LOCUS       NM_008301               2527 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus heat shock protein 2 (Hspa2), transcript variant 1,
            mRNA.
ACCESSION   NM_008301
VERSION     NM_008301.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2527)
  AUTHORS   Pfaltzgraff,N.G., Liu,B., de Rooij,D.G., Page,D.C. and Mikedis,M.M.
  TITLE     Destabilization of mRNAs enhances competence to initiate meiosis in
            mouse spermatogenic cells
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38884383
REFERENCE   2  (bases 1 to 2527)
  AUTHORS   Katano,W., Mori,S., Sasaki,S., Tajika,Y., Tomita,K., Takeuchi,J.K.
            and Koshiba-Takeuchi,K.
  TITLE     Sall1 and Sall4 cooperatively interact with Myocd and SRF to
            promote cardiomyocyte proliferation by regulating CDK and cyclin
            genes
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38014633
REFERENCE   3  (bases 1 to 2527)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2527)
  AUTHORS   Zhang,W., Shi,B., Li,S., Liu,Z., Li,S., Dong,S., Cheng,Y., Zhu,J.,
            Zhang,G. and Zhong,M.
  TITLE     Sleeve gastrectomy improves lipid dysmetabolism by downregulating
            the USP20-HSPA2 axis in diet-induced obese mice
  JOURNAL   Front Endocrinol (Lausanne) 13, 1041027 (2022)
   PUBMED   36636478
  REMARK    GeneRIF: Sleeve gastrectomy improves lipid dysmetabolism by
            downregulating the USP20-HSPA2 axis in diet-induced obese mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2527)
  AUTHORS   Rong,Y., Zhu,Y.Z., Yu,J.L., Wu,Y.W., Ji,S.Y., Zhou,Y., Jiang,Y.,
            Jin,J., Fan,H.Y., Shen,L. and Sha,Q.Q.
  TITLE     USP16-mediated histone H2A lysine-119 deubiquitination during
            oocyte maturation is a prerequisite for zygotic genome activation
  JOURNAL   Nucleic Acids Res 50 (10), 5599-5616 (2022)
   PUBMED   35640597
REFERENCE   6  (bases 1 to 2527)
  AUTHORS   Roux,A.F., Nguyen,V.T., Squire,J.A. and Cox,D.W.
  TITLE     A heat shock gene at 14q22: mapping and expression
  JOURNAL   Hum Mol Genet 3 (10), 1819-1822 (1994)
   PUBMED   7849706
REFERENCE   7  (bases 1 to 2527)
  AUTHORS   Bonnycastle,L.L., Yu,C.E., Hunt,C.R., Trask,B.J., Clancy,K.P.,
            Weber,J.L., Patterson,D. and Schellenberg,G.D.
  TITLE     Cloning, sequencing, and mapping of the human chromosome 14 heat
            shock protein gene (HSPA2)
  JOURNAL   Genomics 23 (1), 85-93 (1994)
   PUBMED   7829106
REFERENCE   8  (bases 1 to 2527)
  AUTHORS   Khan,F., Clarke,V. and D'Eustachio,P.
  TITLE     Refinement of the DNA marker maps of mouse chromosome 12
  JOURNAL   Genomics 21 (1), 128-137 (1994)
   PUBMED   8088780
REFERENCE   9  (bases 1 to 2527)
  AUTHORS   Rosario,M.O., Perkins,S.L., O'Brien,D.A., Allen,R.L. and Eddy,E.M.
  TITLE     Identification of the gene for the developmentally expressed 70 kDa
            heat-shock protein (P70) of mouse spermatogenic cells
  JOURNAL   Dev Biol 150 (1), 1-11 (1992)
   PUBMED   1537426
REFERENCE   10 (bases 1 to 2527)
  AUTHORS   Zakeri,Z.F., Wolgemuth,D.J. and Hunt,C.R.
  TITLE     Identification and sequence analysis of a new member of the mouse
            HSP70 gene family and characterization of its unique cellular and
            developmental pattern of expression in the male germ line
  JOURNAL   Mol Cell Biol 8 (7), 2925-2932 (1988)
   PUBMED   3405224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132261.1 and BC052350.1.
            
            On Jul 20, 2022 this sequence version replaced NM_008301.4.
            
            Transcript Variant: This variant (1) is the longest transcript. All
            variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC004714.1, AK132261.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2431              AK132261.1         5-2435
            2432-2527           BC052350.1         2429-2524
FEATURES             Location/Qualifiers
     source          1..2527
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 33.73 cM"
     gene            1..2527
                     /gene="Hspa2"
                     /gene_synonym="70kDa; Hsp70-2; HSP70.2; HSP70A2"
                     /note="heat shock protein 2"
                     /db_xref="GeneID:15512"
                     /db_xref="MGI:MGI:96243"
     exon            1..2527
                     /gene="Hspa2"
                     /gene_synonym="70kDa; Hsp70-2; HSP70.2; HSP70A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2024
                     /gene="Hspa2"
                     /gene_synonym="70kDa; Hsp70-2; HSP70.2; HSP70A2"
                     /note="heat shock 70kDa protein 2; heat shock protein
                     70.2; heat shock protein, 70 kDa 2"
                     /codon_start=1
                     /product="heat shock-related 70 kDa protein 2"
                     /protein_id="NP_032327.2"
                     /db_xref="CCDS:CCDS25993.1"
                     /db_xref="GeneID:15512"
                     /db_xref="MGI:MGI:96243"
                     /translation="MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVA
                     FTDTERLIGDAAKNQVAMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKP
                     KVQVEYKGEMKTFFPEEISSMVLTKMKEIAEAYLGGKVQSAVITVPAYFNDSQRQATK
                     DAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDG
                     IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRT
                     LSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDKGQI
                     QEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQ
                     DLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGER
                     AMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITN
                     DKGRLSKDDIDRMVQEAERYKSEDEANRDRVAAKNAVESYTYNIKQTVEDEKLRGKIS
                     EQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGGSS
                     GGPTIEEVD"
     regulatory      2503..2508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspa2"
                     /gene_synonym="70kDa; Hsp70-2; HSP70.2; HSP70A2"
                     /note="hexamer: AGTAAA"
     polyA_site      2527
                     /gene="Hspa2"
                     /gene_synonym="70kDa; Hsp70-2; HSP70.2; HSP70A2"
                     /note="major polyA site"
ORIGIN      
        1 gggagacgct agtcgcgctc gtggagagtt gtgagaagcg accgttggct caggtcccgg
       61 cttgcgcttg cctctcctga cgctttcgtc ctaacgttgc tttgcctgtt ttttcagtca
      121 ggatgtctgc ccgcggcccg gctatcggca tcgacctggg caccacttac tcgtgcgtgg
      181 gggtattcca acatggcaag gtggagatca tcgccaacga ccagggtaac cgcaccaccc
      241 ccagctacgt ggccttcact gacaccgagc gtctcatcgg cgacgccgcc aagaaccaag
      301 tggccatgaa ccccacaaac accatcttcg acgccaagcg gctgatcgga cggaagttcg
      361 aggacgccac agtgcagtcc gatatgaagc actggccgtt ccgagtggtg agcgaaggtg
      421 ggaagcccaa agtgcaggtg gaatataaag gggagatgaa gaccttcttc cctgaggaga
      481 tttcttccat ggtcctcact aagatgaagg agatcgccga agcctacctg gggggcaagg
      541 tgcagagcgc agtcatcact gttcctgcct atttcaacga ctcgcagcgc caggccacca
      601 aggatgcggg caccatcacc ggcctcaacg tgttgcgcat catcaatgag cccacagcag
      661 cggccatcgc ctacggcctg gataagaagg gctgtgcggg cggcgagaag aacgtgctca
      721 tctttgacct gggcgggggc accttcgatg tgtccatcct gaccatcgag gatggcatct
      781 ttgaggtgaa gtccacggcc ggcgataccc acctgggtgg cgaagacttc gacaaccgta
      841 tggtcagcca cctggcggag gagttcaagc gcaaacacaa gaaggacatt gggcccaaca
      901 agcgcgctgt gcgccggctg cgcaccgcct gcgagcgcgc taagcgcacc ctgagctcgt
      961 ccacgcaggc cagcatagag atcgactcgc tctacgaggg cgtggatttc tacacgtcca
     1021 tcacccgcgc ccgcttcgag gagctcaacg ccgatctctt ccgagggacc ctggagccgg
     1081 tggaaaaggc gctgcgcgat gccaagctag acaagggcca gatccaggag atagtgctgg
     1141 tgggcggctc aacccgcatc cctaagatcc agaagctcct gcaagatttc ttcaacggca
     1201 aggagctgaa caagagcatt aatcccgacg aggcggtggc ctacggcgcc gctgtgcagg
     1261 cggctatcct catcggcgac aagtcggaaa atgtgcagga tctgctgtta ctcgacgtga
     1321 ctccattgtc gctcggcatc gaaacagctg gcggtgtcat gaccccactc atcaagagaa
     1381 acaccacgat ccccaccaag cagacgcaga ccttcactac ctactcagac aaccagagca
     1441 gcgtgctggt gcaagtgtac gagggcgaac gggccatgac caaggacaat aacctcttgg
     1501 gcaagttcga cctgactggg atccccccag caccccgtgg ggtcccccag atcgaggtca
     1561 cctttgacat cgatgccaac ggcatcctta acgtcactgc tgccgacaag agcaccggta
     1621 aagaaaataa aatcaccata accaacgaca agggtcggct gagcaaagac gacattgacc
     1681 ggatggtgca ggaggcggag cggtacaaat cggaagatga agcaaatcgc gatcgcgtgg
     1741 cagccaaaaa tgcggtggag tcctatacct acaacatcaa gcagaccgtg gaagacgaga
     1801 aactgagggg caagattagc gagcaggaca aaaacaagat cctcgacaag tgtcaggagg
     1861 tgatcaactg gcttgaccga aaccagatgg cagagaaaga tgagtacgaa cacaagcaga
     1921 aagagcttga gagagtgtgc aaccccatca tcagcaaact ttaccaaggc ggtccaggcg
     1981 gcggcggctc ctctggaggg cccaccatcg aggaagtgga ctaggcttgc gctggagtcc
     2041 gcgtaaacct cttttccttt cttttctttt ttcttttttt ttttttttcc ttttctccct
     2101 tttgttttgg tttcttttaa atgtccttgt gccaagtaag atctattatt ggaagtcttt
     2161 agcctggtgc atacatatga aaggaaaggt gcaacaactt agtttagtta taaaaggtta
     2221 gttctaaaag tttgatttgg gggaaaaatg aggtttctct ttaatgcatt tagagcgatt
     2281 gctgatttaa gctctttttg ttgttgttaa gcttacgtat gtacatggag atttgcttga
     2341 aagtagaacc ctgatgctcg cacacctgac ctgtggaagc ttggttacac taagacacag
     2401 gaaagcttga attgtttatt tttatgtact atgagatgaa agtaagcact gcagtgatat
     2461 taaagacagg tatattctgt aaacacataa atgcacattt aaagtaaagc tgaaattgat
     2521 ctcaaaa
//
