LOCUS       NM_015765               1791 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus heat shock protein 14 (Hspa14), transcript variant 1,
            mRNA.
ACCESSION   NM_015765 XM_003084478 XM_003086217
VERSION     NM_015765.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1791)
  AUTHORS   Fang,H., Wu,Y., Huang,X., Wang,W., Ang,B., Cao,X. and Wan,T.
  TITLE     Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1
            (HSP70L1) to activate dendritic cells and induce Th1 response
  JOURNAL   J Biol Chem 286 (35), 30393-30400 (2011)
   PUBMED   21730052
  REMARK    GeneRIF: TLR4 is a key receptor mediating the interaction of
            Hsp70L1 with DCs and subsequently enhancing the induction of Th1
            immune response by Hsp70L1/antigen fusion protein
REFERENCE   3  (bases 1 to 1791)
  AUTHORS   Sferruzzi-Perri,A.N., Macpherson,A.M., Roberts,C.T. and
            Robertson,S.A.
  TITLE     Csf2 null mutation alters placental gene expression and trophoblast
            glycogen cell and giant cell abundance in mice
  JOURNAL   Biol Reprod 81 (1), 207-221 (2009)
   PUBMED   19228596
REFERENCE   4  (bases 1 to 1791)
  AUTHORS   Hudson,J.W., Chen,L., Fode,C., Binkert,C. and Dennis,J.W.
  TITLE     Sak kinase gene structure and transcriptional regulation
  JOURNAL   Gene 241 (1), 65-73 (2000)
   PUBMED   10607900
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY121986.1, U08215.1, BU505607.1 and BI734146.1.
            
            On or before Oct 12, 2011 this sequence version replaced
            XM_003084478.1, XM_003086217.1, NM_015765.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U08215.1, SRR1660817.301460.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                BY121986.1         145-213
            70-696              U08215.1           30-656
            697-1014            BU505607.1         348-665
            1015-1504           BI734146.1         118-607
            1505-1791           U08215.1           1471-1757
FEATURES             Location/Qualifiers
     source          1..1791
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 1.97 cM"
     gene            1..1791
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /note="heat shock protein 14"
                     /db_xref="GeneID:50497"
                     /db_xref="MGI:MGI:1354164"
     exon            1..181
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1654
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /note="isoform 1 is encoded by transcript variant 1; heat
                     shock protein 4; heat shock 70kDa protein 14; heat shock
                     70 kDa protein 14; heat shock protein, 70 kDa 4"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 14 isoform 1"
                     /protein_id="NP_056580.2"
                     /db_xref="CCDS:CCDS15653.1"
                     /db_xref="GeneID:50497"
                     /db_xref="MGI:MGI:1354164"
                     /translation="MAAIGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAIVAYSER
                     EQVVGLAAKQSRIRHVSSTVVKVKQILGRSSADPQAQKYISESKCLVIEKNGKLRYEI
                     DTGEETKLVNPEDVARLIFSKMKETAHSVLGSDANDVVVTVPFDFGEKQKSALGEAAG
                     AAGFNVLRLIHEPSAALLAYGIGQDHPTGKSNVLVFKLGGTSLSLSVMEVNSGMYRVL
                     STNTSDNIGGAHFTDTLAQYLASEFQRLFKHDVRGNARAMMKLMNSAEVAKHSLSTLG
                     SANCFVDSLYEGQDFDCNVSRARFELLCSPLFNKCTEAIRELLRQTGFTADDINKVVL
                     CGGSSRIPKLQQLIKDLFPAVDLLNSIPPDEVIPIGAAIEAGILVGKESTSGDDSVMI
                     ECSAKDILVKGVDESGADRFTVLFPSGTPLPARRQHTLQAPGRVSSVCLELYESEGKN
                     SAKEEAKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLQVTCTDQDTGKCEAITVEVA
                     S"
     exon            182..262
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..345
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..394
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..500
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..591
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..696
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..858
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1014
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1117
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1330
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1504
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1575
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1791
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1731..1736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
     polyA_site      1752
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /experiment="experimental evidence, no additional details
                     recorded"
     regulatory      1771..1776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspa14"
                     /gene_synonym="70kDa; Hsp70-4; HSP70L1; hsr.1; NST-1"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 agaccggacg cagtaggcgg gcgggaacgt gaagtctccg cagtgcctga tgggcttgtt
       61 ccgaggaagc tagctgaagc tgctgaaggg tccttcgttg agctgccgtg gtctccgccg
      121 ccttatggcg gcgatcggcg tgcacctggg ctgcacatca gcctgtgtgg ctgtctacaa
      181 ggatggccgg gccgatgtgg ttgcaaatga tgcaggggat agagtcacac cagccattgt
      241 tgcttactcg gaacgtgaac aggtggttgg actggcagca aaacaaagta gaataagaca
      301 tgtttcaagc acagtagtga aagtgaaaca gatccttggc agaagctctg cagatccaca
      361 agctcagaaa tacatctcag aaagtaaatg cttagtcatt gagaaaaatg ggaagttgcg
      421 gtatgaaata gatacaggag aagaaacaaa acttgttaat ccagaagatg ttgccagact
      481 gatattcagt aaaatgaaag aaacagcgca ttctgtcctg ggctcagatg caaatgacgt
      541 ggttgtcact gtcccatttg actttggaga aaagcagaag tctgctctgg gggaggcggc
      601 tggagctgct ggatttaacg tgctgcggct gatccatgag ccgtctgcag ctctccttgc
      661 ttatgggatt ggacaagacc accctaccgg gaagagcaat gttttggtgt ttaagcttgg
      721 aggaacgtcc ttatcgctca gtgtcatgga agttaacagt gggatgtatc gggtcctttc
      781 cacaaacacc agtgacaaca tagggggcgc acatttcaca gacaccttag cacagtacct
      841 ggcttcggag ttccagaggt tgttcaaaca tgatgtgaga ggaaatgccc gagccatgat
      901 gaaattgatg aacagcgctg aagtggccaa gcattctctg tcaaccttgg gaagtgccaa
      961 ctgctttgta gattccttgt atgaaggtca agactttgat tgcaatgtgt ccagagcaag
     1021 atttgagctg ctctgttctc cgctttttaa caaatgtaca gaagcaatcc gggagctctt
     1081 gcgccagact ggattcacag cagatgatat caacaaggtt gtgctgtgtg gtggatcttc
     1141 cagaatccca aagctgcagc agctgattaa agatctcttc ccagccgtgg acctcctcaa
     1201 ctctatccct ccagatgagg tcatccctat tggtgcagcc atagaagccg ggattcttgt
     1261 tgggaaagag agcacgtcag gagatgactc tgtcatgata gagtgttcag ccaaggatat
     1321 tttagttaag ggagtggatg agtcaggtgc cgacagattc acagtactgt ttccctctgg
     1381 gaccccgctg ccagcccgaa gacagcacac actgcaggcc cccgggaggg tgtcttccgt
     1441 ttgccttgaa ctctatgagt ctgaggggaa gaactctgct aaagaggagg ccaagtttgc
     1501 acaggttgta ctccaggact tagataaaaa agaaaatgga ttgcgtgata tattagctgt
     1561 tcttactatg aaaagggatg gatctttaca ggtgacgtgc acagaccaag acaccggcaa
     1621 gtgtgaggcc attactgttg aggttgcatc ctgactcttc agataaacca agatggtttt
     1681 tagaactata atatcaacat aatttggttt tgtgtataag tgttgtttat aataaactgc
     1741 tttttcaatg aaggtataag ctatgtttct attaaaatac aatttattac t
//
