LOCUS       NM_019960                781 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus heat shock protein 3 (Hspb3), mRNA.
ACCESSION   NM_019960
VERSION     NM_019960.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 781)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 781)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 781)
  AUTHORS   La Padula,V., Staszewski,O., Nestel,S., Busch,H., Boerries,M.,
            Roussa,E., Prinz,M. and Krieglstein,K.
  TITLE     HSPB3 protein is expressed in motoneurons and induces their
            survival after lesion-induced degeneration
  JOURNAL   Exp Neurol 286, 40-49 (2016)
   PUBMED   27567740
  REMARK    GeneRIF: This study demonstrated that the endogenous HSPB3 protein
            distribution in the spinal cords of chicken and mouse embryos and
            in the postnatal nervous system (central and peripheral) of
            chicken, mouse and human.
REFERENCE   4  (bases 1 to 781)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 781)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 781)
  AUTHORS   Kondaurova,E.M., Naumenko,V.S., Sinyakova,N.A. and Kulikov,A.V.
  TITLE     Map3k1, Il6st, Gzmk, and Hspb3 gene coexpression network in the
            mechanism of freezing reaction in mice
  JOURNAL   J Neurosci Res 89 (2), 267-273 (2011)
   PUBMED   21162133
  REMARK    GeneRIF: It was suggested that a high predisposition to catalepsy
            in mice can be defined by the Map3k1, Il6st, Gzmk, and Hspb3 genes'
            coexpression network.
REFERENCE   7  (bases 1 to 781)
  AUTHORS   Huang,L., Min,J.N., Masters,S., Mivechi,N.F. and Moskophidis,D.
  TITLE     Insights into function and regulation of small heat shock protein
            25 (HSPB1) in a mouse model with targeted gene disruption
  JOURNAL   Genesis 45 (8), 487-501 (2007)
   PUBMED   17661394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009633.1.
            
            On Dec 16, 2009 this sequence version replaced NM_019960.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK009633.1, BY709295.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-781               AK009633.1         2-782
FEATURES             Location/Qualifiers
     source          1..781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 64.01 cM"
     gene            1..781
                     /gene="Hspb3"
                     /gene_synonym="2310035K17Rik; Hsbp3; spb3"
                     /note="heat shock protein 3"
                     /db_xref="GeneID:56534"
                     /db_xref="MGI:MGI:1928479"
     exon            1..781
                     /gene="Hspb3"
                     /gene_synonym="2310035K17Rik; Hsbp3; spb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..649
                     /gene="Hspb3"
                     /gene_synonym="2310035K17Rik; Hsbp3; spb3"
                     /note="small heat shock protein B3; heat shock 27kD
                     protein 3"
                     /codon_start=1
                     /product="heat shock protein beta-3"
                     /protein_id="NP_064344.1"
                     /db_xref="CCDS:CCDS26785.1"
                     /db_xref="GeneID:56534"
                     /db_xref="MGI:MGI:1928479"
                     /translation="MAKIILRHLIETPVRYQEEFEARGLEDCRLDHTLYALPGPTIED
                     LSKARGAGTPQALAEDSASTEKPPGEGKSRFQILLDVVQFLPEDIIIQTFEGWLLIKA
                     QHGTRMDEHGFISRSFTRQYKLPDGVETKDLSAILCHDGILVVEVKDSLGTK"
     regulatory      753..758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspb3"
                     /gene_synonym="2310035K17Rik; Hsbp3; spb3"
                     /note="hexamer: ATTAAA"
     polyA_site      781
                     /gene="Hspb3"
                     /gene_synonym="2310035K17Rik; Hsbp3; spb3"
                     /note="major polyA site"
ORIGIN      
        1 attcattgtc agtgtgtgtg aaaagacaag agtcagtgtg ccggtctgat tcagccccaa
       61 ttaagctgcc gtctgggcag gactgtaaac ggagctgcta ggactaagaa tcgagtccgc
      121 aggcaacgcc agagactaga cactcacgga agggaagtgg ttcaacgctg gagtcgcctc
      181 tgctatggca aaaatcattt tgaggcacct catagagacc ccagtgcgtt atcaggagga
      241 gtttgaagct cgaggcttag aagactgcag actggatcat acactatacg cactgcccgg
      301 gccaaccatc gaggacctga gtaaagccag aggcgcaggc acgccacagg ctctggcaga
      361 ggactcagcc tccacggaga agccacccgg agaaggcaaa tcccgtttcc agatcctgct
      421 ggatgtggtc cagttcctgc ccgaggacat catcatccag accttcgagg gctggctgct
      481 gatcaaggca cagcacggaa ccagaatgga cgaacacggg tttatatcgc ggagtttcac
      541 cagacagtac aaactgccag atggagtcga aaccaaagat ttgtctgcca tcctctgtca
      601 tgatggaatc ttggtggtgg aagtcaaaga ttcactaggg accaagtgaa agccttttgg
      661 ttgctcttca taccccagga aggaagatga aagccaggga caccccggga atgcttaaac
      721 ttttgagatg gattgctgtc acttttatga ggattaaaaa aaaccaaatg tatccaccgt
      781 t
//
