LOCUS       NM_010480               2850 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus heat shock protein 90, alpha (cytosolic), class A
            member 1 (Hsp90aa1), mRNA.
ACCESSION   NM_010480
VERSION     NM_010480.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2850)
  AUTHORS   Hu,S., Tang,Y., Li,X., Li,W., Zeng,Y., Jiang,M., Chen,R., Zheng,P.,
            Yang,L., Song,Z., Xie,D., Chen,Y. and Yuan,Y.
  TITLE     Hsp90aa1/JUN/Ccl2 regulatory axis mediates migration and
            differentiation of NSPCs, promoting the onset and progression of
            early post-ischemic stroke epilepsy
  JOURNAL   Neurobiol Dis 200, 106635 (2024)
   PUBMED   39128813
  REMARK    GeneRIF: Hsp90aa1/JUN/Ccl2 regulatory axis mediates migration and
            differentiation of NSPCs, promoting the onset and progression of
            early post-ischemic stroke epilepsy.
REFERENCE   2  (bases 1 to 2850)
  AUTHORS   Borisova,E., Newman,A.G., Couce Iglesias,M., Dannenberg,R.,
            Schaub,T., Qin,B., Rusanova,A., Brockmann,M., Koch,J., Daniels,M.,
            Turko,P., Jahn,O., Kaplan,D.R., Rosario,M., Iwawaki,T.,
            Spahn,C.M.T., Rosenmund,C., Meierhofer,D., Kraushar,M.L.,
            Tarabykin,V. and Ambrozkiewicz,M.C.
  TITLE     Protein translation rate determines neocortical neuron fate
  JOURNAL   Nat Commun 15 (1), 4879 (2024)
   PUBMED   38849354
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2850)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2850)
  AUTHORS   Schraps,N., Tirre,M., Pyschny,S., Reis,A., Schlierbach,H.,
            Seidl,M., Kehl,H.G., Schanzer,A., Heger,J., Jux,C. and
            Drenckhahn,J.D.
  TITLE     Cardiomyocyte maturation alters molecular stress response
            capacities and determines cell survival upon mitochondrial
            dysfunction
  JOURNAL   Free Radic Biol Med 213, 248-265 (2024)
   PUBMED   38266827
REFERENCE   5  (bases 1 to 2850)
  AUTHORS   Zhang,C., Chen,X., Liu,R. and Zhao,G.
  TITLE     HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in
            Mice and Human Neuroglioma Cells
  JOURNAL   Neurochem Res 49 (3), 706-717 (2024)
   PUBMED   38055149
  REMARK    GeneRIF: HSP90 Inhibition Attenuated Isoflurane-Induced
            Neurotoxicity in Mice and Human Neuroglioma Cells.
REFERENCE   6  (bases 1 to 2850)
  AUTHORS   Moore,S.K., Appella,E., Villar,C.J. and Kozak,C.A.
  TITLE     Mapping of the mouse 86-kDa heat-shock protein expressed gene
            (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4,
            9, and 11
  JOURNAL   Genomics 10 (4), 1019-1029 (1991)
   PUBMED   1916807
REFERENCE   7  (bases 1 to 2850)
  AUTHORS   Lees-Miller,S.P. and Anderson,C.W.
  TITLE     The human double-stranded DNA-activated protein kinase
            phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two
            NH2-terminal threonine residues
  JOURNAL   J Biol Chem 264 (29), 17275-17280 (1989)
   PUBMED   2507541
REFERENCE   8  (bases 1 to 2850)
  AUTHORS   Legagneux,V., Mezger,V., Quelard,C., Barnier,J.V., Bensaude,O. and
            Morange,M.
  TITLE     High constitutive transcription of HSP86 gene in murine embryonal
            carcinoma cells
  JOURNAL   Differentiation 41 (1), 42-48 (1989)
   PUBMED   2806771
REFERENCE   9  (bases 1 to 2850)
  AUTHORS   Hoffmann,T. and Hovemann,B.
  TITLE     Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related
            genes encode formerly identified tumour-specific transplantation
            antigens
  JOURNAL   Gene 74 (2), 491-501 (1988)
   PUBMED   2469626
REFERENCE   10 (bases 1 to 2850)
  AUTHORS   Reeves,R.H., Gallahan,D., O'Hara,B.F., Callahan,R. and
            Gearhart,J.D.
  TITLE     Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2 and
            localization of the Down syndrome region on mouse chromosome 16
  JOURNAL   Cytogenet Cell Genet 44 (2-3), 76-81 (1987)
   PUBMED   2882955
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL596265.12
            and AC152827.4.
            
            On Apr 28, 2007 this sequence version replaced NM_010480.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004658.1, AK167171.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AL596265.12        108237-108380
            145-306             AL596265.12        108952-109113
            307-673             AL596265.12        109214-109580
            674-807             AL596265.12        109928-110061
            808-1128            AL596265.12        110289-110609
            1129-1294           AL596265.12        110756-110921
            1295-1485           AL596265.12        111130-111320
            1486-1489           AL596265.12        111465-111468
            1490-1633           AC152827.4         194923-195066       c
            1634-1902           AC152827.4         194507-194775       c
            1903-2236           AC152827.4         194017-194350       c
            2237-2850           AC152827.4         192939-193552       c
FEATURES             Location/Qualifiers
     source          1..2850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 60.75 cM"
     gene            1..2850
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /note="heat shock protein 90, alpha (cytosolic), class A
                     member 1"
                     /db_xref="GeneID:15519"
                     /db_xref="MGI:MGI:96250"
     exon            1..144
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2346
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /EC_number="3.6.4.10"
                     /note="heat shock protein, 1; heat shock protein 1, alpha;
                     TSTA; HSP86; HSP 86; heat shock 86 kDa; tumor-specific
                     transplantation 86 kDa antigen; heat shock protein, 89
                     kDa; heat shock protein, 86 kDa 1; heat shock protein
                     90kDa alpha (cytosolic), class A member 1"
                     /codon_start=1
                     /product="heat shock protein HSP 90-alpha"
                     /protein_id="NP_034610.1"
                     /db_xref="CCDS:CCDS26172.1"
                     /db_xref="GeneID:15519"
                     /db_xref="MGI:MGI:96250"
                     /translation="MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIF
                     LRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIGMTKAD
                     LINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQY
                     AWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPI
                     TLFVEKERDKEVSDDEAEEKEEKEEEKEKEEKESDDKPEIEDVGSDEEEEEKKDGDKK
                     KKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEG
                     QLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDS
                     EDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGI
                     HEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAF
                     VERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKK
                     TKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNS
                     TMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDP
                     QTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMPPLEGDDDTSRMEEVD"
     exon            145..306
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            307..673
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            674..807
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1128
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1294
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1485
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1633
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1902
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2236
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2850
                     /gene="Hsp90aa1"
                     /gene_synonym="86kDa; 89kDa; hsp4; Hsp86-1; Hsp89; Hsp90;
                     Hspca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaggttcc ggaggcttct ggaaagaagc gccgcgcgct gggcgggccc gcctctatat
       61 aaggccggcg cagggggcgg cgcgccagtt gcttcagtgt cctggtgcgg agcgtcacgt
      121 ctcgtgcgtg ttcattcagc cacgatgcct gaggaaaccc agacccaaga ccaaccaatg
      181 gaggaggagg aggtcgagac ctttgccttt caggcagaaa ttgcccagtt aatgtccttg
      241 atcatcaata ccttctactc gaacaaagag atctttctga gggagctcat ctccaattca
      301 tcggacgctc tggataaaat ccgttacgag agcctgacgg accccagtaa actggactcg
      361 gggaaggagc tgcacatcaa tctcattccc agcaaacagg accgaaccct gaccattgtg
      421 gataccggga ttggaatgac caaggccgac ttgatcaata accttggcac cattgccaag
      481 tcgggcacca aagccttcat ggaggctttg caggctggtg cagatatctc tatgattggc
      541 cagtttggtg ttggttttta ctctgcctat ttggttgctg agaaagtgac tgtcatcacg
      601 aagcataacg acgatgagca gtatgcctgg gagtcctcag ctgggggatc cttcacagtg
      661 aggactgaca caggtgaacc aatgggtcgt ggaacaaagg ttatcttgca tctgaaagaa
      721 gaccaaacag agtatttgga ggaaaggaga ataaaggaga tcgtgaagaa gcattctcag
      781 ttcattggct atcccattac tctctttgtg gagaaggaac gagataagga agtcagtgat
      841 gatgaggctg aagaaaagga agagaaagag gaagagaaag aaaaagaaga aaaggagtct
      901 gatgataaac ctgaaataga agatgttggc tctgatgaag aagaggagga gaagaaggat
      961 ggtgacaaga agaaaaagaa gaagataaag gaaaagtaca ttgatcaaga agaactcaac
     1021 aaaacaaagc cgatttggac gagaaatcct gatgacatca ctaatgagga atatggagag
     1081 ttctacaaga gcttaactaa cgattgggaa gaacacttgg cagtaaagca tttttctgtt
     1141 gaaggacaat tagaattccg ggcccttctt tttgtcccaa gacgcgctcc ttttgatctg
     1201 tttgaaaaca gaaagaaaaa gaacaacatc aagttgtatg ttcgcagagt ttttatcatg
     1261 gataactgtg aggaattaat ccctgagtat ctgaatttca ttagaggggt agtggattct
     1321 gaggatctcc ctctaaatat ttcccgtgaa atgctgcaac aaagtaaaat tctgaaagtt
     1381 atcagaaaga atttggtcaa gaaatgctta gaactattta ctgaactagc agaagataaa
     1441 gagaactaca aaaagtttta tgagcagttc tcaaaaaata taaagcttgg aattcacgag
     1501 gactctcaga atcggaagaa gctttcagag ctgttgcggt actacacatc tgcttctggg
     1561 gacgagatgg tttctctgaa ggactactgt accagaatga aggaaaacca gaagcacatc
     1621 tattttatca caggtgagac caaggaccag gttgctaact ccgcctttgt ggaacgtctc
     1681 cgaaagcatg gcttagaagt aatttatatg attgagccca ttgatgagta ttgtgtgcaa
     1741 cagctgaagg aatttgaggg caagaccttg gtgtctgtta ccaaagaagg actggaactt
     1801 ccagaagatg aagaggaaaa gaagaaacag gaagagaaaa agacaaaatt tgagaacctc
     1861 tgcaaaatta tgaaagatat tttggagaag aaggttgaaa aggtggttgt gtcaaaccga
     1921 ctggtgacat ccccgtgctg tattgtcaca agcacatatg ggtggacagc aaacatggag
     1981 agaatcatga aagctcaagc cctcagagac aactcaacaa tgggttacat ggcagcaaag
     2041 aaacacctgg agataaatcc tgatcactcc attattgaaa ccttaaggca aaaggcagag
     2101 gctgacaaga atgacaaatc tgtgaaggat ctggtcatct tgctgtatga aactgcactc
     2161 ctatcttctg gcttcagtct ggaagatccc cagacccatg ctaacaggat ctacaggatg
     2221 atcaagcttg gtctaggtat tgatgaggat gatcctactg tggatgacac cagtgctgct
     2281 gtaactgaag aaatgcctcc cctggaagga gatgacgaca catcacgcat ggaagaagta
     2341 gactaagtca ccagaactat gtgtttgctt accttcattc cttctgataa tatattttcc
     2401 atgatttttg tttatttttg ttaacattta aaacatctgt gtggcatgaa aactaagggg
     2461 aagataaaat ttctacatgt gatactgtga tactataggt ttaactcaag aggttgatag
     2521 agcgtttgtt ataagacgta acgtaaccta ctgttcatgt ttgctctggt ctgaagtgtt
     2581 tagctgttga gctggattcc ttaggagacc aaattaagat ggcttaaatt acatcttaaa
     2641 attttcattt cctgtagtta attctgcatg tattagtctt agaagtaaac acaagttaaa
     2701 acaacctgac aggaattccc caagtggctt gttttccaaa gtcccgagaa caaccctaag
     2761 tttcctaggt cttgtaactc agcaaggctt gtgaatggaa ataacagtgc ccaatcacat
     2821 tctgctttaa aagataaata cagaggagat
//
