LOCUS       NM_175199               5733 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus heat shock protein 12A (Hspa12a), transcript variant
            2, mRNA.
ACCESSION   NM_175199
VERSION     NM_175199.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5733)
  AUTHORS   Yu,W., Kong,Q., Jiang,S., Li,Y., Wang,Z., Mao,Q., Zhang,X., Liu,Q.,
            Zhang,P., Li,Y., Li,C., Ding,Z. and Liu,L.
  TITLE     HSPA12A maintains aerobic glycolytic homeostasis and Histone3
            lactylation in cardiomyocytes to attenuate myocardial
            ischemia/reperfusion injury
  JOURNAL   JCI Insight 9 (7), e169125 (2024)
   PUBMED   38421727
  REMARK    GeneRIF: HSPA12A maintains aerobic glycolytic homeostasis and
            Histone3 lactylation in cardiomyocytes to attenuate myocardial
            ischemia/reperfusion injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5733)
  AUTHORS   Jia,Y., Yu,Y., Gao,C., Li,Y., Li,C., Ding,Z., Kong,Q. and Liu,L.
  TITLE     Roles of heat shock protein A12A in the development of diabetic
            cardiomyopathy
  JOURNAL   Cell Stress Chaperones 29 (2), 272-284 (2024)
   PUBMED   38485044
  REMARK    GeneRIF: Roles of heat shock protein A12A in the development of
            diabetic cardiomyopathy.
REFERENCE   3  (bases 1 to 5733)
  AUTHORS   Wang,J., Lu,T., Gui,Y., Zhang,X., Cao,X., Li,Y., Li,C., Liu,L. and
            Ding,Z.
  TITLE     HSPA12A controls cerebral lactate homeostasis to maintain
            hippocampal neurogenesis and mood stabilization
  JOURNAL   Transl Psychiatry 13 (1), 280 (2023)
   PUBMED   37580315
  REMARK    GeneRIF: HSPA12A controls cerebral lactate homeostasis to maintain
            hippocampal neurogenesis and mood stabilization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5733)
  AUTHORS   Du,S., Zhang,X., Jia,Y., Peng,P., Kong,Q., Jiang,S., Li,Y., Li,C.,
            Ding,Z. and Liu,L.
  TITLE     Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to
            attenuate liver ischemia/reperfusion injury via suppressing
            glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes
  JOURNAL   Theranostics 13 (11), 3856-3871 (2023)
   PUBMED   37441587
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5733)
  AUTHORS   Li,T., Wu,J., Yu,W., Mao,Q., Cheng,H., Zhang,X., Li,Y., Li,C.,
            Ding,Z. and Liu,L.
  TITLE     HSPA12A Stimulates p38/ERK-AP-1 Signaling to Promote Angiogenesis
            and Is Required for Functional Recovery Postmyocardial Infarction
  JOURNAL   Oxid Med Cell Longev 2022, 2333848 (2022)
   PUBMED   35783189
  REMARK    GeneRIF: HSPA12A Stimulates p38/ERK-AP-1 Signaling to Promote
            Angiogenesis and Is Required for Functional Recovery Postmyocardial
            Infarction.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5733)
  AUTHORS   Mao,Y., Kong,Q., Li,R., Zhang,X., Gui,Y., Li,Y., Li,C., Zhao,Y.,
            Liu,L. and Ding,Z.
  TITLE     Heat shock protein A12A encodes a novel prosurvival pathway during
            ischaemic stroke
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (5 Pt A), 1862-1872 (2018)
   PUBMED   29530582
  REMARK    GeneRIF: findings suggest that HSPA12A expression encodes a
            critical novel prosurvival pathway during ischaemic stroke.
REFERENCE   7  (bases 1 to 5733)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 5733)
  AUTHORS   Chiellini,C., Costa,M., Novelli,S.E., Amri,E.Z., Benzi,L.,
            Bertacca,A., Cohen,P., Del Prato,S., Friedman,J.M. and Maffei,M.
  TITLE     Identification of cathepsin K as a novel marker of adiposity in
            white adipose tissue
  JOURNAL   J Cell Physiol 195 (2), 309-321 (2003)
   PUBMED   12652657
REFERENCE   9  (bases 1 to 5733)
  AUTHORS   Han,Z., Truong,Q.A., Park,S. and Breslow,J.L.
  TITLE     Two Hsp70 family members expressed in atherosclerotic lesions
  JOURNAL   Proc Natl Acad Sci U S A 100 (3), 1256-1261 (2003)
   PUBMED   12552099
  REMARK    GeneRIF: HSPA12A and HSPA12B may play roles in genetic
            susceptibility to atherosclerosis
REFERENCE   10 (bases 1 to 5733)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141925.1.
            
            On Apr 6, 2007 this sequence version replaced NM_175199.2.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon and uses an alternate start codon, compared to
            variant 1. It encodes isoform 2, which has a shorter and distinct
            N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141925.1, SRR1660815.75441.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5733              AK141925.1         2-5734
FEATURES             Location/Qualifiers
     source          1..5733
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 54.51 cM"
     gene            1..5733
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /note="heat shock protein 12A"
                     /db_xref="GeneID:73442"
                     /db_xref="MGI:MGI:1920692"
     exon            1..138
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2123
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /note="isoform 2 is encoded by transcript variant 2; heat
                     shock 70kDa protein 12A; heat shock 70 kDa protein 12A"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 12A isoform 2"
                     /protein_id="NP_780408.1"
                     /db_xref="CCDS:CCDS38032.1"
                     /db_xref="GeneID:73442"
                     /db_xref="MGI:MGI:1920692"
                     /translation="MADKEAGGGDAGPRETAPTSTYSSPARSLGDTGITPLSPSHILN
                     DADPVSEQQTFLVVVAIDFGTTSSGYAYSFTKEPECIHVMRRWEGGDPGVSNQKTPTT
                     ILLTPERKFHSFGYAARDFYHDLDPSEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANG
                     KKVKALEIFAYALQYFKEQALKELSDQAGSDFENSDVRWVITVPAIWKQPAKQFMREA
                     AYQAGLASPENSEQLIIALEPEAASIYCRKLRLHQMIELSSKAVVNGYSASDTVGAGF
                     AQAKEHVRRNRQSRTFLVENVIGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGH
                     LKELYKATGGPYGSLGVDYEFEKLLCKIFGEDFIEQFKIKRPAAWVDLMIAFESRKRA
                     AAPDRTNPLNITLPFSFIDYYKKFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNA
                     LFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGGFAEAPLLQQAVQTAFGDKCRIIIPQ
                     DVGLTILKGAVLFGLDPAVIKVRRSPLTYGVGVLNRYVEGKHPPEKLLVKDGTRWCTD
                     VFDKFISADQSVALGELVKRSYTPAKPSQLVIIINIYSSEHDNVSFITDPGVKKCGTL
                     RLDLTGSGGTAVPARREIQTIMQFGDTEIKATAVDITTSKSVKVGIDFLNY"
     exon            139..224
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     exon            225..349
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     exon            350..536
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     exon            537..641
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     exon            642..758
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     exon            759..930
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1017
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1122
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1381
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1485
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..5733
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5733
                     /gene="Hspa12a"
                     /gene_synonym="1700063D12Rik; D5Mgi40; Gm19925; mKIAA0417"
                     /note="putative"
ORIGIN      
        1 agagtggtgc tcccgctgtc cagaggctca gacctagctc gggagcctaa gatttagcac
       61 cggaggctcc tttcccgggc tgaggctgca ggaccatggc ggacaaggaa gctggcggtg
      121 gagacgccgg gccccgagaa acagccccca catctacata ttcctctccg gccaggagtc
      181 tcggggacac aggaataaca cctctgtccc cttcccatat cttgaacgat gctgaccccg
      241 tctctgagca gcagaccttt ctcgtggtgg tggccatcga ctttgggacc acgtccagtg
      301 gctatgccta cagctttacc aaggagccag aatgtatcca cgtgatgcgg agatgggaag
      361 gaggtgaccc tggtgtttcc aaccagaaga ccccgaccac catcttgctg acaccagaga
      421 ggaagttcca cagctttggg tacgctgcca gggacttcta ccatgacctg gaccccagtg
      481 aggccaagca atggctgtac ttggagaagt tcaagatgaa actccacacc acaggggacc
      541 tcaccatgga cacagactta acagcagcaa atggcaagaa ggtcaaagcc ctcgagatct
      601 tcgcttacgc cctgcagtac ttcaaggagc aggctctgaa ggaactgagt gaccaggcag
      661 ggtcggactt tgagaactct gacgtcagat gggtcatcac agtgcctgcc atctggaagc
      721 aaccagccaa gcagttcatg agagaagctg cctaccaggc aggcctggcc tcccccgaga
      781 actcggagca gctcatcatt gccctggagc ccgaggccgc ctccatctac tgccggaagc
      841 ttcggctgca ccagatgatt gagctcagca gcaaggcggt ggtcaatggg tacagtgcca
      901 gtgacacagt aggagcgggg tttgcacagg ctaaggaaca tgttcgacgt aaccggcaga
      961 gtcggacctt tttggtggag aatgtcatag gagaaatctg gtctgagctg gaggaagggg
     1021 acaagtacgt ggttgttgac agtggcggag gcacagtaga cctgaccgtc catcagatac
     1081 ggttaccaga ggggcacctc aaggagctgt acaaagcaac aggtggaccg tacggatccc
     1141 tgggagtgga ttatgaattt gaaaaactcc tttgtaaaat atttggagag gattttatcg
     1201 aacagttcaa gatcaaacgc ccggcagcct gggttgacct aatgattgcc tttgagtctc
     1261 gcaaaagagc tgctgcacca gatcgaacca atcccctgaa catcactctg cccttctcct
     1321 tcattgacta ctacaagaag ttccggggcc acagcgtgga gcatgcattg aggaagagca
     1381 atgtggactt tgtgaagtgg tcctcccagg gcatgctgag gatgagccca gatgccatga
     1441 acgccctctt caagccgacc atcgacagca tcatcgagca cctccgggac ctgtttcaga
     1501 agccagaggt atccacggtc aagttcctct ttctggtggg tggctttgca gaggcgcccc
     1561 ttttgcagca ggcagtgcag accgcttttg gcgacaaatg caggatcatc atcccgcagg
     1621 atgtgggcct caccatcctc aagggcgctg tcctcttcgg cctggaccct gccgttatca
     1681 aggtgcgccg gtcccctctc acctacggag taggtgtgct gaaccgctac gtggaaggga
     1741 agcaccctcc cgagaagcta ttggtcaagg acggcacacg ctggtgcacc gacgtcttcg
     1801 acaagttcat ctccgccgac cagtctgtgg ctctggggga gctggtcaag cgtagctaca
     1861 ccccggccaa gccttcccag ctggtcatca tcatcaacat ctacagctct gagcatgata
     1921 acgtcagctt catcactgac ccaggggtga aaaagtgtgg cacgctccgc ttggatctca
     1981 cggggagcgg cggcacagcg gttcccgccc gcagagagat ccagaccatc atgcagttcg
     2041 gggacactga gatcaaggcc acggccgtcg acataaccac ctcaaagagt gtcaaagtgg
     2101 ggatcgactt cttaaattac taatgtaact gtccctcctg gccaccagcc ccctgggact
     2161 catctgcatt tgctgacctc agcctgactg ttctgtccct gatcctgacc ctcgccactg
     2221 cccacctgaa tttcagtagg catgaaccag agtgaagatg aactaaggat tctttttgag
     2281 ggttcaccgg agcaagagaa acctcaaaaa tcaatatcac gacgtggaaa taggaagttt
     2341 gaggatcccc agagcagcca gccttcacgg gttcctgggt ggtcaaacag cccttagtga
     2401 ggactgggtg cagcctgctt ggaagagggc tctgaaaggg aaggcttagg acgcccactc
     2461 tgtgccgggg gcagggtagg gtgggggaaa cattcattgg aggtctttta aaatgatctt
     2521 ggatggctgt gaataggaaa taccagcttc ctgcagagtt aattccttct ctttatggtg
     2581 ggactcacag aggtgactca gtggcagctt acagtattct ttgtttttta agctggtggg
     2641 agaagaccgc ctacaccagg caccatgttc tcatataatt tagattccaa ggaggctcag
     2701 tgaaggctag ggcaacattg gctaactcaa ccaggatggg ggtcggggta agagtgtgga
     2761 tgccttgatt ttccagagca ggtcaaactt gctttggtgg aacctgtaca ctgaagagtt
     2821 agtgaggtac cccaaattac agcagtaccc ccttctctgg agagtataca ttctgagact
     2881 cctgagtgga tgaccaaatg ggtagatagt tccaaacctt atctatacac tatgtttttt
     2941 ctacatatac atacctagga caaagttcaa tttaataaag tagtaagaga ttagcagtag
     3001 tgactaatga caaattagga cagtgatgaa aacactttga taaaatgtat acgaatttgg
     3061 tctatctcag tatatctgat tactacacaa caccgctgtg catttttgga ccccagttaa
     3121 ttgaaaaccc agtaaatgaa aacccagatc agaaagtgat tctcagaaca atgaagcgtg
     3181 agttcagaga tcatgcatga ttctaggtga ccttagcaga aatttaattg gagaaaatag
     3241 agtttcagtt tactctgttt atatctaaaa attcaaaaca gccttgccaa ccatgcacat
     3301 tttcagttaa ccctttcctt ccccctcttc ttaatcccac cataaggaaa tattaaagga
     3361 ggttctattc catgaaatgt ctccatcaaa cctgcagctt ttcacattca cctaaaagca
     3421 gtacgtaaac ctagacccgt gaaggcaggc ctgtggctct ccagcctcag aatcgctggt
     3481 gcttgtcagg agcagggtcc tgaacctaat cccttccaga ctctgggtct gcagtcgtag
     3541 tgttggaatg tgagaattcc ctccaagctg aagtgaccac agaccacagt gtgtggcctt
     3601 aacaatccct gtcagatttc cctcagggaa gagtgcctgt acttacactc tgctctctag
     3661 gtaagagggt tggaggtcca cctgccctcg gaggctgttg cccttttaac ccccacagga
     3721 aggatcagag aaggaaaaaa gacagcagga gaggaaccac gaaaaagaag cctcccaagg
     3781 ccaggttctg tgttcctcct cctgtgcaag gctagacttg ccaacattca acattcaaga
     3841 gccaaatgag ggtaaagaat caagaatctg actcatagtc cttcttatct cttcagaact
     3901 ctctttctta tctgctggaa ttcatcctga tttaaaacac tggaagcatg cataatgaat
     3961 ggatggacag gcgaatgaat ggatggacag acggacagac agacggatgg atgggtggat
     4021 ggatggacag atacagaatg agggaaggga cttcaaatgc aagttggatt tgtgaaccat
     4081 catcatagcc aatatgcaga tttttaaaaa gcattttgaa tttcaaccta ttgtcttctt
     4141 ttccacaccg cttgccgcag aactccctgc cagaatgtga aaaaaaaaaa tgctatcaaa
     4201 ccacagaaca agcgaatggg aaccccaaac tggacggcag ggtctcaaat ccagacctca
     4261 ggatgcctgc tttctaggac tcctgctaac cctgcttcag aagctcatgg gtgtttccag
     4321 ccacagtcct caaatagact ttcgattttg ttataatgga tataatttta tgtacataga
     4381 acgcgagaat cttgtataaa atctttattt ctacttgtgc ttgtttgaaa gggaaaatac
     4441 tcgcaatttt ggttaataac gctgctgcct gtaagctcca cagcttcatt tcttaactgt
     4501 cctcactggt tgctgtctgt gctgttaccc cacagtggac gatgcatgcg agactgagca
     4561 atagacagag gtgccttggg tcagaatact ctgatcacac agactaaccc agatgacagc
     4621 ttcatcagac ccctccacac ctgcacaccc ctacccaaag ctgaacggtc tgcataaaga
     4681 gtaatgtagc aattctcccg tctagacttt gagagctgaa cgtactggtt ctggaagcga
     4741 tgcctaccaa aacgctttgt gtctggcaga gtggcgtgct tcatgatcaa aggaaccaag
     4801 tactccatgg gccaaggttt ccgttgggtc gaatgagtgg gagcaatgta ctcaagccct
     4861 tattgtcctg gctaacaaag cactccttac cgtatgtctg cctatctcct tgcctcctat
     4921 gttgcttaag cgagctgata gaaatctgca ctgttagcaa actgatgatg gggaaagggt
     4981 gtgatttcac tggacttcct ttggacccag agatgcagtc ccagtagcca aactctttta
     5041 gtataaagat ctccaatcta tccctaccct gactgaaata atcctactag gaacactgga
     5101 agagtacacc tggaacacat tccccagtct tagaaagttc cagaaggtct gtggtcttga
     5161 ccgattgtcc tttgcatagg ttatctggtc acttaactaa cctttccagg acacagcagg
     5221 cattcgtaaa tgcagagtga caggcaggag ggaagaggag gtgctacaga agaggttcta
     5281 gggagccatg gctgagtcca ggttacagag cctgccccgc ccttagaatg ttacttagac
     5341 caagtttagc ttttagagtc caggtctggt taattgccag ggtagcaaag aattgcatgc
     5401 accaatataa acaggagtca aaaatgcatt attaatcgaa gatgaacttc acattgtagt
     5461 gacgtaatag ttgtgattag gctgcgcagt acgtatgccg gggaatggct taagtggatg
     5521 gctagtataa aagttgatgg ccataatatc tcttaacacc tctcatctgc ttgcaatatg
     5581 gaacaatatc ctaagatctc aaccactggg aggcttgttc actacaagat agatccaaac
     5641 gtcacagaat tctgcagcag ttcacaacta gacagcattg tgtctgcaaa ctcttgtctt
     5701 cacagattct aataaagtaa acctctcaat ttc
//
