LOCUS       NM_001331153            2368 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus heat shock factor 1 (Hsf1), transcript variant 2,
            mRNA.
ACCESSION   NM_001331153 XM_006520472
VERSION     NM_001331153.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2368)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2368)
  AUTHORS   Liu,W., Xia,S., Yao,F., Huo,J., Qian,J., Liu,X., Bai,L., Song,Y.
            and Qian,J.
  TITLE     Deactivation of the Unfolded Protein Response Aggravated Renal AA
            Amyloidosis in HSF1 Deficiency Mice
  JOURNAL   Mol Cell Biol 44 (5), 165-177 (2024)
   PUBMED   38758542
  REMARK    GeneRIF: Deactivation of the Unfolded Protein Response Aggravated
            Renal AA Amyloidosis in HSF1 Deficiency Mice.
REFERENCE   3  (bases 1 to 2368)
  AUTHORS   Dai,C. and Sampson,S.B.
  TITLE     HSF1: Guardian of Proteostasis in Cancer
  JOURNAL   Trends Cell Biol 26 (1), 17-28 (2016)
   PUBMED   26597576
  REMARK    Review article
REFERENCE   4  (bases 1 to 2368)
  AUTHORS   Jiang,S., Tu,K., Fu,Q., Schmitt,D.C., Zhou,L., Lu,N. and Zhao,Y.
  TITLE     Multifaceted roles of HSF1 in cancer
  JOURNAL   Tumour Biol 36 (7), 4923-4931 (2015)
   PUBMED   26108999
  REMARK    Review article
REFERENCE   5  (bases 1 to 2368)
  AUTHORS   Home,T., Jensen,R.A. and Rao,R.
  TITLE     Heat shock factor 1 in protein homeostasis and oncogenic signal
            integration
  JOURNAL   Cancer Res 75 (6), 907-912 (2015)
   PUBMED   25724679
  REMARK    Review article
REFERENCE   6  (bases 1 to 2368)
  AUTHORS   Neueder,A., Achilli,F., Moussaoui,S. and Bates,G.P.
  TITLE     Novel isoforms of heat shock transcription factor 1, HSF1gammaalpha
            and HSF1gammabeta, regulate chaperone protein gene transcription
  JOURNAL   J Biol Chem 289 (29), 19894-19906 (2014)
   PUBMED   24855652
  REMARK    GeneRIF: after heat shock, HSF1gamma isoforms are exported from the
            nucleus more rapidly or degraded more quickly than HSF1alpha or
            HSF1beta
REFERENCE   7  (bases 1 to 2368)
  AUTHORS   Vihervaara,A. and Sistonen,L.
  TITLE     HSF1 at a glance
  JOURNAL   J Cell Sci 127 (Pt 2), 261-266 (2014)
   PUBMED   24421309
  REMARK    Review article
REFERENCE   8  (bases 1 to 2368)
  AUTHORS   Zhang,Y., Koushik,S., Dai,R. and Mivechi,N.F.
  TITLE     Structural organization and promoter analysis of murine heat shock
            transcription factor-1 gene
  JOURNAL   J Biol Chem 273 (49), 32514-32521 (1998)
   PUBMED   9829985
REFERENCE   9  (bases 1 to 2368)
  AUTHORS   Goodson,M.L. and Sarge,K.D.
  TITLE     Regulated expression of heat shock factor 1 isoforms with distinct
            leucine zipper arrays via tissue-dependent alternative splicing
  JOURNAL   Biochem Biophys Res Commun 211 (3), 943-949 (1995)
   PUBMED   7598726
REFERENCE   10 (bases 1 to 2368)
  AUTHORS   Sarge,K.D., Zimarino,V., Holm,K., Wu,C. and Morimoto,R.I.
  TITLE     Cloning and characterization of two mouse heat shock factors with
            distinct inducible and constitutive DNA-binding ability
  JOURNAL   Genes Dev 5 (10), 1902-1911 (1991)
   PUBMED   1717345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157566.6, CB245398.1, BQ445304.1, BU925102.1 and AK075651.1.
            
            On Sep 10, 2016 this sequence version replaced XM_006520472.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. It encodes
            isoform gammabeta which is shorter compared to isoform gammaalpha.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KM043055.1, ERR3363658.5137449.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC157566.6         158987-159025       c
            40-727              CB245398.1         1-688
            728-1216            BQ445304.1         108-596
            1217-1369           BU925102.1         1-153
            1370-1453           AC157566.6         137172-137255       c
            1454-1900           BU925102.1         154-600
            1901-2368           AK075651.1         1511-1978
FEATURES             Location/Qualifiers
     source          1..2368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.95 cM"
     gene            1..2368
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /note="heat shock factor 1"
                     /db_xref="GeneID:15499"
                     /db_xref="MGI:MGI:96238"
     exon            1..356
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1835
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /note="isoform gammabeta is encoded by transcript variant
                     2; heat shock factor protein 1"
                     /codon_start=1
                     /product="heat shock factor protein 1 isoform gammabeta"
                     /protein_id="NP_001318082.1"
                     /db_xref="CCDS:CCDS88785.1"
                     /db_xref="GeneID:15499"
                     /db_xref="MGI:MGI:96238"
                     /translation="MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSF
                     HVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHP
                     CFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLA
                     MKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNS
                     AHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSP
                     LASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSI
                     LRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDNLARAPQMSGVARLFP
                     CPSSFLHGRVQPGNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDIQELLSPQEP
                     PRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDY
                     TDDPTISLLTGTEPHKAKDPTVS"
     exon            357..465
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..602
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..727
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..803
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..865
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..962
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1099
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1369
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1453
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1559
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1629
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..2368
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2112..2117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /note="hexamer: CATAAA"
     polyA_site      2136
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /note="major polyA site"
     regulatory      2164..2169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /note="hexamer: AATAAA"
     polyA_site      2187
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /note="major polyA site"
     regulatory      2223..2228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /note="hexamer: AATATA"
     regulatory      2250..2255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
                     /note="hexamer: GATAAA"
     polyA_site      2255
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
     polyA_site      2270
                     /gene="Hsf1"
                     /gene_synonym="Hsf1alpha; Hsf1beta; HSTF; HSTF 1"
ORIGIN      
        1 cgcaagggct gggccggcaa agtaggcagg ggagatcacg gcgcctgcgc acagaggcta
       61 caggtctggc cctagcgaga gcgcgccggt cgcaagatgg ctgcggccat gcgaggcctt
      121 gctgtgtgtg cgcagcgggc ggcggagcgg cccggacggc aggggcagcg acgacactag
      181 ctcagccttc agccactctt ctaaaaggcc accccagcct ctgcctgctt tcgtccgaga
      241 tggatctggc cgtgggcccc ggtgcagcgg ggcccagcaa cgtcccggcc ttcctaacca
      301 agctgtggac cctcgtgagc gacccggaca cagacgcgct catctgctgg agcccgagtg
      361 ggaacagctt ccacgtgttt gaccagggcc agtttgccaa ggaggtgctg cccaagtact
      421 tcaagcacaa caacatggct agcttcgtgc ggcagctcaa catgtatggc ttccgaaaag
      481 tagtccacat tgagcagggt ggcctggtca agcctgagag agatgacacc gagttccagc
      541 atccttgttt cttgcgtgga caggaacagc tccttgagaa catcaagagg aaagtgacca
      601 gcgtgtccac cctgaagagt gaggacataa aaatacgcca ggacagtgtc acccggctgt
      661 tgacagatgt gcagctgatg aaggggaaac aggagtgtat ggactccaag ctcctggcca
      721 tgaagcacga gaacgaggcc ctgtggcggg aggtggccag ccttcggcag aagcatgccc
      781 agcagcaaaa agttgtcaac aagctcattc agttcctgat ctcactggtg cagtcgaacc
      841 ggatcctggg ggtgaagaga aagatccctc tgatgttgag tgacagcaac tcagcacact
      901 ctgtgcccaa gtatggtcga cagtactccc tggagcatgt ccatggtcct ggcccatact
      961 cagctccatc tccagcctac agcagctcta gcctttactc ctctgatgct gtcaccagct
     1021 ctggacccat aatctccgat atcactgagc tggctcccac cagccctttg gcctccccag
     1081 gcaggagcat agatgagagg cctctgtcca gcagcactct ggtccgtgtc aagcaagagc
     1141 cccccagccc acctcacagc cctcgggtac tggaggcgag ccctgggcgc ccatcctcca
     1201 tggatacccc tttgtcccca actgccttca ttgactccat ccttcgagag agcgagccta
     1261 cccctgctgc ctcaaacaca gcccctatgg acacaaccgg agcccaagcc cccgcactcc
     1321 cgaccccctc cacccctgag aagtgcctca gcgtagcctg cctagacaat ttggctcgcg
     1381 ctccacagat gtctggggtc gcccgcctct tcccctgccc ctcttccttt ctgcatggcc
     1441 gagtccagcc agggaacgag ctaagtgatc acctggatgc catggactcc aacctggaca
     1501 acctgcagac catgctgaca agccacggct tcagtgtgga caccagtgcc ctgctggaca
     1561 ttcaggagct tctgtctcca caagagcctc ccaggcctat tgaggcagag aacagtaacc
     1621 ccgactcagg aaagcagctg gtgcactaca cggctcagcc tctgttcctg ctggatcctg
     1681 atgctgtgga cacagggagc agtgagctgc ctgtgctctt tgagctgggg gagagctcct
     1741 acttctctga gggggatgac tacacggatg atcccaccat ctctcttctg acaggcactg
     1801 aaccccataa agccaaggac cccactgtct cctagagctc tcaggagttg tcaggctggc
     1861 ttgtgcctgg cccccaacct atccctagga catggctggt cctagggaga caaaacagtt
     1921 gggtagtcca ggggacccta ggtcaagtca ccacaacccc agtggagcac agatggaact
     1981 tggtcctggg cagtaccttg gatcaggagg aagatcctga gggctgcata cctgctgcct
     2041 ttaccccagc cccaggtcta ctctctggtc acagcttcac agccacactt ggactgaccc
     2101 tgcaggttgt tcataaaatt gtattttgga tttttacatg agagtcccct ttaacccttc
     2161 acaaataaat atatatatac atacatacat acatacatac atatatatat atatatgtat
     2221 ataatatatg cacacagaga tggtcagatg ataaacaggc tctactgtga ccacctgtat
     2281 gtttccccct gccctgcggg accccgacgg tggaatgtag gcagagctca gacctcacta
     2341 catctccttg gaagatactt gcaaggct
//
