LOCUS       NM_197944               1225 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus hematopoietic SH2 domain containing (Hsh2d), mRNA.
ACCESSION   NM_197944
VERSION     NM_197944.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   King,R.G., Herrin,B.R. and Justement,L.B.
  TITLE     Differential expression of the adaptor protein HSH2 controls the
            quantitative and qualitative nature of the humoral response
  JOURNAL   J Immunol 187 (7), 3565-3577 (2011)
   PUBMED   21873522
  REMARK    GeneRIF: These data demonstrate that changes in HSH2 expression
            have profound effects on the humoral immune response.
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Perchonock,C.E., Pajerowski,A.G., Nguyen,C., Shapiro,M.J. and
            Shapiro,V.S.
  TITLE     The related adaptors, adaptor in lymphocytes of unknown function X
            and Rlk/Itk-binding protein, have nonredundant functions in
            lymphocytes
  JOURNAL   J Immunol 179 (3), 1768-1775 (2007)
   PUBMED   17641043
  REMARK    GeneRIF: Although adaptor in lymphocytes of unknown function X
            (ALX) is coexpressed with related adaptor Rlk/Itk-binding protein
            (RIBP) on both T- and B-lymphocytes throughout cell development, no
            redundancy or synergy is found.
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   Perchonock,C.E., Fernando,M.C., Quinn,W.J. 3rd, Nguyen,C.T.,
            Sun,J., Shapiro,M.J. and Shapiro,V.S.
  TITLE     Negative regulation of interleukin-2 and p38 mitogen-activated
            protein kinase during T-cell activation by the adaptor ALX
  JOURNAL   Mol Cell Biol 26 (16), 6005-6015 (2006)
   PUBMED   16880512
  REMARK    GeneRIF: These results suggest that ALX, in association with LAX,
            negatively regulates T-cell activation through inhibition of p38.
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   Herrin,B.R. and Justement,L.B.
  TITLE     Expression of the adaptor protein hematopoietic Src homology 2 is
            up-regulated in response to stimuli that promote survival and
            differentiation of B cells
  JOURNAL   J Immunol 176 (7), 4163-4172 (2006)
   PUBMED   16547253
  REMARK    GeneRIF: HSH2 expression is coordinately up-regulated with known
            antiapoptotic molecules and directly correlates with B cell
            survival
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Herrin,B.R., Groeger,A.L. and Justement,L.B.
  TITLE     The adaptor protein HSH2 attenuates apoptosis in response to
            ligation of the B cell antigen receptor complex on the B lymphoma
            cell line, WEHI-231
  JOURNAL   J Biol Chem 280 (5), 3507-3515 (2005)
   PUBMED   15569688
  REMARK    GeneRIF: endogenous HSH2 expression correlates directly with
            survival of WEHI-231 cells, which supports the hypothesis that HSH2
            modulates the apoptotic response through its ability to directly or
            indirectly promote mitochondrial stability
REFERENCE   6  (bases 1 to 1225)
  AUTHORS   Greene,T.A., Powell,P., Nzerem,C., Shapiro,M.J. and Shapiro,V.S.
  TITLE     Cloning and characterization of ALX, an adaptor downstream of CD28
  JOURNAL   J Biol Chem 278 (46), 45128-45134 (2003)
   PUBMED   12960172
  REMARK    GeneRIF: ALX is an adaptor involved in T cell activation and
            interleukin-2 (IL-2) promoter activation
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY319653.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY319653.1, AK157000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.87 cM"
     gene            1..1225
                     /gene="Hsh2d"
                     /gene_synonym="ALX; Hsh2"
                     /note="hematopoietic SH2 domain containing"
                     /db_xref="GeneID:209488"
                     /db_xref="MGI:MGI:2676364"
     exon            1..20
                     /gene="Hsh2d"
                     /gene_synonym="ALX; Hsh2"
                     /inference="alignment:Splign:2.1.0"
     exon            21..167
                     /gene="Hsh2d"
                     /gene_synonym="ALX; Hsh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1047
                     /gene="Hsh2d"
                     /gene_synonym="ALX; Hsh2"
                     /note="adaptor protein ALx2; hematopoietic SH2 protein;
                     adaptor in lymphocytes of unknown function X"
                     /codon_start=1
                     /product="hematopoietic SH2 domain-containing protein"
                     /protein_id="NP_922935.1"
                     /db_xref="CCDS:CCDS22410.1"
                     /db_xref="GeneID:209488"
                     /db_xref="MGI:MGI:2676364"
                     /translation="MAEARRLPPPLPPRLDWFVHTQADLLAQSGIPEWFHGTISREAA
                     ENMLESQPLGTFLIRVSHSHVGYTLSYKAQTCCRHFMVKLSEDGTCAFAGDHMTHASL
                     HALVTFHQQKPIRPFGELLTQACGQEDPANVDYEDLFLYSNALVQDAESQILRTEVQR
                     SSCPPEEASERKPSTTTKGEFASASCSPKALFEDSGQKLWKNLRSLPQTSQRVKQRLT
                     SHLLAMNLLGDARQVAQQHHSPVTRAFSWDSTSHSEDSCAATTSLQNPAEPQALRGRE
                     ATFRDSRPASWRKAFSGVKAWRGKVVRALSAQEPVDFPEAQGWLPEEYLPPPPFAPGY
                     "
     exon            168..257
                     /gene="Hsh2d"
                     /gene_synonym="ALX; Hsh2"
                     /inference="alignment:Splign:2.1.0"
     exon            258..423
                     /gene="Hsh2d"
                     /gene_synonym="ALX; Hsh2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..543
                     /gene="Hsh2d"
                     /gene_synonym="ALX; Hsh2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1225
                     /gene="Hsh2d"
                     /gene_synonym="ALX; Hsh2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacaacccaa gctgtccaag gtgaccacct tctctggatg ccatggcaga agccaggagg
       61 ctgcccccac cactacctcc tcggctggac tggtttgtgc acacccaggc ggacctgcta
      121 gcccaatccg ggatccccga gtggttccat ggcaccatct cccgagaggc tgctgagaac
      181 atgttggagt cacaacccct ggggactttt cttatccgag tcagccacag ccatgtgggc
      241 tacacccttt cctacaaagc ccagacttgc tgccgtcact tcatggtgaa actttcagaa
      301 gatgggactt gtgccttcgc tggggaccac atgacccacg cctctctgca tgccctggtc
      361 accttccacc aacaaaagcc tattcggcca ttcggggagc tgttgaccca ggcctgcggg
      421 caggaggatc cagcaaacgt ggactatgag gatctcttcc tatactcaaa tgccctggtt
      481 caggatgctg aaagccaaat tctgagaacg gaagttcaaa ggtcttcctg cccacctgag
      541 gaggcttctg aaaggaagcc atccacaaca actaaaggag aattcgcatc agcttcctgc
      601 tccccaaaag cccttttcga ggattctgga cagaaactgt ggaagaacct gaggtcccta
      661 cctcagacta gccagagggt gaaacagcga ctcacttcac acctgttggc catgaacctg
      721 ctgggggatg ccaggcaagt ggcacagcag caccacagcc ctgtgactcg agcattcagt
      781 tgggacagta ctagccactc cgaggactcc tgtgcagcca ccacgtctct tcaaaaccct
      841 gcagaacccc aggccctgag aggcagagaa gccaccttca gggactccag gcctgccagc
      901 tggaggaagg cattctcagg ggtcaaagcc tggcgtggaa aggtggtaag ggccctgtca
      961 gcccaggagc ctgtggactt tccagaagcc cagggctggt tgcctgagga ataccttcca
     1021 ccaccacctt tcgcccctgg gtactgatag aactttctgt atcttgggta ttcctcatct
     1081 ctcctttagg tccccatcct tgtcctcaca gccagagaac tgtgctgaag aggttaaggg
     1141 gctgaatcct gcaggtgcca gctaagggag ctgattgtcc taataataat agaattactg
     1201 ctacctcttt agggacctgg tggaa
//
