LOCUS       NM_030201               4079 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus heat shock protein 70 family, member 13 (Hspa13),
            transcript variant 1, mRNA.
ACCESSION   NM_030201
VERSION     NM_030201.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4079)
  AUTHORS   Zhai,B., Liu,X., Xu,Y., Zhu,G., Zhou,S., He,Y., Wang,X., Su,W.,
            Han,G. and Wang,R.
  TITLE     Single-cell atlas of splenocytes reveals a critical role of a novel
            plasma cell-specific marker Hspa13 in antibody class-switching
            recombination and somatic hypermutation
  JOURNAL   Mol Immunol 141, 79-86 (2022)
   PUBMED   34837777
  REMARK    GeneRIF: Single-cell atlas of splenocytes reveals a critical role
            of a novel plasma cellspecific marker Hspa13 in antibody
            class-switching recombination and somatic hypermutation.
REFERENCE   2  (bases 1 to 4079)
  AUTHORS   He,Y., Xu,R., Zhai,B., Fang,Y., Hou,C., Xing,C., Xiao,H., Chen,G.,
            Wang,X., Ma,N., Han,G. and Wang,R.
  TITLE     Hspa13 Promotes Plasma Cell Production and Antibody Secretion
  JOURNAL   Front Immunol 11, 913 (2020)
   PUBMED   32547538
  REMARK    GeneRIF: Hspa13 Promotes Plasma Cell Production and Antibody
            Secretion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4079)
  AUTHORS   Grizenkova,J., Akhtar,S., Hummerich,H., Tomlinson,A., Asante,E.A.,
            Wenborn,A., Fizet,J., Poulter,M., Wiseman,F.K., Fisher,E.M.,
            Tybulewicz,V.L., Brandner,S., Collinge,J. and Lloyd,S.E.
  TITLE     Overexpression of the Hspa13 (Stch) gene reduces prion disease
            incubation time in mice
  JOURNAL   Proc Natl Acad Sci U S A 109 (34), 13722-13727 (2012)
   PUBMED   22869728
  REMARK    GeneRIF: Hspa13 (Stch) gene has a role in prion disease incubation
            time in mice
REFERENCE   4  (bases 1 to 4079)
  AUTHORS   Heimel,J.A., Hermans,J.M., Sommeijer,J.P. and Levelt,C.N.
  CONSRTM   Neuro-Bsik Mouse Phenomics consortium
  TITLE     Genetic control of experience-dependent plasticity in the visual
            cortex
  JOURNAL   Genes Brain Behav 7 (8), 915-923 (2008)
   PUBMED   18700840
REFERENCE   5  (bases 1 to 4079)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4079)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4079)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 4079)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 4079)
  AUTHORS   Moore,C.S., Lee,J.S., Birren,B., Stetten,G., Baxter,L.L. and
            Reeves,R.H.
  TITLE     Integration of cytogenetic with recombinational and physical maps
            of mouse chromosome 16
  JOURNAL   Genomics 59 (1), 1-5 (1999)
   PUBMED   10395793
REFERENCE   10 (bases 1 to 4079)
  AUTHORS   Reeves,R.H., Rue,E., Yu,J. and Kao,F.T.
  TITLE     Stch maps to mouse chromosome 16, extending the conserved synteny
            with human chromosome 21
  JOURNAL   Genomics 49 (1), 156-157 (1998)
   PUBMED   9570963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY133105.1, BC085181.1 and CO043820.1.
            
            On Apr 16, 2009 this sequence version replaced NM_030201.2.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.164222.1,
                                           SRR1660811.95268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY133105.1         2-41
            41-1620             BC085181.1         1-1580
            1621-4062           BC085181.1         1582-4023
            4063-4079           CO043820.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..4079
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 43.36 cM"
     gene            1..4079
                     /gene="Hspa13"
                     /gene_synonym="1600002I10Rik; B230217N24Rik; Stch"
                     /note="heat shock protein 70 family, member 13"
                     /db_xref="GeneID:110920"
                     /db_xref="MGI:MGI:1309463"
     exon            1..84
                     /gene="Hspa13"
                     /gene_synonym="1600002I10Rik; B230217N24Rik; Stch"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1475
                     /gene="Hspa13"
                     /gene_synonym="1600002I10Rik; B230217N24Rik; Stch"
                     /note="stress 70 protein chaperone, microsome-associated,
                     human homolog; heat shock 70 kDa protein 13; microsomal
                     stress-70 protein ATPase core; stress-70 protein chaperone
                     microsome-associated 60 kDa protein; stress 70 protein
                     chaperone, microsome-associated, 60kD human homolog; heat
                     shock protein 70kDa family, member 13"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 13 precursor"
                     /protein_id="NP_084477.1"
                     /db_xref="CCDS:CCDS28273.1"
                     /db_xref="GeneID:110920"
                     /db_xref="MGI:MGI:1309463"
                     /translation="MAGEMTILGSAVLTLLLAGYLAQQYLPLPTPKVIGIDLGTTYCS
                     VGVFFPGTGKVKVIPDENGHISIPSMVSFTDGDVYVGYESLELADSNPQNTIYDAKRF
                     IGKIFTPEELEAEVGRYPFKVLHRNGMAEFSVTSNETIIVSPEFVGSRLLLKLKEMAE
                     EYLGMPVANAVISVPAEFDLQQRNSTIQAANLAGLKILRVINEPTAAAMAYGLHKVDV
                     FYVLVIDLGGGTLDVSLLNKQGGMFLTRAMSGNNKLGGQDFNQRLLQHLYKEIYQTYG
                     FLPSRKEEIHRLRQAVEMVKLNLTIHQSAQVSVLLTVEGKDSKEPQNGDSELPKDQLT
                     PGDGHHVNRVFRPGLSESKSGKSQVLFETEVSRKLFDALNEDLFQKILVPIQQVLKEG
                     LLDKTEIDEVVLVGGSTRIPRIRQVIQEFFGKDPNTSVDPDLAVVTGVAIQAGIDGGS
                     WPLQVSALEIPNKHLQKTNFN"
     exon            85..425
                     /gene="Hspa13"
                     /gene_synonym="1600002I10Rik; B230217N24Rik; Stch"
                     /inference="alignment:Splign:2.1.0"
     exon            426..639
                     /gene="Hspa13"
                     /gene_synonym="1600002I10Rik; B230217N24Rik; Stch"
                     /inference="alignment:Splign:2.1.0"
     exon            640..807
                     /gene="Hspa13"
                     /gene_synonym="1600002I10Rik; B230217N24Rik; Stch"
                     /inference="alignment:Splign:2.1.0"
     exon            808..4066
                     /gene="Hspa13"
                     /gene_synonym="1600002I10Rik; B230217N24Rik; Stch"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4037..4042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hspa13"
                     /gene_synonym="1600002I10Rik; B230217N24Rik; Stch"
                     /note="hexamer: AATAAA"
     polyA_site      4062
                     /gene="Hspa13"
                     /gene_synonym="1600002I10Rik; B230217N24Rik; Stch"
                     /note="major polyA site"
ORIGIN      
        1 gactaggggg cggtgcctcc catcggtaca gtcatccttc tgcctgttcg gcgggactga
       61 tggccggaga gatgacgatc ttaggttcag ctgttttgac tctcctcttg gcgggctact
      121 tggcacaaca gtatttacca ttgcctacgc caaaagtgat tggcattgac ctgggtacca
      181 cctactgttc ggttggtgta ttttttcccg ggacaggaaa agtgaaggtg attccagatg
      241 aaaacgggca tatcagcatc cccagcatgg tgtccttcac ggacggtgat gtgtatgtgg
      301 gctatgagag cctagagctg gctgattcaa atcctcaaaa cacaatctat gatgccaaac
      361 ggttcatcgg gaagatcttc accccggagg agctggaggc tgaagttggc agatacccat
      421 ttaaggtttt acacagaaat gggatggctg agttttctgt gacaagtaat gaaaccatca
      481 tcgtttctcc agagtttgtc ggctctcgat tgctgctgaa gctaaaggag atggccgagg
      541 aatacctcgg catgccggtt gccaatgctg tcatttctgt gcctgcagaa ttcgacctac
      601 aacagagaaa ttcaacaatc caagctgcca accttgctgg gctgaagatc ttgagggtga
      661 taaatgagcc tacagcagca gcgatggcct atggtctcca caaggttgac gtgttctacg
      721 tgttggtcat agacttgggt ggaggaactc ttgatgtgtc gttactgaat aaacaaggag
      781 ggatgttcct aacacgagcg atgtctggaa acaacaaact tggaggacaa gacttcaatc
      841 agaggctgct tcagcattta tataaagaga tctatcaaac gtacggcttt ctcccttcca
      901 ggaaagagga aatccacaga ttaagacagg cggtggagat ggtcaagcta aacttgacaa
      961 ttcatcagtc tgcccaggta tcagttttac tcactgtgga ggggaaggac agcaaggaac
     1021 ctcagaatgg tgactctgaa ctgccaaaag accagctcac cccaggagat ggtcaccatg
     1081 tgaatagagt gtttagacct ggcctttctg aaagcaagag tggaaaaagt caggttttgt
     1141 ttgagacaga agtatcccgc aagctctttg atgccctcaa tgaagatctc tttcagaaaa
     1201 tactcgtacc cattcagcaa gtattaaaag aaggcctctt agacaagacg gaaattgacg
     1261 aggtggttct agttgggggt tctactcgta ttcctcggat ccgccaagtt attcaggagt
     1321 tctttggaaa ggacccgaat acatctgtag accctgacct ggcagtggtg acaggagtgg
     1381 ccatccaagc tgggattgat ggaggctcct ggcctctcca agttagtgct ttggaaattc
     1441 ccaataagca tttacagaaa accaacttca actgaactga gggagtgctg gtaactgacc
     1501 ctgtcttggc gtgttaagga tttccatgtg acgcctcctc cagaaaagga gtccatgaag
     1561 tcactcaaaa attcccaaaa ggacatttat acaggacaac tttacatagt gttttgtttt
     1621 agaatcgaat atgaccagat gagtcttgtt tgggtgtgca aaaaaaaaaa gctcagtatt
     1681 tctaaagtaa cagagttgag taaaactctc ctggattctg gaagtaggta gccatccgca
     1741 cttactagtc tggaaacttt aaatagtgcc aactatgagg cccaagttct tactgaattt
     1801 tattagtagg ggctgataat ttctttattt ggttttcaca tatagctctt aaggacttga
     1861 agaactgtta tgtcaggtat ttacactggc tgggagatag cagtattatt aaactgcata
     1921 gatagtattc accaactgcc atgtaatttg tactttcaaa aatccactat ctttttacat
     1981 attacatcct cctaatctac agattttaat atatttgaaa gaccagtttt tcttcccaaa
     2041 atagctaaag atttattcag atctctttct gccagatagt agaacatgcc ctgtttaaac
     2101 tgtagtcttt ttatcttcag ggcgtcattt tctgcttgta ttttcacacc tctgctttgt
     2161 aagaataaaa aagacagtag aaagttacca gttgcctttt caaagcgttg atgtcacaat
     2221 aaagctgtat tactctctcc atttgttttt gctatccaag accattgggt atttgtagca
     2281 gctgtttggt tttggttatg ttgtttcccc ttttcccagg atcaaaccta gaaatgcaag
     2341 actatagtca aactacttta gacatttagg caaggggctc acaagttcaa agcctgtctg
     2401 agctacccag gaagttctag accaatatag gcaacttagt gagatcctgt tgctgtctca
     2461 aaagctgaga gggagatagg gaggggagaa gagaagaagc aagcaagcca gatggccaca
     2521 agggccagtg aagaaaatac tctatgttga ctttgcgatg cccatgttat tggaagatat
     2581 atgtcattat atttgcttta atgaaagtat tcacatacaa gaattatatc ctggctatct
     2641 tgttctttta aagtatatcc tgtttatcag tgttgtaata actaaagaag agaactaaaa
     2701 ttttgaaaaa gatcaagcac ttcagcttcc caaagagtaa tgctggaagg tggtaggatt
     2761 tggttttgtt ttttgtttgt ttggttggtt ggtttggtat ttttgcagct ttataaaaaa
     2821 ttttttttgc ttagtagtga agttgcgatt aaattaacag tcatttccat gtaccaaagc
     2881 gcatgcaatt aggtagatag aaaaacataa aatgccgtgc tttgatttta gaactaatgg
     2941 agaaatgcca aagatgagcc cttcacagca ttgtgaaaat attcaagact gtgaatcttt
     3001 gattttcaga ttgaaaaaca tctaggaaca tgtttgaggc tacatgtact gcagtctcca
     3061 catgtacttg gaattctcac gttagccatt taggattata aacagcaaac ttgaatttct
     3121 cagatgtatg acaactcaag acatgaacaa aatcaatttg cagaatggag cagataaata
     3181 atactaaaat gggaagataa atgttttttt ttgaaaaaac aggatggtgg tgttggaggt
     3241 ggggctatgt agttagcatc ctcttcctta gtagttacaa tgttaaaacc atgaaggaaa
     3301 ttgtcttcaa tcaattgtta gagtcatgtg tacctaatcc tgacaccagt gtagtttatt
     3361 taaaaggtac aaatgaatcc tgaaaggggc catttgttaa aatctgagat catttttcat
     3421 aaaatttgct ttttagttgt acatttggct aaattttttt taagtatgta actttaaaaa
     3481 tactaagtaa tatgtaattt attttatatc aatgttttgg tactatgttt tcactcaaac
     3541 cacttatcag ataccactgt gtataatatg aattcaatat gacagttact gtatagaaca
     3601 gattgtgcct cttaaaaatg tgtgtacagg taattcatat tttgttgtaa atctatagca
     3661 gttttgcttt taaattgtgt actttatttt ccacccatga ctagcttgga gtatattttt
     3721 gatgtatata aatacaaaaa gagagagagc cgatgtgatg cttacagaca ttcactagca
     3781 agtgataaaa tttcagaagt gtcacatctt actgcattta ctgcatcccg tgtctcctgg
     3841 catttctgca gttttctgca tagttctcat ttagaagagc tagttcttat gtgaacagtt
     3901 tctttagaac tttgattaac aagctatggc ttgtaaccag tggagttaaa tgctgacttg
     3961 atccacaaag ttaatgaggc tgtgtacccc ccctccaact gtaatctttt cagttgacag
     4021 tacttcataa ttttctaata aaatctgtgt tattcttttg gacaaaaaaa aaaaaaaaa
//
