LOCUS       NM_008302               2507 bp    mRNA    linear   ROD 09-OCT-2024
DEFINITION  Mus musculus heat shock protein 90 alpha (cytosolic), class B
            member 1 (Hsp90ab1), mRNA.
ACCESSION   NM_008302
VERSION     NM_008302.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Liu,Y., Wang,X., Wang,J., Jin,Q., Cai,W., Pan,C., Nivar,J., Tao,Y.,
            Cao,H. and Li,J.
  TITLE     ClassIIb histone deacetylase participates in perioperative
            neurocognitive disorders in elderly mice via HSP90/GR signaling
            pathway
  JOURNAL   Exp Neurol 380, 114922 (2024)
   PUBMED   39142371
  REMARK    GeneRIF: ClassIIb histone deacetylase participates in perioperative
            neurocognitive disorders in elderly mice via HSP90/GR signaling
            pathway.
REFERENCE   2  (bases 1 to 2507)
  AUTHORS   Liu,Z., Bian,X., Li,L., Liu,L., Feng,C., Wang,Y., Ni,J., Li,S.,
            Lu,D., Li,Y., Ma,C., Yu,T., Xiao,X., Xue,N., Wang,Y., Zhang,C.,
            Ma,X., Gao,X., Fan,X., Liu,X. and Fan,G.
  TITLE     SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents
            Myocardial Fibrosis by Paracrine Signaling
  JOURNAL   Adv Sci (Weinh) 11 (34), e2400741 (2024)
   PUBMED   38992961
  REMARK    GeneRIF: SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes
            Prevents Myocardial Fibrosis by Paracrine Signaling.
REFERENCE   3  (bases 1 to 2507)
  AUTHORS   Borisova,E., Newman,A.G., Couce Iglesias,M., Dannenberg,R.,
            Schaub,T., Qin,B., Rusanova,A., Brockmann,M., Koch,J., Daniels,M.,
            Turko,P., Jahn,O., Kaplan,D.R., Rosario,M., Iwawaki,T.,
            Spahn,C.M.T., Rosenmund,C., Meierhofer,D., Kraushar,M.L.,
            Tarabykin,V. and Ambrozkiewicz,M.C.
  TITLE     Protein translation rate determines neocortical neuron fate
  JOURNAL   Nat Commun 15 (1), 4879 (2024)
   PUBMED   38849354
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2507)
  AUTHORS   Xing,Y., Li,P., Jia,Y., Zhang,K., Liu,M. and Jiang,J.
  TITLE     Dorsal root ganglion-derived exosomes deteriorate neuropathic pain
            by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis
  JOURNAL   Biol Res 57 (1), 28 (2024)
   PUBMED   38750549
  REMARK    GeneRIF: Dorsal root ganglion-derived exosomes deteriorate
            neuropathic pain by activating microglia via the
            microRNA-16-5p/HECTD1/HSP90 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2507)
  AUTHORS   Wang,B.Y., Liu,S.Y., Hao,K.M. and Qi,W.X.
  TITLE     [Age-dependent expression of HSP90 in the hippocampus of APP/PS1
            mice]
  JOURNAL   Sheng Li Xue Bao 76 (2), 257-265 (2024)
   PUBMED   38658375
  REMARK    GeneRIF: [Age-dependent expression of HSP90 in the hippocampus of
            APP/PS1 mice].
REFERENCE   6  (bases 1 to 2507)
  AUTHORS   Shaknovich,R., Shue,G. and Kohtz,D.S.
  TITLE     Conformational activation of a basic helix-loop-helix protein
            (MyoD1) by the C-terminal region of murine HSP90 (HSP84)
  JOURNAL   Mol Cell Biol 12 (11), 5059-5068 (1992)
   PUBMED   1406681
REFERENCE   7  (bases 1 to 2507)
  AUTHORS   Pongratz,I., Mason,G.G. and Poellinger,L.
  TITLE     Dual roles of the 90-kDa heat shock protein hsp90 in modulating
            functional activities of the dioxin receptor. Evidence that the
            dioxin receptor functionally belongs to a subclass of nuclear
            receptors which require hsp90 both for ligand binding activity and
            repression of intrinsic DNA binding activity
  JOURNAL   J Biol Chem 267 (19), 13728-13734 (1992)
   PUBMED   1320028
REFERENCE   8  (bases 1 to 2507)
  AUTHORS   Minami,Y., Kawasaki,H., Miyata,Y., Suzuki,K. and Yahara,I.
  TITLE     Analysis of native forms and isoform compositions of the mouse
            90-kDa heat shock protein, HSP90
  JOURNAL   J Biol Chem 266 (16), 10099-10103 (1991)
   PUBMED   2037568
REFERENCE   9  (bases 1 to 2507)
  AUTHORS   Moore,S.K., Rijli,F. and Appella,E.
  TITLE     Characterization of the mouse 84-kD heat shock protein gene family
  JOURNAL   DNA Cell Biol 9 (6), 387-400 (1990)
   PUBMED   1976316
REFERENCE   10 (bases 1 to 2507)
  AUTHORS   Moore,S.K., Kozak,C., Robinson,E.A., Ullrich,S.J. and Appella,E.
  TITLE     Cloning and nucleotide sequence of the murine hsp84 cDNA and
            chromosome assignment of related sequences
  JOURNAL   Gene 56 (1), 29-40 (1987)
   PUBMED   2445630
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC163677.2.
            
            On Nov 17, 2006 this sequence version replaced NM_008302.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF465639.1, BC088985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC163677.2         31238-31332
            96-242              AC163677.2         32588-32734
            243-449             AC163677.2         32880-33086
            450-609             AC163677.2         33322-33481
            610-743             AC163677.2         33700-33833
            744-1052            AC163677.2         33933-34241
            1053-1409           AC163677.2         34673-35029
            1410-1557           AC163677.2         35112-35259
            1558-1826           AC163677.2         35373-35641
            1827-2160           AC163677.2         35937-36270
            2161-2507           AC163677.2         36375-36721
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.59 cM"
     gene            1..2507
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /note="heat shock protein 90 alpha (cytosolic), class B
                     member 1"
                     /db_xref="GeneID:15516"
                     /db_xref="MGI:MGI:96247"
     exon            1..95
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2270
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /note="heat shock 90kDa protein 1, beta; heat shock
                     protein 1, beta; TSTA; HSP 84; heat shock 84 kDa;
                     tumor-specific transplantation 84 kDa antigen; heat shock
                     protein, 84 kDa 1; heat shock protein 90kDa alpha
                     (cytosolic), class B member 1; retinal degeneration slow
                     protein"
                     /codon_start=1
                     /product="heat shock protein HSP 90-beta"
                     /protein_id="NP_032328.2"
                     /db_xref="CCDS:CCDS28812.1"
                     /db_xref="GeneID:15516"
                     /db_xref="MGI:MGI:96247"
                     /translation="MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELI
                     SNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNL
                     GTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESS
                     AGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLE
                     KEREKEISDDEAEEEKGEKEEEDKEDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKY
                     IDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF
                     IPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISR
                     EMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR
                     LSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGF
                     EVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKL
                     MKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKK
                     HLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
                     MIKLGLGIDEDEVTAEEPSAAVPDEIPPLEGDEDASRMEEVD"
     exon            96..242
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            243..449
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            450..609
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            610..743
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1052
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1409
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1557
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1826
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2160
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2507
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2487..2492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /note="hexamer: AATAAA"
     polyA_site      2507
                     /gene="Hsp90ab1"
                     /gene_synonym="90kDa; Hsp84; Hsp84-1; Hsp90; Hspcb"
                     /note="major polyA site"
ORIGIN      
        1 gagtcacccc cgcgcagcct aggcttgccg tgcgagtcgg acttggtccg ggcccaccac
       61 cctgctctgt actactactc ggctttcccg tcaagatgcc tgaggaagtg caccatggag
      121 aggaggaggt ggagaccttt gcctttcagg cagaaattgc ccagctcatg tccctcatca
      181 tcaacacttt ctattcaaac aaggagattt tcctccgcga gttgatctct aatgcttcag
      241 atgccctgga caagattcga tatgagagcc tgacggaccc ttctaagttg gacagtggga
      301 aagagctgaa aattgacatc atccccaacc ctcaggagcg cacgctgact ttggtggaca
      361 caggcattgg catgaccaag gctgacctca ttaataacct gggaaccatt gctaagtctg
      421 gcacgaaggc gttcatggag gctctccagg ctggtgcaga catctccatg atcgggcagt
      481 ttggtgtcgg attctactcg gcctatctag ttgcagagaa agtggttgtg atcacgaagc
      541 acaatgatga tgagcagtat gcctgggagt cgtctgcggg tggctccttc accgtccggg
      601 cagaccatgg tgagcccatt ggccggggta ccaaagtgat ccttcacctc aaagaagacc
      661 agacagagta cttggaggag aggagggtca aggaagtggt gaagaaacat tcgcagttca
      721 taggctatcc catcaccctc tatttggaga aggaacggga gaaggagatc agtgatgatg
      781 aggcagagga agagaaaggt gagaaagagg aggaagataa ggaggatgag gagaagccta
      841 agattgaaga tgtgggatcc gatgaggaag atgacagcgg caaagacaag aaaaagaaaa
      901 caaagaagat caaagagaag tacattgacc aggaggagct gaacaagaca aagcctatct
      961 ggaccagaaa cccggatgac atcacgcagg aggagtatgg cgaattctat aagagcctca
     1021 ccaatgactg ggaggaccac ttggcagtca agcacttctc tgtagaaggt cagttggaat
     1081 tcagggcatt gctcttcatt ccccggcggg ctcccttcga cctttttgag aacaagaaga
     1141 agaagaacaa catcaaattg tatgtccgcc gtgtgttcat catggacagc tgtgacgagc
     1201 tgatacctga gtacctcaac tttatccgcg gtgtggttga ctccgaggac ctgcccctga
     1261 acatctcccg ggagatgctg cagcagagca agatcctgaa ggtcatccgc aagaacatcg
     1321 tcaagaagtg cctggagctc ttctccgagc tggctgagga caaggagaac tacaagaagt
     1381 tctatgaggc cttctccaaa aatttaaagc ttggaattca tgaagattcc actaaccgac
     1441 gccgcctctc tgagctcctt cgctatcaca cctctcagtc tggagatgag atgacctcct
     1501 tgtcagagta tgtgtctcgc atgaaggaga cccagaagtc catctactat atcactggtg
     1561 agagcaaaga gcaagtggcc aactctgcct ttgtggagcg agtgcggaag cggggcttcg
     1621 aggtggtgta tatgactgag cctattgacg agtactgcgt gcagcagctc aaggagtttg
     1681 atgggaagag cctggtctca gtgactaagg agggcctgga gctaccagag gacgaggaag
     1741 agaagaagaa aatggaggag agcaaggcaa agtttgagaa tctctgcaag ctcatgaagg
     1801 agatcttgga caagaaggtt gaaaaggtga caatctccaa taggcttgtg tcttcaccct
     1861 gctgcattgt gacaagcacc tatggctgga cagccaacat ggaacggatc atgaaggccc
     1921 aggcactgcg agacaactct acaatgggct acatgatggc caaaaaacac ctggagatca
     1981 accctgacca ccccatcgtg gagaccctgc ggcagaaggc tgaggcagac aaaaacgaca
     2041 aagctgtcaa ggacctggtg gtgctgctgt ttgaaactgc tctgctctcc tctggtttct
     2101 cacttgagga tccccaaacc cactccaacc gcatctaccg catgattaaa ctaggcctgg
     2161 gcatcgatga agatgaggtc actgcagagg agcccagtgc tgctgttcct gatgagatcc
     2221 cccctctgga aggcgatgag gatgcctcgc gcatggaaga ggtggattaa agcctcctgg
     2281 aagaagccct gccctctgta tagtatcccc gtggctcccc cagcagccct gacccacctg
     2341 gctctctgct catgtctaca agaatcttct atcctgtcct gtgccttaag gcaggaagat
     2401 cccctcccac agaatagcag ggttgggtgt tatgtattgt ggtttttttg tttgttttat
     2461 tttgttctaa aattaaaagt atgcaaaata aagaagatgc agtttta
//
