LOCUS       NP_034609                641 aa            linear   ROD 27-APR-2025
DEFINITION  heat shock 70 kDa protein 1A [Mus musculus].
ACCESSION   NP_034609 XP_207062 XP_359371 XP_489786
VERSION     NP_034609.2
DBSOURCE    REFSEQ: accession NM_010479.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 641)
  AUTHORS   Lang,B.J., Holton,K.M., Guerrero-Gimenez,M.E., Okusha,Y.,
            Magahis,P.T., Shi,A., Neguse,M., Venkatesh,S., Nhu,A.M.,
            Gestwicki,J.E. and Calderwood,S.K.
  TITLE     Heat shock protein 72 supports extracellular matrix production in
            metastatic mammary tumors
  JOURNAL   Cell Stress Chaperones 29 (3), 456-471 (2024)
   PUBMED   38703814
  REMARK    GeneRIF: Heat shock protein 72 supports extracellular matrix
            production in metastatic mammary tumors.
REFERENCE   2  (residues 1 to 641)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 641)
  AUTHORS   Uchida,A., Imaimatsu,K., Suzuki,H., Han,X., Ushioda,H., Uemura,M.,
            Imura-Kishi,K., Hiramatsu,R., Takase,H.M., Hirate,Y., Ogura,A.,
            Kanai-Azuma,M., Kudo,A. and Kanai,Y.
  TITLE     SOX17-positive rete testis epithelium is required for Sertoli valve
            formation and normal spermiogenesis in the male mouse
  JOURNAL   Nat Commun 13 (1), 7860 (2022)
   PUBMED   36543770
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 641)
  AUTHORS   Salazar-Petres,E., Pereira-Carvalho,D., Lopez-Tello,J. and
            Sferruzzi-Perri,A.N.
  TITLE     Placental structure, function, and mitochondrial phenotype relate
            to fetal size in each fetal sex in micedagger
  JOURNAL   Biol Reprod 106 (6), 1292-1311 (2022)
   PUBMED   35293971
REFERENCE   5  (residues 1 to 641)
  AUTHORS   Wilkerson,B.A., Zebroski,H.L., Finkbeiner,C.R., Chitsazan,A.D.,
            Beach,K.E., Sen,N., Zhang,R.C. and Bermingham-McDonogh,O.
  TITLE     Novel cell types and developmental lineages revealed by single-cell
            RNA-seq analysis of the mouse crista ampullaris
  JOURNAL   Elife 10, e60108 (2021)
   PUBMED   34003106
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 641)
  AUTHORS   Fijneman,R.J., Oomen,L.C., Snoek,M. and Demant,P.
  TITLE     A susceptibility gene for alveolar lung tumors in the mouse maps
            between Hsp70.3 and G7 within the H2 complex
  JOURNAL   Immunogenetics 41 (2-3), 106-109 (1995)
   PUBMED   7806281
REFERENCE   7  (residues 1 to 641)
  AUTHORS   Gunther,E. and Walter,L.
  TITLE     Genetic aspects of the hsp70 multigene family in vertebrates
  JOURNAL   Experientia 50 (11-12), 987-1001 (1994)
   PUBMED   7988674
  REMARK    Review article
REFERENCE   8  (residues 1 to 641)
  AUTHORS   Yoshino,M., Sagai,T., Lindahl,K.F., Toyoda,Y., Shirayoshi,Y.,
            Matsumoto,K., Sugaya,K., Ikemura,T., Moriwaki,K. and Shiroishi,T.
  TITLE     Recombination in the class III region of the mouse major
            histocompatibility complex
  JOURNAL   Immunogenetics 40 (4), 280-286 (1994)
   PUBMED   7916002
REFERENCE   9  (residues 1 to 641)
  AUTHORS   Kothary,R., Perry,M.D., Moran,L.A. and Rossant,J.
  TITLE     Cell-lineage-specific expression of the mouse hsp68 gene during
            embryogenesis
  JOURNAL   Dev Biol 121 (2), 342-348 (1987)
   PUBMED   3582732
REFERENCE   10 (residues 1 to 641)
  AUTHORS   Lowe,D.G. and Moran,L.A.
  TITLE     Molecular cloning and analysis of DNA complementary to three mouse
            Mr = 68,000 heat shock protein mRNAs
  JOURNAL   J Biol Chem 261 (5), 2102-2112 (1986)
   PUBMED   2868009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087117.9.
            
            On Jan 31, 2007 this sequence version replaced NP_034609.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK132331.1, AK171820.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.51 cM"
     Protein         1..641
                     /product="heat shock 70 kDa protein 1A"
                     /note="68 kDa heat shock protein; heat shock protein, 70
                     kDa 3; heat shock 70kDa protein 1A; inducible heat shock
                     protein 70; heat shock 70 kDa protein 3"
                     /calculated_mol_wt=69948
     Region          1..641
                     /region_name="PTZ00009"
                     /note="heat shock 70 kDa protein; Provisional"
                     /db_xref="CDD:240227"
     Region          2..386
                     /region_name="Nucleotide-binding domain (NBD).
                     /evidence=ECO:0000250|UniProtKB:P11142"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61696.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (Q61696.2)"
     Site            77
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (Q61696.2)"
     Site            108
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (Q61696.2)"
     Site            246
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (Q61696.2)"
     Site            348
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (Q61696.2)"
     Region          394..509
                     /region_name="Substrate-binding domain (SBD).
                     /evidence=ECO:0000250|UniProtKB:P11142"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61696.2)"
     Site            469
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (Q61696.2)"
     Site            561
                     /site_type="methylation"
                     /note="N6,N6,N6-trimethyllysine, by METTL21A, alternate.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8;
                     N6,N6-dimethyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (Q61696.2)"
     Site            604
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61696.2)"
     Region          618..641
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61696.2)"
     Site            631
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (Q61696.2)"
     Site            633
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (Q61696.2)"
     Site            636
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (Q61696.2)"
     CDS             1..641
                     /gene="Hspa1a"
                     /gene_synonym="hsp68; Hsp70-3; Hsp70.3; hsp70A1; Hsp72"
                     /coded_by="NM_010479.2:232..2157"
                     /db_xref="CCDS:CCDS50080.1"
                     /db_xref="GeneID:193740"
                     /db_xref="MGI:MGI:96244"
ORIGIN      
        1 makntaigid lgttyscvgv fqhgkveiia ndqgnrttps yvaftdterl igdaaknqva
       61 lnpqntvfda krligrkfgd avvqsdmkhw pfqvvndgdk pkvqvnykge srsffpeeis
      121 smvltkmkei aeaylghpvt navitvpayf ndsqrqatkd agviaglnvl riineptaaa
      181 iaygldrtgk gernvlifdl gggtfdvsil tiddgifevk atagdthlgg edfdnrlvsh
      241 fveefkrkhk kdisqnkrav rrlrtacera krtlssstqa sleidslfeg idfytsitra
      301 rfeelcsdlf rgtlepveka lrdakmdkaq ihdlvlvggs tripkvqkll qdffngrdln
      361 ksinpdeava ygaavqaail mgdksenvqd lllldvapls lgletaggvm talikrnsti
      421 ptkqtqtftt ysdnqpgvli qvyegeramt rdnnllgrfe lsgippaprg vpqievtfdi
      481 dangilnvta tdkstgkank ititndkgrl skeeiermvq eaerykaede vqrdrvaakn
      541 alesyafnmk savedeglkg klseadkkkv ldkcqevisw ldsntladke efvhkreele
      601 rvcspiisgl yqgagapgag gfgaqapkga sgsgptieev d
//
