LOCUS       NM_028902               2867 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus heat shock transcription factor 2 binding protein
            (Hsf2bp), mRNA.
ACCESSION   NM_028902 XM_484622 XM_904809
VERSION     NM_028902.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2867)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2867)
  AUTHORS   Bi,J., Zhang,J., Ke,M., Wang,T., Wang,M., Liu,W., Du,Z., Ren,Y.,
            Zhang,S., Wu,Z., Lv,Y. and Wu,R.
  TITLE     HSF2BP protects against acute liver injury by regulating
            HSF2/HSP70/MAPK signaling in mice
  JOURNAL   Cell Death Dis 13 (9), 830 (2022)
   PUBMED   36167792
  REMARK    GeneRIF: HSF2BP protects against acute liver injury by regulating
            HSF2/HSP70/MAPK signaling in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2867)
  AUTHORS   Guan,Y., Lin,H., Leu,N.A., Ruthel,G., Fuchs,S.Y., Busino,L., Luo,M.
            and Wang,P.J.
  TITLE     SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early
            meiotic recombination
  JOURNAL   Nucleic Acids Res 50 (9), 5129-5144 (2022)
   PUBMED   35489071
REFERENCE   4  (bases 1 to 2867)
  AUTHORS   Dahlet,T., Truss,M., Frede,U., Al Adhami,H., Bardet,A.F., Dumas,M.,
            Vallet,J., Chicher,J., Hammann,P., Kottnik,S., Hansen,P., Luz,U.,
            Alvarez,G., Auclair,G., Hecht,J., Robinson,P.N., Hagemeier,C. and
            Weber,M.
  TITLE     E2F6 initiates stable epigenetic silencing of germline genes during
            embryonic development
  JOURNAL   Nat Commun 12 (1), 3582 (2021)
   PUBMED   34117224
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2867)
  AUTHORS   Felipe-Medina,N., Caburet,S., Sanchez-Saez,F., Condezo,Y.B., de
            Rooij,D.G., Gomez-H,L., Garcia-Valiente,R., Todeschini,A.L.,
            Duque,P., Sanchez-Martin,M.A., Shalev,S.A., Llano,E., Veitia,R.A.
            and Pendas,A.M.
  TITLE     A missense in HSF2BP causing primary ovarian insufficiency affects
            meiotic recombination by its novel interactor C19ORF57/BRME1
  JOURNAL   Elife 9, e56996 (2020)
   PUBMED   32845237
  REMARK    GeneRIF: A missense in HSF2BP causing primary ovarian insufficiency
            affects meiotic recombination by its novel interactor
            C19ORF57/BRME1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2867)
  AUTHORS   Wu,Y., Liao,S., Wang,X., Wang,S., Wang,M. and Han,C.
  TITLE     HSF2BP represses BNC1 transcriptional activity by sequestering BNC1
            to the cytoplasm
  JOURNAL   FEBS Lett 587 (14), 2099-2104 (2013)
   PUBMED   23707421
  REMARK    GeneRIF: HSF2BP may play a pivotal role in regulating BNC1
            transcriptional activity and subcellular localization during
            spermatogenesis.
REFERENCE   7  (bases 1 to 2867)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 2867)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   9  (bases 1 to 2867)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   10 (bases 1 to 2867)
  AUTHORS   Davisson,M.T., Bechtel,L.J., Akeson,E.C., Fortna,A., Slavov,D. and
            Gardiner,K.
  TITLE     Evolutionary breakpoints on human chromosome 21
  JOURNAL   Genomics 78 (1-2), 99-106 (2001)
   PUBMED   11707078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV650538.1 and AK016553.1.
            
            On or before Jul 25, 2009 this sequence version replaced
            XM_904809.3, XM_484622.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016553.1, LC424536.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DV650538.1         1-28
            29-2867             AK016553.1         14-2852
FEATURES             Location/Qualifiers
     source          1..2867
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.25 cM"
     gene            1..2867
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /note="heat shock transcription factor 2 binding protein"
                     /db_xref="GeneID:74377"
                     /db_xref="MGI:MGI:1921627"
     exon            1..64
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1033
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /note="meiotic localizer of BRCA2"
                     /codon_start=1
                     /product="heat shock factor 2-binding protein"
                     /protein_id="NP_083178.1"
                     /db_xref="CCDS:CCDS50056.1"
                     /db_xref="GeneID:74377"
                     /db_xref="MGI:MGI:1921627"
                     /translation="MAATVGDGSGTEEACRNMESKEEFVKVRKKDLERLTTEVMQIRD
                     FLPRILNGELLESFQKLKMVEKNLERKEQELEQLIMDREHFKARLETAQADSGREKKE
                     KLALRQQLNEAKQQLLQQAEYCTQMGAVTCTLLWGVSSSEEVVKTILGGDKALKFFNI
                     TGQTMESFVKSLDGDVKEVDSDENQFVFALAGIVTNVAAIACGREFLVNSSRVLLDTM
                     LQLLGDLKPGQCTKLKVLMLMSLYNVSINSKGLKYITESPGFIPLLWWLLSDPDAEVC
                     LHTLRLIQSVVLEPDVFSKVASELQSSLPLQRILAMSKSRNSHLQSAAQELLEDLRAL
                     DCNV"
     exon            65..215
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /inference="alignment:Splign:2.1.0"
     exon            216..319
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /inference="alignment:Splign:2.1.0"
     exon            320..469
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..602
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..720
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..824
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..2867
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1520..1525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /note="hexamer: AATAAA"
     regulatory      1548..1553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /note="hexamer: AATATA"
     polyA_site      1554
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /note="major polyA site"
     polyA_site      1569
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
     regulatory      1705..1710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /note="hexamer: ATTAAA"
     polyA_site      1730
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
                     /note="hexamer: AATGAA"
     polyA_site      2082
                     /gene="Hsf2bp"
                     /gene_synonym="4932437G14Rik; Meilb2"
ORIGIN      
        1 agctgaggca gcggctatgg ccgcaaccgt gggcgacggg tccggtactg aggaggcctg
       61 ccggaacatg gaatctaaag aagaatttgt taaagtcaga aagaaggacc tggaacggct
      121 gacgacggaa gtgatgcaaa tacgggactt cttacccaga atactaaatg gggagttact
      181 ggaaagtttc cagaaattaa agatggtaga aaaaaacctg gaaagaaaag aacaagaatt
      241 agagcaactg ataatggacc gtgaacactt caaagcccgg ctagaaactg cacaggcaga
      301 cagtgggagg gagaagaagg agaagttggc tcttcgacag cagctgaatg aggcaaaaca
      361 gcagctcctc cagcaggcag agtattgcac acaaatggga gctgtcacct gtaccctcct
      421 ctggggggtt tccagcagcg aggaggtcgt caaaaccatt ctaggaggag acaaagcatt
      481 gaagtttttc aacataactg gccagacgat ggagagtttt gtgaagtcat tggatgggga
      541 tgtcaaggag gttgattctg atgaaaatca atttgtcttt gcactggctg gaattgtaac
      601 aaatgttgcc gccattgcgt gtggtcgtga attcttggtg aattccagcc gggtgctcct
      661 ggacaccatg ttgcagctgc tgggggactt aaagcctggc cagtgcacca aactcaaagt
      721 tctaatgctg atgtccctgt ataatgtgag catcaattca aaaggcttga aatacatcac
      781 tgagagtcct ggatttatcc ctttgctgtg gtggcttttg agtgatccag acgcggaagt
      841 gtgtcttcat accctgcggc tcatccagtc tgtggttcta gaaccagacg tcttctccaa
      901 ggtggcctct gagctccaga gctccttacc cttgcagcgc atcctggcca tgtccaagag
      961 ccgcaactcc cacctgcagt ctgctgccca ggagctcctg gaagacctcc gcgccctgga
     1021 ctgtaatgtt tagatgtgct ctaccaccag gagcccggtg aaaatgccag tggtccatcc
     1081 cctcccaggc ttctaactcc atgttcaaaa ctagatgtca ctgtatgtca tgtgttagag
     1141 attgcaggcc ttgagggact agagatggac atgatgggtc agcatcctac ctcttcctcc
     1201 tgggagtgca cacttgttag gcagctggtt aatcttgcca gagcagtgac caaaaaaatg
     1261 tcacctttga atgcatggaa actctcaaag tgttttctca gagtagcttc ttgctgcccc
     1321 ggaggctgcc tgcagcatgg gagtttagat cactaaacac catggtcagt gtttcccaga
     1381 agcatttctg tgatggcctg tgctcttccc ctggtaactg gaacccctcc gcacaggctt
     1441 accaacctag ccttttgtcg cttactattt cacatgcatc ggacagtcga tctctgtctt
     1501 ggtgctgctt ttatttttga ataaagctga gtcagtatca cattctcaat ataatcttgg
     1561 gtttaggaag tggtgtcctt tgtacattaa ctatgttatt tgtctaggaa aacactttcc
     1621 ttattttgtt ctggcccctt cactatgaac ttaaagcaaa tgtgggaagg tagcttgaag
     1681 atgaacacta tgagattaaa ttccattaaa tggtcatcca tctgcctgca ctcatgtgcc
     1741 tgtgcatgtg tgggctgctg ttcatgcagc catgacacta cgtagcttct gcttaaagat
     1801 actggcagag gacaaaagac aacatgctgc cctgtcacaa atagggagat gtgcggcagg
     1861 agatgtccat ttaagtcagc atacaccatc ccttctctgg caggacaagt tgctgcaggg
     1921 cattgagctt agacatcctg tgagggagga agtgtccctt tgcagtggca gcctcggcac
     1981 acatgttgag ctgcttctct gtgtgtggtg ttgtagagtg agttcgtttt cttgtaagag
     2041 gatgtgtgct ttatgttgaa tgaagaactc aagagaaagg catggccgct tgggtctgtg
     2101 gagcactaac tcggcagagc aaggtagagg taaagcgctt acgattcatg gaggggagca
     2161 ggcatgggtc caccatctgt gctgggcggc tccccgtgaa gggtaagtga gtgcacatgg
     2221 tggcgtcatg gcaccccttc cttctgcttg tttaacatcc tagccagggg agctgcagtg
     2281 atccgcttgt gcttctctag ggttgctgag ctttctctac caaaaaggcc tcacctagtg
     2341 tagataagaa taaaccgcca gccacgtggt ggtgggacgc acctttatct cagcactcgg
     2401 gaggctgagg caagcagatc tttgtgagtt cctggacagc aagggctgca cagagaaaca
     2461 ctgtctcaaa caacaaaaca aaacaaaaca aaacaaaaca aaacaaaaca aaacaaaaca
     2521 aaaatgagaa ggaggaggag gaagaaggaa agaaaagctg cagtagcagc ccctgctgcc
     2581 taccctaagt atcctggggg tggcggttat tagatggcca tgagcgcttg atcatccctt
     2641 ctgttctgag cacattctaa gcaagtatct ttgggcagat tctcctacaa ttgctatgca
     2701 caggtttcct ttgtgagcag tgtagggagt accaaaggac ccaggccagt gaccctactc
     2761 ttcactgcaa gtccaatagg aaatcatggc ctccttaatt ttcttctgta tctagtaatt
     2821 taaagaaaac ctactcagct aaaaaaataa aaatataaat tgaggtg
//
