LOCUS       NM_013558               2415 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus heat shock protein 1-like (Hspa1l), mRNA.
ACCESSION   NM_013558
VERSION     NM_013558.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2415)
  AUTHORS   Nakatsuka,A., Yamaguchi,S., Eguchi,J., Kakuta,S., Iwakura,Y.,
            Sugiyama,H. and Wada,J.
  TITLE     A Vaspin-HSPA1L complex protects proximal tubular cells from
            organelle stress in diabetic kidney disease
  JOURNAL   Commun Biol 4 (1), 373 (2021)
   PUBMED   33742129
  REMARK    GeneRIF: A Vaspin-HSPA1L complex protects proximal tubular cells
            from organelle stress in diabetic kidney disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2415)
  AUTHORS   Wang,X., Xie,W., Yao,Y., Zhu,Y., Zhou,J., Cui,Y., Guo,X., Yuan,Y.,
            Zhou,Z. and Liu,M.
  TITLE     The heat shock protein family gene Hspa1l in male mice is
            dispensable for fertility
  JOURNAL   PeerJ 8, e8702 (2020)
   PUBMED   32231871
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2415)
  AUTHORS   Williams,P.A., Kobilnyk,H.E., McMillan,E.A. and Strochlic,T.I.
  TITLE     MAPKAP kinase 2-mediated phosphorylation of HspA1L protects male
            germ cells from heat stress-induced apoptosis
  JOURNAL   Cell Stress Chaperones 24 (6), 1127-1136 (2019)
   PUBMED   31642047
  REMARK    GeneRIF: These results describe a novel signaling pathway by which
            HspA1L activity is enhanced in response to hyperthermia during
            spermatogenesis.
REFERENCE   4  (bases 1 to 2415)
  AUTHORS   Nakajima,R., Okano,H. and Noce,T.
  TITLE     JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during
            Spermatogenesis
  JOURNAL   PLoS One 11 (9), e0163466 (2016)
   PUBMED   27649575
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2415)
  AUTHORS   Hjerpe,R., Bett,J.S., Keuss,M.J., Solovyova,A., McWilliams,T.G.,
            Johnson,C., Sahu,I., Varghese,J., Wood,N., Wightman,M., Osborne,G.,
            Bates,G.P., Glickman,M.H., Trost,M., Knebel,A., Marchesi,F. and
            Kurz,T.
  TITLE     UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance
            by the Proteasome
  JOURNAL   Cell 166 (4), 935-949 (2016)
   PUBMED   27477512
REFERENCE   6  (bases 1 to 2415)
  AUTHORS   Fijneman,R.J., Oomen,L.C., Snoek,M. and Demant,P.
  TITLE     A susceptibility gene for alveolar lung tumors in the mouse maps
            between Hsp70.3 and G7 within the H2 complex
  JOURNAL   Immunogenetics 41 (2-3), 106-109 (1995)
   PUBMED   7806281
REFERENCE   7  (bases 1 to 2415)
  AUTHORS   Gunther,E. and Walter,L.
  TITLE     Genetic aspects of the hsp70 multigene family in vertebrates
  JOURNAL   Experientia 50 (11-12), 987-1001 (1994)
   PUBMED   7988674
  REMARK    Review article
REFERENCE   8  (bases 1 to 2415)
  AUTHORS   Snoek,M., Olavesen,M.G., van Vugt,H., Milner,C.M., Teuscher,C. and
            Campbell,R.D.
  TITLE     Coding sequences and levels of expression of Hsc70t are identical
            in mice with different Orch-1 alleles
  JOURNAL   Immunogenetics 40 (2), 159-162 (1994)
   PUBMED   8026864
REFERENCE   9  (bases 1 to 2415)
  AUTHORS   Gasser,D.L., Sternberg,N.L., Pierce,J.C., Goldner-Sauve,A.,
            Feng,H., Haq,A.K., Spies,T., Hunt,C., Buetow,K.H. and Chaplin,D.D.
  TITLE     P1 and cosmid clones define the organization of 280 kb of the mouse
            H-2 complex containing the Cps-1 and Hsp70 loci
  JOURNAL   Immunogenetics 39 (1), 48-55 (1994)
   PUBMED   7993390
REFERENCE   10 (bases 1 to 2415)
  AUTHORS   Matsumoto,M. and Fujimoto,H.
  TITLE     Cloning of a hsp70-related gene expressed in mouse spermatids
  JOURNAL   Biochem Biophys Res Commun 166 (1), 43-49 (1990)
   PUBMED   2302214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY099756.1, BC129895.1 and AC087117.9.
            
            On Jan 31, 2007 this sequence version replaced NM_013558.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D85732.1, BC129895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               BY099756.1         3-131
            130-2313            BC129895.1         1-2184
            2314-2415           AC087117.9         87744-87845
FEATURES             Location/Qualifiers
     source          1..2415
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.51 cM"
     gene            1..2415
                     /gene="Hspa1l"
                     /gene_synonym="Hsc70t; Msh5"
                     /note="heat shock protein 1-like"
                     /db_xref="GeneID:15482"
                     /db_xref="MGI:MGI:96231"
     exon            1..160
                     /gene="Hspa1l"
                     /gene_synonym="Hsc70t; Msh5"
                     /inference="alignment:Splign:2.1.0"
     exon            161..2415
                     /gene="Hspa1l"
                     /gene_synonym="Hsc70t; Msh5"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2099
                     /gene="Hspa1l"
                     /gene_synonym="Hsc70t; Msh5"
                     /note="heat shock protein cognate 70, testis; heat
                     shock-related protein hsc70t; heat shock 70 kDa protein
                     1L; heat shock 70kDa protein 1-like; spermatid-specific
                     heat shock protein 70; inducible heat shock protein 70;
                     heat shock 70 kDa-like protein 1"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 1-like"
                     /protein_id="NP_038586.2"
                     /db_xref="CCDS:CCDS28670.1"
                     /db_xref="GeneID:15482"
                     /db_xref="MGI:MGI:96231"
                     /translation="MAANKGMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYV
                     AFTDTERLIGDAAKNQVAMNPQNTVFDAKRLIGRKFNDPVVQSDMKLWPFQVINEAGK
                     PKVMVSYKGEKKAFYPEEISSMVLTKMKETAEAFLGHNVTNAVITVPAYFNDSQRQAT
                     KDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVLIFDLGGGTFDVSILTIDDGI
                     FEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTL
                     SSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDAKMDKAKIH
                     DIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQD
                     LLLLDVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERA
                     MTRDNNLLGRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITND
                     KGRLSKEEIERMVQEAERYKAEDEGQREKIAAKNALESYAFNMKSAVGDEGLKDKISE
                     SDKKKILDKCNEVLSWLEANQLAEKDEFDHKRKELENMCNPIITKLYQSGCTGPTCTP
                     GYTPGRAATGPTIEEVD"
ORIGIN      
        1 gaggctctgt cccagcacag gctcaaagtt gccgggaggg gcggggtggg gggtgggggg
       61 gaccccggct gctcagtttg gatgttcctg gagctccctg ctcgtagggg ctcagcgact
      121 tcaaattttc caaactggat cgaaggcgta gagatcccag gcctcggaaa accatggctg
      181 ctaataaagg aatggcgatc ggcatcgact tgggcaccac ctactcgtgc gtgggcgtgt
      241 tccagcacgg caaggtggag atcatcgcca acgaccaggg caaccgcacg acccctagct
      301 acgtggcctt caccgacacc gagcgcctca tcggagacgc tgccaagaac caggtggcca
      361 tgaatcccca gaacactgtt tttgatgcca aacgtctaat tggcaggaag tttaatgatc
      421 ctgttgtgca gtcagatatg aagctttggc catttcaagt gatcaatgaa gccggcaaac
      481 ccaaggtgat ggtgtcctat aaaggagaga agaaagcctt ctacccagag gagatctcat
      541 ccatggtact gacgaagatg aaggagactg cagaggcttt tttgggccac aatgtcacca
      601 acgctgtgat cacggtgcca gcctatttca atgactctca gcggcaagcc accaaggatg
      661 caggtgtcat cgcaggactc aatgtgctga gaataatcaa tgagcccacg gcggccgcca
      721 tcgcctacgg cttggataaa ggaagtcacg gagagcggca cgtgctcatc ttcgacctgg
      781 ggggtggcac gttcgacgtg tccatcctga cgatcgacga cggcatcttc gaggtgaagg
      841 ccacggcggg cgacacgcac ctgggagggg aggacttcga caaccggctg gtgagccact
      901 tcgtggagga gttcaagagg aagcacaaga aggacatcag ccagaacaag cgcgcggtgc
      961 ggcggctgcg cactgcgtgt gagagggcca agaggacgct gtcgtccagc acccaggcaa
     1021 acctggagat cgactcttta tatgagggca tcgacttcta cacgtccatc actagagcac
     1081 ggtttgaaga gctgtgtgca gacctattta gaggcacact tgagcccgtg gaaaagtctc
     1141 ttcgggatgc caagatggat aaggctaaaa tccatgacat tgttctagta gggggctcca
     1201 cccgcatccc aaaggtgcaa aaactgcttc aggactactt taatggacgg gatctcaaca
     1261 agagtatcaa tcccgatgag gcagtcgcct acggagctgc agtccaggca gctattttaa
     1321 tgggcgacaa atctgaaaaa gtacaggatt tgcttttgtt ggacgtagct cccctgtctc
     1381 taggattgga gacagctggg ggtgtgatga ctgtactgat caagcgcaac tccaccatcc
     1441 ccaccaagca gacgcagatc ttcaccacct actcggacaa ccagcccggg gtgctgatcc
     1501 aggtgtacga gggcgagaga gccatgacgc gcgacaacaa cctgctgggg cgctttgact
     1561 tgactggaat acctcctgca cctaggggcg tgccacagat cgaggtgacc ttcgacatcg
     1621 acgccaacgg tatcctgaac gtcacggcca tggacaagag caccggcaag gccaacaaga
     1681 tcaccatcac caacgacaag ggtcgcctga gcaaggagga gattgagcgc atggtgcagg
     1741 aggccgagcg ctacaaagcg gaggatgagg gccagaggga gaaaatcgct gccaaaaatg
     1801 ccttagaatc gtacgccttt aatatgaaga gcgctgtggg tgatgagggt ctgaaggaca
     1861 agatcagcga gtccgataaa aagaaaatac tggataaatg caatgaggtc ctttcctggc
     1921 tggaggccaa ccagctggct gagaaagatg agtttgatca taaaagaaaa gaactggaaa
     1981 atatgtgtaa tccgatcatc acaaaactgt accagagcgg atgcaccggg cccacctgta
     2041 cgccagggta tactcccggc agggctgcca caggccctac catcgaggaa gtagattagc
     2101 cttttccaga attgcagggt gctagggtgc ctctaggcga attttattca tcttcaaaca
     2161 tcaatatgat tcttgaactg actggactca agcctacgtc accatccttt gggatcccga
     2221 tggagaagcc tcgaactcga ccttttcaca cccccaccct ctcatctatg atcctgaact
     2281 ggacctttag gaaaaccagg cccctctttg agccatttga agaatttgga tgtctgttat
     2341 ttattatcca caccccacct ttctccttcc tgtgtggatg gttatttgtc tctcagtaaa
     2401 tttgttccca aagga
//
