LOCUS       NM_024441                910 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus heat shock protein 2 (Hspb2), transcript variant 1,
            mRNA.
ACCESSION   NM_024441
VERSION     NM_024441.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 910)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 910)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 910)
  AUTHORS   Xu,Y., Jia,Y., Wu,N., Wang,J., He,L. and Yang,D.
  TITLE     CD93 Ameliorates Diabetic Wounds by Promoting Angiogenesis via the
            p38MAPK/MK2/HSP27 Axis
  JOURNAL   Eur J Vasc Endovasc Surg 66 (5), 707-721 (2023)
   PUBMED   37295599
  REMARK    GeneRIF: CD93 Ameliorates Diabetic Wounds by Promoting Angiogenesis
            via the p38MAPK/MK2/HSP27 Axis.
REFERENCE   4  (bases 1 to 910)
  AUTHORS   Zoupa,M., Xavier,G.M., Bryan,S., Theologidis,I., Arno,M. and
            Cobourne,M.T.
  TITLE     Gene expression profiling in the developing secondary palate in the
            absence of Tbx1 function
  JOURNAL   BMC Genomics 19 (1), 429 (2018)
   PUBMED   29866044
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 910)
  AUTHORS   Sevin,M., Kubovcakova,L., Pernet,N., Causse,S., Vitte,F.,
            Villeval,J.L., Lacout,C., Cordonnier,M., Rodrigues-Lima,F.,
            Chanteloup,G., Mosca,M., Chretien,M.L., Bastie,J.N., Audia,S.,
            Sagot,P., Ramla,S., Martin,L., Gleave,M., Mezger,V., Skoda,R.,
            Plo,I., Garrido,C., Girodon,F. and de Thonel,A.
  TITLE     HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target
            in myelofibrosis
  JOURNAL   Nat Commun 9 (1), 1431 (2018)
   PUBMED   29650953
  REMARK    GeneRIF: HSP27 is a partner of JAK2-STAT5 and a potential
            therapeutic target in myelofibrosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 910)
  AUTHORS   Kozawa,O., Niwa,M., Hatakeyama,D., Tokuda,H., Oiso,Y., Matsuno,H.,
            Kato,K. and Uematsu,T.
  TITLE     Specific induction of heat shock protein 27 by glucocorticoid in
            osteoblasts
  JOURNAL   J Cell Biochem 86 (2), 357-364 (2002)
   PUBMED   12112005
  REMARK    GeneRIF: results strongly suggest that glucocorticoid stimulates
            the induction of neither HSP70 nor HSP90, but HSP27 in osteoblasts,
            and that p38 MAP kinase is involved in the induction of HSP27
REFERENCE   7  (bases 1 to 910)
  AUTHORS   Brady,J.P., Garland,D.L., Green,D.E., Tamm,E.R., Giblin,F.J. and
            Wawrousek,E.F.
  TITLE     AlphaB-crystallin in lens development and muscle integrity: a gene
            knockout approach
  JOURNAL   Invest Ophthalmol Vis Sci 42 (12), 2924-2934 (2001)
   PUBMED   11687538
REFERENCE   8  (bases 1 to 910)
  AUTHORS   Meeson,A.P., Radford,N., Shelton,J.M., Mammen,P.P., DiMaio,J.M.,
            Hutcheson,K., Kong,Y., Elterman,J., Williams,R.S. and Garry,D.J.
  TITLE     Adaptive mechanisms that preserve cardiac function in mice without
            myoglobin
  JOURNAL   Circ Res 88 (7), 713-720 (2001)
   PUBMED   11304494
REFERENCE   9  (bases 1 to 910)
  AUTHORS   Kannan,R., Ouyang,B., Wawrousek,E., Kaplowitz,N. and Andley,U.P.
  TITLE     Regulation of GSH in alphaA-expressing human lens epithelial cell
            lines and in alphaA knockout mouse lenses
  JOURNAL   Invest Ophthalmol Vis Sci 42 (2), 409-416 (2001)
   PUBMED   11157875
REFERENCE   10 (bases 1 to 910)
  AUTHORS   Andley,U.P., Song,Z., Wawrousek,E.F., Brady,J.P., Bassnett,S. and
            Fleming,T.P.
  TITLE     Lens epithelial cells derived from alphaB-crystallin knockout mice
            demonstrate hyperproliferation and genomic instability
  JOURNAL   FASEB J 15 (1), 221-229 (2001)
   PUBMED   11149910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012780.1, BC064051.1 and BU704695.1.
            
            On Sep 11, 2009 this sequence version replaced NM_024441.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064051.1, CB587574.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AK012780.1         2-167
            167-819             BC064051.1         106-758
            820-910             BU704695.1         292-382
FEATURES             Location/Qualifiers
     source          1..910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 27.75 cM"
     gene            1..910
                     /gene="Hspb2"
                     /gene_synonym="27kDa; 2810021G24Rik; HSP27; MKBP"
                     /note="heat shock protein 2"
                     /db_xref="GeneID:69253"
                     /db_xref="MGI:MGI:1916503"
     exon            1..178
                     /gene="Hspb2"
                     /gene_synonym="27kDa; 2810021G24Rik; HSP27; MKBP"
                     /inference="alignment:Splign:2.1.0"
     exon            179..840
                     /gene="Hspb2"
                     /gene_synonym="27kDa; 2810021G24Rik; HSP27; MKBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      814..819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspb2"
                     /gene_synonym="27kDa; 2810021G24Rik; HSP27; MKBP"
                     /note="hexamer: AATAAA"
     polyA_site      834
                     /gene="Hspb2"
                     /gene_synonym="27kDa; 2810021G24Rik; HSP27; MKBP"
                     /note="major polyA site"
ORIGIN      
        1 ctggctctcc ctgaagccgg tggggtcgcc ttgatcttgt tggggcagta cttgggatca
       61 gggctactag tcgcaacagc agtcatgtcg ggccgcacag tgccacacgc ccacccagcc
      121 actgccgagt acgaatttgc caaccccagc cgtctgggcg agcagcgctt cggagaaggc
      181 ctcctgccag aagagatcct gacccccacc ctctatcacg gctactatgt tcggcctcgg
      241 gccgccagag ctggcgaggg cgccagggca ggggcctcag agctcaggct cagtgaaggc
      301 aagttccagg cgtttctgga tgtgagccac tttaccccag atgaggtgac ggtgaggact
      361 gtggataacc tgctggaggt gtctgcccga cacccccagc gtctggatcg ccacggcttc
      421 gtgtcccgag agttctgtcg cacctatgtc ctgcctgcag atgtggaccc ctggcgggtt
      481 cgagctgctc tatcccatga tggcatcctt aacttggagg cgccgcgggg tggccggcat
      541 ttggacacgg aagtcaatga agtctacatc tccctgcttc ctgctcctcc tgaccccgag
      601 gaagaggaag agatagccag agttgagccc tgactgccag cgatagaccc agcacccagt
      661 gaatcccctg tctacctccc gtggtgattc cataaatcca ccacacccca gagggagcag
      721 catccctggg agatggcatc ggtgcatggt ccacagtgta tggtttggtc ccttgatgta
      781 tcaaagcctt tgatttaatt ctgggtgggg ctgaataaac caaaacctgg gggccttgtt
      841 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      901 aaaaaaaaaa
//
