LOCUS       NM_011631               2759 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus heat shock protein 90, beta (Grp94), member 1
            (Hsp90b1), mRNA.
ACCESSION   NM_011631
VERSION     NM_011631.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Kim,D.S., Song,L., Gou,W., Kim,J., Liu,B., Wei,H.,
            Muise-Helmericks,R.C., Li,Z. and Wang,H.
  TITLE     GRP94 is an IGF-1R chaperone and regulates beta cell death in
            diabetes
  JOURNAL   Cell Death Dis 15 (5), 374 (2024)
   PUBMED   38811543
  REMARK    GeneRIF: GRP94 is an IGF-1R chaperone and regulates beta cell death
            in diabetes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Xu,Y., Li,X., Cheng,F., Zhao,B., Fang,M., Li,Z. and Meng,S.
  TITLE     Heat shock protein gp96 drives natural killer cell maturation and
            anti-tumor immunity by counteracting Trim28 to stabilize Eomes
  JOURNAL   Nat Commun 15 (1), 1106 (2024)
   PUBMED   38321029
  REMARK    GeneRIF: Heat shock protein gp96 drives natural killer cell
            maturation and anti-tumor immunity by counteracting Trim28 to
            stabilize Eomes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Sun,S., Zhu,R., Zhu,M., Wang,Q., Li,N. and Yang,B.
  TITLE     Visualization of conformational transition of GRP94 in solution
  JOURNAL   Life Sci Alliance 7 (2), e202302051 (2023)
   PUBMED   37949474
  REMARK    GeneRIF: Visualization of conformational transition of GRP94 in
            solution.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Fu,J.L., Zheng,S.Y., Wang,Y., Hu,X.B., Xiao,Y., Wang,J.M.,
            Zhang,L., Wang,L., Nie,Q., Hou,M., Bai,Y.Y., Gan,Y.W., Liang,X.M.,
            Xie,L.L. and Li,D.W.
  TITLE     HSP90beta prevents aging-related cataract formation through
            regulation of the charged multivesicular body protein (CHMP4B) and
            p53
  JOURNAL   Proc Natl Acad Sci U S A 120 (31), e2221522120 (2023)
   PUBMED   37487085
  REMARK    GeneRIF: HSP90beta prevents aging-related cataract formation
            through regulation of the charged multivesicular body protein
            (CHMP4B) and p53.
REFERENCE   5  (bases 1 to 2759)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2759)
  AUTHORS   Kozak,C.A., Peyser,M., Krall,M., Mariano,T.M., Kumar,C.S.,
            Pestka,S. and Mock,B.A.
  TITLE     Molecular genetic markers spanning mouse chromosome 10
  JOURNAL   Genomics 8 (3), 519-524 (1990)
   PUBMED   1981053
REFERENCE   7  (bases 1 to 2759)
  AUTHORS   Kim,S.K., Kim,Y.K. and Lee,A.S.
  TITLE     Expression of the glucose-regulated proteins (GRP94 and GRP78) in
            differentiated and undifferentiated mouse embryonic cells and the
            use of the GRP78 promoter as an expression system in embryonic
            cells
  JOURNAL   Differentiation 42 (3), 153-159 (1990)
   PUBMED   1692794
REFERENCE   8  (bases 1 to 2759)
  AUTHORS   Koyasu,S., Nishida,E., Miyata,Y., Sakai,H. and Yahara,I.
  TITLE     HSP100, a 100-kDa heat shock protein, is a
            Ca2+-calmodulin-regulated actin-binding protein
  JOURNAL   J Biol Chem 264 (25), 15083-15087 (1989)
   PUBMED   2768254
REFERENCE   9  (bases 1 to 2759)
  AUTHORS   Chang,S.C., Erwin,A.E. and Lee,A.S.
  TITLE     Glucose-regulated protein (GRP94 and GRP78) genes share common
            regulatory domains and are coordinately regulated by common
            trans-acting factors
  JOURNAL   Mol Cell Biol 9 (5), 2153-2162 (1989)
   PUBMED   2546060
REFERENCE   10 (bases 1 to 2759)
  AUTHORS   Srivastava,P.K., Chen,Y.T. and Old,L.J.
  TITLE     5'-structural analysis of genes encoding polymorphic antigens of
            chemically induced tumors
  JOURNAL   Proc Natl Acad Sci U S A 84 (11), 3807-3811 (1987)
   PUBMED   2438686
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J03297.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03297.1, BC011439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.05 cM"
     gene            1..2759
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /note="heat shock protein 90, beta (Grp94), member 1"
                     /db_xref="GeneID:22027"
                     /db_xref="MGI:MGI:98817"
     exon            1..138
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2498
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /note="94 kDa glucose-regulated protein; polymorphic tumor
                     rejection antigen 1; endoplasmic reticulum resident
                     protein 99; tumor rejection antigen gp96; heat shock
                     protein 90 kDa beta member 1; tumor rejection antigen
                     (gp96) 1; transforming growth factor alpha regulated gene
                     2"
                     /codon_start=1
                     /product="endoplasmin precursor"
                     /protein_id="NP_035761.1"
                     /db_xref="CCDS:CCDS36019.1"
                     /db_xref="GeneID:22027"
                     /db_xref="MGI:MGI:98817"
                     /translation="MRVLWVLGLCCVLLTFGFVRADDEVDVDGTVEEDLGKSREGSRT
                     DDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLR
                     ELISNASDALDKIRLISLTDENALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELV
                     KNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNND
                     TQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVRKYSQFIN
                     FPIYVWSSKTETVEEPLEEDEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWE
                     LMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTS
                     APRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET
                     LQQHKLLKVIRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAK
                     LLRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVI
                     YLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREATEKEFEPLLNWMKD
                     KALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQK
                     KTFEINPRHPLIRDMLRRIKEDEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIE
                     RMLRLSLNIDPEAQVEEEPEEEPEDTSEDAEDSEQDEGEEMDAGTEEEEEETEKESTE
                     KDEL"
     exon            139..241
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..383
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..500
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..832
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..944
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1064
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1181
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1319
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1397
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1463
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1733
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1979
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2116
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2195
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2351
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2471
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2759
                     /gene="Hsp90b1"
                     /gene_synonym="endoplasmin; ERp99; gp96; GRP94; TA-3;
                     Targ2; Tra-1; Tra1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggaggtgtg aggagcttag actcgggatt gggggggtgg aggcggctcc tgagaccgaa
       61 aaggacttgc gactcgccgg ccacgcacca tgagggtcct gtgggtgttg ggcctctgct
      121 gtgtcctgct gaccttcggg ttcgtcagag ctgatgatga agtcgacgtg gatggcacag
      181 tggaagagga cctgggtaaa agccgagaag gctcaaggac agatgatgaa gttgtgcaga
      241 gagaggaaga agctattcag ttggatgggt taaacgcatc acagataaga gaacttagag
      301 aaaaatctga aaagttcgcc ttccaagctg aagtgaacag gatgatgaaa cttatcatca
      361 attctttgta taaaaataaa gagattttcc tgagagaact gatttcaaat gcttctgatg
      421 ctttagacaa gataaggctc atctccctaa ctgatgaaaa tgcactcgct ggaaatgagg
      481 agttaacggt caagattaag tgtgacaaag agaaaaacct gctgcatgtc acagacacgg
      541 gtgtaggaat gactagagag gagttggtta aaaatctcgg caccatagcc aaatctggaa
      601 caagcgagtt tttaaacaaa atgacagaag ctcaagaaga tggtcagtca acctctgaac
      661 tgattggcca gtttggtgtc ggtttttatt ctgccttcct tgtagcagat aaggtcattg
      721 tcacatcgaa acacaacaat gatacccagc acatctggga atcagactcc aatgaattct
      781 ctgtaattgc tgacccaaga ggaaacacac taggtcgtgg aacaacaatt actcttgtct
      841 taaaagaaga agcatctgat taccttgaat tggacacaat taaaaatctt gtcaggaagt
      901 actctcagtt catcaacttt cccatctacg tgtggagtag caagacagag actgttgagg
      961 agcccttgga agaagatgaa gcagcaaaag aagagaaaga agaatctgat gatgaagctg
     1021 cagtagagga ggaagaagaa gaaaagaaac caaaaactaa gaaagttgaa aaaactgtgt
     1081 gggattggga acttatgaat gatatcaaac caatatggca gagaccatcc aaagaagtag
     1141 aagaagacga atacaaagct ttctacaaat cattttcaaa ggaaagtgat gaccccatgg
     1201 cttatatcca cttcactgca gaaggggagg tcaccttcaa gtcgattttg tttgtaccca
     1261 catctgcacc tcgaggtctg tttgatgaat atggatctaa gaagagtgat tatattaagc
     1321 tgtatgtacg ccgcgtattc atcacagatg acttccatga tatgatgccc aaatacctta
     1381 attttgtcaa aggtgttgtg gattccgatg atctccccct caatgtttcc cgtgagactc
     1441 ttcagcaaca taaattgctc aaggtgatta ggaagaagct tgtccgaaaa actctggaca
     1501 tgatcaagaa gattgctgat gagaagtata acgacacttt ctggaaggag ttcggcacga
     1561 atatcaagct tggtgtgatt gaagaccact caaatcgaac acggcttgct aaacttctta
     1621 ggttccagtc ttctcaccat tcaactgaca ttactagttt agaccagtat gtggaaagaa
     1681 tgaaggaaaa acaggacaaa atctacttca tggctgggtc aagcagaaag gaggcggaat
     1741 cttctccatt tgttgagaga cttctgaaga agggctatga agtcatttat ctcacagagc
     1801 ctgtggatga atactgcatt caggctcttc ccgagtttga tgggaagagg tttcagaatg
     1861 ttgccaaaga aggggtgaag tttgatgaga gtgagaaaac taaagaaagt cgggaagcaa
     1921 cagagaagga gtttgaacct ctgctcaact ggatgaaaga taaggccctc aaggacaaga
     1981 tagaaaaggc tgtggtgtcg cagcgcctca cagagtctcc ctgtgctctt gtggccagtc
     2041 agtatggatg gtctggcaac atggagagga tcatgaaggc acaagcatac cagacgggca
     2101 aggacatctc tacaaattac tatgccagtc aaaagaaaac gttcgaaatc aatcctagac
     2161 acccactgat cagagacatg ttgcggcgga ttaaggaaga tgaagatgac aagacagtca
     2221 tggatcttgc tgtagttttg tttgaaacgg caacacttcg gtcaggatat cttctaccag
     2281 acaccaaggc gtatggagat agaatagaaa gaatgcttcg cctcagttta aacattgacc
     2341 ctgaagcaca ggtggaggaa gaaccagaag aagagcctga agacacctca gaagacgcag
     2401 aagactcaga gcaggatgag ggagaagaga tggatgcagg gacagaagaa gaagaggagg
     2461 aaacagaaaa ggaatctaca gagaaggatg aattgtaaat tatactctcg ctatgaatcc
     2521 cgtgtggaga gggaatgtga agttttgaag tcatttcttt tgagagactt gttttggatg
     2581 cttccccaag cctccttctc ccctgcactg taaaatgttg ggattatggg tcacaggaag
     2641 aagtggtttt tttagttgaa ttttttttaa cattcctcct gaatgtaaat ttgtactatt
     2701 taactgacta ttggtgtaaa atcttgtcat gtgtataaaa ataaaaaaag atcccaaat
//
