LOCUS       NM_001310755            3277 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus heat shock transcription factor 3 (Hsf3), transcript
            variant 3, mRNA.
ACCESSION   NM_001310755
VERSION     NM_001310755.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3277)
  AUTHORS   Yoshimura,S., Shimada,R., Kikuchi,K., Kawagoe,S., Abe,H.,
            Iisaka,S., Fujimura,S., Yasunaga,K.I., Usuki,S., Tani,N., Ohba,T.,
            Kondoh,E., Saio,T., Araki,K. and Ishiguro,K.I.
  TITLE     Atypical heat shock transcription factor HSF5 is critical for male
            meiotic prophase under non-stress conditions
  JOURNAL   Nat Commun 15 (1), 3330 (2024)
   PUBMED   38684656
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3277)
  AUTHORS   Fujimoto,M., Hayashida,N., Katoh,T., Oshima,K., Shinkawa,T.,
            Prakasam,R., Tan,K., Inouye,S., Takii,R. and Nakai,A.
  TITLE     A novel mouse HSF3 has the potential to activate nonclassical
            heat-shock genes during heat shock
  JOURNAL   Mol Biol Cell 21 (1), 106-116 (2010)
   PUBMED   19864465
  REMARK    GeneRIF: mHSF3 represents a unique heat shock transcription factor
            that has the potential to activate only nonclassical heat-shock
            genes to protect cells from detrimental stresses.
REFERENCE   3  (bases 1 to 3277)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732365.17, AL929273.8 and AL831708.9.
            
            On Jul 29, 2020 this sequence version replaced NM_001310755.1.
            
            Transcript Variant: This variant (3) has multiple differences,
            compared to variant 1. These differences result in a distinct 5'
            UTR and cause translation initiation at an alternate start codon,
            compared to variant 1. The encoded protein (isoform 3) is shorter
            than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB510447.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-610               AL732365.17        46550-47159         c
            611-719             AL929273.8         50535-50643         c
            720-847             AL929273.8         31817-31944         c
            848-972             AL929273.8         22914-23038         c
            973-1048            AL929273.8         15695-15770         c
            1049-1110           AL929273.8         15397-15458         c
            1111-1192           AL929273.8         14004-14085         c
            1193-1323           AL929273.8         13686-13816         c
            1324-1539           AL929273.8         8191-8406           c
            1540-1639           AL929273.8         6428-6527           c
            1640-3277           AL831708.9         110657-112294       c
FEATURES             Location/Qualifiers
     source          1..3277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 42.69 cM"
     gene            1..3277
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /note="heat shock transcription factor 3"
                     /db_xref="GeneID:245525"
                     /db_xref="MGI:MGI:3045337"
     exon            1..610
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /inference="alignment:Splign:2.1.0"
     CDS             545..1651
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /note="isoform 3 is encoded by transcript variant 3; heat
                     shock factor protein 3"
                     /codon_start=1
                     /product="heat shock factor protein 3 isoform 3"
                     /protein_id="NP_001297684.1"
                     /db_xref="CCDS:CCDS85791.1"
                     /db_xref="GeneID:245525"
                     /db_xref="MGI:MGI:3045337"
                     /translation="MLRPVERGYFYSPDSPNSRRVQDGHSFQIVNEETFAREVLPKYF
                     KHNKITSFIRQLNMYGFRKVFALQTEKTSQENKISIEFQHPLFKRGEACLLANIKRKV
                     PTIKIEGASLYSDEFQKIVTEMQEFKDMQRKMDAKYTQMKQDYSNLYHEVTNLRKKYC
                     AQQQLLTRVLHFILDLMSENHTVLKKRKRSLSFISEDSDSEWDHQYFRIPEDKKEAME
                     ILKDGYELVEDKYKSLLDRVMPILKESKKLISSGDQPSGDDGEHPKVPVQDKPMNEES
                     LTIQLDLTIPVLPEQITEESVEQEPKDISLELDLSSQDSILMKDKSDNLYNNIINRDK
                     KDMHHTEGNLLELNSLLSRKALNYDSDHFSETII"
     exon            611..719
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /inference="alignment:Splign:2.1.0"
     exon            720..847
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /inference="alignment:Splign:2.1.0"
     exon            848..972
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1048
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1110
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1192
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1323
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1539
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1639
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..3277
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3260..3265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /note="hexamer: AATAAA"
     polyA_site      3277
                     /gene="Hsf3"
                     /gene_synonym="B230358A15Rik; HSF 3; HSTF 3"
                     /note="major polyA site"
ORIGIN      
        1 gaggatctcc ggaggaatta caaggaggtg ggctgtttat gttgcttgct agttggcttt
       61 gctgagctgg gatgaaaatg catctttggt gtggccagcc aaagcccacg ggcagattcc
      121 aactgcctgg gttaagaaat aggaggacaa gttgtgtaac tcggtggtag aaatgctgat
      181 aatgacagtg acaatagtaa tgccacgaag atctcttaag atttaaactg tactctggat
      241 ttttttttta atttttgtag cccacaccgt ttctgtctct tctgcaaaga aaaggcagtg
      301 aaaagtcact ggactaagta ggacctacgt cctaggtctt ctggtgttgg caataattcg
      361 ctggctggat ctagcctagg gccttgcttc actgtggtcc tttccatttg tatgatgagg
      421 gtcttaaggc agatatgaag ccattcatct ctgtaaaagt cactagtcta tgattctatg
      481 aagtcgcctt ttaaataata agagcacctg agaaagaaat gtaaggaaag aatgtgtgaa
      541 gaatatgcta cgccctgttg agaggggcta tttctactca ccagactccc caaactcacg
      601 aagagtacag gatggccaca gctttcagat tgtgaatgaa gaaacttttg ccagagaagt
      661 actaccaaaa tacttcaaac ataacaaaat aacaagcttt attagacaac tcaacatgta
      721 tggtttccga aaggtgtttg cactgcagac tgaaaagaca agccaggaga ataaaatatc
      781 tattgaattt cagcatccac ttttcaaaag gggagaagcc tgtcttcttg caaacattaa
      841 acgaaaggtg ccaacaataa aaattgaagg tgccagcctc tactctgatg agtttcagaa
      901 aattgtgact gaaatgcaag agtttaaaga catgcagagg aagatggatg ccaaatatac
      961 acaaatgaaa caggactatt caaacctata tcatgaagtt acaaacctaa gaaagaagta
     1021 ctgtgcacaa caacaactgc tgacacgggt actccatttt atcttggatt tgatgagtga
     1081 aaaccataca gtactaaaaa agaggaaaag gtcattatca ttcatatctg aagattcaga
     1141 ttctgaatgg gatcatcagt atttccgtat tccagaggac aagaaggaag ctatggagat
     1201 attaaaagat ggttacgaac tcgttgaaga caaatataaa agtctccttg atagagtcat
     1261 gccaattttg aaagaatcca aaaagttaat ttcatctgga gaccagccaa gtggagatga
     1321 tggagaacac cctaaagtgc cagttcagga taaacctatg aatgaagagt cactgaccat
     1381 tcagttggat ttgaccatac cagtattacc agaacaaata actgaagaat ctgttgaaca
     1441 agaacctaag gatatttctc tggaattaga tctttcttct caggattcaa ttttaatgaa
     1501 agataaatca gacaatttat ataacaatat aattaacagg gataaaaagg atatgcatca
     1561 tactgaagga aatttgttag agctaaattc attactatct aggaaggcat tgaattatga
     1621 ctctgatcat ttcagtgaga caatcatatg atacaatgta tggaaacacc agagcttttc
     1681 ctattggatg agataccaat gtgtgatttt ggagaaaatc ttcaagatta tgacagactt
     1741 ttagaggatc tgaagaaccc accaaatgtc atatcagctt tatgtgacca tgattatgta
     1801 acctccaata tttctactct acaagaagat actattgaaa atagtattcc tcagttatgt
     1861 atggaagcca atggggaatc cagtgtgttc ccttttctca ttctcaaccc tgttactaat
     1921 attttttgaa gagcatattg aaatcaatct tctgttacaa tttattttga gtcttaatga
     1981 atctcattta gatattcaat ggctgctggc tagtattatg tatcttcatt tggaaatttc
     2041 tgtaacttaa attaatatgt taaaattata gccccccaac atctagacaa gctttggcaa
     2101 ctaggataaa attcagacca caagaaaaca taggtaatat atccaaattt taatataata
     2161 agaagttagt ttttaatttt taaactaatg atgttctagt actttgttac tagaatagag
     2221 attaatgtta ttgcattttt aagtaattag aaattttctg tagctagatt ttgtttatag
     2281 taaagaaaca attattgcaa aatttaaaag caaggtttag agttaatgaa aacgatgtta
     2341 ctcctagatt ttactgatac atttattcta tagcttccca ctttattttc tgtcttacac
     2401 tatttttact tcctcaagaa agttaaaatt tcagcaggat atgatttttt tctgtataat
     2461 ggccatctca tatacaatca aagtcaacat actgactctc atataaatcc ttcaacaaaa
     2521 actccaagaa tcaaactcaa gcaaacattt tcctaaaaag catgcagaaa cccaagaaca
     2581 agtgatttat tcaaaaataa atttaaaaat tcacagtaaa ccatttctca actatattta
     2641 tctatcattt ctactgtaat ctctagctat atcagtattc tttgacagat atgtagttat
     2701 tagatagaat attatctttc aaaaatagta tggttttacc taaacttgaa gcagttttca
     2761 tactatttca actgttctaa caccaacttt catacatggc taaacattga gtaccatagc
     2821 acatagaatc taagagtatc tgtttagttg aagaagcact ttagaatatg tttaaggtct
     2881 tatgttagta agctgaatac taaaacatca agcatctaaa gggcccagtc tgtaacactt
     2941 tattactgct ttatcctacc tgctaaaggg tctacaaatt tagcttgttt tttagtcctt
     3001 ttatttttca aagtttaaca tgttcttcaa taggctcact aatgaagtca gatttaacag
     3061 aaaggggaaa taggtcatta ttttcagtat ccatttttaa aatgtgtatt tgtttaaata
     3121 aaatggtttg tgtaattttg agaattctta aggaaagtcc agatctcatt tagtgatggc
     3181 tgagcttttg atatgcagga gtaacctgga atatttcaaa aactgaaaaa catcttgtca
     3241 ctgtaatgct atataagtca ataaagagtt gagcata
//
