LOCUS       NM_008297               2623 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus heat shock factor 2 (Hsf2), mRNA.
ACCESSION   NM_008297
VERSION     NM_008297.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Yoshimura,S., Shimada,R., Kikuchi,K., Kawagoe,S., Abe,H.,
            Iisaka,S., Fujimura,S., Yasunaga,K.I., Usuki,S., Tani,N., Ohba,T.,
            Kondoh,E., Saio,T., Araki,K. and Ishiguro,K.I.
  TITLE     Atypical heat shock transcription factor HSF5 is critical for male
            meiotic prophase under non-stress conditions
  JOURNAL   Nat Commun 15 (1), 3330 (2024)
   PUBMED   38684656
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   de Thonel,A., Ahlskog,J.K., Daupin,K., Dubreuil,V., Berthelet,J.,
            Chaput,C., Pires,G., Leonetti,C., Abane,R., Barris,L.C., Leray,I.,
            Aalto,A.L., Naceri,S., Cordonnier,M., Benasolo,C., Sanial,M.,
            Duchateau,A., Vihervaara,A., Puustinen,M.C., Miozzo,F.,
            Fergelot,P., Lebigot,E., Verloes,A., Gressens,P., Lacombe,D.,
            Gobbo,J., Garrido,C., Westerheide,S.D., David,L., Petitjean,M.,
            Taboureau,O., Rodrigues-Lima,F., Passemard,S., Saberan-Djoneidi,D.,
            Nguyen,L., Lancaster,M., Sistonen,L. and Mezger,V.
  TITLE     CBP-HSF2 structural and functional interplay in Rubinstein-Taybi
            neurodevelopmental disorder
  JOURNAL   Nat Commun 13 (1), 7002 (2022)
   PUBMED   36385105
  REMARK    Erratum:[Nat Commun. 2023 Sep 28;14(1):6067. doi:
            10.1038/s41467-023-41869-4.. PMID: 37770591]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Goodson,M.L., Park-Sarge,O.K. and Sarge,K.D.
  TITLE     Tissue-dependent expression of heat shock factor 2 isoforms with
            distinct transcriptional activities
  JOURNAL   Mol Cell Biol 15 (10), 5288-5293 (1995)
   PUBMED   7565677
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Revel,F., Renard,J.P. and Duranthon,V.
  TITLE     PCR-generated cDNA libraries from reduced numbers of mouse oocytes
  JOURNAL   Zygote 3 (3), 241-250 (1995)
   PUBMED   8903793
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Yang,X., Dale,E.C., Diaz,J. and Shyamala,G.
  TITLE     Estrogen dependent expression of heat shock transcription factor:
            implications for uterine synthesis of heat shock proteins
  JOURNAL   J Steroid Biochem Mol Biol 52 (5), 415-419 (1995)
   PUBMED   7748806
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Sarge,K.D., Park-Sarge,O.K., Kirby,J.D., Mayo,K.E. and
            Morimoto,R.I.
  TITLE     Expression of heat shock factor 2 in mouse testis: potential role
            as a regulator of heat-shock protein gene expression during
            spermatogenesis
  JOURNAL   Biol Reprod 50 (6), 1334-1343 (1994)
   PUBMED   8080921
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Sarge,K.D., Zimarino,V., Holm,K., Wu,C. and Morimoto,R.I.
  TITLE     Cloning and characterization of two mouse heat shock factors with
            distinct inducible and constitutive DNA-binding ability
  JOURNAL   Genes Dev 5 (10), 1902-1911 (1991)
   PUBMED   1717345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053976.1, AK052270.1 and BB823041.1.
            
            On Apr 11, 2009 this sequence version replaced NM_008297.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052270.1, BC018414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-805               AK053976.1         2-806
            806-966             AK052270.1         705-865
            967-967             AK053976.1         1000-1000
            968-2615            AK052270.1         867-2514
            2616-2623           BB823041.1         466-473
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.19 cM"
     gene            1..2623
                     /gene="Hsf2"
                     /note="heat shock factor 2"
                     /db_xref="GeneID:15500"
                     /db_xref="MGI:MGI:96239"
     exon            1..217
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1678
                     /gene="Hsf2"
                     /note="HSF 2; HSTF 2; heat shock transcription factor 2"
                     /codon_start=1
                     /product="heat shock factor protein 2"
                     /protein_id="NP_032323.3"
                     /db_xref="CCDS:CCDS23852.1"
                     /db_xref="GeneID:15500"
                     /db_xref="MGI:MGI:96239"
                     /translation="MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRF
                     AKEILPKYFKHNNMASFVRQLNMYGFRKVVHIESGIIKQERDGPVEFQHPYFKQGQDD
                     LLENIKRKVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKE
                     VSELRAKHAQQQQVIRKIVQFIVTLVQNNQLVSLKRKRPLLLNTNGAPKKNLYQHIVK
                     EPTDNHHHKVPHSRTEGLKSRERISDDIIIYDVTDDNVDEENIPVIPETNEDVVVDSS
                     NQYPDIVIVEDDNEDEYAPVIQSGEQSEPAREPLRVGSAGSSSPLMSSAVQLNGSSSL
                     TSEDPVTMMDSILNDNINLLGKVELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDS
                     ENKGLEATKSSVVQHVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNSASAIEQGSTTA
                     SSEVVPSVDKPIEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPL
                     DSDMPLLDS"
     exon            218..326
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            327..454
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            455..579
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            580..655
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..717
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..805
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..954
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1191
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1297
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1382
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..2623
                     /gene="Hsf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2326..2331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf2"
                     /note="hexamer: AATAAA"
     polyA_site      2349
                     /gene="Hsf2"
                     /note="major polyA site"
     regulatory      2600..2605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf2"
                     /note="hexamer: AATAAA"
     polyA_site      2620
                     /gene="Hsf2"
ORIGIN      
        1 gtggtgtgcg ttccccggag cagcagctgc tgccaccgcc gctgctgccg ccgccgccgc
       61 cgccgccgcc gctgcgacct ccgcgttcgg tagtagaatt tggaatccct gcaccgggct
      121 aacaatgaag cagagttcca acgtgccggc tttcctcagc aagctgtgga cgcttgtgga
      181 ggaaacccac accaacgagt tcatcacctg gagtcagaat ggacaaagtt ttctggtctt
      241 ggatgagcaa agatttgcaa aggaaattct tcctaagtac ttcaaacaca ataacatggc
      301 gagctttgtg agacaactaa atatgtatgg cttccgaaaa gtagtgcata tcgaatctgg
      361 aattatcaaa caggaaagag atggccctgt tgaatttcag catccttatt tcaagcaagg
      421 ccaggatgac ctgttggaga acattaaaag gaaggtttca tcttcaaaac cagaggaaaa
      481 taaaattcgt caggaagatt taacaaaaat tattagtagt gctcagaagg ttcaaataaa
      541 acaagaaact attgagtcca ggctttcaga attaaaaagt gagaatgaat ccctttggaa
      601 ggaggtgtca gaactaagag caaagcatgc ccagcagcaa caagttattc ggaagattgt
      661 ccagtttatt gttacattgg ttcagaataa tcaacttgtg agtttaaaac gtaaaaggcc
      721 tctacttcta aacacaaatg gagccccaaa gaagaatcta tatcagcaca tagtcaaaga
      781 accaactgat aatcaccatc ataaagttcc acacagcagg actgaaggtt taaagtcaag
      841 agaacggatt tcagatgaca taattattta tgatgttact gacgataatg tggatgaaga
      901 aaatattcca gttattccag aaacaaatga ggatgttgta gtggattcct ccaaccagta
      961 tcctgacatt gtcattgttg aagatgacaa cgaggatgag tatgctcctg tcattcagag
     1021 tggagagcag agtgaaccag ccagagaacc cttacgtgtg gggagtgctg gcagcagcag
     1081 ccctctcatg tctagtgctg tccagctaaa cggctcctcc agtctgacct cagaagaccc
     1141 tgtgaccatg atggactcca ttctgaatga caacattaac ctgttaggaa aggttgagct
     1201 gttggattac cttgacagta ttgattgcag tttagaggac ttccaagcta tgctctcagg
     1261 aagacagttt agcatagacc cagatcttct ggttgattct gagaataagg gactagaagc
     1321 taccaagagc agtgttgttc aacatgtgtc agaagaggga agaaaatcta aatccaagcc
     1381 agacaaacaa cttatccagt atactgcctt tccacttctt gcattcctgg atgggaactc
     1441 tgcatctgct attgaacagg ggagtacaac tgcatcgtca gaagttgtgc cttctgtaga
     1501 taaacccata gaagtcgatg agctcctgga tagcagcctg gatccagaac cgacccagag
     1561 taagcttgtc cgcctggaac cattgactga agcggaagct agtgaagcca cactcttcta
     1621 tttatgtgaa cttgctcctg cacctctgga tagtgatatg ccgcttttag atagttaaac
     1681 tcccaagtgg acactgtata tattcatcaa aatgatgaag tatttatttt aaagtatcat
     1741 ttggtacttt gttctgtaaa ttactttttg tttaatccga tactgtggaa tcaaagcacc
     1801 ttttgctttt ctcactaacc atactctcac atagctttca gatgctactc gactgcctag
     1861 gcatatacgt tttaatgcac attactggca tatcttaagt tcaattcaaa tggccatttt
     1921 ctccagttgt aattggattt tttttttttt tttttttttt ttttttacaa atatgaccat
     1981 taatcccagc taaacttgtt tattttcaat tgagtttaag tgtctagaac taaagtagaa
     2041 aactctggcc cagttacttt tattaaatat ttttcacttg gcttatttct aaaactggga
     2101 acataaagtg cctgtatctt gtaatatttc atgtctttgt tggttcagag aaatttattc
     2161 ctgttagcag aaacggcaaa gtgtacacga gtactcagtc actgatgtgg tactagctcc
     2221 agatacatag agaatgtgga gaccgggtgt gcttagcccc acccatttag actagtttaa
     2281 gtatgttttc tggtttttgt tcttttgaac catggtattt agtaaaataa atatgatgga
     2341 tgtcgagtac tattgtttgt tgagtcgtct ttggaagtga tcccacatga agtggttttt
     2401 ccttctcata ggaagaaggt ggctttaaat tgtgttgtcc attatcacac tgtgagtcac
     2461 atcagggtct ttgtgcttta cctgggaggg gcggggggag actgtgtatt gcagtatggg
     2521 aggaatatga tgcttctgac cttaatgtgt tttaatgttc tttgtttaaa aagtatactg
     2581 gcttgctttc tatgtttcta ataaagaacc aagagaaaaa ttc
//
