tgttcttgta acataatgct cctctgccca gcccactttc
     1021 agacttaaaa ctccaggcac ctaaattctt gaatactatt ctgacttcca attcttggga
     1081 aaactattcc caactaacca ggaaccccaa actcaaactg tatggacact tcaacttctc
     1141 cagatgtgct aggccaatga acaagaaccc ttgagttcct ctgtcctggc tgcccatctg
     1201 cagccagatg tcttagggag cctccttcac atctgccatt ctctaaggtc acaccttcac
     1261 tgccaacatt tcccatctcc gcaggccttc ctaccatcag tccccaataa atgcacttga
     1321 gatttgtcaa aaaaaaaaaa aaaaaa
//
