LOCUS       NM_001045527            4158 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus heat shock transcription factor family member 5
            (Hsf5), mRNA.
ACCESSION   NM_001045527 XM_282974 XM_914515
VERSION     NM_001045527.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4158)
  AUTHORS   Yoshimura,S., Shimada,R., Kikuchi,K., Kawagoe,S., Abe,H.,
            Iisaka,S., Fujimura,S., Yasunaga,K.I., Usuki,S., Tani,N., Ohba,T.,
            Kondoh,E., Saio,T., Araki,K. and Ishiguro,K.I.
  TITLE     Atypical heat shock transcription factor HSF5 is critical for male
            meiotic prophase under non-stress conditions
  JOURNAL   Nat Commun 15 (1), 3330 (2024)
   PUBMED   38684656
  REMARK    GeneRIF: Atypical heat shock transcription factor HSF5 is critical
            for male meiotic prophase under non-stress conditions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4158)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4158)
  AUTHORS   Barutc,A.R., Frit,A.J., McCor,R.P., Nick,J.A. and Asla,M.
  TITLE     Heat shock factor 5 establishes the male germ-line meiotic sex
            chromosome inactivation through regulation of Smarca4
  JOURNAL   Heliyon 9 (5), e15194 (2023)
   PUBMED   37206036
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4158)
  AUTHORS   Kogo,H., Kowa-Sugiyama,H., Yamada,K., Bolor,H., Tsutsumi,M.,
            Ohye,T., Inagaki,H., Taniguchi,M., Toda,T. and Kurahashi,H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596086.9, AK166561.1 and BX639497.1.
            
            On or before Sep 2, 2006 this sequence version replaced
            XM_282974.6, XM_914515.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-742               AL596086.9         95495-96236
            743-1117            AL596086.9         101076-101450
            1118-1215           AL596086.9         109923-110020
            1216-1578           AL596086.9         113942-114304
            1579-2228           AK166561.1         21-670
            2229-3833           AL596086.9         135944-137548
            3834-4158           BX639497.1         4-328               c
FEATURES             Location/Qualifiers
     source          1..4158
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 52.16 cM"
     gene            1..4158
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
                     /note="heat shock transcription factor family member 5"
                     /db_xref="GeneID:327992"
                     /db_xref="MGI:MGI:2685585"
     exon            1..742
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1983
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
                     /note="HSF 5; HSTF 5; heat shock transcription factor 5;
                     protein expressed in male leptotene and zygotene
                     spermatocytes 220"
                     /codon_start=1
                     /product="heat shock factor protein 5"
                     /protein_id="NP_001038992.1"
                     /db_xref="CCDS:CCDS36269.1"
                     /db_xref="GeneID:327992"
                     /db_xref="MGI:MGI:2685585"
                     /translation="MEEALLSTPINPNNFPAKLWRLVNSPRYRSIRWDGRGEGLLIDQ
                     PLFEAELLSPPGPGAGGAGGAGSSGGGGGSGVGAAGAEPELFKTTNFTSFIRQLNLYG
                     FRKVVLGGPGAAGPGPGPGAGGPAGDGPLHHFHSPHFRRDQPQLLVHLKRLTSANKAK
                     LAAGLEVPCRPPNRFQRLLITSASASASASTSPLQHQDPPPQPAGPRPEQHGPVAVGQ
                     FHRSFRRDNLSPYSYVSTSSHNHSAFPLKGLDRTPIPPRTWQNSLGMHPGQVETSPTF
                     SDKGVPFPVLQRFPTEVTYTLQPSATSVHVQQGPQTMVSSSQKYSNYTPSAQYSQAYY
                     PTAVLQCCSPPTHMDALSSCVTPTASSYAHCNYFQNPPMQSSYPVEFLPSNWPCSATD
                     ENKKTEVNLEAVFQIVDELHSSPKLEMVKVEPVETQCPSSQANRGQHILPNANSSNPS
                     STSQASQLEPLTPVGSDITSFVVGTEQAITCSLPQSPEYIYTIHTAQPLENSTMQESA
                     TIQQTHVKLKEQLNHNPSPSSVVFVQEGLPFSTPQVDSSIKCQTNPSENILPSEQMGF
                     LISEMGPANKSTKDTGLSTPARYRERRSNSQGKSPDLHLLVDVACKQEHFPKEEELKE
                     "
     exon            743..1117
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1215
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1737
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1912
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..4158
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2816..2821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
                     /note="hexamer: ATTAAA"
     polyA_site      2840
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
     regulatory      4135..4140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
                     /note="hexamer: AATAAA"
     polyA_site      4158
                     /gene="Hsf5"
                     /gene_synonym="Gm739; MLZ-220"
                     /note="major polyA site"
ORIGIN      
        1 ggcggccggg cgctggcagg agggggcagg gcgcagcgaa ggcccggggg atcgagaacg
       61 gtgggagagc caggctcggc ggggcgaggc ccagggcccg ggcgggcgat ggaggaggcg
      121 ctgctgtcca cccccatcaa ccccaacaac ttccccgcca agctgtggcg gctggtgaac
      181 agccctcggt accgctccat ccgctgggac ggccgaggcg aggggctgct catcgaccag
      241 ccgctcttcg aggccgagct gctcagcccg cccggcccgg gtgccggggg cgcgggggga
      301 gccgggagca gcggcggggg cggcggcagc ggcgtcgggg cggccggggc cgagccggag
      361 ctcttcaaaa ccaccaactt caccagcttc atccgccagc tcaacctcta cggcttccgc
      421 aaggtggtgc tgggtgggcc gggggcggcg gggcccgggc ccgggcctgg ggctggcggg
      481 ccggcgggcg acgggccact ccaccacttc cacagcccgc atttccgccg cgaccagcct
      541 cagctgctcg ttcacctcaa gaggctcacc agtgccaaca aggccaagct ggcggccgga
      601 ctggaggtgc cctgtcgccc gcccaaccgc ttccagcggc tcctcatcac gtcagcctcc
      661 gcctcggcct cagcttctac ctccccgctg cagcatcagg acccgccgcc ccaacctgct
      721 gggcctcggc cagagcagca tggaccagtg gctgtaggac aatttcaccg gtcattccgg
      781 cgagataatt tgtctcctta ttcctacgta tcaacttcat cccacaacca cagcgctttc
      841 cctctgaaag gtttagatcg caccccgatt cctcccagaa cgtggcagaa ctcccttgga
      901 atgcaccctg gacaagtgga gacgtctccc actttttcag ataaaggggt tccatttcct
      961 gtactgcaga gatttccaac tgaggttaca tatacgctgc agcccagcgc cacatctgta
     1021 cacgttcaac aaggtcctca aacgatggtc agctcctccc aaaaatatag taactacaca
     1081 ccctcagcgc agtactccca agcctactat ccaacagctg tgctgcagtg ctgctctcct
     1141 cccacccaca tggacgccct cagcagctgt gtcactccta ctgcctcttc ctatgcacac
     1201 tgtaattact tccagaatcc tccaatgcaa tcttcctatc cagttgaatt tctgccttct
     1261 aattggcctt gcagtgctac tgatgaaaat aaaaagacag aagtaaatct agaggctgtc
     1321 tttcagatag tagatgagtt gcactcctcc cctaagctgg agatggtaaa ggtggagcct
     1381 gttgagactc agtgtccgtc atctcaggct aacagaggcc agcatatctt acccaatgca
     1441 aacagcagca acccatcttc caccagtcag gctagccagc tggagccact cactcctgta
     1501 ggctcagata ttacgtcttt tgtggttgga acagaacaag caattacctg ctctctacca
     1561 cagtcacctg agtacatcta taccatccac acagctcaac ctttggaaaa tagcacaatg
     1621 caggaatctg caaccatcca acaaactcat gtcaaactga aggagcagct aaatcataac
     1681 ccatctccgt cttcagtagt atttgtgcag gaagggctac cattcagcac accgcaggtg
     1741 gatagcagta taaaatgcca gaccaatccc tcggagaata tcttgccttc agaacaaatg
     1801 ggattcctta tttcagaaat ggggcctgct aacaagtcta ctaaagacac aggtttatcc
     1861 actccagcta gatacagaga gcgaagaagc aactcacaag gaaagtcccc tgatcttcat
     1921 ctgctggtgg acgtggcctg caagcaggaa cacttcccaa aggaggagga gttaaaagaa
     1981 tgagaagctg ggtgacagcc gtgacatcgt gcgctagcca cagctggagg ggacaggcgc
     2041 tgcacatgac acactgttgg gagtttttca gttctgttaa ggaaaaaaaa aagcatcttt
     2101 tttgtttttg ttaattgaga ttttgttaaa ttggaaattg ggagtttgat attcactcca
     2161 actgttcagt ccagatcgct taccttggca aactgctaaa cagctagcgg cctttttttt
     2221 ttttttttaa ttttttttat gctgcccaga ttcctttcaa atgaaaagtc ctggccttca
     2281 agaagcatct aaaaactact gtgttgatgg tactggagca gtgtgtgtgc tgagtcgtga
     2341 tgccatcttg aactgtagtc agcacagtgt cgcctgtctg gagtcacagt gtgacccttt
     2401 aaggaagagg gtatgataaa ccaagacaca agaggtcacc aatagcacaa gtccaagcgg
     2461 gtcagggccc cgggaggacg ctggaaaacg ctcgttttct aagtgagtaa ccaagaacgg
     2521 gctcttgatt ctgaacccac gtcctgtttg aagagcaagg catccggact tggcccatcc
     2581 atcacactaa cagcctctga gtctttaata ttcatgggag tgttttttcc cattttcatg
     2641 tctttcttta atttgaatga taaattatca taaatagtaa gaaagttttg ttaatatcac
     2701 ttacataaat gtcttctaaa gaaaaatatt taatttgttt aattatattt ataaatgctg
     2761 atagatgtaa aagttttaaa gctttgtgtt tgtattaaca ttgcagagtg gaaggattaa
     2821 aggacgcatg tgtaatttta tgtttgaagg gtaaatgtac aatatgtaga caaaagcact
     2881 gagaggttaa cactgttttc ttattttaga tttttacatt cagctagtat agattctcat
     2941 ctataagggg tattgtgtgc aaatctgggg ggaaattgct tggtatcatt tactggaagc
     3001 tatgctgtaa tttgaaacaa acctatattt gaaatattaa atggcttaag cttctgagag
     3061 acttttggac agtggagtag actatcacca attttcttat ccctctgttg gactgtgcac
     3121 ttgagtagtc gaattgtggg gctgttttta aggagaagga ggagatttta gatgtccagt
     3181 ttttgtagcc aatccatgtc cacccagtga cagcaagaac ttttgtaatt taatggattt
     3241 tcaggactag aactttcttg ctgaataccc ccccaccccc acacacacac ccagtttcct
     3301 aataagcgct gcagaaataa aaggaaaggt ctgtggattt aaagctaatg aagcaagcag
     3361 cgcttcagtg gcattgccac tgtaccagcc attgcaggtt cacagctcac ttcctgcttt
     3421 gcgctgggcc ttcccaatgg cattagaccc agaagtgtcg cagaggtcga gctgctctgg
     3481 agggtgagct ctggattagt ccacagcgac tcagtttaat tttgaaacta ggttttgaaa
     3541 aatgactctc tgaccatcta attagactat ttgtgctcct tcctgggcac ctaatcatct
     3601 ttactaggga ggcttgaaag atacccagac gattgagacg tctacatcta tctgtgccaa
     3661 atgtcttggc aaaatatgtg aaaaggagac cggcttctaa tgaaggacct ttgccttttc
     3721 tctgtcacat tgaagagctg gtaagctgtg taggtgatag ttcttcccct cgagatgcct
     3781 ttcttagcct tgtggctatg gaaagaggta atacctttag aggaacgtgt gtcaggcaga
     3841 gccttggcac agacatggtt tcagtggtct tcaggcttga tcgatgagat gccttgatct
     3901 gctctccaaa cgtttttaca gacgagcata ccagatagag gagctggatc tcctgctctg
     3961 ctcactgcct ggagcccatc tcctaaagcc atcgtcagtg acttgtgcaa atagcaagca
     4021 gtcaagtgga atgtgcatgt gaacaagcca gcagggcctg acacacactt gagttcctgt
     4081 ctagcacatt cgcgtttcag caccttaagc accgatcagt ttcagtcagt caacaataaa
     4141 atgaatgttc caactaga
//
