LOCUS       NM_010479               2798 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus heat shock protein 1A (Hspa1a), mRNA.
ACCESSION   NM_010479 XM_207062 XM_359371 XM_489786
VERSION     NM_010479.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2798)
  AUTHORS   Lang,B.J., Holton,K.M., Guerrero-Gimenez,M.E., Okusha,Y.,
            Magahis,P.T., Shi,A., Neguse,M., Venkatesh,S., Nhu,A.M.,
            Gestwicki,J.E. and Calderwood,S.K.
  TITLE     Heat shock protein 72 supports extracellular matrix production in
            metastatic mammary tumors
  JOURNAL   Cell Stress Chaperones 29 (3), 456-471 (2024)
   PUBMED   38703814
  REMARK    GeneRIF: Heat shock protein 72 supports extracellular matrix
            production in metastatic mammary tumors.
REFERENCE   2  (bases 1 to 2798)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2798)
  AUTHORS   Uchida,A., Imaimatsu,K., Suzuki,H., Han,X., Ushioda,H., Uemura,M.,
            Imura-Kishi,K., Hiramatsu,R., Takase,H.M., Hirate,Y., Ogura,A.,
            Kanai-Azuma,M., Kudo,A. and Kanai,Y.
  TITLE     SOX17-positive rete testis epithelium is required for Sertoli valve
            formation and normal spermiogenesis in the male mouse
  JOURNAL   Nat Commun 13 (1), 7860 (2022)
   PUBMED   36543770
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2798)
  AUTHORS   Salazar-Petres,E., Pereira-Carvalho,D., Lopez-Tello,J. and
            Sferruzzi-Perri,A.N.
  TITLE     Placental structure, function, and mitochondrial phenotype relate
            to fetal size in each fetal sex in micedagger
  JOURNAL   Biol Reprod 106 (6), 1292-1311 (2022)
   PUBMED   35293971
REFERENCE   5  (bases 1 to 2798)
  AUTHORS   Wilkerson,B.A., Zebroski,H.L., Finkbeiner,C.R., Chitsazan,A.D.,
            Beach,K.E., Sen,N., Zhang,R.C. and Bermingham-McDonogh,O.
  TITLE     Novel cell types and developmental lineages revealed by single-cell
            RNA-seq analysis of the mouse crista ampullaris
  JOURNAL   Elife 10, e60108 (2021)
   PUBMED   34003106
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2798)
  AUTHORS   Fijneman,R.J., Oomen,L.C., Snoek,M. and Demant,P.
  TITLE     A susceptibility gene for alveolar lung tumors in the mouse maps
            between Hsp70.3 and G7 within the H2 complex
  JOURNAL   Immunogenetics 41 (2-3), 106-109 (1995)
   PUBMED   7806281
REFERENCE   7  (bases 1 to 2798)
  AUTHORS   Gunther,E. and Walter,L.
  TITLE     Genetic aspects of the hsp70 multigene family in vertebrates
  JOURNAL   Experientia 50 (11-12), 987-1001 (1994)
   PUBMED   7988674
  REMARK    Review article
REFERENCE   8  (bases 1 to 2798)
  AUTHORS   Yoshino,M., Sagai,T., Lindahl,K.F., Toyoda,Y., Shirayoshi,Y.,
            Matsumoto,K., Sugaya,K., Ikemura,T., Moriwaki,K. and Shiroishi,T.
  TITLE     Recombination in the class III region of the mouse major
            histocompatibility complex
  JOURNAL   Immunogenetics 40 (4), 280-286 (1994)
   PUBMED   7916002
REFERENCE   9  (bases 1 to 2798)
  AUTHORS   Kothary,R., Perry,M.D., Moran,L.A. and Rossant,J.
  TITLE     Cell-lineage-specific expression of the mouse hsp68 gene during
            embryogenesis
  JOURNAL   Dev Biol 121 (2), 342-348 (1987)
   PUBMED   3582732
REFERENCE   10 (bases 1 to 2798)
  AUTHORS   Lowe,D.G. and Moran,L.A.
  TITLE     Molecular cloning and analysis of DNA complementary to three mouse
            Mr = 68,000 heat shock protein mRNAs
  JOURNAL   J Biol Chem 261 (5), 2102-2112 (1986)
   PUBMED   2868009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087117.9.
            
            On Jan 31, 2007 this sequence version replaced NM_010479.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK132331.1, AK171820.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2798              AC087117.9         77976-80773         c
FEATURES             Location/Qualifiers
     source          1..2798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.51 cM"
     gene            1..2798
                     /gene="Hspa1a"
                     /gene_synonym="hsp68; Hsp70-3; Hsp70.3; hsp70A1; Hsp72"
                     /note="heat shock protein 1A"
                     /db_xref="GeneID:193740"
                     /db_xref="MGI:MGI:96244"
     exon            1..2798
                     /gene="Hspa1a"
                     /gene_synonym="hsp68; Hsp70-3; Hsp70.3; hsp70A1; Hsp72"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..2157
                     /gene="Hspa1a"
                     /gene_synonym="hsp68; Hsp70-3; Hsp70.3; hsp70A1; Hsp72"
                     /note="68 kDa heat shock protein; heat shock protein, 70
                     kDa 3; heat shock 70kDa protein 1A; inducible heat shock
                     protein 70; heat shock 70 kDa protein 3"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 1A"
                     /protein_id="NP_034609.2"
                     /db_xref="CCDS:CCDS50080.1"
                     /db_xref="GeneID:193740"
                     /db_xref="MGI:MGI:96244"
                     /translation="MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAF
                     TDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPK
                     VQVNYKGESRSFFPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKD
                     AGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFE
                     VKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSS
                     STQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDL
                     VLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLL
                     LLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMT
                     RDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKG
                     RLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEAD
                     KKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGA
                     QAPKGASGSGPTIEEVD"
     regulatory      2376..2381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspa1a"
                     /gene_synonym="hsp68; Hsp70-3; Hsp70.3; hsp70A1; Hsp72"
                     /note="hexamer: AATAAG"
     polyA_site      2401
                     /gene="Hspa1a"
                     /gene_synonym="hsp68; Hsp70-3; Hsp70.3; hsp70A1; Hsp72"
     regulatory      2775..2780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspa1a"
                     /gene_synonym="hsp68; Hsp70-3; Hsp70.3; hsp70A1; Hsp72"
                     /note="hexamer: AATAAA"
     polyA_site      2798
                     /gene="Hspa1a"
                     /gene_synonym="hsp68; Hsp70-3; Hsp70.3; hsp70A1; Hsp72"
                     /note="major polyA site"
ORIGIN      
        1 accagacgct gacagctact cagaaccaaa tctggttcca tccagagaca agcgaagaca
       61 agagaagcag agcgagcggc gcgttcccga tcctcggcca ggaccagcct tccccagagc
      121 atccctgccg cggagcgcaa ccttcccagg agcatccctg ccgcggagcg caactttccc
      181 cggagcatcc acgccgcgga gcgcagcctt ccagaagcag agcgcggcgc catggccaag
      241 aacacggcga tcggcatcga cctgggcacc acctactcgt gcgtgggcgt gttccagcac
      301 ggcaaggtgg agatcatcgc caacgaccag ggcaaccgca cgacccccag ctacgtggcc
      361 ttcaccgaca ccgagcgcct catcggagac gccgccaaga accaggtggc gctgaacccg
      421 cagaacaccg tgttcgacgc gaagcggctg atcggccgca agttcggcga tgcggtggtg
      481 cagtccgaca tgaagcactg gcccttccag gtggtgaacg acggcgacaa gcccaaggtg
      541 caggtgaact acaagggcga gagccggtcg ttcttcccgg aggagatctc gtccatggtg
      601 ctgacgaaga tgaaggagat cgctgaggcg tacctgggcc acccggtgac caacgcggtg
      661 atcacggtgc ccgcctactt caacgactct cagcggcagg ccaccaagga cgcgggcgtg
      721 atcgccggtc taaacgtgct gcggatcatc aacgagccca cggcggccgc catcgcctac
      781 gggctggacc ggaccggcaa gggcgagcgc aacgtgctca tcttcgacct ggggggcggc
      841 acgttcgacg tgtccatcct gacgatcgac gacggcatct tcgaggtgaa ggccacggcg
      901 ggcgacacgc acctgggagg ggaggacttc gacaaccggc tggtgagcca cttcgtggag
      961 gagttcaaga ggaagcacaa gaaggacatc agccagaaca agcgcgcggt gcggcggctg
     1021 cgcactgcgt gtgagagggc caagaggacg ctgtcgtcca gcacccaggc cagcctggag
     1081 atcgactctc tgttcgaggg catcgacttc tacacatcca tcacgcgggc gcggttcgaa
     1141 gagctgtgct cagacctgtt ccgcggcacg ctggagcccg tggagaaggc cctgcgcgac
     1201 gccaagatgg acaaggcgca gatccacgac ctggtgctgg tgggcggctc gacgcgcatc
     1261 cccaaggtgc agaagctgct gcaggacttc ttcaacgggc gcgacctgaa caagagcatc
     1321 aacccggacg aggcggtggc ctacggggcg gcggtgcagg cggccatcct gatgggggac
     1381 aagtcggaga acgtgcagga cctgctgctg ctggacgtgg cgccgctgtc gctgggcctg
     1441 gagactgcgg gcggcgtgat gacggcgctc atcaagcgca actccaccat ccccaccaag
     1501 cagacgcaga ccttcaccac ctactcggac aaccagcccg gggtgctgat ccaggtgtac
     1561 gagggcgaga gggccatgac gcgcgacaac aacctgctgg ggcgcttcga actgagcggc
     1621 atcccgccgg cgcccagggg cgtgccacag atcgaggtga ccttcgacat cgacgccaac
     1681 ggcatcctga acgtcacggc caccgacaag agcaccggca aggccaacaa gatcaccatc
     1741 accaacgaca agggccgcct gagcaaggag gagatcgagc gcatggtgca ggaggccgag
     1801 cgctacaagg ccgaggacga ggtgcagcgc gacagggtgg ccgccaagaa cgcgctcgaa
     1861 tcctatgcct tcaacatgaa gagcgccgtg gaggacgagg gtctcaaggg caagctcagc
     1921 gaggctgaca agaagaaggt gctggacaag tgccaggagg tcatctcctg gctggactcc
     1981 aacacgctgg ccgacaagga ggagttcgtg cacaagcggg aggagctgga gcgggtgtgc
     2041 agccccatca tcagtgggct gtaccagggt gcgggtgctc ctggggctgg gggcttcggg
     2101 gcccaggcgc ccaagggagc ctctggctca ggacccacca tcgaggaggt ggattagagg
     2161 cctctgctgg ctctcccggt gctggctagg agacagatat gtggccttga ggactgtcat
     2221 tatttcaagt ttagtacttc actccttagt ttgtcctgca atcaagtcct agacttaggg
     2281 aaactaaact gtctttcagt tactttgtgt attgcacgtg ggctttatct tccctgttaa
     2341 ttaacactgc aagtgtgtct ttgtaaatat aaataaataa gtatatatat tcttcaattc
     2401 agcactgccc cgctgatgtg atttgttttg caggacagcc aaagctatgt agagagatat
     2461 tctgtatcag aatacacaaa gagacagaga tatgttatga aaacatcagg agactgttga
     2521 gttctttgtg tttggactct cccctgggcc acattgttga tacatgcttg tgtcgggtcc
     2581 ttcagaggcc agggctggat tactgacagc ggagactctg ctgcttctcc ttgcgtttat
     2641 aatcttgcat ggtggttgca ctgtaggact tgtttccagg ttggtgaact tggaggtgaa
     2701 gtgacagcac cagcatgtgt tcagttttta cacaaccatc ctgaactcgg gtcaattttt
     2761 accggtcatt tgaaaataaa cttcaaaatc acttgcca
//
