LOCUS       NM_001256042            1739 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus heat shock transcription factor 4 (Hsf4), transcript
            variant 1, mRNA.
ACCESSION   NM_001256042
VERSION     NM_001256042.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1739)
  AUTHORS   Zhang,L., Liu,X., Li,W., Liu,K., Zhang,J., Liu,X. and Wang,J.
  TITLE     Integrative transcriptomic profiling of ncRNAs and mRNAs in
            developing mouse lens
  JOURNAL   Front Genet 15, 1405715 (2024)
   PUBMED   38933921
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1739)
  AUTHORS   Yoshimura,S., Shimada,R., Kikuchi,K., Kawagoe,S., Abe,H.,
            Iisaka,S., Fujimura,S., Yasunaga,K.I., Usuki,S., Tani,N., Ohba,T.,
            Kondoh,E., Saio,T., Araki,K. and Ishiguro,K.I.
  TITLE     Atypical heat shock transcription factor HSF5 is critical for male
            meiotic prophase under non-stress conditions
  JOURNAL   Nat Commun 15 (1), 3330 (2024)
   PUBMED   38684656
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1739)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1739)
  AUTHORS   Zhang,J., Jiang,N., Du,C., Guo,H., Meng,R., Hou,X., Liu,M., Hu,Y.
            and Cui,X.
  TITLE     HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a
            During Lens Terminal Differentiation
  JOURNAL   Invest Ophthalmol Vis Sci 64 (7), 5 (2023)
   PUBMED   37266953
  REMARK    GeneRIF: HSF4 Transcriptionally Activates Autophagy by Regulating
            ATG9a During Lens Terminal Differentiation.
REFERENCE   5  (bases 1 to 1739)
  AUTHORS   Cui,X., Du,C., Wan,S., Wu,D., Yan,L., Zhang,J., Li,J., Li,H.,
            Yang,Z., Zhang,H., Zhang,J., Mu,H., Zhang,F., Peng,X., Liu,M. and
            Hu,Y.
  TITLE     Deficiency of heat shock factor 4 promotes lens epithelial cell
            senescence through upregulating p21cip1 expression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1867 (11), 166233 (2021)
   PUBMED   34339841
  REMARK    GeneRIF: Deficiency of heat shock factor 4 promotes lens epithelial
            cell senescence through upregulating p21(cip1) expression.
REFERENCE   6  (bases 1 to 1739)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
REFERENCE   7  (bases 1 to 1739)
  AUTHORS   Fujimoto,M., Izu,H., Seki,K., Fukuda,K., Nishida,T., Yamada,S.,
            Kato,K., Yonemura,S., Inouye,S. and Nakai,A.
  TITLE     HSF4 is required for normal cell growth and differentiation during
            mouse lens development
  JOURNAL   EMBO J 23 (21), 4297-4306 (2004)
   PUBMED   15483628
  REMARK    GeneRIF: Data reveal the lens-specific role of heat shock
            transcription factor 4 (HSF4), and indicate that HSF1 and HSF4 are
            involved in regulating expression of growth factor genes.
REFERENCE   8  (bases 1 to 1739)
  AUTHORS   Jablonski,M.M., Lu,L., Wang,X., Chesler,E.J., Carps,E., Qi,S.,
            Gu,J. and Williams,R.W.
  TITLE     The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near
            cadherin 1
  JOURNAL   Mol Vis 10, 577-587 (2004)
   PUBMED   15343150
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1739)
  AUTHORS   Pirkkala,L., Nykanen,P. and Sistonen,L.
  TITLE     Roles of the heat shock transcription factors in regulation of the
            heat shock response and beyond
  JOURNAL   FASEB J 15 (7), 1118-1131 (2001)
   PUBMED   11344080
  REMARK    Review article
REFERENCE   10 (bases 1 to 1739)
  AUTHORS   Tanabe,M., Sasai,N., Nagata,K., Liu,X.D., Liu,P.C., Thiele,D.J. and
            Nakai,A.
  TITLE     The mammalian HSF4 gene generates both an activator and a repressor
            of heat shock genes by alternative splicing
  JOURNAL   J Biol Chem 274 (39), 27845-27856 (1999)
   PUBMED   10488131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124584.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029349.1, BC138130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC124584.5         123483-123678       c
            197-305             AC124584.5         122824-122932       c
            306-433             AC124584.5         122583-122710       c
            434-558             AC124584.5         122367-122491       c
            559-634             AC124584.5         122030-122105       c
            635-699             AC124584.5         121830-121894       c
            700-802             AC124584.5         121271-121373       c
            803-927             AC124584.5         120895-121019       c
            928-1155            AC124584.5         120546-120773       c
            1156-1261           AC124584.5         118728-118833       c
            1262-1327           AC124584.5         118566-118631       c
            1328-1397           AC124584.5         118367-118436       c
            1398-1739           AC124584.5         117634-117975       c
FEATURES             Location/Qualifiers
     source          1..1739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1739
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /note="heat shock transcription factor 4"
                     /db_xref="GeneID:26386"
                     /db_xref="MGI:MGI:1347058"
     exon            1..196
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1552
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /note="isoform 1 is encoded by transcript variant 1; heat
                     shock factor protein 4; heat shock factor 4; DNA binding
                     protein; binds heat shock DNA elements"
                     /codon_start=1
                     /product="heat shock factor protein 4 isoform 1"
                     /protein_id="NP_001242971.1"
                     /db_xref="CCDS:CCDS57639.1"
                     /db_xref="GeneID:26386"
                     /db_xref="MGI:MGI:1347058"
                     /translation="MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGT
                     SFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQ
                     HPSFVRGREQLLERVRRKVPALRGDDSRWRPEDLSRLLGEVQALRGVQESTEARLQEL
                     RQQNEILWREVVTLRQSHSQQHRVIGKLIQCLFGPLQTGPSSTGAKRKLSLMLDEGSA
                     CSASAKFNACPVSGALLQDPYFIQSPLPETTLGLSPHRARGPIISDIPEDSPSPEGHR
                     LSPSGGCRRVKGLALLKEEPASPGGDGEAGLALAPNECDFCVTAPPPLPVAVVQAILE
                     GKGSYSPEGPRSVQQPEPRGPREVPDRGTLGLDRGNRSPESLLPPMLLRPAPETLEPV
                     APVDVLGPSLHGREWTLMDLDMELSLMQPLAPETDEAELTVKELNSSGVGKDHTLGTP
                     LMLDVQADLEGAALSVPGALTLYNVTESNASYLDPGASPSSP"
     exon            197..305
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            306..433
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            434..558
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            559..634
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            635..699
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            700..802
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            803..927
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1155
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1261
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1327
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1397
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1739
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1717..1722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /note="hexamer: CATAAA"
     polyA_site      1734
                     /gene="Hsf4"
                     /gene_synonym="HSF 4; HSTF 4; HSTF4; ldis1; mHSF4"
                     /note="major polyA site"
ORIGIN      
        1 agcactttcg cggctttgac aagcccgcag cggccgggct ggaacgctga gcccggccgg
       61 ccgagactgc gccatgcagg aagcgccagc tgcgctgccc acggagccag gccccagccc
      121 ggtacctgcc ttcctcggca agctatgggc gctggtaggc gacccaggca ccgaccacct
      181 catccgctgg agcccgagtg gcaccagctt cctcgtaagt gatcagagcc gcttcgccaa
      241 ggaagtgctg ccccagtact tcaagcacag caacatggcg agctttgttc gccaactcaa
      301 catgtatggt tttcggaagg tggtgagcat cgagcaaggt ggcctgctca gaccagagcg
      361 tgaccacgtt gagtttcagc atccgagctt cgtgcgaggc cgcgagcagc tactggagcg
      421 cgtgcgccgc aaggtacctg cgctgcgagg cgatgacagt cgatggcgtc cggaagacct
      481 gagccgactg ctgggagagg tgcaagcttt gagaggagtg caggagagca cggaggcacg
      541 gctgcaggaa ctcaggcagc agaacgagat cttgtggcga gaggtggtaa ctttgcggca
      601 gagccacagt cagcagcacc gggtcatcgg caagctaatc cagtgcctgt ttgggccact
      661 tcagacaggg cccagcagta caggagccaa gagaaaactg tccctaatgc tagatgaggg
      721 gagcgcctgt tcagcatctg ccaaattcaa tgcctgccct gtgtctggtg ctctcctcca
      781 ggacccctac tttatccagt cgcccctccc agagaccacg ttgggcctca gccctcacag
      841 ggccagaggg cccatcatct ctgacatccc agaagattct ccatctcctg aaggacacag
      901 gctttctccc tccggtggtt gcaggagggt gaagggcctg gcactgctca aagaagagcc
      961 ggccagtcca gggggggatg gcgaggccgg gctggccctg gccccaaacg agtgtgactt
     1021 ctgcgtgaca gcacccccac cgctgcccgt ggctgtggtg caggccatcc tggaagggaa
     1081 agggagctac agccctgagg ggcccaggag tgtacaacag cctgaaccaa ggggccccag
     1141 ggaggtacct gacaggggaa ctctgggcct ggatcggggt aaccggagcc cagagagtct
     1201 gctaccccca atgctgcttc ggcctgcccc tgaaactctg gagcccgtgg cacctgtgga
     1261 tgtgctcggc cctagcctgc atggacgaga atggaccttg atggatctgg acatggagtt
     1321 gtctctgatg cagcccttgg caccagagac ggatgaagca gagctgacgg tcaaggagtt
     1381 gaattcttct ggtgtaggga aagaccacac actgggaact ccactcatgc tagatgtcca
     1441 ggcggatttg gagggtgcag ccctgtctgt gcctggggct ttaaccctgt acaacgtcac
     1501 cgagagcaac gcctcctact tggatcctgg agccagtccc tcctctccct gagatctgca
     1561 tccctctgaa aaagcctggc taaggaacta gcacgcaaca gcacacccct ttaggcttcc
     1621 tggcgccccc ccccgccccc cggcccccgc cccaggaggt gagcgaagcc ctctgtatgc
     1681 gacagcccct ctccactacc ccagtgaatc ctgcaacata aactgcattc cctactctg
//
