LOCUS       NM_013560                913 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus heat shock protein 1 (Hspb1), mRNA.
ACCESSION   NM_013560
VERSION     NM_013560.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 913)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 913)
  AUTHORS   He,J., Hou,X., Wu,J., Wang,K., Qi,X., Wei,Z., Sun,Y., Wang,C.,
            Yao,H. and Liu,K.
  TITLE     Hspb1 protects against severe acute pancreatitis by attenuating
            apoptosis and ferroptosis via interacting with Anxa2 to restore the
            antioxidative activity of Prdx1
  JOURNAL   Int J Biol Sci 20 (5), 1707-1728 (2024)
   PUBMED   38481805
  REMARK    GeneRIF: Hspb1 protects against severe acute pancreatitis by
            attenuating apoptosis and ferroptosis via interacting with Anxa2 to
            restore the antioxidative activity of Prdx1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 913)
  AUTHORS   Espinoza,K.S., Hermanson,K.N., Beard,C.A., Schwartz,N.U.,
            Snider,J.M., Low,B.E., Wiles,M.V., Hannun,Y.A., Obeid,L.M. and
            Snider,A.J.
  TITLE     A novel HSPB1S139F mouse model of Charcot-Marie-Tooth Disease
  JOURNAL   Prostaglandins Other Lipid Mediat 169, 106769 (2023)
   PUBMED   37625781
REFERENCE   4  (bases 1 to 913)
  AUTHORS   Broadway-Stringer,S., Jiang,H., Wadmore,K., Hooper,C., Douglas,G.,
            Steeples,V., Azad,A.J., Singer,E., Reyat,J.S., Galatik,F.,
            Ehler,E., Bennett,P., Kalisch-Smith,J.I., Sparrow,D.B., Davies,B.,
            Djinovic-Carugo,K., Gautel,M., Watkins,H. and Gehmlich,K.
  TITLE     Insights into the Role of a Cardiomyopathy-Causing Genetic Variant
            in ACTN2
  JOURNAL   Cells 12 (5), 721 (2023)
   PUBMED   36899856
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 913)
  AUTHORS   Nam,M.H., Nahomi,R.B., Pantcheva,M.B., Dhillon,A., Chiodo,V.A.,
            Smith,W.C. and Nagaraj,R.H.
  TITLE     AAV2-Mediated Expression of HspB1 in RGCs Prevents Somal Damage and
            Axonal Transport Deficits in a Mouse Model of Ocular Hypertension
  JOURNAL   Transl Vis Sci Technol 11 (11), 8 (2022)
   PUBMED   36355386
  REMARK    GeneRIF: AAV2-Mediated Expression of HspB1 in RGCs Prevents Somal
            Damage and Axonal Transport Deficits in a Mouse Model of Ocular
            Hypertension.
REFERENCE   6  (bases 1 to 913)
  AUTHORS   Cooper,L.F. and Uoshima,K.
  TITLE     Differential estrogenic regulation of small M(r) heat shock protein
            expression in osteoblasts
  JOURNAL   J Biol Chem 269 (11), 7869-7873 (1994)
   PUBMED   8132504
REFERENCE   7  (bases 1 to 913)
  AUTHORS   Frohli,E., Aoyama,A. and Klemenz,R.
  TITLE     Cloning of the mouse hsp25 gene and an extremely conserved hsp25
            pseudogene
  JOURNAL   Gene 128 (2), 273-277 (1993)
   PUBMED   8514193
REFERENCE   8  (bases 1 to 913)
  AUTHORS   Klemenz,R., Andres,A.C., Frohli,E., Schafer,R. and Aoyama,A.
  TITLE     Expression of the murine small heat shock proteins hsp 25 and alpha
            B crystallin in the absence of stress
  JOURNAL   J Cell Biol 120 (3), 639-645 (1993)
   PUBMED   8425893
REFERENCE   9  (bases 1 to 913)
  AUTHORS   Gaestel,M., Schroder,W., Benndorf,R., Lippmann,C., Buchner,K.,
            Hucho,F., Erdmann,V.A. and Bielka,H.
  TITLE     Identification of the phosphorylation sites of the murine small
            heat shock protein hsp25
  JOURNAL   J Biol Chem 266 (22), 14721-14724 (1991)
   PUBMED   1860870
REFERENCE   10 (bases 1 to 913)
  AUTHORS   Gaestel,M., Gross,B., Benndorf,R., Strauss,M., Schunk,W.H.,
            Kraft,R., Otto,A., Bohm,H., Stahl,J., Drabsch,H. et al.
  TITLE     Molecular cloning, sequencing and expression in Escherichia coli of
            the 25-kDa growth-related protein of Ehrlich ascites tumor and its
            homology to mammalian stress proteins
  JOURNAL   Eur J Biochem 179 (1), 209-213 (1989)
   PUBMED   2645135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA013886.1, BC099463.1 and AV458710.1.
            
            On Oct 31, 2007 this sequence version replaced NM_013560.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU754621.1, BC018257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AA013886.1         1-105
            106-898             BC099463.1         1-793
            899-913             AV458710.1         328-342
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.51 cM"
     gene            1..913
                     /gene="Hspb1"
                     /gene_synonym="27kDa; Hsp25"
                     /note="heat shock protein 1"
                     /db_xref="GeneID:15507"
                     /db_xref="MGI:MGI:96240"
     exon            1..516
                     /gene="Hspb1"
                     /gene_synonym="27kDa; Hsp25"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..770
                     /gene="Hspb1"
                     /gene_synonym="27kDa; Hsp25"
                     /note="heat shock 27kDa protein 1; p25; HSP 25; HSP 27;
                     heat shock 25 kDa protein; heat shock 27 kDa protein;
                     growth-related 25 kDa protein; heat shock protein, 25 kDa"
                     /codon_start=1
                     /product="heat shock protein beta-1"
                     /protein_id="NP_038588.2"
                     /db_xref="CCDS:CCDS39320.1"
                     /db_xref="GeneID:15507"
                     /db_xref="MGI:MGI:96240"
                     /translation="MTERRVPFSLLRSPSWEPFRDWYPAHSRLFDQAFGVPRLPDEWS
                     QWFSAAGWPGYVRPLPAATAEGPAAVTLAAPAFSRALNRQLSSGVSEIRQTADRWRVS
                     LDVNHFAPEELTVKTKEGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTLVSSS
                     LSPEGTLTVEAPLPKAVTQSAEITIPVTFEARAQIGGPEAGKSEQSGAK"
     exon            517..580
                     /gene="Hspb1"
                     /gene_synonym="27kDa; Hsp25"
                     /inference="alignment:Splign:2.1.0"
     exon            581..903
                     /gene="Hspb1"
                     /gene_synonym="27kDa; Hsp25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      874..879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspb1"
                     /gene_synonym="27kDa; Hsp25"
                     /note="hexamer: AATAAA"
     polyA_site      902
                     /gene="Hspb1"
                     /gene_synonym="27kDa; Hsp25"
                     /note="major polyA site"
ORIGIN      
        1 gccattaata gagacctgaa gcaccgcctg ctaaaaatac ccggctgggc acacataaaa
       61 gcacgctggg gctccagtcc ggcacttctc ggatcctcag cccagtgctt ctagatcctc
      121 agccttgacc agccaagaac atgaccgagc gccgcgtgcc cttctcgctg ctgcggagcc
      181 cgagctggga accattccgg gactggtacc ctgcacacag ccgcctcttc gatcaagctt
      241 tcggggtgcc ccggttgccc gatgagtggt cgcagtggtt cagcgccgct gggtggcccg
      301 gatacgtgcg cccgctgccc gccgcgaccg ccgagggccc cgcggcggtg accctggccg
      361 caccagcctt cagccgagcg ctcaaccgac agctcagcag cggggtctcg gagatccgac
      421 agacggctga tcgctggcgc gtgtccctgg acgtcaacca cttcgctccg gaggagctca
      481 cagtgaagac caaggaaggc gtggtggaga tcactggcaa gcacgaagaa aggcaggacg
      541 aacatggcta catctctcgg tgcttcaccc ggaaatacac gctccctcca ggtgtggacc
      601 ccaccctagt gtcctcttcc ctatcccctg agggcacact taccgtggag gctccgttgc
      661 ccaaagcagt cacgcagtca gcggagatca ccattccggt tactttcgag gcccgcgccc
      721 aaattggggg cccagaagct gggaagtctg aacagtctgg agccaagtag aagccatcag
      781 cctgctgcct atctcccata gccattgctg gccacccctc tctgtcaatc tgtgcgctct
      841 tttgatacat acatttacct gctgtttttc tcaaataaaa gttgcaagct actgctcacc
      901 accaaaaaaa aaa
//
