LOCUS       NM_001270429            1645 bp    mRNA    linear   ROD 01-FEB-2024
DEFINITION  Mus musculus hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
            steroid delta-isomerase 8 (Hsd3b8), mRNA.
ACCESSION   NM_001270429 XM_001480492
VERSION     NM_001270429.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1645)
  AUTHORS   Clarke,T.R., Bain,P.A., Burmeister,M. and Payne,A.H.
  TITLE     Isolation and characterization of several members of the murine
            Hsd3b gene family
  JOURNAL   DNA Cell Biol 15 (5), 387-399 (1996)
   PUBMED   8924213
REFERENCE   2  (bases 1 to 1645)
  AUTHORS   Park,C.H., Abbaszade,I.G. and Payne,A.H.
  TITLE     Expression of multiple forms of 3 beta-hydroxysteroid dehydrogenase
            in the mouse liver during fetal and postnatal development
  JOURNAL   Mol Cell Endocrinol 116 (2), 157-164 (1996)
   PUBMED   8647315
REFERENCE   3  (bases 1 to 1645)
  AUTHORS   Bain,P.A., Meisler,M.H., Taylor,B.A. and Payne,A.H.
  TITLE     The genes encoding gonadal and nongonadal forms of 3
            beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are
            closely linked on mouse chromosome 3
  JOURNAL   Genomics 16 (1), 219-223 (1993)
   PUBMED   8486361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139379.4.
            
            On Jul 6, 2012 this sequence version replaced XM_001480492.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW475425.1, BG970094.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC139379.4         166628-166713       c
            87-283              AC139379.4         165998-166194       c
            284-448             AC139379.4         159935-160099       c
            449-1645            AC139379.4         155246-156442       c
FEATURES             Location/Qualifiers
     source          1..1645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.8 cM"
     gene            1..1645
                     /gene="Hsd3b8"
                     /gene_synonym="Gm10681; Hsd3b4"
                     /note="hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 8"
                     /db_xref="GeneID:100043456"
                     /db_xref="MGI:MGI:3711284"
     exon            1..86
                     /gene="Hsd3b8"
                     /gene_synonym="Gm10681; Hsd3b4"
                     /inference="alignment:Splign:2.1.0"
     exon            87..283
                     /gene="Hsd3b8"
                     /gene_synonym="Gm10681; Hsd3b4"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1260
                     /gene="Hsd3b8"
                     /gene_synonym="Gm10681; Hsd3b4"
                     /EC_number="1.1.1.-"
                     /note="3 beta-hydroxysteroid dehydrogenase type 4; 3
                     beta-hydroxysteroid dehydrogenase type IV;
                     3-beta-hydroxy-5-ene steroid dehydrogenase;
                     NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid
                     dehydrogenase; Progesterone reductase; 3-beta-HSD IV"
                     /codon_start=1
                     /product="hydroxy-delta-5-steroid dehydrogenase, 3 beta-
                     and steroid delta-isomerase-like"
                     /protein_id="NP_001257358.1"
                     /db_xref="CCDS:CCDS57247.1"
                     /db_xref="GeneID:100043456"
                     /db_xref="MGI:MGI:3711284"
                     /translation="MPGWSCLVTGAGGFLGQRIVRMLVQEEELQEIRALFRTFGRKQE
                     EELSKLQTKTKVTVLKGDILDAQCLKRACQGMSAVIHTAAAIDPLGAASRQTILDVNL
                     KGTQLLLDACVEANVPTFIYSSSVLVAGPNSYKEIILNAHEEEHHESTWSNPYPYSKK
                     MAEKAVLAANGSILKNGGTLHTCALRLSFIYGEECQVTSTTVKTALKNNSIIKKNATF
                     SIANPVYVGNAAWAHILAARSLQDPKKSPSIQGQFYYITDDTPHQSYDDLKCTLSKEW
                     GLRLDTSWSLPLPLLYWLAFLLETVSFLLRPVYNYRPPFNRLLITVLNSVFTFSYKKA
                     QRDLGYEPLVSWEEAKQKTSEWIGTLVMQHREIGNKKSQ"
     exon            284..448
                     /gene="Hsd3b8"
                     /gene_synonym="Gm10681; Hsd3b4"
                     /inference="alignment:Splign:2.1.0"
     exon            449..1645
                     /gene="Hsd3b8"
                     /gene_synonym="Gm10681; Hsd3b4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacattacta gaaactgata tatcaaacaa gggagtagaa gccttgtgcc actttctctt
       61 tcctcagcct gtgcatcact tcctctgagt accttatatc acatctgcac cctcaactat
      121 ctgattcctg tgttgaccat gcctgggtgg agctgcctgg tgacaggagc aggagggttt
      181 cttggccaga ggattgtccg aatgttggtg caggaggaag agctgcagga gatcagagcc
      241 ctgttcagga ccttcggtcg aaaacaggaa gaggaattgt ccaagctgca gacaaagacc
      301 aaggtgacag tactgaaggg agacattctg gatgcccagt gcctgaagag agcctgccag
      361 ggcatgtctg ctgtcatcca caccgctgct gctattgacc cccttggtgc cgcttccaga
      421 cagaccatcc tagatgtcaa tctgaaaggt actcagctcc tactggatgc ttgtgtggaa
      481 gccaacgtgc caacattcat ctacagcagc tcagtgcttg tggctggacc aaattcctac
      541 aaggagatca tcctgaatgc ccatgaggag gagcatcatg aaagcacatg gtctaaccca
      601 tacccataca gcaaaaagat ggctgagaag gcagtgctgg cagccaatgg gagcatcctg
      661 aaaaatggtg gcactttgca tacttgtgcc ttaagactct ctttcatcta tggggaagaa
      721 tgccaagtca cttcaaccac tgtgaaaaca gcactgaaga acaacagcat aattaagaaa
      781 aatgccacat tctccatcgc caacccagtg tatgtgggca atgcagcctg ggctcacatt
      841 ctggctgcca ggagcctaca ggaccctaag aagtccccaa gcatccaagg acagttctat
      901 tacattacag atgacacccc tcaccaaagc tatgatgact taaaatgcac cctgagcaag
      961 gagtggggcc tccgccttga taccagctgg agtcttcctc tgcccctgct ctactggctt
     1021 gccttcctcc tggaaactgt gagcttcctg ctacgtccag tctacaacta tagaccacca
     1081 tttaaccgcc tcttgatcac agtgctaaat agtgtattca ccttctccta caagaaggct
     1141 cagcgagatc tgggctatga gccacttgtc agctgggagg aagccaagca gaaaacctca
     1201 gagtggatcg gaacactagt gatgcagcac agggagattg gaaacaaaaa gtcacagtga
     1261 tatgaagagg gagaggacat ggccctgggt gttattaggt cctccagaaa gggacttaga
     1321 aacaatccaa ctcttaacaa ttccatttta cactctgtcc aacttgtctt tgggtcacca
     1381 gaagccttgc aagtcactgg cccagttgca acccttcagc tctaagcact tgtccagcaa
     1441 tgcacaagat gtgcctcagc tgctgtgacc caaggatagg tggctgatag tgagttgcct
     1501 ggaacctctt gtaggttaga atttcatcag ggcttcctca tctcctttcc atgtgccaac
     1561 gcatttcgtg tctgagaaaa ttcccatacc tttatgaagc tcaaagaaaa gaacaataaa
     1621 atcttttaat gcttaatgtg gaaaa
//
